"The main result of our study is that patients with high levels of Omega-3 fish oil in the blood appear to have a slowing of the biological aging process over five years as measured by the change in telomere length. It's also the first study that shows that a dietary factor may be able to slow down telomere shortening."
-Ramin Farzaneh-Far, M.D., of the University of California at San Francisco, lead author of "Association of Marine Omega-3 Fatty Acid Levels with Telomeric Aging in Patients with Coronary Heart Disease" JAMA 2010;303(3):250-257.
This week's big medical news story appeared in JAMA and it is one more reason why you want to be sure to get your Omega-3s everyday--while lowering your intake of the Omega-6s.
We already knew that the Omega-3s were amazing.
- They're anti-inflammatory and anti-clotting
- They prevent age-related cognitive decline
- They lower triglycerides
- They lower blood pressure
- They slow age-related macular degeneration
- They keep blood vessels flexible
- They lower depression
- They decrease joint stiffness in rheumatoid and osteo-arthritis
- They're necessary for fetal and infant brain development
So What Did The JAMA Heart And Soul Study Tell Us That We Didn't Already Know?
The UCSF researchers followed 608 outpatients with stable coronary artery disease for 5-8 years. At the start of the study they measured everyone's levels of Omega-3's and the length of their leukocyte telomeres--which is a marker of aging. Remember though--this was an observational study, not a gold-standard double-blind randomized controlled study.
Here's how the lead researcher Dr. Ramin Farzaneh-Far explains the results:
"The main result from our study is that patients with high levels of Omega-3's fish oil in the blood appear to have a slowing of the biological aging process over five years as measured by the change in telomere length.""Patients with the highest levels of Omega-3 fish oils were found to display the slowest decrease in telomere length, whereas those with the lowest levels of Omega-3 fish oils in the blood had the fastest rate of telomere shortening, suggesting that these patients were aging faster than those with the higher fish oil levels in their blood."
"By measuring telomere length at two different times we are able to see the speed at which the telomeres are shortening and that gives us some indication of how rapidly the biological aging process is taking place in these patients."
What Are Telomeres And How Exactly Do They Affect The Aging Process?
PLASTIC TIPS ON SHOELACES--that's the analogy often used to describe telomeres. They are the red caps sitting on the ends of these blue chromosomes. Just like plastic shoelace tips that keep the laces from fraying--the telomeres protect valuable genetic material needed for our cells to divide properly, and to repair worn-out cells. They are also strong markers for aging (see the graph below and get depressed). Not only do they shorten as we age, over time the telomeres can become damaged and shorten because of inflammation, smoking, obesity, or lack of exercise. Emmuanel Skorkalakes, of the Wistar Institue in Philadelphia, explains, This week's JAMA study is just one more bit of evidence that shows how our lifestyle choices can affect telomere length--and promote healthy aging. All About Omega-3's. Does It Really Have To Be Fish Oil? Yes, the JAMA study used Omega-3 fish oil, but Omega-3s really originate in green leafy plants--not in fish. Susan Allport is a medical researcher who is an expert in "all things Omega-3". She has written a brilliant article in the September 2009 issue of Prevention, "The Vanishing Youth Nutrient" that does an excellent job of explaining why we need Omega-3s in our diet, why so many physicians equate Omega-3 with fish, and why Omega-3 is sorely lacking in our diets. Click here for the article. Why Is Our Diet So High in Omega-6s, And So Low In Healthy Omega 3's? I highly recommend you read Susan Allport's article in Prevention, as well as her book, The Queen of Fats. She does an excellent job of explaining the good, the bad, and the ugly of the fat world. If you need any more convincing on the wonders of Omega-3, watch Allport's brief video, The Rat Race, comparing rats fed on diets rich in Omega-3s with those fed on diets deficient in Omega-3s. Click here if you aren't seeing the video.
"When the telomeres become short, then you start cutting into actual chromosomes where there are genes essential for our body. To prevent the fraying DNA in all those aging cells from seeding maliganant tumors, the body turns them dormant. Your body shuts down more and more cells every day and you become old."
FACEBOOK COMMENTS:


Only plants can make omega-3 fatty acids. Animals(including people) can link the basic omega-3 units into longer chains, but only plants can manufacture omega-3s. When researchers reference "omega-3 fish oil" they are ignoring this very basic fact.
Similarly, only plants can make essential amino acids for proteins. As the base of the food chain, whole plant foods are the original source of virtually all our nutrients. The only exceptions are vitamins B12 (bacteria) and D (sun).
Healthy Librarian: You are 100% right Janice. Thanks for making the point. The researchers used fish oil in their study--but why not go to the source of omega-3 with green plants, flax, chia, or walnuts? And there's always algae-sourced Omega-3s in capsules.
Wonderful article! Thank you for making the important distinction that plants are the true source of Omega-3s. Fish is neither a compassionate nor healthful food choice, and it's about time it stopped being promoted as such.