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From: Dr Gosia O'Reilly (
Subject:         similar to mine
Date: August 29, 2014 at 7:11 am PST

In Reply to: My B-12 Protocol posted by MM on August 28, 2014 at 3:02 pm:

I take mega dose of B12 daily too.

"Recent scientific studies reporting that oral supplementation (in large doses) is a better and effective option even for those with B12 malabsorption [14,15,22,23,39] (which quashes the basis for a long-held popular belief to the contrary).

In particular, the analysis in [64] suggests that despite that prevalence of the view amongst the hospital doctors that “patients with pernicious anaemia cannot absorb adequate amounts of oral vitamin B12 (cobalamin) and therefore require regular intramuscular injections“, and in spite of “concerns, which have been propagated in standard texts, about unpredictable absorption“, there exist evidence that oral cobalamin in high doses may be as effective as, and perhaps superior to injections. This is because apart from the well-known route of B12 absorption through a transport system that involves the terminal ileum and intrinsic factor, which is believed to be 60% efficient, there exists another transport system that does not depend on these two, which is believed to be 1% efficient, and which was discovered in in the 1950s and 1960s. Specifically, about 1% of a high dose of B12 gets absorbed through that system, which happens to be enough to treat the deficiency effectively."


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