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From: Kelly (
Subject:         Fructose Intolerance
Date: September 18, 2013 at 7:25 am PST

Hello Dr. Graham,

I really love your 80 10 10 book and all your food n sport
resources. Thank you so much for them!

For the last 3 months I have been attempting the 811 diet
and have had HUGE problems. Since starting I have developed
severe hypoglycaemia. and terrible symptoms after eating a
large fruit meal. I shake uncontrollably and became VERY
sleepy and faint. I went to see my Dr. and he thinks I might
Fructose Intolerance and gut fermentation. I cannot afford
to get the tests done he is suggesting though!
I'm so upset as I was desperately hoping 80 10 10 might
help my body heal from my hypothyroid condition. I've typed
out some stuff that he gave me. Would you be able to have a
read through for me?

Fruit is high in sugar in the form of fructose, which is
readily fermented. In some people this interferes with the
mechanism by which the liver corrects low blood sugar
thereby making this problem very much worse. Eating
excessive sugar at one meal, or excessive refined
carbohydrate, which is rapidly digested into sugar, can
suddenly overwhelm the muscle and the liverís normal control
of blood sugar levels.

Fructose intolerance. Fructose is fruit sugar generally
perceived to be a healthy alternative to glucose. No problem
if one is tolerant of fructose or if it is taken in small
amounts, but intolerance of fructose or excessive intake can
result in hypoglycaemia. This is because the control
mechanisms that apply to glucose are bypassed if the system
is awash with fructose. In fructose intolerance (aldolase
type B deficiency), fructose-1-phosphate builds up because
it inhibits glycogen phosphorylase which is essential for
the provision of glucose from glycogen and it also inhibits
fructose-16-biphosphatase which is essential for provision
of glucose from protein and fat. This combination can result
in severe hypoglycaemia because it means effectively the
body cannot mobilise glucose from stores in the liver for
when blood sugar levels fall. This combination can lead to
severe hypoglycaemia.

Even if the enzyme works perfectly well, excessive fructose
intake will stress the same pathways. Sugar stores in the
liver cannot be mobilised. Because liver uses up short chain
fatty acids for the production of glucose to try to avoid
this hypoglycaemia, this tendency can be measured by looking
at short chain fatty acids in the blood and also measuring
levels of fructose-6-phosphate which gets induced in this
situation. These three metabolic problems i.e. levels of
short chain fatty acids, levels of fructose-6-phosphate and
LDH isoenzyme (indicative of liver damage), can help
diagnose this problem.

I do apologise that this is so long Dr. Graham

Thank you for any help you might be able to give.

With Love


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