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From: TSS (216-119-163-25.ipset45.wt.net)
Subject: U.K. GOV. WILL ANNOUNCE A DEFINITE LINK BETWEEN SPORADIC CJD AND BSE aka MAD COW DISEASE !!!
Date: February 10, 2003 at 4:38 pm PST
Subject: Re: BSE is 'linked' to CJD deaths (SPORADIC)
Date: Mon, 10 Feb 2003 17:17:52 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@uni-karlsruhe.de
References: <3E47B779.8040300@wt.net>######## Bovine Spongiform Encephalopathy #########Greetings list members, i just got this note from another lowly sporadic CJD
family member in the UK. thought i would pass it through.
but i can imagine the wheels of politics and the work of
CJD/BSE spin artist and all the Lobbyist working right
now. it's FFC (fear factor control) and BSeee at it's finest
hour in the White House CDC/NIH/USDA/APHIS/FSIS. what will there excuse be now? i guarantee you right now, they will say its not
here, we have had an extensive BSE/CJD surveillance
system in place since pre-1990, and what they are finding
in the UK is not the same as what has been seen in the USA.
all this will be said, with CJD not being a reportable
disease but only in a handful of states, all this and only
a handful of cattle ever tested, and all this without a
CJD Questionnaire that ask not one question pertaining
to route/source. i can hear them now$$$ UK GOVERNMENT WILL ANNOUNCE A DEFINITE LINK BETWEEN SPORADIC CJD AND BSE
TOMORROW !!! TERRY I HAVE BEEN RELIABLY INFORMED BY A REPORTER THAT THE
GOVERNMENT WILL BE ANNOUNCING TOMORROW THAT A LINK BETWEEN
BSE AND SPORADIC CJD HAS BEEN ESTABLISHED.
I AM GIVING A RADIO INTERVIEW EARLY TOMORROW MORNING.
I PRAY TO GOD THAT THE GOVERNMENT WILL ADMIT TO THIS LINK
AND THIS WILL GIVE YOU THE FINAL PIECE OF EVIDENCE THAT YOU
NEED TO MAKE YOUR COUNTRY RECOGNISE THE LINK. xxxxxxxx me too/// Subject: re-BSE prions propagate as either variant CJD-like or sporadic CJD
Date: Thu, 28 Nov 2002 10:23:43 -0000
From: "Asante, Emmanuel A"
To: "'flounder@wt.net'" Dear Terry, I have been asked by Professor Collinge to respond to your
request. I am a Senior Scientist in the MRC Prion Unit and the lead
author on the paper. I have attached a pdf copy of the paper for your
attention. Thank you for your interest in the paper. In respect of your first question, the simple answer is, yes. As you
will find in the paper, we have managed to associate the alternate
phenotype to type 2 PrPSc, the commonest sporadic CJD. It is too early to be able to claim any further sub-classification in
respect of Heidenhain variant CJD or Vicky Rimmer's version. It will
take further studies, which are on-going, to establish if there are
sub-types to our initial finding which we are now reporting. The main
point of the paper is that, as well as leading to the expected new
variant CJD phenotype, BSE transmission to the 129-methionine genotype
can lead to an alternate phenotype which is indistinguishable from type
2 PrPSc. I hope reading the paper will enlighten you more on the subject. If I
can be of any further assistance please to not hesitate to ask. Best wishes. Emmanuel Asante <>
____________________________________Dr. Emmanuel A Asante
MRC Prion Unit & Neurogenetics Dept.
Imperial College School of Medicine (St. Mary's)
Norfolk Place, LONDON W2 1PG
Tel: +44 (0)20 7594 3794
Fax: +44 (0)20 7706 3272 PLEASE SEE FULL TEXT OF THIS ARTICLE; http://www.vegsource.com/talk/madcow/messages/9912118.html ROUND TABLE ON BSE -- WASHINGTON -- 27-28 JUNE 1989 snip... The summary does tend to give a particular slant to the epidemiology of
BSE which is not totally sound. It is a possibility that the agent of
BSE may be in the cattle population in a number of countries already
apart from the USA and that clinical cases are occurring on rare
occasions. It is also important to off the possibility of the
relationship between BSE and certain low-temperature rendering systems.
For that reason a number of other countries apart from the USA and
France are at risk and, in particular, the Netherlands, Denmark,
Germany and Belgium. For these reasons it would be wise to move to an
international ban on the feeding of ruminant protein to ruminants. Clearly the summary also needs to refer to the incidence of BSE in the
UK and not solely to Great Britain. No doubt this has been tidied up
in your comments on the summary conclusions. It is a pity that more of
the comments put forward by Dr. Kimberlin have not been included in the
summary since his views on page 13 are succinct and valuable... snip... http://www.bseinquiry.gov.uk/files/yb/1989/08/29003001.pdf Is there a Scrapie-like disease in cattle ? IN CONFIDENCE R.F. MARSH snip... re-mink rancher 'Wisconsin' dead stock feeder using >95%
downer or dead dairy and a few horses... http://www.bseinquiry.gov.uk/files/yb/1987/06/10004001.pdf Part of the Proceedings of an International Roundtable on Bovine
Spongiform Encephalopathy, Bethesda, Maryland, USA, June 27-28, 1989. The possibility of infection with BSE in the United States, as defined
by studies on the disease in Great Britain, is judged to be low on the
basis of the following: (1) meat and bonemeals imported into the United
States from Great Britain between 1980 and 1988 were used mainly in
poultry, not ruminant feed; (2) the Scrapie Eradication Program had
reduced the prevalence of scrapie in the United States compared with
that in Great Britain; and (3) little, if any, rendered animal products
are used for protein supplements in cattle feed in the United States.
However, there is some evidence that there may already be a scrapie-like
disease in cattle in the United States. This evidence comes from
epidemiologic studies on an incident of transmissible mink
encephalopathy (TME) in Stetsonville, Wis, in 1985. This mink farmer
used no commercially available animal by-product mixtures in his feed,
but instead slaughtered all animals going into the mink diet, which
included mostly (>95%) "downer" dairy cows, a few horses, but never
sheep. To examine the possibility that cattle may have been the source
of this incident of TME, two 6-week-old Holstein bull calves were
inoculated intracerebrally with mink brain from the affected farm. The
bulls developed neurologic disease 18 and 19 months after inoculation.
Both brains had spongiform degeneration at necropsy and both were
transmissible back to mink by either intracerebral (incubation period of
4 months) or oral (incubation period of 7 months) inoculation
Whereas TME has been thought to be caused by feeding scrapie-infected
sheep to mink, this theory has no conclusive evidence. Experimental oral
inoculation of mink with several different sources of sheep scrapie has
never been successful, and an incubation period of less than 12 months
has never (sic) produced by intracerebral inoculation. Transmissible
mink encephalopathy can develop naturally by infection with incubation
periods of less than 12 months.
There is reason to believe that scrapie has not been transmitted in the
United States from sheep to cattle by rendered protein concentrates as
it was in Great Britain. However, some circumstantial evidence exists
that cattle may be a source of some TME infections. It is recommended
that we increase our surveillance for a BSE-like disease in American
cattle by encouraging state diagnostic laboratories to formalin-fix
specimens of midbrain and brain stem from bovine brains submitted for
rabies testing. If results of these tests are negative, these fixed
tissues can then be examined for evidence of spongiform degeneration of
the gray matter.
-Comments on bovine spongiform encephalopathy
J Am Vet Med Assoc 197 (4): (1990)
Letter to the Editor, Journal of the American Veterinary Medical
Association, August 15, 1990
In my article, "Bovine spongiform encephalopathy in the United States"
(JAVMA, May 15, 1990, p 1677), I stated that "little, if any, rendered
animal products are used for protein supplements in cattle feed in the
United States." I have since learned that this is incorrect, because of
the recent trend of using less assimilated "by-pass" proteins in cattle
feed. A large amount of meat-and-bone meal is being fed to American
cattle, and this change in feeding practice has greatly increased the
risk of bovine spongiform encephalopathy (BSE) developing in the United
States.
Epidemiologic studies on BSE in Great Britain have indicated that the
disease originated in cattle by exposure to the heat-resistant
transmissible agent in compounded feed containing rendered animal
protein. The most likely source of infection was assumed to be
meat-and-bone meal prepared from scrapie-infected sheep, but it is also
possible that a heretofore unrecognized scrapie-like infection of cattle
could have been spread in the same manner.
Because of concern for the possible development of BSE in the United
States, the American rendering industry discontinued the processing of
fallen and sick sheep last December. In my opinion, this was a prudent
policy, but one that will not prevent the possible transmission of BSE
from cattle to cattle. As emphasized in my article, there is some
evidence that BSE-like infection may already exist in American cattle.
The current practice of feeding meat-and-bone meal to cattle solidifies
the most important means to perpetuate and amplify the disease cycle.
In Great Britain, BSE has produced a great economic and emotional
burden. We must take all reasonable measures to prevent BSE from
developing in the United States. Therefore, the practice of using animal
protein in cattle feed should be discontinued as soon as possible.
Waiting until the first case of BSE is diagnosed in the United States
will certainly be "closing the barn door after the horse is gone." With
a disease having a 3- to 6-year incubation period, thousands of animals
would be exposed before we recognize the problem and, if that happens,
we would be in for a decade of turmoil.
R. F. Marsh, DVM, PhD
Madison, Wis
=============
PAGE 25 Transmission Studies Mule deer transmissions of CWD were by intracerebral inoculation
and compared with natural cases resulted in a more rapidly
progressive clinical disease with repeated episodes of synocopy
ending in coma. One control animal became affected, it is believed
through contamination of inoculam (?saline). Further CWD
transmissions were carried out by Dick Marsh into ferret, mink
and squirrel monkey. Transmission occurred in _all_ of these
species with the shortest incubation period in the ferret. http://www.vegsource.com/talk/lyman/messages/7536.html http://www.vegsource.com/talk/lyman/messages/7535.html FULL TEXT OF GOA REPORT BELOW (takes a while to load) 2. Mad Cow Disease: Improvements in the Animal Feed Ban and Other
Regulatory Areas Would Strengthen U.S. Prevention Efforts. GAO-02-183,
January 25. http://www.gao.gov/cgi-bin/getrpt?GAO-02-183
============================================= Subject: SCRAPIE 'USA' ANNUAL REPORT (105 newly infected flocks 2002) &
CWD IN USA
Date: Tue, 10 Dec 2002 08:17:17 -0600
From: "Terry S. Singeltary Sr."
To: flounder@wt.netDate: Mon, 9 Dec 2002 21:21:10 -0600
Reply-To: Bovine Spongiform Encephalopathy
Sender: Bovine Spongiform Encephalopathy
From: "Terry S. Singeltary Sr."
Subject: SCRAPIE 'USA' ANNUAL REPORT (105 newly infected flocks
2002) & CWD IN USAAs of September 30, 2002, there were 45 scrapie infected and source
flocks (figure 3). There were 105 newly infected flocks, reported in
FY2002 (figure 4). In addition, 379 scrapie cases were confirmed and
reported by the National Veterinary Services Laboratories (NVSL) in FY
2002 (figure 5) and (figure 6). Five cases of scrapie in goats were
reported in FY 2002 (figure 7), the last of which was confirmed in
August 2002. New infected and source flocks numbers and the number of
these flocks released in FY 2002 are depicted in chart 4. One hundred
(100) flocks which is 67 percent of the scrapie infected and source
flocks present in FY 2002 were released or put on clean-up plans in FY2002. Slaughter Surveillance Slaughter Surveillance is currently in Phase II which is intended to
determine the prevalence of scrapie in the US culled sheep population.
Through September 2002 samples from 3,269 sheep were submitted to NVSL
for testing. Samples from a total of 6,795 sheep have been submitted
since the beginning of Phase II on April 1, 2002. Surveillance regions
are depicted in (figure 8). Scrapie Testing During FY 2002 11,751 animals have been tested for scrapie which
includes: 2,711 regular necropsy cases, 1,343 third eyelid biopsies for
the test validation project, 546 third eyelid biopsies for the
regulatory program, and approximately 7,151 animals for Phase I & II of
SOSS (chart 5). Laboratory testing has been taking 10 - 11 days on
average with a range of 3 - 34 days. Ear Tag Orders During FY 2002 9.9 million plastic and 6.0 million metal tags were
distributed by APHIS (chart 6). http://www.aphis.usda.gov/vs/nahps/scrapie/annual_report/annual-report.html NEW SCRAPIE INFECTED AND SOURCE FLOCKS http://www.aphis.usda.gov/vs/nahps/scrapie/annual_report/figure04.gif DISTRIBUTION OF CHRONIC WASTING DISEASE THROUGHOUT THE STATES (as of
Oct. 2002) http://www.aphis.usda.gov/vs/nahps/cwd/cwd-distribution.html CWD USA surveillance http://www.aphis.usda.gov/vs/nahps/cwd/cwd-state.html Subject: BSE--U.S. 50 STATE CONFERENCE CALL Jan. 9, 2001
Date: Tue, 9 Jan 2001 16:49:00 -0800
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy BSE-Lhttp://vegancowboy.org/TSS-part1of8.htm #Docket No. 01-068-1 Risk Reduction Strategies for Potential BSE
Pathways Involving Downer Cattle and Dead Stock of Cattle and Other
Species - TSS 1/21/03 (2) http://www.vegsource.com/talk/madcow/messages/9912348.html In Reply to: Docket No. 01-068-1 Risk Reduction Strategies for Potential
BSE Pathways Involving Downer Cattle and Dead Stock of Cattle and Other
Species [TSS SUBMISSION] January 21, 2003 http://www.vegsource.com/talk/madcow/messages/9912358.html Re: Docket No. 01-068-1 -- (200,000 USA DOWNERS ANNUALLY) TSS 1/21/03 http://www.vegsource.com/talk/madcow/messages/9912360.html Re: Docket No. 02N-0273 – Substances Prohibited From Use In Animal Food
Or Feed; http://www.vegsource.com/talk/madcow/messages/9912338.html # Re: [Docket No. 99-017-2] Blood and Tissue Collection at Slaughtering
Establishments [TSS SUBMISSION] http://www.vegsource.com/talk/madcow/messages/9912402.html My submission to federal gov. on BSE and
the 'lack of' surveillance; https://199.132.50.48/E-Commen.nsf/85255e6f0052055e85255d7f005ed8bc/c147d3037a26dfe285256ab000769557?OpenDocument https://199.132.50.48/E-Commen.nsf/($All)?OpenView https://199.132.50.48/E-Commen.nsf/8178b1c14b1e9b6b8525624f0062fe9f/c147d3037a26dfe285256ab000769557?OpenDocument TSS Submission will be on the 'slides' of the Jan. 19, meeting...tss http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2.htm CJD WATCH http://www.fortunecity.com/healthclub/cpr/349/part1cjd.htm CJD Watch/NEWS message board http://disc.server.com/Indices/167318.html USA GBR risk assessment on BSE _MUST_ be changed to
include all animal TSEs ASAP. GBR BSE risk assessment of the USA should be changed to
GBR III immediately. http://www.testcowsnow.com USA MAD COW cover-up http://www.vegsource.com/talk/lyman/messages/9558.html CJD WATCH http://www.fortunecity.com/healthclub/cpr/349/part1cjd.htm CJD Watch message board http://disc.server.com/Indices/167318.html TSS MADCOW http://www.vegsource.com/talk/madcow/index.html Moms death from hvCJD http://www.vegsource.com/talk/lyman/messages/7252.html 'MOMS AUTOPSY REPORT' http://www.vegsource.com/talk/lyman/messages/7548.html http://www.testcowsnow.com
tss
Terry S. Singeltary Sr. wrote:
> ######## Bovine Spongiform Encephalopathy
> #########
>
> BSE is 'linked' to CJD deaths
>
> Feb 10 2003
>
> By The Journal
>
> Families of North-East CJD victims are demanding an inquiry after a new
> study said the BSE epidemic in cattle might have caused their loved
> ones' deaths.
>
> Government health advisors meet tomorrow to discuss the findings.
>
> Until now, it has been assumed that BSE-infected meat was responsible
> for only the variant CJD - a disease identified in 1996 and affecting
> mainly young people.
>
> But experiments with mice by Prof John Collinge and colleagues at
> University College London suggest a link between BSE and what has until
> now always been known as "sporadic" or classical CJD.
>
> It has always been believed this condition was caused by a normal prion
> protein in the brain spontaneously changing into the abnormal dangerous
> form.
>
> But Prof Collinge's research suggests that many of the classical CJD
> deaths may indeed be diet-related.
>
> During the experiments mice were injected with BSE - Bovine Spongiform
> Encephalopathy - and saw them develop both the variant and sporadic
> strains.
>
> Prof Collinge said the findings may change the way in which victims of
> CJD are counselled.
>
> Prof Collinge said the findings could mean huge changes in the
> counselling of sporadic CJD patients and their families.
>
> "When you counsel those who have the classical sporadic disease, you
> tell them this is not related to what you read in the newspapers, it
> arises spontaneously out of the blue.
>
> "I guess we can no longer say that."
>
> The Department of Health has confirmed its specialist advisory body on
> CJD - the Spongiform Encephalopathy Advisory Committee - will be
> discussing the implications of the findings tomorrow.
>
> Last night Margaret Guy, whose mother Doreen, 61, of Seaham, County
> Durham, died of "sporadic" CJD in 1993, said the new research gave hope
> to those who had not yet been given any satisfactory answers.
>
> "There are hundreds of us who just feel our cases have been swept under
> the carpet and ignored," said Margaret, who now lives in Chiswick, London.
>
> "My mum died of CJD the same as anyone else - it never made any sense to
> say that cases before 1996 were one form of the disease and after that
> date were a new form.
>
> "It always seemed so random.
>
> "What we need now is a full investigation so this vital report is not
> ignored."
>
> Deaths from sporadic CJD reported in Britain in the 1990s peaked at
> around 89 a year in 1998 and the number has stayed around the 80 mark
> ever since - far more than the 28 variant CJD cases in 2000, the worst
> year so far for variant CJD.
>
> The number of people in the North-East officially confirmed to have died
> of vCJD is 13.
>
> The number thought to have died of classical CJD is believed to number
> at least 200.
>
> A spokesman for the Department of Health said: "These are interesting
> and potentially important findings, which we will need to consider in
> detail."
>
> The £55m in compensation given by the Department of Health is not
> available for sporadic CJD victims or relatives, and there is no way yet
> scientists can distinguish between cases that arose from spontaneous
> changing in the form of the prion protein linked to both diseases, and
> those that might be diet-related.
>
> Newcastle scientist Dr Harash Narang, who has spent many years
> researching CJD, said: "What Professor Collinge's research shows is that
> many of those who have been classified as dying from sporadic CJD in the
> past may in fact have died from BSE."
>
> Page 2: Differences between classical CJD and vCJD....
>
> http://icnewcastle.icnetwork.co.uk/0100news/0100local/page.cfm?objectid=12624781&method=full&siteid=50081
>
>
> BSE is 'linked' to CJD deaths
>
> Differences between classical CJD and vCJD
>
> Age when obvious symptoms occur after many years of incubation:
>
> Identified in 1920s. Disease mainly of middle-aged and elderly.
> Incidence roughly one in a million, but steadily rising from 33 to 89 a
> year.
>
> Identified in 1996. Average age late 20s. Found mainly in Britain: 130
> cases with 122 deaths so far. Six in France, one each in Italy, Ireland,
> Canada, and United States.
>
> Until now assumed a normal prion protein in the brain spontaneously
> changed into abnormal dangerous form. Recently suggested some cases
> possibly caused by surgical contamination during operations. BSE or
> similar diseases could now be factor.
>
> Largely blamed on consumption of cheap cattle meat and offals during
> 1980s. Tough food controls meant to have significantly reduced risk.
> Concern remains over whether sheep might also have become infected with
> BSE and entered food chain.
>
> Page 3: Duration of illness and symptoms...
>
> http://icnewcastle.icnetwork.co.uk/0100news/0100local/page.cfm?objectid=12624781&method=full&siteid=50081&page=2
>
>
> BSE is 'linked' to CJD deaths
>
> Duration of illness and symptoms
>
> Time between obvious symptoms and death typically a few months. Loss of
> balance, sense of direction, and control over limbs and bodily
> functions. Fear, anxiety.
>
> First symptoms often indicate psychological problems. Duration often
> well over a year. Several physical symptoms similar to sporadic CJD.
>
> More questions, more victims
>
> This weekend marked the seventh anniversary of the death of Peter Hall,
> of Chester-le-Street, from vCJD.
>
> He was 20 years old and one of the first in the UK to be diagnosed with
> the new disease.
>
> His parents, Frances and Derek, have been campaigning ever since and 18
> months ago won a victory when the Government agreed to compensate the
> families of victims of vCJD.
>
> Last night Frances, who is now secretary of the Human BSE Foundation,
> said: "When Peter died in 1996 I never thought that seven years later we
> still would not understand the disease that killed him.
>
> "And yet here we are with yet more questions and more victims.
>
> "This new study could have major implications for those who have died of
> CJD since BSE - particularly the young ones who until now were diagnosed
> with sporadic CJD.
>
> "But it will take time and I suspect it will be years rather than months
> before we understand what is happening."
>
> Page 4: Hospital report due out soon...
>
> http://icnewcastle.icnetwork.co.uk/0100news/0100local/page.cfm?objectid=12624781&method=full&siteid=50081&page=3
>
>
> BSE is 'linked' to CJD deaths
>
> Hospital report due out soon
>
> An investigation into how North-East patients were potentially exposed
> to the deadly brain disease CJD is due to be published soon, health
> officials have confirmed.
>
> A draft report into the incident at Middlesbrough General Hospital last
> year has been completed by Dr Bill Kirkup, regional director of public
> health in the North-East.
>
> Dr Kirkup was asked by Chief Medical Officer Sir Liam Donaldson to
> investigate the incident, where 24 people were operated on with
> instruments used on someone who was later found to have CJD.
>
> The hospital denies any procedural lapse as there was nothing to suggest
> the original patient had the disease prior to surgery. But the
> Department of Health said the instruments should have been quarantined
> to avoid contamination.
>
> A DoH spokesman said: "There's a draft report that has been completed
> and we're hoping to be able to publish the findings shortly."
>
> http://icnewcastle.icnetwork.co.uk/0100news/0100local/page.cfm?objectid=12624781&method=full&siteid=50081&page=4
>
>
> TSS
>
> ########### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html
> ############
>
>########### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html ############
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