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From: TSS (216-119-163-226.ipset45.wt.net)
Subject: sporadic CJD and deer meat association in 1993 EU/UK !!!
Date: October 18, 2002 at 3:29 pm PST
Subject: Re: DEER SPONGIFORM ENCEPHALOPATHY SURVEY & HOUND STUDY
Date: Fri, 18 Oct 2002 23:12:22 +0100
From: Steve Dealler
Reply-To: Bovine Spongiform Encephalopathy
Organization: Netscape Online member
To: BSE-L@uni-karlsruhe.de
References: <3DAF5023.4080804@wt.net>######## Bovine Spongiform Encephalopathy #########Dear Terry,
An excellent piece of review as this literature is desparately difficult to get
back from Government sites. What happened with the deer was that an association between deer meat eating and
sporadic CJD was found in about 1993. The evidence was not great but did not
disappear after several years of asking CJD cases what they had eaten.
I think that the work into deer disease largely stopped because it was not helpful
to the UK industry...and no specific cases were reported.
Well, if you dont look adequately like they are in USA currenly then you wont find
any! Steve Dealler "Terry S. Singeltary Sr." wrote: > ######## Bovine Spongiform Encephalopathy #########
>
> Greetings BSE-L,
>
> is there any other CWD surveys/testing in the UK on their deer?
> what sort of testing has been done to date on UK/EU deer?
> any input would be helpful... thank you
>
> DEER SPONGIFORM ENCEPHALOPATHY SURVEY
>
> http://www.bse.org.uk/files/yb/1991/11/20004001.pdf
>
> http://www.bse.org.uk/files/yb/1992/11/04002001.pdf
>
> hope they did not go by the wayside as the hound study;
>
> http://www.bse.org.uk/files/yb/1991/10/18001001.pdf
>
> http://www.bse.org.uk/files/yb/1993/12/06001001.pdf
>
> 37.Putative TSE in hounds - work started 1990 -(see para 41)
>
> Robert Higgins, a Veterinary Investigation Officer at Thirsk,
> had been working on a hound survey in 1990. Gerald Wells
> and I myself received histological sections from this survey
> along with the accompanying letter (YB90/11.28/1.1) dated
> November 1990. This letter details spongiform changes found
> in brains from hunt hounds failing to keep up with the rest of
> the pack, along with the results of SAF extractions from
> fresh brain material from these same animals. SAFs were not
> found in brains unless spongiform changes were also present.
> The spongiform changes were not pathognomonic (ie.
> conclusive proof) for prion disease, as they were atypical,
> being largely present in white matter rather than grey matter in
> the brain and spinal cord. However, Tony Scott, then head of
> electron microscopy work on TSEs, had no doubt that these
> SAFs were genuine and that these hounds therefore must have
> had a scrapie-like disease. I reviewed all the sections
> myself (original notes appended) and although the pathology
> was not typical, I could not exclude the possibility that this was
> a scrapie-like disorder, as white matter vacuolation is seen
> in TSEs and Wallerian degeneration was also present in the
> white matter of the hounds, another feature of scrapie.
>
> 38.I reviewed the literature on hound neuropathology, and
> discovered that micrographs and descriptive neuropathology from
> papers on 'hound ataxia' mirrored those in material from
> Robert Higgins' hound survey. Dr Tony Palmer (Cambridge) had
> done much of this work, and I obtained original sections
> from hound ataxia cases from him. This enabled me provisionally to
> conclude that Robert Higgins had in all probability detected
> hound ataxia, but also that hound ataxia itself was possibly a
> TSE. Gerald Wells confirmed in 'blind' examination of single
> restricted microscopic fields that there was no distinction
> between the white matter vacuolation present in BSE and
> scrapie cases, and that occurring in hound ataxia and the hound
> survey cases.
>
> 39.Hound ataxia had reportedly been occurring since the 1930's,
> and a known risk factor for its development was the feeding
> to hounds of downer cows, and particularly bovine offal.
> Circumstantial evidence suggests that bovine offal may also be
> causal in FSE, and TME in mink. Despite the inconclusive
> nature of the neuropathology, it was clearly evident that this
> putative canine spongiform encephalopathy merited further
> investigation.
>
> 40.The inconclusive results in hounds were never confirmed,
> nor was the link with hound ataxia pursued. I telephoned Robert
> Higgins six years after he first sent the slides to CVL.
> I was informed that despite his submitting a yearly report to the
> CVO including the suggestion that the hound work be continued,
> no further work had been done since 1991. This was
> surprising, to say the very least.
>
> 41.The hound work could have provided valuable evidence
> that a scrapie-like agent may have been present in cattle offal long
> before the BSE epidemic was recognised. The MAFF hound
> survey remains unpublished.
>
> Histopathological support to various other published
> MAFF experiments
>
> 42.These included neuropathological examination of material
> from experiments studying the attempted transmission of BSE to
> chickens and pigs (CVL 1991) and to mice (RVC 1994).
>
> http://www.bse.org.uk/witness/htm/stat067.htm
>
> nothing to offer scientifically;
>
> http://www.bse.org.uk/files/yb/1991/10/17001001.pdf
>
> maddogs and Englishman
>
> http://www.bse.org.uk/files/yb/1990/11/28001001.pdf
>
> kind regards,
> terry
>
> ########### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html ############
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