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From: TSS ()
Subject: BOVINE SPONGIFORM ENCEPHALOPATHY IN THE UNITED STATES OF AMERICA OIE 2ND REPORT and BIO-RAD COMMENTS ON CONFIRMATION
Date: July 1, 2005 at 9:16 am PST


BOVINE SPONGIFORM ENCEPHALOPATHY IN THE UNITED STATES OF AMERICA

See also: 9 January 2004

(Date of previous case of bovine spongiform encephalopathy in the United States of America reported to the OIE: December 2003 [in an imported animal]).

Immediate notification report

Information received on 27 June 2005 from Dr Peter Fernandez, Associate Administrator, Animal and Plant Health Inspection Service (APHIS), United States Department of Agriculture (USDA), Washington, DC:

Report date: 27 June 2005.

Reason for immediate notification: re-occurrence of a listed disease or infection in a country or zone/compartment following a report declaring the outbreak(s) ended.

Date of first confirmation of the event: 23 December 2004.

Date of start of the event: November 2004.

Nature of diagnosis: clinical and laboratory.

Description of affected population: the affected cow was born before the United States instituted a ruminant-to-ruminant feed ban, which was placed in August 1997. The USDA has initiated an investigation to determine the animal’s herd of origin.

Diagnosis:

This particular animal was identified for testing because, as a non-ambulatory animal, it was considered to be at higher risk for bovine spongiform encephalopathy (BSE).

The initial rapid screening test on the animal in November 2004 yielded an inconclusive result - this triggered the USDA to conduct the internationally accepted confirmatory immunohistochemical (IHC) test. The IHC test was negative, and thus the animal was considered negative.

As a result of an internal review by the USDA’s Office of Inspector General (OIG), the OIG recommended that additional tests (using Western blot techniques) be conducted on the three samples that had yielded inconclusive results, but had tested negative on the confirmatory IHC test.

Two of these samples were further confirmed negative, but one sample yielded a positive result using the Western blot technique. This sample was also sent to the OIE Reference Laboratory for BSE in Weybridge, United Kingdom, where the Western blot test and an additional IHC test also yielded a positive result.

Laboratories where diagnosis was made Diagnostic tests used Date Results
National Veterinary Services Laboratory, Ames, Iowa rapid screening test November 2004 inconclusive
immunohistochemistry November 2004 negative
Western blot June 2005 positive
VLA Weybridge, United Kingdom - immunohistochemistry

- Western blot
June 2005 positive

Source of outbreak or origin of infection: unknown or inconclusive.

Control measures: as a non-ambulatory or “downer” animal, the cow had been prohibited from entering the human food supply. The carcass of the animal was incinerated.

Other details/comments:

- The first detection of BSE in the United States was made in December 2003 (see Disease Information, 16 (52), 280, dated 26 December 2003, and Disease Information, 17 (1), 1, dated 2 January 2004). The animal was determined and shown to have been imported from Canada (See Disease Information, 17 (2), 3, dated 9 January 2004). This case confirms a second detection in the United States.

- Given the variation in test results for this case, the USDA has changed its testing protocol. If another BSE rapid screening test results in inconclusive findings, the United States will run both the IHC and the Western blot confirmatory tests.

*
* *

http://www.oie.int/eng/info/hebdo/AIS_64.HTM#Sec4

Greetings,

WHY is it that USDA and OIE reports the Bio-Rad test as only one 'inconclusive' back in Nov. 2004, when in fact, 2 rapid Bio-rad tests were in fact POSITIVE, or as they now term it, "initial reactive" why is this?

>>>Results have confirmed that the sample from an animal that tested "initial reactive" on screening tests in November 2004 has tested positive for BSE (bovine spongiform encephalopathy). These results corroborate the initial findings of two Bio-Rad BSE screening tests conducted on the suspect cow last November. <<<

06/29/2005

Bio-Rad Comments on Positive Confirmation of BSE Test Result

Company Affirms the Accuracy and Reliability of its Rapid Screening Test
HERCULES, CA - June 29, 2005 - On Friday, June 24th the U.S. Department of Agriculture (USDA) announced the results of final confirmatory tests conducted at the world reference laboratory for BSE, the Veterinary Laboratories Agency (VLA), in Weybridge, England and the USDA's laboratory in Ames, Iowa. Results have confirmed that the sample from an animal that tested "initial reactive" on screening tests in November 2004 has tested positive for BSE (bovine spongiform encephalopathy). These results corroborate the initial findings of two Bio-Rad BSE screening tests conducted on the suspect cow last November. According to the USDA, the VLA conducted a combination of confirmatory tests including IHC (immunohistochemistry) and Western Blot methods to confirm this case of BSE.

"These results are consistent with our experience in 27 countries around the world - that the Bio-Rad BSE screening test has an exceptional level of accuracy and is highly regarded in the scientific community," said Bio-Rad Vice President Brad Crutchfield. "We are pleased that the test has been performing as expected in the USDA's BSE surveillance program."

According to the USDA, the disease was difficult to detect because the animal had a very low level of abnormal prion protein in the brain and those abnormalities were isolated and not consistent throughout the brain. As a result, the USDA's confirmatory tests produced inconsistent--both positive and negative results-from sample to sample. It is for this reason that the high sensitivity of the Bio-Rad test is a critical factor in the success of the USDA surveillance program because it identifies even the most difficult-to-detect abnormal prions.

Bio-Rad is the leading provider of tests used for detecting TSEs (Transmissible Spongiform Encephalopathies). To date, the company has provided more than 35 million BSE tests to laboratories throughout Europe and Japan. Independent field studies have shown the Bio-Rad BSE test to have the highest level of sensitivity and specificity of any rapid screening test available. The test detects the presence of the resistant form of prion protein, or PrPres, linked to BSE and can identify these prions at extremely low levels. This capability to detect very low levels of prions helps assure that BSE infected animals do not go undetected.

The USDA initiated its enhanced BSE surveillance program in June 2004. Since then, USDA-approved laboratories and the National Veterinary Service Laboratory (NVSL) have used the Bio-Rad rapid BSE test to screen nearly 400,000 cattle.

Bio-Rad also supplies the U.S. with tests for other TSEs, including its Chronic Wasting Disease (CWD) test which is the only test approved by the USDA for use on all three species affected with CWD (white tailed deer, mule deer and elk). The company's screening test used to detect scrapie in sheep and goats was recently licensed by the USDA.

Bio-Rad Laboratories, Inc. (www.bio-rad.com) is a multinational manufacturer and distributor of life science research products and clinical diagnostics. It is based in Hercules, California, and serves more than 70,000 research and industry customers worldwide through a network of more than 30 wholly owned subsidiary offices.

Veterinary Laboratories Agency (VLA) is an executive agency of Great Britain's Department for Environment, Food and Rural Affairs (DEFRA), consisting of a regional network of 16 laboratories throughout the UK. The Agency provides all sectors of the animal health industry with animal disease surveillance, diagnostic services and veterinary scientific research. Since 1991, the VLA has been the World Organization for Animal Health (OIE) Reference Laboratory for scrapie and BSE and in 2001 the European Commission officially designated VLA as the Community Reference Laboratory for TSEs. The VLA was responsible for the first description of BSE in 1996 and the subsequent description of and research relating to TSEs in other species.

Various statements made within this press release may constitute "forward-looking statements" for purposes of the Securities and Exchange Commission's "safe harbor" provisions under the Private Securities Litigation Reform Act of 1995 and Rule 3b-6 under the Securities Exchange Act of 1934. The forward-looking statements contained herein involve risks and uncertainties that could cause results to differ materially from the Company's expectations.

For more information, contact:
Susan Berg, Corporate Communications
Bio-Rad Laboratories, Inc.
Phone: (510) 741-6063
E-mail: susan_berg@bio-rad.com


http://www.bio-rad.com/B2B/BioRad/offices/about/wn-press.jsp?BV_SessionID=@@@@1248243605.1120233980@@@@&BV_EngineID=ccceaddfdeflhiicfngcfkmdhkkdfll.0&divName=Corporate&siteSection=about&whichSection=Announcements&language=English&displayHTML=%2fpages%2fCRP%2f06_29_05.html

BIO-RAD

> > -------- Original Message --------
> > Subject: USA BIO-RADs INCONCLUSIVEs
> > Date: Fri, 17 Dec 2004 15:37:28 -0600
> > From: "Terry S. Singeltary Sr."
> > To: susan_berg@bio-rad.com
> >
> >
> >
> > Hello Susan and Bio-Rad,
> >
> > Happy Holidays!
> >
> > I wish to ask a question about Bio-Rad and USDA BSE/TSE testing
> > and there inconclusive. IS the Bio-Rad test for BSE/TSE that
complicated,
> > or is there most likely some human error we are seeing here?
> >
> > HOW can Japan have 2 positive cows with
> > No clinical signs WB+, IHC-, HP- ,
> > BUT in the USA, these cows are considered 'negative'?
> >
> > IS there more politics working here than science in the USA?
> >
> > What am I missing?
> >
> >
> >
> > -------- Original Message --------
> > Subject: Re: USDA: More mad cow testing will demonstrate beef's safety
> > Date: Fri, 17 Dec 2004 09:26:19 -0600
> > From: "Terry S. Singeltary Sr."
> > snip...end
> >
> >
> > Experts doubt USDA's mad cow results
>
>
>
> snip...END
>
> WELL, someone did call me from Bio-Rad about this,
> however it was not Susan Berg.
> but i had to just about take a blood oath not to reveal
> there name. IN fact they did not want me to even mention
> this, but i feel it is much much to important. I have omitted
> any I.D. of this person, but thought I must document this ;
>
> Bio-Rad, TSS phone conversation 12/28/04
>
> Finally spoke with ;
>
>
> Bio-Rad Laboratories
> 2000 Alfred Nobel Drive
> Hercules, CA 94547
> Ph: 510-741-6720
> Fax: 510-741-5630
> Email: XXXXXXXXXXXXXXXXXX
>
> at approx. 14:00 hours 12/28/04, I had a very pleasant
> phone conversation with XXXX XXXXX about the USDA
> and the inconclusive BSE testing problems they seem
> to keep having. X was very very cautious as to speak
> directly about USDA and it's policy of not using WB.
> X was very concerned as a Bio-Rad official of retaliation
> of some sort. X would only speak of what other countries
> do, and that i should take that as an answer. I told X
> I understood that it was a very loaded question and X
> agreed several times over and even said a political one.
>
> my question;
>
> Does Bio-Rad believe USDA's final determination of False positive,
> without WB, and considering the new
> atypical TSEs not showing positive with -IHC and -HP ???
>
> ask if i was a reporter. i said no, i was with CJD Watch
> and that i had lost my mother to hvCJD. X did not
> want any of this recorded or repeated.
>
> again, very nervous, will not answer directly about USDA for fear of
> retaliation, but again said X tell
> me what other countries are doing and finding, and that
> i should take it from there.
> "very difficult to answer"
>
> "very political"
>
> "very loaded question"
>
> outside USA and Canada, they use many different confirmatory tech. in
> house WB, SAF, along with
> IHC, HP, several times etc. you should see at several
> talks meetings (TSE) of late Paris Dec 2, that IHC- DOES NOT MEAN IT IS
> NEGATIVE. again, look what
> the rest of the world is doing.
> said something about Dr. Houston stating;
> any screening assay, always a chance for human
> error. but with so many errors (i am assuming
> X meant inconclusive), why are there no investigations, just false
> positives?
> said something about ''just look at the sheep that tested IHC- but were
> positive''. ...
>
>
> TSS
>
> -------- Original Message --------
> Subject: Your questions
> Date: Mon, 27 Dec 2004 15:58:11 -0800
> From: To: flounder@wt.net
>
>
>
> Hi Terry:
>
> ............................................snip Let me know your phone
> number so I can talk to you about the Bio-Rad BSE test.
> Thank you
>
> Regards
>
>
>
> Bio-Rad Laboratories
> 2000 Alfred Nobel Drive
> Hercules, CA 94547
> Ph: 510-741-6720
> Fax: 510-741-5630
> Email: =================================
>
>
> END...TSS
>
>
> ######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html
##########

Greetings list members,


>>>DEFRA's Matthew said that USDA's different results from its BSE tests may
have more to do with the quality of the samples being studied than the
effectiveness of the tests.<<<


>>>That situation, he said, isn't uncommon. "There can be variations in the
amount of abnormal prions in the brain stem and you could take one sample
that's got enough in it and another sample that hasn't got enough.... If you
can't confirm your initial result by applying a second test then it's good
practice to try a third." <<<


SO, seems this would mean that the June 2004 Enhanced BSE cover-up and the
testing of those 388,309 head of cattle to date, were terribly flawed,
therefore were meaningless and should ALL be retested with proper TSE
protocol. IF USDA changes testing protocol again, would this not mean these
test were flawed and meaningless?


ANOTHER reason is by only looking at one portion of the brain, you miss the
rest of the brain that could be potentally infected. kinda like a 1 in 10
chance of finding something. but this is par for the course with these
folks....TSS


USDA 2003

We have to be careful that we don't get so set in the way we do things that
we forget to look for different emerging variations of disease. We've gotten
away from collecting the whole brain in our systems. We're using the brain
stem and we're looking in only one area. In Norway, they were doing a
project and looking at cases of Scrapie, and they found this where they did
not find lesions or PRP in the area of the obex. They found it in the
cerebellum and the cerebrum. It's a good lesson for us. Ames had to go
back and change the procedure for looking at Scrapie samples. In the USDA,
we had routinely looked at all the sections of the brain, and then we got
away from it. They've recently gone back.
Dr. Keller: Tissues are routinely tested, based on which tissue provides an
'official' test result as recognized by APHIS
.

Dr. Detwiler: That's on the slaughter. But on the clinical cases, aren't
they still asking for the brain? But even on the slaughter, they're looking
only at the brainstem. We may be missing certain things if we confine
ourselves to one area.


snip.............


Dr. Detwiler: It seems a good idea, but I'm not aware of it.
Another important thing to get across to the public is that the negatives
do not guarantee absence of infectivity. The animal could be early in the
disease and the incubation period. Even sample collection is so important.
If you're not collecting the right area of the brain in sheep, or if
collecting lymphoreticular tissue, and you don't get a good biopsy, you
could miss the area with the PRP in it and come up with a negative test.
There's a new, unusual form of Scrapie that's been detected in Norway. We
have to be careful that we don't get so set in the way we do things that we
forget to look for different emerging variations of disease. We've gotten
away from collecting the whole brain in our systems. We're using the brain
stem and we're looking in only one area. In Norway, they were doing a
project and looking at cases of Scrapie, and they found this where they did
not find lesions or PRP in the area of the obex. They found it in the
cerebellum and the cerebrum. It's a good lesson for us. Ames had to go
back and change the procedure for looking at Scrapie samples. In the USDA,
we had routinely looked at all the sections of the brain, and then we got
away from it. They've recently gone back.

Dr. Keller: Tissues are routinely tested, based on which tissue provides an
'official' test result as recognized by APHIS
.

Dr. Detwiler: That's on the slaughter. But on the clinical cases, aren't
they still asking for the brain? But even on the slaughter, they're looking
only at the brainstem. We may be missing certain things if we confine
ourselves to one area.


snip...


FULL TEXT;


Completely Edited Version
PRION ROUNDTABLE


Accomplished this day, Wednesday, December 11, 2003, Denver, Colorado

Terry S. Singeltary Sr.

P.O. Box 42

Bacliff, Texas USA 77518

Mad Cow USA -- posted by stauber@tds.net
============================================================
Fellow grillers,

For years now Texan Terry S. Singletary has been an unpaid one-man wrecking
crew aimed at the lies and deceptions of the US FDA, USDA and the meat and
animal feed industry, ever since his mother died of CJD. He has become a
self-taught walking encyclopedia. I send a July 4th salute to a real
American patriot! Thanks to Terry for all his years of personal dedication
and commitment. This issue has come as far as it has because of Terry and
scores of other active family members and friends who have lost loved ones
to CJD in the United States. Thanks to all of you.

John Stauber
Co-author, Mad Cow USA

PS:
And for all you beef lovers on the 4th of July, I have two words:
³certified organic².
Since the USDA has criminalized private testing for mad cow disease in
the US, it is impossible for US consumers to purchase beef from animals that
have tested free of BSE. (Unless you are importing your beef from EU
nations or Japan - but that¹s illegal, too.)
However, ³certified organic beef ³ is guaranteed to come from animals
that have NEVER been weaned on cattle blood, or fed cattle blood and fat, or
fed Opoultry litter¹ heavily contaminated with cattle meat and bone meal, or
fed meat, bone meal, blood and fat from pigs. Contrary to all the lies and
blather from the feds and the PR flacks about the ³firewall feed ban,² it
does not exist in the United States, it¹s a public relations invention.
Conventional dairy and beef cattle in the US are routinely fed these
slaughterhouse by-products, with hundreds of millions of pounds of mammalian
and ruminant protein legally going into cattle feed annually.
So, enjoy your certified organic beef, or your grilled veggie burger,
and when you hear all the patriotic speeches this weekend think of real red,
white and blue patriots like Terry.

------ Forwarded Message
From: "Terry S. Singeltary Sr."
Date: Fri, 01 Jul 2005 08:21:36 -0500

Subject: TEXAS MAD COW GRILLING INSTRUCTIONS FOR T-BONE STEAKS
Date: June 30, 2005 at 9:17 pm PST

TEXAS MAD COW GRILLING INSTRUCTIONS FOR T-BONE STEAKS

SOME POTENTIAL EXPOSURE WOULD RESULT FROM THE PRESENCE OF SPINAL CORD IN
CERTAIN BONE-IN CUTS OF BEEF, LIKE T-BONE STEAKS......


http://www.aphis.usda.gov/lpa/issues/bse/risk_assessment/mainreporttext.pdf

Anatomy of the T-Bone
Anatomically, it is a lumbar vertebra sawed in half through the vertebral
column. The downward stroke on the 'T' is a transverse process of the
vertebra, and the flesh surrounding it was the spinal muscles. The small
semi-circle at the top of the 'T' is half the vertebral foramen.

Although the spinal cord is removed by packers during processing, there is
still concern (in the European Union) that it could be a source of
Creutzfeldt-Jakob disease, more popularly known as mad cow disease. This is
because spinal tissue contains nerve cells, and these can experimentally
transmit the prion that causes this disease.

SO, WHILE grilling those T-bones, just be sure to heat up old sparky to
about 600 degrees C. turn that baby to ash and then hope it does not still
contain TSE agent.

Published online before print March 14, 2000, 10.1073/pnas.050566797;
Proc. Natl. Acad. Sci. USA, Vol. 97, Issue 7, 3418-3421, March 28, 2000


Medical Sciences
New studies on the heat resistance of
hamster-adapted scrapie agent: Threshold
survival after ashing at 600°C suggests an
inorganic template of replication

Paul Brown*,, Edward H. Rau, Bruce K. Johnson*, Alfred E. Bacote*,
Clarence J. Gibbs Jr.*, and D. Carleton Gajdusek§

* Laboratory of Central Nervous System Studies, National Institute of
Neurological Disorders and Stroke, and Environmental
Protection Branch, Division of Safety, Office of Research Services, National
Institutes of Health, Bethesda, MD 20892; and
§ Institut Alfred Fessard, Centre National de la Recherche Scientifique,
91198 Gif sur Yvette, France

Contributed by D. Carleton Gajdusek, December 22, 1999

Abstract


One-gram samples from a pool of crude brain tissue from hamsters infected
with the 263K strain
of hamster-adapted scrapie agent were placed in covered quartz-glass
crucibles and exposed for
either 5 or 15 min to dry heat at temperatures ranging from 150°C to
1,000°C. Residual infectivity
in the treated samples was assayed by the intracerebral inoculation of
dilution series into healthy
weanling hamsters, which were observed for 10 months; disease transmissions
were verified by
Western blot testing for proteinase-resistant protein in brains from
clinically positive hamsters.
Unheated control tissue contained 9.9 log10LD50/g tissue; after exposure to
150°C, titers equaled or exceeded 6 log10LD50/g,
and after exposure to 300°C, titers equaled or exceeded 4 log10LD50/g.
Exposure to 600°C completely ashed the brain samples,
which, when reconstituted with saline to their original weights, transmitted
disease to 5 of 35 inoculated hamsters. No
transmissions occurred after exposure to 1,000°C. These results suggest that
an inorganic molecular template with a
decomposition point near 600°C is capable of nucleating the biological
replication of the scrapie agent.

transmissible spongiform encephalopathy | scrapie | prion | medical waste |
incineration

Introduction


The infectious agents responsible for transmissible spongiform
encephalopathy (TSE) are
notoriously resistant to most physical and chemical methods used for
inactivating pathogens,
including heat. It has long been recognized, for example, that boiling is
ineffective and that higher
temperatures are most efficient when combined with steam under pressure
(i.e., autoclaving). As a
means of decontamination, dry heat is used only at the extremely high
temperatures achieved
during incineration, usually in excess of 600°C. It has been assumed,
without proof, that incineration
totally inactivates the agents of TSE, whether of human or animal origin. It
also has been assumed that the replication of these
agents is a strictly biological process (1), although the notion of a
"virus" nucleant of an inorganic molecular cast of the infectious
-pleated peptide also has been advanced (2). In this paper, we address these
issues by means of dry heat inactivation studies.

full text;

http://www.pnas.org/cgi/content/full/97/7/3418

infectivity surviving ashing to 600*C is (in my opinion) degradable but
infective. based on Bown & Gajdusek, (1991), landfill and burial may be
assumed to have a reduction factor of 98% (i.e. a factor of 50) over 3
years. CJD-infected brain-tissue remained infectious after storing at
room-temperature for 22 months (Tateishi et al, 1988). Scrapie agent is
known to remain viable after at least 30 months of desiccation (Wilson et
al, 1950). and pastures that had been grazed by scrapie-infected sheep still
appeared to be contaminated with scrapie agent three years after they were
last occupied by sheep (Palsson, 1979).

http://europa.eu.int/comm/food/fs/sc/ssc/out58_en.pdf

PAUL BROWN SCRAPIE SOIL TEST

http://www.bseinquiry.gov.uk/files/sc/seac07/tab03.pdf


1: J Neurol Neurosurg Psychiatry 1994 Jun;57(6):757-8


Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes
contaminated during neurosurgery.

Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC.

Laboratory of Central Nervous System Studies, National Institute of
Neurological Disorders and Stroke, National Institutes of Health, Bethesda,
MD 20892.

Stereotactic multicontact electrodes used to probe the cerebral cortex of a
middle aged woman with progressive dementia were previously implicated in
the accidental transmission of Creutzfeldt-Jakob disease (CJD) to two
younger patients. The diagnoses of CJD have been confirmed for all three
cases. More than two years after their last use in humans, after three
cleanings and repeated sterilisation in ethanol and formaldehyde vapour, the
electrodes were implanted in the cortex of a chimpanzee. Eighteen months
later the animal became ill with CJD. This finding serves to re-emphasise
the potential danger posed by reuse of instruments contaminated with the
agents of spongiform encephalopathies, even after scrupulous attempts to
clean them.

PMID: 8006664 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=8006664&dopt=Abstract


AND IF YOU THINK THAT NOV. 2004 TEXAS MAD COW THAT WAS INCONCLUSIVE FOR 7+
MONTHS is something, then you should see that other TEXAS MAD COW, the one
that got away;

FDA Statement
FOR IMMEDIATE RELEASE
Statement
May 4, 2004
Media Inquiries: 301-827-6242
Consumer Inquiries: 888-INFO-FDA

Statement on Texas Cow With Central Nervous System Symptoms
On Friday, April 30 th , the Food and Drug Administration learned that a cow
with central nervous system symptoms had been killed and shipped to a
processor for rendering into animal protein for use in animal feed.

FDA, which is responsible for the safety of animal feed, immediately began
an investigation. On Friday and throughout the weekend, FDA investigators
inspected the slaughterhouse, the rendering facility, the farm where the
animal came from, and the processor that initially received the cow from the
slaughterhouse.

FDA's investigation showed that the animal in question had already been
rendered into "meat and bone meal" (a type of protein animal feed). Over the
weekend FDA was able to track down all the implicated material. That
material is being held by the firm, which is cooperating fully with FDA.

Cattle with central nervous system symptoms are of particular interest
because cattle with bovine spongiform encephalopathy or BSE, also known as
"mad cow disease," can exhibit such symptoms. In this case, there is no way
now to test for BSE. But even if the cow had BSE, FDA's animal feed rule
would prohibit the feeding of its rendered protein to other ruminant animals
(e.g., cows, goats, sheep, bison).

FDA is sending a letter to the firm summarizing its findings and informing
the firm that FDA will not object to use of this material in swine feed
only. If it is not used in swine feed, this material will be destroyed. Pigs
have been shown not to be susceptible to BSE. If the firm agrees to use the
material for swine feed only, FDA will track the material all the way
through the supply chain from the processor to the farm to ensure that the
feed is properly monitored and used only as feed for pigs.

To protect the U.S. against BSE, FDA works to keep certain mammalian protein
out of animal feed for cattle and other ruminant animals. FDA established
its animal feed rule in 1997 after the BSE epidemic in the U.K. showed that
the disease spreads by feeding infected ruminant protein to cattle.

Under the current regulation, the material from this Texas cow is not
allowed in feed for cattle or other ruminant animals. FDA's action
specifying that the material go only into swine feed means also that it will
not be fed to poultry.

FDA is committed to protecting the U.S. from BSE and collaborates closely
with the U.S. Department of Agriculture on all BSE issues. The animal feed
rule provides crucial protection against the spread of BSE, but it is only
one of several such firewalls. FDA will soon be improving the animal feed
rule, to make this strong system even stronger.

####

http://www.fda.gov/bbs/topics/news/2004/NEW01061.html

AND DON'T FORGET WHAT WE FEED TEXAS MAD COWS;

FOR IMMEDIATE RELEASE
P01-05
January 30, 2001
Print Media: 301-827-6242
Consumer Inquiries: 888-INFO-FDA

----------------------------------------------------------------------------
----

Note: On Dec. 23, 2003, the U.S. Department of Agriculture reported that a
cow in Washington state had tested positive for bovine spongiform
encephalopathy (BSE, or mad cow disease). As a result, information on this
Web page stating that no BSE cases had been found in the United States is
now incorrect. However, because other information on this page continues to
have value, the page will remain available for viewing.

FDA ANNOUNCES TEST RESULTS FROM TEXAS FEED LOT


Today the Food and Drug Administration announced the results of tests taken
on feed used at a Texas feedlot that was suspected of containing meat and
bone meal from other domestic cattle -- a violation of FDA's 1997
prohibition on using ruminant material in feed for other ruminants. Results
indicate that a very low level of prohibited material was found in the feed
fed to cattle.

FDA has determined that each animal could have consumed, at most and in
total, five-and-one-half grams - approximately a quarter ounce -- of
prohibited material. These animals weigh approximately 600 pounds.

It is important to note that the prohibited material was domestic in origin
(therefore not likely to contain infected material because there is no
evidence of BSE in U.S. cattle), fed at a very low level, and fed only once.
The potential risk of BSE to such cattle is therefore exceedingly low, even
if the feed were contaminated.

According to Dr. Bernard Schwetz, FDA's Acting Principal Deputy
Commissioner, "The challenge to regulators and industry is to keep this
disease out of the United States. One important defense is to prohibit the
use of any ruminant animal materials in feed for other ruminant animals.
Combined with other steps, like U.S. Department of Agriculture's (USDA) ban
on the importation of live ruminant animals from affected countries, these
steps represent a series of protections, to keep American cattle free of
BSE."

Despite this negligible risk, Purina Mills, Inc., is nonetheless announcing
that it is voluntarily purchasing all 1,222 of the animals held in Texas and
mistakenly fed the animal feed containing the prohibited material.
Therefore, meat from those animals will not enter the human food supply. FDA
believes any cattle that did not consume feed containing the prohibited
material are unaffected by this incident, and should be handled in the beef
supply clearance process as usual.

FDA believes that Purina Mills has behaved responsibly by first reporting
the human error that resulted in the misformulation of the animal feed
supplement and then by working closely with State and Federal authorities.

This episode indicates that the multi-layered safeguard system put into
place is essential for protecting the food supply and that continued
vigilance needs to be taken, by all concerned, to ensure these rules are
followed routinely.

FDA will continue working with USDA as well as State and local officials to
ensure that companies and individuals comply with all laws and regulations
designed to protect the U.S. food supply.


http://www.fda.gov/bbs/topics/NEWS/2001/NEW00752.html

W.H.O. Dr Maura Ricketts BSE/TSE .1 GRAM LETHAL realplayer audio

http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram


Risk of oral infection with bovine spongiform encephalopathy agent in
primates

Corinne Ida Lasmézas, Emmanuel Comoy, Stephen Hawkins, Christian Herzog,
Franck Mouthon, Timm Konold, Frédéric Auvré, Evelyne Correia, Nathalie
Lescoutra-Etchegaray, Nicole Salès, Gerald Wells, Paul Brown, Jean-Philippe
Deslys
Summary The uncertain extent of human exposure to bovine spongiform
encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease
(vCJD)--is compounded by incomplete knowledge about the efficiency of oral
infection and the magnitude of any bovine-to-human biological barrier to
transmission. We therefore investigated oral transmission of BSE to
non-human primates. We gave two macaques a 5 g oral dose of brain homogenate
from a BSE-infected cow. One macaque developed vCJD-like neurological
disease 60 months after exposure, whereas the other remained free of disease
at 76 months. On the basis of these findings and data from other studies, we
made a preliminary estimate of the food exposure risk for man, which
provides additional assurance that existing public health measures can
prevent transmission of BSE to man.

Published online January 27, 2005

http://www.thelancet.com/journal/journal.isa

1: J Infect Dis 1980 Aug;142(2):205-8


Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of sheep
and goats were transmitted to squirrel monkeys (Saimiri sciureus) that were
exposed to the infectious agents only by their nonforced consumption of
known infectious tissues. The asymptomatic incubation period in the one
monkey exposed to the virus of kuru was 36 months; that in the two monkeys
exposed to the virus of Creutzfeldt-Jakob disease was 23 and 27 months,
respectively; and that in the two monkeys exposed to the virus of scrapie
was 25 and 32 months, respectively. Careful physical examination of the
buccal cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has remained
asymptomatic during the 39 months that it has been under observation.

PMID: 6997404
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=6997404&dopt=Abstract

FIRE UP THOSE GRILLS, who needs to test these cows for mad cow disease.
Johanns says everything is o.k.

Course, i don't think there is a grill in Texas that will cook up to
600-1000 degrees celsius.

THE June 2004 BSE ENHANCED BSE SURVEILLANCE and those 388,000 some odd cows
tested to date, don't count now.

THEY must all be retested, and Johann must go for his part in this cover-up.
Johann must resign!

HIS actions and others have caused millions to become exposed to this deadly
agent.

WE must test all cattle for human/animal consumption.

THE MRR POLICY GW et al dreamed up, must GO, trashed, nada. it was nothing
more than a tool to legally trade all strains of TSEs globally. IT was
nothing more than about commodities and futures, open borders at all cost,
to hell with human health.

THE BSE GBR risk assessments must be adhered to and strengthened to include
all TSEs.

dont let the incubation period fool you.

have a safe 4th of July...

TSS


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