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From: TSS ()
Subject: Re: Feds skipped key mad cow disease test in 2004 case USDA changes its protocols after animal initially had been cleared
Date: June 17, 2005 at 11:56 am PST

In Reply to: Re: Feds skipped key mad cow disease test in 2004 case USDA changes its protocols after animal initially had been cleared posted by TSS on June 17, 2005 at 11:46 am:

-------- Original Message --------
Subject: Re: CJD/BSE/BaSE TSS FEDERAL DOCKETS AND PEER REVIEW JOURNALS
Date: Mon, 11 Apr 2005 11:14:04 -0500
From: "Terry S. Singeltary Sr."
To: "Hines, Cragg"
References: <425A9EB4.9080905@wt.net>


hell, they have a home town guy been fighting the feds for
what i consider another cover-up, in relations to the NIH
destroying our loved ones brain tissue samples, due to
more sensitive TSE testing coming out of the pipeline and
they are simply afraid of what they will find and this old French
CJD case dating back to the 70s that NIH official is saying
it is nvCJD, which would put this nightmare back 15 years
or so. been in many National and International papers, peer review
medical journals, and the Chronicle refuses to pick it up. nope,
i am getting ready to retire from this. nobody cares yet. not enough
body bags, and they are ignoring the obvious. BUT, THIS IS
TABU, and nobody speaks of it. the only thing keep alzheimers
not being classified as a TSE, they claim it is not infectious, or
is it ;

IN STRICT CONFIDENCE

TRANSMISSION OF ALZHEIMER-TYPE PLAQUES TO PRIMATES

http://www.bseinquiry.gov.uk/files/yb/1993/01/05004001.pdf


I HAVE PROVEN TEXAS HAS COVERED UP MAD COW
DISEASE. I have sent this data to Houston Chronicle. they do not
speak of it. they refuse to print the data about the TEXAS mad cows
cover-up. I sent all the data to you. I plan on retiring soon, the pay
is just too much for me, and i have ignored my family long enough...

terry


http://images.washtimes.com/upi-breaking/20050407-110535-2570r.htm

http://www.upi.com/view.cfm?StoryID=20050323-061733-6847r

http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20050401-16375100-bc-us-nihbrains.xml


http://washingtontimes.com/upi-breaking/20050401-033307-7296r.htm

http://washingtontimes.com/upi-breaking/20050323-053919-8481r.htm

http://www.washtimes.com/upi-breaking/20050331-095613-8807r.htm

http://www.southasianews.com/showNews.asp?nid=1264


Terry S. Singeltary Sr. wrote:

> Hello Mr. Hines,
>
> IF i had a dollar for every letter about this to houston chronicle
> i had sent, we both would be rich. thanks for replying, i just
> hope it has enlightened you on this topic........
>
> kindest regards,
> terry
>
> Hines, Cragg wrote:
>
>> Thanks for your e-mails. You may want to submit a letter to the
>> editor making your points. It can be sent to viewpoints@chron.com.
>> -----Original Message-----
>> From: Terry S. Singeltary Sr. [mailto:flounder@wt.net] Sent: Sunday,
>> April 10, 2005 10:20 AM
>> To: Hines, Cragg
>> Subject: CJD/BSE/BaSE TSS FEDERAL DOCKETS AND PEER REVIEW JOURNALS
>>
>> Docket No, 04-047-l Regulatory Identification No. (RIN) 091O-AF46
>> NEW BSE SAFEGUARDS (comment submission)
>>
>> https://web01.aphis.usda.gov/regpublic.nsf/0/eff9eff1f7c5cf2b87256ecf000df08d?OpenDocument
>>
>>
>> Docket No. 03-080-1 -- USDA ISSUES PROPOSED RULE TO ALLOW LIVE ANIMAL
>> IMPORTS FROM CANADA
>>
>> https://web01.aphis.usda.gov/BSEcom.nsf/0/b78ba677e2b0c12185256dd300649f9d?OpenDocument&AutoFramed
>>
>>
>>
>> Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION]
>>
>> http://www.fda.gov/ohrms/dockets/dockets/03n0312/03N-0312_emc-000001.txt
>>
>> Docket Management Docket: 02N-0273 - Substances Prohibited From Use in
>>
>> Animal Food or Feed; Animal Proteins Prohibited in Ruminant Feed
>>
>> Comment Number: EC -10
>>
>> Accepted - Volume 2
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be07.html
>>
>>
>>
>> PART 2
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be09.html
>>
>>
>>
>> PDF]Freas, William TSS SUBMISSION
>>
>> File Format: PDF/Adobe Acrobat -
>>
>> Page 1. J Freas, William From: Sent: To: Subject: Terry S. Singeltary
>>
>> Sr. [flounder@wt.net] Monday, January 08,200l 3:03 PM freas ...
>>
>>
>>
>> http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf
>>
>>
>>
>> Asante/Collinge et al, that BSE transmission to the 129-methionine
>>
>> genotype can lead to an alternate phenotype that is indistinguishable
>>
>> from type 2 PrPSc, the commonest _sporadic_ CJD;
>>
>>
>>
>> http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm
>>
>>
>>
>> Docket Management Docket: 96N-0417 - Current Good Manufacturing Practice
>> in Manufacturing, Packing, or Holding Dietary Ingredients a
>> Comment Number: EC -2
>> Accepted - Volume 7
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Mar03/031403/96N-0417-EC-2.htm
>>
>>
>>
>> [PDF] Appendices to PL107-9 Inter-agency Working Group Final Report 1-1
>> File Format: PDF/Adobe Acrobat - View as HTML
>> Agent, Weapons of Mass Destruction Operations Unit Federal Bureau of
>> those who provided comments in response to Docket No. ...
>> Meager 8/18/01 Terry S. Singeltary Sr ...
>>
>>
>> www.aphis.usda.gov/lpa/pubs/pubs/PL107-9_Appen.pdf
>>
>> Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION
>> TO DOCKET 2003N-0312]
>>
>> http://www.fda.gov/ohrms/dockets/dockets/03n0312/03N-0312_emc-000001.txt
>>
>> # Docket No: 02-088-1 RE-Agricultural Bioterrorism Protection Act of
>> 2002; [TSS SUBMISSION ON POTENTIAL FOR BSE/TSE & FMD 'SUITCASE BOMBS'] -
>> TSS 1/27/03 (0)
>>
>> Docket Management
>>
>> Docket: 02N-0276 - Bioterrorism Preparedness; Registration of Food
>> Facilities, Section 305
>> Comment Number: EC-254 [TSS SUBMISSION]
>>
>> http://www.fda.gov/ohrms/dockets/dockets/02n0276/02N-0276-EC-254.htm
>>
>> Dockets Entered On October 2, 2003 Table of Contents, Docket #,
>> Title, 1978N-0301,
>>
>> OTC External Analgesic Drug Products, ... EMC 7, Terry S. Singeltary Sr.
>> Vol #: 1, ...
>>
>> www.fda.gov/ohrms/dockets/dailys/03/oct03/100203/100203.htm
>>
>>
>> Daily Dockets Entered on 02/05/03
>>
>> DOCKETS ENTERED on 2/5/03. ... EMC 4 Terry S. Singeltary Sr. Vol#: 2.
>> ... Vol#: 1.
>>
>> 03N-0009 Federal Preemption of State & Local Medical Device
>> Requireme. ...
>>
>>
>> www.fda.gov/ohrms/dockets/dailys/03/Feb03/020503/020503.htm
>>
>>
>> Docket Management
>>
>> Docket: 02N-0370 - Neurological Devices; Classification of Human Dura
>> Mater
>>
>> Comment Number: EC -1
>>
>> Accepted - Volume 1
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be11.html
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004bdfe.html
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004bdfc.html
>>
>>
>> Daily Dockets - 04/10/03
>> ... 00D-1662 Use of Xenotransplantation Products in Humans.
>> EMC 98 Terry S. Singeltary Sr. Vol#: 3. 01F ...
>> www.fda.gov/ohrms/dockets/dailys/03/Apr03/041003/041003.htm -
>> 05-20-2003 - Cached
>>
>> 2003D-0186
>> Guidance for Industry: Use of Material From Deer and Elk In Animal Feed
>>
>>
>>
>>
>> EMC 1
>> Terry S. Singeltary Sr.
>> Vol #:
>> 1
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/Jun03/060903/060903.htm
>>
>>
>> 2003D-0186
>> Guidance for Industry: Use of Material From Deer and Elk In Animal Feed
>>
>>
>> EMC 7
>> Terry S. Singeltary Sr.
>> Vol #:
>> 1
>>
>> 2003D-0186
>> Guidance for Industry: Use of Material From Deer and Elk In Animal Feed
>>
>>
>> EMC 7
>> Terry S. Singeltary Sr.
>> Vol #:
>> 1
>>
>>
>> http://www.fda.gov/ohrms/dockets/dailys/03/oct03/100203/100203.htm
>>
>> 01N-0423 Substances Prohibited from use in animal food/Feed Ruminant
>>
>> APE 5 National Renderers Association, Inc. Vol#: 2
>>
>> APE 6 Animal Protein Producers Industry Vol#: 2
>>
>> APE 7 Darling International Inc. Vol#: 2
>>
>> EMC 1 Terry S. Singeltary Sr. Vol#: 3
>>
>> http://www.fda.gov/ohrms/dockets/dailys/01/Oct01/101501/101501.htm
>>
>> Send Post-Publication Peer Review to journal:
>>
>>
>> Re: RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob
>>
>> disease in the United States
>>
>>
>> Email Terry S. Singeltary:
>>
>>
>> flounder@wt.net
>>
>>
>>
>> I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to
>>
>> comment on the CDC's attempts to monitor the occurrence of emerging
>>
>> forms of CJD. Asante, Collinge et al [1] have reported that BSE
>>
>> transmission to the 129-methionine genotype can lead to an alternate
>>
>> phenotype that is indistinguishable from type 2 PrPSc, the commonest
>>
>> sporadic CJD. However, CJD and all human TSEs are not reportable
>>
>> nationally. CJD and all human TSEs must be made reportable in every
>>
>> state and internationally. I hope that the CDC does not continue to
>>
>> expect us to still believe that the 85%+ of all CJD cases which are
>>
>> sporadic are all spontaneous, without route/source. We have many TSEs in
>>
>> the USA in both animal and man. CWD in deer/elk is spreading rapidly and
>>
>> CWD does transmit to mink, ferret, cattle, and squirrel monkey by
>>
>> intracerebral inoculation. With the known incubation periods in other
>>
>> TSEs, oral transmission studies of CWD may take much longer. Every
>>
>> victim/family of CJD/TSEs should be asked about route and source of this
>>
>> agent. To prolong this will only spread the agent and needlessly expose
>>
>> others. In light of the findings of Asante and Collinge et al, there
>>
>> should be drastic measures to safeguard the medical and surgical arena
>>
>> from sporadic CJDs and all human TSEs. I only ponder how many sporadic
>>
>> CJDs in the USA are type 2 PrPSc?
>>
>>
>> http://www.neurology.org/cgi/eletters/60/2/176#535
>>
>>
>>
>> LANCET INFECTIOUS DISEASE JOURNAL
>>
>>
>> Volume 3, Number 8 01 August 2003
>>
>>
>> Newsdesk
>>
>>
>> Tracking spongiform encephalopathies in North America
>>
>>
>> Xavier Bosch
>>
>> My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost
>>
>> my mom to hvCJD (Heidenhain variant CJD) and have been searching for
>>
>> answers ever since. What I have found is that we have not been told the
>>
>> truth. CWD in deer and elk is a small portion of a much bigger problem.
>>
>>
>> 49-year-old Singeltary is one of a number of people who have remained
>>
>> largely unsatisfied after being told that a close relative died from a
>>
>> rapidly progressive dementia compatible with spontaneous
>>
>> Creutzfeldt-Jakob disease (CJD). So he decided to gather hundreds of
>>
>> documents on transmissible spongiform encephalopathies (TSE) and
>>
>> realised that if Britons could get variant CJD from bovine spongiform
>>
>> encephalopathy (BSE), Americans might get a similar disorder from
>>
>> chronic wasting disease (CWD)the relative of mad cow disease seen among
>>
>> deer and elk in the USA. Although his feverish search did not lead him
>>
>> to the smoking gun linking CWD to a similar disease in North American
>>
>> people, it did uncover a largely disappointing situation.
>>
>>
>> Singeltary was greatly demoralised at the few attempts to monitor the
>>
>> occurrence of CJD and CWD in the USA. Only a few states have made CJD
>>
>> reportable. Human and animal TSEs should be reportable nationwide and
>>
>> internationally, he complained in a letter to the Journal of the
>>
>> American Medical Association (JAMA 2003; 285: 733). I hope that the CDC
>>
>> does not continue to expect us to still believe that the 85% plus of all
>>
>> CJD cases which are sporadic are all spontaneous, without route or
>> source.
>>
>>
>> Until recently, CWD was thought to be confined to the wild in a small
>>
>> region in Colorado. But since early 2002, it has been reported in other
>>
>> areas, including Wisconsin, South Dakota, and the Canadian province of
>>
>> Saskatchewan. Indeed, the occurrence of CWD in states that were not
>>
>> endemic previously increased concern about a widespread outbreak and
>>
>> possible transmission to people and cattle.
>>
>>
>> To date, experimental studies have proven that the CWD agent can be
>>
>> transmitted to cattle by intracerebral inoculation and that it can cross
>>
>> the mucous membranes of the digestive tract to initiate infection in
>>
>> lymphoid tissue before invasion of the central nervous system. Yet the
>>
>> plausibility of CWD spreading to people has remained elusive.
>>
>>
>> Part of the problem seems to stem from the US surveillance system. CJD
>>
>> is only reported in those areas known to be endemic foci of CWD.
>>
>> Moreover, US authorities have been criticised for not having performed
>>
>> enough prionic tests in farm deer and elk.
>>
>>
>> Although in November last year the US Food and Drug Administration
>>
>> issued a directive to state public-health and agriculture officials
>>
>> prohibiting material from CWD-positive animals from being used as an
>>
>> ingredient in feed for any animal species, epidemiological control and
>>
>> research in the USA has been quite different from the situation in the
>>
>> UK and Europe regarding BSE.
>>
>>
>> Getting data on TSEs in the USA from the government is like pulling
>>
>> teeth, Singeltary argues. You get it when they want you to have it,
>>
>> and only what they want you to have.
>>
>>
>> Norman Foster, director of the Cognitive Disorders Clinic at the
>>
>> University of Michigan (Ann Arbor, MI, USA), says that current
>>
>> surveillance of prion disease in people in the USA is inadequate to
>>
>> detect whether CWD is occurring in human beings; adding that, the
>>
>> cases that we know about are reassuring, because they do not suggest the
>>
>> appearance of a new variant of CJD in the USA or atypical features in
>>
>> patients that might be exposed to CWD. However, until we establish a
>>
>> system that identifies and analyses a high proportion of suspected prion
>>
>> disease cases we will not know for sure. The USA should develop a
>>
>> system modelled on that established in the UK, he points out.
>>
>>
>>
>> Ali Samii, a neurologist at Seattle VA Medical Center who recently
>>
>> reported the cases of three hunterstwo of whom were friendswho died
>>
>> from pathologically confirmed CJD, says that at present there are
>>
>> insufficient data to claim transmission of CWD into humans; adding that
>>
>> [only] by asking [the questions of venison consumption and deer/elk
>>
>> hunting] in every case can we collect suspect cases and look into the
>>
>> plausibility of transmission further. Samii argues that by making both
>>
>> doctors and hunters more aware of the possibility of prions spreading
>>
>> through eating venison, doctors treating hunters with dementia can
>>
>> consider a possible prion disease, and doctors treating CJD patients
>>
>> will know to ask whether they ate venison.
>>
>>
>> CDC spokesman Ermias Belay says that the CDC will not be investigating
>>
>> the [Samii] cases because there is no evidence that the men ate
>>
>> CWD-infected meat. He notes that although the likelihood of CWD
>>
>> jumping the species barrier to infect humans cannot be ruled out 100%
>>
>> and that [we] cannot be 100% sure that CWD does not exist in humans&
>>
>> the data seeking evidence of CWD transmission to humans have been very
>>
>> limited.
>>
>>
>>
>>
>> http://infection.thelancet.com/journal/journal.isa
>>
>>
>>
>>
>> he complained in a letter to the Journal of the American Medical
>>
>>
>>
>> Association (JAMA 2003; 285: 733). I hope that the CDC does not
>>
>> continue to expect us to still believe that the 85% plus of all CJD
>>
>> cases which are sporadic are all spontaneous, without route or
>> source.<<<
>>
>>
>>
>> actually, that quote was from a more recent article in the Journal of
>>
>> Neurology (see below), not the JAMA article...
>>
>>
>>
>> Full Text
>>
>> Diagnosis and Reporting of Creutzfeldt-Jakob Disease
>>
>> Singeltary, Sr et al. JAMA.2001; 285: 733-734.
>>
>>
>>
>> http://jama.ama-assn.org/cgi/content/full/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=dignosing+and+reporting+creutzfeldt+jakob+disease&searchid=1048865596978_1528&stored_search=&FIRSTINDEX=0&journalcode=jama
>>
>>
>>
>>
>> BRITISH MEDICAL JOURNAL
>>
>>
>>
>> SOMETHING TO CHEW ON
>>
>>
>>
>> BMJ
>>
>>
>>
>> http://www.bmj.com/cgi/eletters/319/7220/1312/b#EL2
>>
>>
>>
>> BMJ
>>
>>
>>
>> http://www.bmj.com/cgi/eletters/320/7226/8/b#EL1
>>
>>
>>
>> THE PATHOLOGICAL PROTEIN
>>
>> BY Philip Yam
>>
>> Yam Philip Yam News Editor Scientific American www.sciam.com
>> http://www.thepathologicalprotein.com/
>>
>> IN light of Asante/Collinge et al findings that BSE transmission to the
>> 129-methionine genotype can lead to an alternate phenotype that is
>> indistinguishable from type 2 PrPSc, the commonest _sporadic_ CJD;
>>
>> -------- Original Message -------- Subject: re-BSE prions propagate as
>>
>> either variant CJD-like or sporadic CJD Date: Thu, 28 Nov 2002 10:23:43
>>
>> -0000 From: "Asante, Emmanuel A" To:
>> "'flounder@wt.net'"
>>
>> Dear Terry,
>>
>> I have been asked by Professor Collinge to respond to your request. I am
>>
>> a Senior Scientist in the MRC Prion Unit and the lead author on the
>>
>> paper. I have attached a pdf copy of the paper for your attention. Thank
>>
>> you for your interest in the paper.
>>
>> In respect of your first question, the simple answer is, yes. As you
>>
>> will find in the paper, we have managed to associate the alternate
>>
>> phenotype to type 2 PrPSc, the commonest sporadic CJD.
>>
>> It is too early to be able to claim any further sub-classification in
>>
>> respect of Heidenhain variant CJD or Vicky Rimmer's version. It will
>>
>> take further studies, which are on-going, to establish if there are
>>
>> sub-types to our initial finding which we are now reporting. The main
>>
>> point of the paper is that, as well as leading to the expected new
>>
>> variant CJD phenotype, BSE transmission to the 129-methionine genotype
>>
>> can lead to an alternate phenotype which is indistinguishable from type
>>
>> 2 PrPSc.
>>
>>
>>
>> I hope reading the paper will enlighten you more on the subject. If I
>>
>> can be of any further assistance please to not hesitate to ask. Best
>> wishes.
>>
>>
>>
>> Emmanuel Asante
>>
>> <> ____________________________________
>>
>> Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial
>>
>> College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG
>>
>> Tel: +44 (0)20 7594 3794 Fax: +44 (0)20 7706 3272 email:
>>
>> e.asante@ic.ac.uk (until 9/12/02)
>>
>> New e-mail: e.asante@prion.ucl.ac.uk (active from now)
>>
>> ____________________________________
>>
>> snip...
>>
>> full text ;
>>
>> http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm
>>
>>
>> AND the new findings of BASE in cattle in Italy of Identification of a
>> second bovine amyloidotic spongiform encephalopathy: Molecular
>> similarities with sporadic
>>
>> Creutzfeldt-Jakob disease
>>
>>
>> http://www.pnas.org/cgi/content/abstract/0305777101v1
>>
>>
>> Adaptation of the bovine spongiform encephalopathy agent to primates
>> and comparison with Creutzfeldt- Jakob disease: Implications for
>> human health
>>
>> THE findings from Corinne Ida Lasmézas*, [dagger] , Jean-Guy Fournier*,
>> Virginie Nouvel*,
>>
>> Hermann Boe*, Domíníque Marcé*, François Lamoury*, Nicolas Kopp [Dagger
>>
>> ] , Jean-Jacques Hauw§, James Ironside¶, Moira Bruce [||] , Dominique
>>
>> Dormont*, and Jean-Philippe Deslys* et al, that The agent responsible
>> for French iatrogenic growth hormone-linked CJD taken as a control is
>> very different from vCJD but is similar to that found in one case of
>> sporadic CJD and one sheep scrapie isolate;
>>
>> http://www.pnas.org/cgi/content/full/041490898v1
>>
>> Characterization of two distinct prion strains
>> derived from bovine spongiform encephalopathy
>> transmissions to inbred mice
>>
>> http://vir.sgmjournals.org/cgi/content/abstract/85/8/2471
>>
>>
>> ALL animals for human/animal consumption must be tested for TSE.
>>
>> ALL human TSEs must be made reportable Nationally and Internationally,
>> OF ALL AGES...
>>
>> TSS
>>
>>
>>
>>
>>
>> ======================================================
>> This e-mail message is intended only for the personal
>> use of the recipients(s) named above. If you are not
>> an intended recipient, you may not review, copy or
>> distribute this message.
>>
>> If you have received this communication in error,
>> please notify the Houston Chronicle Postmaster
>> (postmaster@chron.com) immediately by e-mail and
>> delete the original message.
>>
>> ======================================================
>>
>>
>>
>>
>>
>
>






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