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From: TSS ()
Subject: Re: Suspect US animal may have rare mad cow strain
Date: June 16, 2005 at 3:25 pm PST

In Reply to: Suspect US animal may have rare mad cow strain posted by TSS on June 16, 2005 at 11:14 am:

##################### Bovine Spongiform Encephalopathy #####################

Greetings,

I posted this long ago from VS research. THEY knew
the had a case of mad cow disease, they knew it was
atypical, the whole time they were covering it up,
thus the June 2004 Enhanced BSE cover up.
maybe this is the atypical strain killing our loved ones,
maybe this is why they sent it to Italy;

new findings of BASE in cattle in Italy of Identification of a
second bovine amyloidotic spongiform encephalopathy: Molecular
similarities with sporadic

Creutzfeldt-Jakob disease


http://www.pnas.org/cgi/content/abstract/0305777101v1


Adaptation of the bovine spongiform encephalopathy agent to primates
and comparison with Creutzfeldt- Jakob disease: Implications for
human health

THE findings from Corinne Ida Lasmézas*, [dagger] , Jean-Guy Fournier*,
Virginie Nouvel*,

Hermann Boe*, Domíníque Marcé*, François Lamoury*, Nicolas Kopp [Dagger

] , Jean-Jacques Hauw§, James Ironside¶, Moira Bruce [||] , Dominique

Dormont*, and Jean-Philippe Deslys* et al, that The agent responsible
for French iatrogenic growth hormone-linked CJD taken as a control is
very different from vCJD but is similar to that found in one case of
sporadic CJD and one sheep scrapie isolate;

http://www.pnas.org/cgi/content/full/041490898v1

Characterization of two distinct prion strains
derived from bovine spongiform encephalopathy
transmissions to inbred mice

http://vir.sgmjournals.org/cgi/content/abstract/85/8/2471


ALL animals for human/animal consumption must be tested for TSE.

ALL human TSEs must be made reportable Nationally and Internationally OF ALL
AGES...TSS


> Research Project: Study of Atypical Bse
>
> Location:
>
>
>
> Virus and Prion Diseases of Livestock
>
>
> Project Number: 3625-32000-073-07
> Project Type: Specific C/A
>
> Start Date: Sep 15, 2004
> End Date: Sep 14, 2007
>
> Objective:
> The objective of this cooperative research project with Dr. Maria
> Caramelli from the Italian BSE Reference Laboratory in Turin, Italy,
> is to conduct comparative studies with the U.S. bovine spongiform
> encephalopathy (BSE) isolate and the atypical BSE isolates identified
> in Italy. The studies will cover the following areas: 1. Evaluation of
> present diagnostics tools used in the U.S. for the detection of
> atypical BSE cases. 2. Molecular comparison of the U.S. BSE isolate
> and other typical BSE isolates with atypical BSE cases. 3. Studies on
> transmissibility and tissue distribution of atypical BSE isolates in
> cattle and other species.
>
> Approach:
> This project will be done as a Specific Cooperative Agreement with the
> Italian BSE Reference Laboratory, Istituto Zooprofilattico
> Sperimentale del Piemonte, in Turin, Italy. It is essential for the
> U.S. BSE surveillance program to analyze the effectiveness of the U.S
> diagnostic tools for detection of atypical cases of BSE. Molecular
> comparisons of the U.S. BSE isolate with atypical BSE isolates will
> provide further characterization of the U.S. BSE isolate. Transmission
> studies are already underway using brain homogenates from atypical BSE
> cases into mice, cattle and sheep. It will be critical to see whether
> the atypical BSE isolates behave similarly to typical BSE isolates in
> terms of transmissibility and disease pathogenesis. If transmission
> occurs, tissue distribution comparisons will be made between cattle
> infected with the atypical BSE isolate and the U.S. BSE isolate.
> Differences in tissue distribution could require new regulations
> regarding specific risk material (SRM) removal.
>
> http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490
>
>> Differences in tissue distribution could require new regulations
>> regarding specific risk material (SRM) removal.
>
>
>
>

snip...end

full text ;

http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf


It was, however, performed in the USA in 1979, when it was shown that cattle
inoculated with the scrapie agent endemic in the flock of Suffolk sheep at
the United States Department of Agriculture in Mission, Texas, developed a
TSE quite unlike BSE. 32

http://www.bseinquiry.gov.uk/report/volume2/chaptea3.htm#820543

The findings of the initial transmission, though not of the clinical or
neurohistological examination, were communicated in October 1988 to Dr
Watson, Director of the CVL, following a visit by Dr Wrathall, one of the
project leaders in the Pathology Department of the CVL, to the United States
Department of Agriculture. 33

http://www.bseinquiry.gov.uk/report/volume2/chaptea3.htm#820546

The results were not published at this point, since the attempted
transmission to mice from the experimental cow brain had been inconclusive.
The results of the clinical and histological differences between
scrapie-affected sheep and cattle were published in 1995. Similar studies in
which cattle were inoculated intracerebrally with scrapie inocula derived
from a number of scrapie-affected sheep of different breeds and from
different States, were carried out at the US National Animal Disease Centre.
34

http://www.bseinquiry.gov.uk/report/volume2/chaptea3.htm#820549

The results, published in 1994, showed that this source of scrapie agent,
though pathogenic for cattle, did not produce the same clinical signs of
brain lesions characteristic of BSE.

http://www.bseinquiry.gov.uk/report/volume2/chaptea3.htm


Visit to USA ... info on BSE and Scrapie


http://www.bseinquiry.gov.uk/files/yb/1988/10/00001001.pdf


WHY is USA insisting _now_ not to use WB, when on the 1st _confirmed_ case
Dec. 23, 2003
USA mad cow, WB was used ???

maybe this is the reason ;

JAPAN BSE # 8 & 9 cow

8. 6/10/2003 Holstein Steer 13/10/2001 23 mths
No clinical signs WB+, IHC-, HP-


9. 4/11/2003 Holstein Steer 13/1/2002
21 mths No clinical signs WB+, IHC-, HP-

===========

More information on the first 11 Japanese BSE-cases can be found on the
website of the Japanese Embassy in the US:

http://www.us.emb-japan.go.jp/english/html/fafacts/bse/bse.htm

it's gonna be a long year........

TSS

######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########


1: J Infect Dis 1980 Aug;142(2):205-8

Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of sheep
and goats were transmitted to squirrel monkeys (Saimiri sciureus) that were
exposed to the infectious agents only by their nonforced consumption of
known infectious tissues. The asymptomatic incubation period in the one
monkey exposed to the virus of kuru was 36 months; that in the two monkeys
exposed to the virus of Creutzfeldt-Jakob disease was 23 and 27 months,
respectively; and that in the two monkeys exposed to the virus of scrapie
was 25 and 32 months, respectively. Careful physical examination of the
buccal cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has remained
asymptomatic during the 39 months that it has been under observation.

PMID: 6997404
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui
ds=6997404&dopt=Abstract

EFSA Scientific Report on the Assessment of the Geographical BSE-Risk (GBR)
of the United States of America (USA)
Publication date: 20 August 2004
Adopted July 2004 (Question N° EFSA-Q-2003-083)

Report

Summary
Summary of the Scientific Report

The European Food Safety Authority and its Scientific Expert Working Group
on the Assessment of the Geographical Bovine Spongiform Encephalopathy (BSE)
Risk (GBR) were asked by the European Commission (EC) to provide an
up-to-date scientific report on the GBR in the United States of America,
i.e. the likelihood of the presence of one or more cattle being infected
with BSE, pre-clinically as well as clinically, in USA. This scientific
report addresses the GBR of USA as assessed in 2004 based on data covering
the period 1980-2003.

The BSE agent was probably imported into USA and could have reached domestic
cattle in the middle of the eighties. These cattle imported in the mid
eighties could have been rendered in the late eighties and therefore led to
an internal challenge in the early nineties. It is possible that imported
meat and bone meal (MBM) into the USA reached domestic cattle and leads to
an internal challenge in the early nineties.

A processing risk developed in the late 80s/early 90s when cattle imports
from BSE risk countries were slaughtered or died and were processed (partly)
into feed, together with some imports of MBM. This risk continued to exist,
and grew significantly in the mid 90's when domestic cattle, infected by
imported MBM, reached processing. Given the low stability of the system, the
risk increased over the years with continued imports of cattle and MBM from
BSE risk countries.

EFSA concludes that the current GBR level of USA is III, i.e. it is likely
but not confirmed that domestic cattle are (clinically or pre-clinically)
infected with the BSE-agent. As long as there are no significant changes in
rendering or feeding, the stability remains extremely/very unstable. Thus,
the probability of cattle to be (pre-clinically or clinically) infected with
the BSE-agent persistently increases.


http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/573_e
n.html


CANADA

http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/scr_a
nnexes/563/sr02_biohaz02_canada_report_annex_en1.pdf

MEXICO

http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/scr_a
nnexes/566/sr04_biohaz02_mexico_report_annex_en1.pdf


Canada and the United States have been raised to level III (presence of BSE
likely but not confirmed, or confirmed at a lower level) following a new
assessment taking into account the most recent evidence. EFSAs Scientific
Expert Working Group on geographic BSE risk assessment also evaluated the
status of Mexico and South Africa which were classified as level III.

http://www.efsa.eu.int/press_room/press_release/575_en.html


From: Terry S. Singeltary Sr. [flounder@wt.net]
Sent: Tuesday, July 29, 2003 1:03 PM
To: fdadockets@oc.fda.gov
Cc: ggraber@cvm.fda.gov; Linda.Grassie@fda.gov; BSE-L
Subject: Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION
TO DOCKET 2003N-0312]

Greetings FDA,

snip...

PLUS, if the USA continues to flagrantly ignore the _documented_ science to
date about the known TSEs in the USA (let alone the undocumented TSEs in
cattle), it is my opinion, every other Country that is dealing with BSE/TSE
should boycott the USA and demand that the SSC reclassify the USA BSE GBR II
risk assessment to BSE/TSE GBR III 'IMMEDIATELY'. for the SSC to _flounder_
any longer on this issue, should also be regarded with great suspicion as
well. NOT to leave out the OIE and it's terribly flawed system of disease
surveillance. the OIE should make a move on CWD in the USA, and make a risk
assessment on this as a threat to human health. the OIE should also change
the mathematical formula for testing of disease. this (in my opinion and
others) is terribly flawed as well. to think that a sample survey of 400 or
so cattle in a population of 100 million, to think this will find anything,
especially after seeing how many TSE tests it took Italy and other Countries
to find 1 case of BSE (1 million rapid TSE test in less than 2 years, to
find 102 BSE cases), should be proof enough to make drastic changes of this
system. the OIE criteria for BSE Country classification and it's
interpretation is very problematic. a text that is suppose to give
guidelines, but is not understandable, cannot be considered satisfactory.
the OIE told me 2 years ago that they were concerned with CWD, but said any
changes might take years. well, two years have come and gone, and no change
in relations with CWD as a human health risk. if we wait for politics and
science to finally make this connection, we very well may die before any
decisions
or changes are made. this is not acceptable. we must take the politics and
the industry out of any final decisions of the Scientific community. this
has been the problem from day one with this environmental man made death
sentence. some of you may think i am exaggerating, but you only have to see
it once, you only have to watch a loved one die from this one time, and you
will never forget, OR forgive...yes, i am still very angry... but the
transmission studies DO NOT lie, only the politicians and the industry do...
and they are still lying to this day...TSS


http://www.fda.gov/ohrms/dockets/dockets/03n0312/03N-0312_emc-000001.txt


With kindest Regards,
I am sincerely,

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

=====================


JOHN CORNYN
TEXAS
UNITED STATES SENATE
WASHINGTON, DC 20510-4305...................

SNIP...END

FULL TEXT;

http://disc.server.com/discussion.cgi?disc=7498;article=2593;title=CJD%20Voi
ce%20Discussion%20Group

TSS

----- Original Message -----
From: "Terry S. Singeltary Sr."
To:
Sent: Thursday, June 16, 2005 1:19 PM
Subject: Suspect US animal may have rare mad cow strain


##################### Bovine Spongiform Encephalopathy
#####################

Suspect US animal may have rare mad cow strain

Thu June 16, 2005 2:05 PM GMT-04:00
By Randy Fabi

WASHINGTON (Reuters) - A rare and puzzling form of mad cow disease that some
believe arises spontaneously may have afflicted the U.S. animal that tested
positive for the ailment last week, a senior Agriculture Department
scientist told Reuters.

The USDA has sent a sample of the suspect animal's brain to an
internationally recognized laboratory in England to pinpoint if the animal
has bovine spongiform encephalopathy (BSE). The USDA said it could take
another week to complete final tests.

Juergen Richt, a member of the USDA team in Ames, Iowa that already tested
the animal, said the unusual test results could point to a relatively new
strain of BSE that infects cattle sporadically, instead of from eating
contaminated food.

But he said it was too early to draw a conclusion about the aging, beef
animal was slaughtered last November and incinerated because it was a
"downer" unable to walk, and banned from the human food supply.

"Nobody knows for sure yet, but the theory is it could be a spontaneous
bovine disease," said the veterinarian medical officer. "There are some
hallmark signs that this could be an atypical case."

The only confirmed U.S. case of mad cow disease was found in a Holstein
dairy cow in Washington state in December 2003.

Since then, scientists in France, Italy, Japan and Belgium have discovered
at least two new BSE strains that differ from the outbreak that swept
European herds in the 1980s.

Cattle brains infected with the two new strains resemble brains of humans
diagnosed with classical Creutzfeldt-Jakob disease, a rare and fatal form of
dementia that infects one in a million people worldwide, researchers said.

Some experts believe the new BSE strains could arise naturally within
cattle, for reasons that remain unknown.

"The jury is still out on this," Richt said. "Is it infectious? That's the
$100,000 question."

Experts expressed concern about the possibility of an animal developing BSE
spontaneously.

"If this is a sporadic case, then it would be very important to keep all of
our current safeguards in place, and put in place additional ones," said
Jean Halloran, director of food policy at Consumers Union.

More than 140 human deaths have been blamed on the original BSE outbreak in
Europe, from people who ate contaminated beef. Since that outbreak, in the
1980s, most nations have banned the use of cattle remains as a protein
supplement in cattle feed.

INFECTIOUS FOR HUMANS?

Richt said a naturally occurring BSE strain would probably infect other
cattle. "Sporadic BSE in cattle would most likely be infectious for other
cattle, but no one can tell you yet if it's infectious for humans," he said.

Scientists were years away from answering these questions, Richt added. But
he said any carcasses infected with a new strain should be treated as any
other BSE-infected animal and segregated from human and animal feed
supplies.

Richt considered the current suspect animal a good candidate for the
atypical strain, with conflicting test results similar to cases in Japan and
Belgium.

A rapid screening test on Nov. 15 returned inconclusive results. A more
sophisticated procedure, immunohistochemistry (IHC) tests, cleared the
animal of any infection.

But last week, the USDA's office of inspector general ordered a third round
of testing. The Western blot procedure used in Japan and Europe showed a
"weak positive."

In atypical cases, weak test results were a result of a wider distribution
of the abnormal or misshaped prion protein, the main signature of the
disease, in an infected brain.

While USDA has refused to say where the animal was detected, some published
reports say it was found in southern Texas, half a continent away from the
only proven U.S. case.

http://www.reuters.ca/locales/c_newsArticle.jsp?type=topNews&localeKey=en_CA
&storyID=8814741

TSS

#################### https://lists.aegee.org/bse-l.html
####################

#################### https://lists.aegee.org/bse-l.html ####################




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