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From: TSS ()
Date: May 7, 2005 at 2:06 pm PST

-------- Original Message --------
Subject: NEGATIVE RESULTS FOR CWD in only four captive deer sampled NY
Date: Sat, 7 May 2005 16:12:44 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy

##################### Bovine Spongiform Encephalopathy #####################

Department of Agriculture & Markets News
Sunday, June 05, 2005
Contact: Jessica A. Chittenden
Sampling Done at Associated Captive Deer Herd Shows No Signs of CWD

The New York State Department of Agriculture and Markets (DAM) today
announced it has received negative test results for chronic wasting
disease (CWD) in four captive deer sampled at a herd associated with the
deer herds confirmed with CWD in Oneida County.

In follow up to the investigation of the first cases of CWD in New York
State, DAM has been obtaining surveillance samples from herds that have
had a direct association with the CWD infected herd detected through
routine surveillance in late March.

The latest herd sampled was a herd that had received animals from the
initial infected herd as recently as 2002. DAM sampled four white-tailed
deer, which were all three years of age or older. These four
white-tailed deer were selected because they would provide the best
indication of the CWD status of the herd. The four samples were sent to
the New York State Veterinary Diagnostic Laboratory at Cornell
University for testing and were all confirmed negative for CWD.

Today, DAM sampled the remaining extant herd that was associated with
the index herd. Three white-tailed deer, ages three and older, were
sampled and results will be made available as soon as the tests are
complete. DAM's ongoing statewide CWD surveillance will continue for all
captive susceptible deer herds. It was this surveillance program that
detected the initial CWD infection, the first known infection in the State.

To date, the State Department of Environmental Conservation (DEC), along
with the U.S. Department of Agricultures Wildlife Services program, has
sampled 290 wild white-tailed deer from Oneida County, two from
neighboring Madison County and 25 from the Town of Arietta, Hamilton
County. DEC has found two positive cases of CWD in the wild deer
population in Oneida County. Since 2002, DEC has conducted statewide
sampling of wild deer for CWD. When combined with sampling efforts in
Oneida, Madison and Hamilton Counties, DEC has collected more than 3,700
samples from wild white-tailed deer. DEC completed its intensive
monitoring of wild deer in the Oneida County area on April 30, 2005.

DEC will continue to sample all deer killed within the containment area
pursuant to nuisance deer permits, road kills and those taken by
hunters. The containment area will be comprised of Oneida County
municipalities, including the cities of Rome, Sherrill, and Utica, as
well as the towns of Augusta, Floyd, Marcy, Trenton, Whitestown, Verona,
Westmoreland, Vernon, Kirkland, New Hartford, Vienna, Annsville, Lee,
and Western. In addition, the Madison County towns of Stockbridge and
Lenox and City of Oneida will also be included. DEC will use the results
of all these efforts to determine the distribution and prevalence of CWD
in wild deer as accurately as possible.

In addition, DEC has implemented emergency regulations regarding the
handling, transport and management of deer in the State. The emergency
regulations are currently in effect and represent an aggressive response
to the recent discovery of chronic wasting disease (CWD) in Oneida
County. DEC's emergency regulations are designed to ensure the proper
handling of deer and prevent further spread of CWD in the wild herd. In
addition, DEC has begun the process of establishing permanent
regulations, which will appear in the State Register and include a
45-day public comment period.

CWD is a transmissible disease that affects the brain and central
nervous system of certain deer and elk. There is no evidence that CWD is
linked to disease in humans or domestic livestock other than deer and
elk. More information on CWD can be found at DAM's website at

> There is no evidence that CWD is linked to disease in humans or
> domestic livestock other than deer and elk

very misleading, and the sampling of only 4 deer just does not say a
great deal ...

Title: Experimental Cross-Species Transmission of Chronic Wasting
Disease (Cwd-Mule Deer) to Domestic Livestock at the National Animal
Disease Center: An Update Authors
item Hamir, Amirali

item Cutlip, Randall

item Miller, Janice
item Richt, Juergen

item Kunkle, Robert - bob

item Williams, Elizabeth - UNIV WYOMING, LARAMIE
item Stack, Mick - VET LABS,WEYBRIDGE,UK
item Chaplin, Melanie - VET LABS,WEYBRIDGE,UK
item Miller, Michael - COLORADO DIV WILDLIFE
item O'Rourke, Katherine

Submitted to: American Association Of Veterinary Laboratory Diagnosticians
Publication Acceptance Date: October 9, 2003
Publication Date: October 9, 2003
Abstract only
Citation: Hamir, A.N., Cutlip, R.C., Miller, J.M., Richt, J.A., Kunkle,
R.A., Williams, E., Stack, M.J., Chaplin, M.J., Miller, M., O'Rourke,
K.I. 2003. Experimental Cross-Species Transmission Of Chronic Wasting
Disease (Cwd-Mule Deer) To Domestic Livestock At The National Animal
Disease Center: An Update [abstract]. 46th Annual Meeting Of The
American Association Of Veterinary Laboratory Diagnosticians. P. 209.
Technical Abstract: To determine the transmissibility of chronic wasting
disease (CWD) to cattle and sheep, 13 calves and 8 lambs were inoculated
intracerebrally with brain suspension from mule deer (CWD-mule deer)
naturally affected with CWD. Both investigations are currently in
progress. The cattle experiment was started in 1997. Five and half years
post inoculation (PI), 10/13 cattle have either died or were euthanized.
Five of these were positive for prion protein (by immunohistochemistry).
However, only the initial 2 cattle, euthanized at 23 and 24 months PI,
had clinical signs (weight loss), and none revealed obvious histologic
changes indicative of spongiform encephalopathy (SE). Three cattle
remain alive and apparently healthy. The ovine experiment is 4 years PI
and so far 2 sheep (both QQ at codon 171) have been euthanized. Only 1
had clinical signs and histopathologic lesions of SE that were
indistinguishable from sheep scrapie, and the brain was positive for
prion protein. Six remaining sheep (2 QQ and 4 QR at 171) are apparently
healthy. These preliminary findings demonstrate that although the
CWD-mule deer agent can be transmitted to cattle and sheep by
intracerebral inoculation, an obvious neurologic manifestation of the
disease is only seen in the latter species. These results also indicate
that the diagnostic techniques currently used for bovine spongiform
encephalopathy (BSE) surveillance would also detect the CWD agent in
cattle and sheep should it occur naturally. Since intracerebral
inoculation is an unnatural route for TSE infection, it has little
bearing on the potential for cattle to become infected under natural
conditions of exposure and these data may not reflect the situation seen
after a natural infection.

> Since intracerebral inoculation is an unnatural route for TSE
> infection, it has little bearing on the potential for cattle to become
> infected under natural conditions of exposure and these data may not
> reflect the situation seen after a natural infection.

exactly the same thing that was said about BSE, until it happened later,
due to a longer
incubation period due to route...

ALSO, cwd transmits to GOAT ;

ARS | Publication request: Preliminary Findings on the ...

... animal species. Except for one intra-cranial transmission of
infection to a goat,
CWD agent has not been transmitted to other domestic animals. To test
the ...
- 40k - Cached

ALSO, CWD has transmitted to PRIMATES ;


Transmission Studies

Mule deer transmissions of CWD were by intracerebral inoculation and
compared with natural cases resulted in a more rapidly
progressive clinical disease with repeated episodes of synocopy ending
in coma. One control animal became affected, it is believed through
contamination of inoculam (?saline). Further CWD transmissions were
carried out by Dick Marsh into ferret, mink and squirrel monkey.
Transmission occurred in all of these species with the shortest
incubation period in the ferret.


The occurrence of CWD must be viewed against the context of the
locations in which it occurred. It was an incidental and unwelcome
complication of the respective wildlife research programmes. Despite its
subsequent recognition as a new disease of cervids, therefore justifying
direct investigation, no specific research funding was forthcoming.
The USDA viewed it as a wildlife problem and consequently not their




1. Dr Clark lately of the Scrapie Research Unit, Mission Texas has
successfully transmitted ovine and caprine scrapie to cattle. The
experimental results have not been published but there are plans to do
this. This work was initiated in 1978. A summary of it is:-

better cut this short, you can read full text of part 2 here;


In Reply to: In Confidence - Perceptions of unconventional slow virus
diseases of animals in the USA - APRIL-MAY 1989 - G A H Wells


WHAT will CWD in humans look like ?

WHAT does USA mad cow disease look like in cattle and humans ?

As implied in the Inset 25, we must not _ASSUME_ that transmission
of BSE to other species will invariably present pathology typical
of a scrapie-like disease...


G A H WELLS 4 January 1991

Is there a Scrapie-like disease in cattle in USA

BASE in cattle in Italy of Identification of a second bovine amyloidotic
spongiform encephalopathy:
Molecular similarities with sporadic Creutzfeldt-Jakob disease

Adaptation of the bovine spongiform encephalopathy agent to primates and
comparison with
Creutzfeldt- Jakob disease: Implications for human health THE findings
from Corinne Ida Lasmézas*,
[dagger] , Jean-Guy Fournier*, Virginie Nouvel*, Hermann Boe*, Domíníque
Marcé*, François Lamoury*,
Nicolas Kopp [Dagger ] , Jean-Jacques Hauw§, James Ironside¶, Moira
Bruce [||] , Dominique Dormont*,
and Jean-Philippe Deslys* et al, that The agent responsible for French
iatrogenic growth hormone-linked CJD
taken as a control is very different from vCJD but is similar to that
found in one case of sporadic CJD and
one sheep scrapie isolate;

Characterization of two distinct prion strains derived from bovine
spongiform encephalopathy transmissions to
inbred mice

Stupidity, greed and the industry is what fuels this disease, and
the tank is full. ONLY, when the US admits we have a problem,
instead of covering it up, will we begin to win this battle. Rendering
a suspected stumbling and staggering mad cow is one thing, and
refusing to use WB and the most sensitive testing for TSE/BSE is
another. BUT it all adds up to just one thing. COVER-UP!

FDA Statement

May 4, 2004

Media Inquiries: 301-827-6242
Consumer Inquiries: 888-INFO-FDA

Statement on Texas Cow With Central Nervous System Symptoms

On Friday, April 30 th , the Food and Drug Administration learned that a
cow with central nervous system symptoms had been killed and shipped to
a processor for rendering into animal protein for use in animal feed.

FDA, which is responsible for the safety of animal feed, immediately
began an investigation. On Friday and throughout the weekend, FDA
investigators inspected the slaughterhouse, the rendering facility, the
farm where the animal came from, and the processor that initially
received the cow from the slaughterhouse.

FDA's investigation showed that the animal in question had already been
rendered into "meat and bone meal" (a type of protein animal feed). Over
the weekend FDA was able to track down all the implicated material. That
material is being held by the firm, which is cooperating fully with FDA.

Cattle with central nervous system symptoms are of particular interest
because cattle with bovine spongiform encephalopathy or BSE, also known
as "mad cow disease," can exhibit such symptoms. In this case, there is
no way now to test for BSE. But even if the cow had BSE, FDA's animal
feed rule would prohibit the feeding of its rendered protein to other
ruminant animals (e.g., cows, goats, sheep, bison).

FDA is sending a letter to the firm summarizing its findings and
informing the firm that FDA will not object to use of this material in
swine feed only. If it is not used in swine feed, this material will be
destroyed. Pigs have been shown not to be susceptible to BSE. If the
firm agrees to use the material for swine feed only, FDA will track the
material all the way through the supply chain from the processor to the
farm to ensure that the feed is properly monitored and used only as feed
for pigs.

To protect the U.S. against BSE, FDA works to keep certain mammalian
protein out of animal feed for cattle and other ruminant animals. FDA
established its animal feed rule in 1997 after the BSE epidemic in the
U.K. showed that the disease spreads by feeding infected ruminant
protein to cattle.

Under the current regulation, the material from this Texas cow is not
allowed in feed for cattle or other ruminant animals. FDA's action
specifying that the material go only into swine feed means also that it
will not be fed to poultry.

FDA is committed to protecting the U.S. from BSE and collaborates
closely with the U.S. Department of Agriculture on all BSE issues. The
animal feed rule provides crucial protection against the spread of BSE,
but it is only one of several such firewalls. FDA will soon be improving
the animal feed rule, to make this strong system even stronger.





APHIS Statement: June 29 Inconclusive BSE Test is Negative

APHIS Statement: First Inconclusive BSE Test is Negative

APHIS Statement Regarding Second Inconclusive BSE Test

APHIS Statement Regarding First Inconclusive BSE Test

Week 25

Week 5
Week 4



AS of March 31, 2005, there were 70 Scrapie infected source flocks
(Figure 3). There were 11 new infected and source flocks reported
in March (Figure 4) with a total of 51 flocks reported for FY 2005
(Figure 5). The total infected and source flocks that have been released
in FY 2005 are 39 (Figure 6), with 1 flock released in March. The
ratio of infected and source flocks released to newly infected and source
flocks for FY 2005 = 0.76 : 1. In addition, as of March 31,
2005, 225 Scrapie cases have been confirmed and reported by the
National Veterinary Services Laboratories (NVSL), of which
53 were RSSS cases (Figure 7). This includes 57 newly confirmed
cases in March 2005 (Figure 8). Fourteen cases of Scrapie in Goats
have been reported since 1990 (Figure 9). The last goat cases was
reported in January 2005. New infected flocks, source flocks, and
flocks released or put on clean-up plans for FY 2005 are depicted
in Figure 10...


Infected and Source Flocks

As of September 30, 2004, there were 67 scrapie infected and source
flocks (figure 3
There were a total of 100** new infected and source flocks reported for
FY 2004 (figure 4
The total infected and source flocks that have been released in FY 2004
are 77 (figure 5
The percent of new infected and source flocks cleaned up or on clean up
plans was 96%. In addition, as of September 30, 2004, 368 scrapie cases
have been confirmed and reported by the National Veterinary Services
Laboratories (NVSL) in FY 2004, of which 54 were RSSS cases (figure 6
and figure 7
Thirteen cases of scrapie in goats have been reported since 1990 (figure
One new goat case was reported in FY 2004. New infected flocks, source
flocks, and flocks released for FY 2004 are depicted in chart 4
One new goat case was reported in FY 2004. Approximately 3,058 animals
were indemnified comprised of 47% non-registered sheep, 44% registered
sheep, 6% non-registered goats and 1% registered goats.

Office Note


A The Present Position with respect to Scrapie
A] The Problem

Scrapie is a natural disease of sheep and goats. It is a slow
and inexorably progressive degenerative disorder of the nervous system
and it ia fatal. It is enzootic in the United Kingdom but not in all

The field problem has been reviewed by a MAFF working group
(ARC 35/77). It is difficult to assess the incidence in Britain for
a variety of reasons but the disease causes serious financial loss;
it is estimated that it cost Swaledale breeders alone $l.7 M during
the five years 1971-1975. A further inestimable loss arises from the
closure of certain export markets, in particular those of the United
States, to British sheep.

It is clear that scrapie in sheep is important commercially and
for that reason alone effective measures to control it should be
devised as quickly as possible.

Recently the question has again been brought up as to whether
scrapie is transmissible to man. This has followed reports that the
disease has been transmitted to primates. One particularly lurid
speculation (Gajdusek 1977) conjectures that the agents of scrapie,
kuru, Creutzfeldt-Jakob disease and transmissible encephalopathy of
mink are varieties of a single "virus". The U.S. Department of
Agriculture concluded that it could "no longer justify or permit
scrapie-blood line and scrapie-exposed sheep and goats to be processed
for human or animal food at slaughter or rendering plants" (ARC 84/77)"
The problem is emphasised by the finding that some strains of scrapie
produce lesions identical to the once which characterise the human

Whether true or not. the hypothesis that these agents might be
transmissible to man raises two considerations. First, the safety
of laboratory personnel requires prompt attention. Second, action
such as the "scorched meat" policy of USDA makes the solution of the
acrapie problem urgent if the sheep industry is not to suffer



1: J Infect Dis 1980 Aug;142(2):205-8

Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of
sheep and goats were transmitted to squirrel monkeys (Saimiri
sciureus) that were exposed to the infectious agents only by their
nonforced consumption of known infectious tissues. The asymptomatic
incubation period in the one monkey exposed to the virus of kuru was
36 months; that in the two monkeys exposed to the virus of
Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and
that in the two monkeys exposed to the virus of scrapie was 25 and
32 months, respectively. Careful physical examination of the buccal
cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has
remained asymptomatic during the 39 months that it has been under

PMID: 6997404

EFSA Scientific Report on the Assessment of the Geographical BSE-Risk
(GBR) of the United States of America (USA)
Publication date: 20 August 2004

Adopted July 2004 (Question N° EFSA-Q-2003-083)

* 167 kB Report
* 105 kB Summary

Summary of the Scientific Report

The European Food Safety Authority and its Scientific Expert Working
Group on the Assessment of the Geographical Bovine Spongiform
Encephalopathy (BSE) Risk (GBR) were asked by the European Commission
(EC) to provide an up-to-date scientific report on the GBR in the United
States of America, i.e. the likelihood of the presence of one or more
cattle being infected with BSE, pre-clinically as well as clinically, in
USA. This scientific report addresses the GBR of USA as assessed in 2004
based on data covering the period 1980-2003.

The BSE agent was probably imported into USA and could have reached
domestic cattle in the middle of the eighties. These cattle imported in
the mid eighties could have been rendered in the late eighties and
therefore led to an internal challenge in the early nineties. It is
possible that imported meat and bone meal (MBM) into the USA reached
domestic cattle and leads to an internal challenge in the early nineties.

A processing risk developed in the late 80s/early 90s when cattle
imports from BSE risk countries were slaughtered or died and were
processed (partly) into feed, together with some imports of MBM. This
risk continued to exist, and grew significantly in the mid 90s when
domestic cattle, infected by imported MBM, reached processing. Given the
low stability of the system, the risk increased over the years with
continued imports of cattle and MBM from BSE risk countries.

EFSA concludes that the current GBR level of USA is III, i.e. it is
likely but not confirmed that domestic cattle are (clinically or
pre-clinically) infected with the BSE-agent. As long as there are no
significant changes in rendering or feeding, the stability remains
extremely/very unstable. Thus, the probability of cattle to be
(pre-clinically or clinically) infected with the BSE-agent persistently

From: Terry S. Singeltary Sr. []
Sent: Tuesday, July 29, 2003 1:03 PM
Cc:;; BSE-L
Subject: Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION
TO DOCKET 2003N-0312]

Greetings FDA,


PLUS, if the USA continues to flagrantly ignore the _documented_ science
to date about the known TSEs in the USA (let alone the undocumented TSEs
in cattle), it is my opinion, every other Country that is dealing with
BSE/TSE should boycott the USA and demand that the SSC reclassify the
USA BSE GBR II risk assessment to BSE/TSE GBR III 'IMMEDIATELY'. for the
SSC to _flounder_ any longer on this issue, should also be regarded with
great suspicion as well. NOT to leave out the OIE and it's terribly
flawed system of disease surveillance. the OIE should make a move on CWD
in the USA, and make a risk assessment on this as a threat to human
health. the OIE should also change the mathematical formula for testing
of disease. this (in my opinion and others) is terribly flawed as well.
to think that a sample survey of 400 or so cattle in a population of 100
million, to think this will find anything, especially after seeing how
many TSE tests it took Italy and other Countries to find 1 case of BSE
(1 million rapid TSE test in less than 2 years, to find 102 BSE cases),
should be proof enough to make drastic changes of this system. the OIE
criteria for BSE Country classification and it's interpretation is very
problematic. a text that is suppose to give guidelines, but is not
understandable, cannot be considered satisfactory. the OIE told me 2
years ago that they were concerned with CWD, but said any changes might
take years. well, two years have come and gone, and no change in
relations with CWD as a human health risk. if we wait for politics and
science to finally make this connection, we very well may die before any
or changes are made. this is not acceptable. we must take the politics
and the industry out of any final decisions of the Scientific community.
this has been the problem from day one with this environmental man made
death sentence. some of you may think i am exaggerating, but you only
have to see it once, you only have to watch a loved one die from this
one time, and you will never forget, OR forgive...yes, i am still very
angry... but the transmission studies DO NOT lie, only the politicians
and the industry do... and they are still lying to this day...TSS




Canada and the United States have been raised to level III (presence of
BSE likely but not confirmed, or confirmed at a lower level) following a
new assessment taking into account the most recent evidence. EFSAs
Scientific Expert Working Group on geographic BSE risk assessment also
evaluated the status of Mexico and South Africa which were classified as
level III.

TSE regulations for all species including man MUST be
the same across the board from state to state, nation to
nation. having regulations differ from state to state, nation
to nation, will never work. IF this BSE MRR policy is
picked up, we will loose this battle for sure. The industry
just thinks they will win, but it will only be a short term
win. The war will be lost...

I just hope I live long enough to see it. ...

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

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