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From: TSS ()
Journal of Virology, May 2005, p. 5847-5849, Vol. 79, No. 9 Cristina Casalone, Cristiano Corona, Maria Ines Crescio, Francesca Martucci, Maria Mazza, Giuseppe Ru, Elena Bozzetta, Pier Luigi Acutis, and Maria Caramelli* CEA, Italian Reference Laboratory for TSE, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Turin, Italy Received 12 July 2004/ Accepted 1 December 2004 Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent European Food Safety Authority opinion recommended research into PrPsc accumulation in the tongues of ruminants. We report on the detection of PrPsc in the tongues of seven scrapie-infected sheep by immunohistochemistry and Western blotting. ------------------------------------------------------------------------ ------------------------------------------------------------------------ TSS
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