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From: TSS ()
Subject: Size frequency distribution of prion protein (PrP) aggregates in variant Creutzfeldt-Jakob disease (vCJD)
Date: March 29, 2005 at 1:08 pm PST

-------- Original Message --------
Subject: Size frequency distribution of prion protein (PrP) aggregates in variant Creutzfeldt-Jakob disease (vCJD)
Date: Tue, 29 Mar 2005 15:12:49 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Size frequency distribution of prion protein (PrP) aggregates in variant
Creutzfeldt-Jakob disease (vCJD)

R. A. Armstrong1, N. J. Cairns2, J. W. Ironside1 and P. L. Lantos1

(1) Vision Sciences, Aston University, Birmingham, United Kingdom

(2) Departments of Neurology, Pathology and Immunology, Washington
University St Louis, School of Medicine, St Louis, MO, USA

(3) National CJD Surveillance Unit, Western General Hospital,
Edinburgh, United Kingdom

(4) Brain Bank, Department of Neuropathology, Institute of Psychiatry,
Kingrsquo s College, London, United Kingdom

Received: 11 November 2004 Accepted: 19 February 2005 Published
online: 23 March 2005

Summary. The frequency distribution of aggregate size of the diffuse
and florid-type prion protein (PrP) plaques was studied in various brain
regions in cases of variant Creutzfeldt-Jakob disease (vCJD). The size
distributions were unimodal and positively skewed and resembled those of
beta -amyloid (Abeta ) deposits in Alzheimerrsquo s disease (AD) and
Downrsquo s syndrome (DS). The frequency distributions of the PrP
aggregates were log-normal in shape, but there were deviations from the
expected number of plaques in specific size classes. More diffuse
plaques were observed in the modal size class and fewer in the larger
size classes than expected and more florid plaques were present in the
larger size classes compared with the log-normal model. It was concluded
that the growth of the PrP aggregates in vCJD does not strictly follow a
log-normal model, diffuse plaques growing to within a more restricted
size range and florid plaques to larger sizes than predicted.

Keywords: Variant Creutzfeldt-Jakob disease (vCJD), prion protein (PrP)
aggregate, size distribution, log-normal distribution, florid plaque,
diffuse plaque, Alzheimerrsquo s disease (AD), beta -amyloid

http://www.springerlink.com/app/home/contribution.asp?wasp=39d13cac39db4cf08474620bed4ada82&referrer=parent&backto=issue,59,69;journal,1,73;linkingpublicationresults,1:101493,1

TSS

######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########





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