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From: TSS ()
Subject: Re: RESEARCH ON SCRAPIE OF SHEEP 1976 USDA
Date: March 22, 2005 at 1:11 pm PST

In Reply to: RESEARCH ON SCRAPIE OF SHEEP 1976 USDA posted by TSS on March 21, 2005 at 3:06 pm:

-------- Original Message --------
Subject: Re: RESEARCH ON SCRAPIE OF SHEEP 1976
Date: Tue, 22 Mar 2005 13:05:34 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@KALIV.UNI-KARLSRUHE.DE
References: <423F5328.4050908@wt.net> <424046D2.80303@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

AGRICULTURAL RESEARCH COUNCIL

REPORT OF THE ADVISORY COMMITTEE ON SCRAPIE

OFFICE NOTE

snip...

Recently the question has again been brought up as to whether scrapie
is transmissible to man. This has followed reports that the disease has
been transmitted to primates. ONE particularly lurid speculation
(Gajdusek 1977) conjectures that the agents of scrapie, kuru,
Creutzfeldt-Jakob disease and transmissible encephalopathy of
mink are varieties of a single ''virus''. THE U.S. Department of
Agriculture CONCLUDED that it could

''NO LONGER JUSTIFY OR PERMIT SCRAPIE-BLOOD
LINE AND SCRAPIE-EXPOSED SHEEP AND GOATS TO BE
PROCESSED FOR HUMAN OR ANIMAL FOOD AT SLAUGHTER
OR RENDERING PLANTS'' (ARC 84/77). The problem is emphasised
by the finding that some strains of scrapie produce lesions IDENTICAL
to the ones which characterise the human dementias...

snip...

full text ;

http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf

http://www.bseinquiry.gov.uk/files/yb/1978/06/01001001.pdf

The recent report from the ARC Advisory Committee on Scrapie*
raised the question of whether those whose occupation suggested they
might be a contact with scrapie had a higher risk of developing Creutzfeldt-
Jakob disease.

http://www.bseinquiry.gov.uk/files/yb/1978/06/27001001.pdf


1: J Infect Dis 1980 Aug;142(2):205-8


Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of
sheep and goats were transmitted to squirrel monkeys (Saimiri
sciureus) that were exposed to the infectious agents only by their
nonforced consumption of known infectious tissues. The asymptomatic
incubation period in the one monkey exposed to the virus of kuru was
36 months; that in the two monkeys exposed to the virus of
Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and
that in the two monkeys exposed to the virus of scrapie was 25 and
32 months, respectively. Careful physical examination of the buccal
cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has
remained asymptomatic during the 39 months that it has been under
observation.

PMID: 6997404

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6997404&dopt=Abstract

Greetings BSE-L members and USDA et al lurkers,

I would be most curious to see the transmission studies that disproves
the above thinking by USDA et al on human risk factors from scrapie ???

WHAT scientific studies made USDA et al change to this ;

There is no scientific evidence to indicate that scrapie poses a risk to
human health.

http://www.aphis.usda.gov/lpa/pubs/fsheet_faq_notice/fs_ahscrapie.html

Infected and Source Flocks

As of September 30, 2004, there were 67 scrapie infected and source
flocks (figure 3
).
There were a total of 100** new infected and source flocks reported for
FY 2004 (figure 4
).
The total infected and source flocks that have been released in FY 2004
are 77 (figure 5
).
The percent of new infected and source flocks cleaned up or on clean up
plans was 96%. In addition, as of September 30, 2004, 368 scrapie cases
have been confirmed and reported by the National Veterinary Services
Laboratories (NVSL) in FY 2004, of which 54 were RSSS cases (figure 6
,
and figure 7
).
Thirteen cases of scrapie in goats have been reported since 1990 (figure
8
).
One new goat case was reported in FY 2004. New infected flocks, source
flocks, and flocks released for FY 2004 are depicted in chart 4
.
One new goat case was reported in FY 2004. Approximately 3,058 animals
were indemnified comprised of 47% non-registered sheep, 44% registered
sheep, 6% non-registered goats and 1% registered goats.

http://www.aphis.usda.gov/vs/nahps/scrapie/yearly_report/yearly-report.html

WOULD someone from USDA et al please provide this evidence for
everyone on this list please, that shows scrapie does not transmit to
humans...

thank you,
kind regards,
Terry

Terry S. Singeltary Sr. wrote:

> AGRICULTURAL RESEARCH COUNCIL
>
> REPORT OF THE ADVISORY COMMITTEE ON SCRAPIE
>
> OFFICE NOTE
>
> snip...
>
> Recently the question has again been brought up as to whether scrapie
> is transmissible to man. This has followed reports that the disease has
> been transmitted to primates. ONE particularly lurid speculation
> (Gajdusek 1977) conjectures that the agents of scrapie, kuru,
> Creutzfeldt-Jakob disease and transmissible encephalopathy of
> mink are varieties of a single ''virus''. THE U.S. Department of
> Agriculture CONCLUDED that it could
>
> ''NO LONGER JUSTIFY OR PERMIT SCRAPIE-BLOOD
> LINE AND SCRAPIE-EXPOSED SHEEP AND GOATS TO BE
> PROCESSED FOR HUMAN OR ANIMAL FOOD AT SLAUGHTER
> OR RENDERING PLANTS'' (ARC 84/77). The problem is emphasised
> by the finding that some strains of scrapie produce lesions IDENTICAL
> to the ones which characterise the human dementias...
>
> snip...
>
> full text ;
>
> http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf
>
> http://www.bseinquiry.gov.uk/files/yb/1978/06/01001001.pdf
>
> The recent report from the ARC Advisory Committee on Scrapie*
> raised the question of whether those whose occupation suggested they
> might be a contact with scrapie had a higher risk of developing
> Creutzfeldt-
> Jakob disease.
>
> http://www.bseinquiry.gov.uk/files/yb/1978/06/27001001.pdf
>
> AS we have a microfilm of certificates of 1973 deaths in ICD order
> of underlying cause we examined some categories in which you are
> interested with the following results :
>
> ICD No. Number of certificates examined
>
> ??? 18 15 mention c-j
>
> snip...
>
> http://www.bseinquiry.gov.uk/files/yb/1978/06/27002001.pdf
>
> (vii) SAMPLES OF SERUM FROM C-J PATIENTS SHOULD BE
> STORED FOR FUTURE STUDY OF ANTIBODY PROFILES.
>
> http://www.bseinquiry.gov.uk/files/yb/1978/10/06001001.pdf
>
> IT was noted that a detailed study of C-J disease was being undertaken
> in France under the auspices of the NIH.
>
> snip...
>
> x) Professor Vessey confirmed that Sir Richard Doll had agreed to look
> at the information available from the study of 34,000 doctors on the
> medical
> register in 1953 to ascertain whether any deaths from C-J disease had been
> recorded.
>
> snip...
>
> http://www.bseinquiry.gov.uk/files/yb/1978/10/06002001.pdf
>
>
>
> Terry S. Singeltary Sr. wrote:
>
>> ##################### Bovine Spongiform Encephalopathy
>> #####################
>>
>> ARC 240/76
>> 12/10/76
>>
>> Research on Scrapie of Sheep
>>
>> At the meeting of Council on 15 June 1976, scrapie of sheep was
>> discussed
>> during consideration of the Report of the Visiting Group to the
>> Animal Diseases
>> Research Association. Several important matters were raised,
>> including the
>> ban recently imposed by the USDA on the use for human food not only
>> of sheep
>> affected with scrapie but also of related or exposed sheep or goats.
>> Council
>> decided further to discuss scrapie at its meeting on 12 October l976
>> with
>> particular reference to the question of whether the Council's Technical
>> Committee on Scrapie Research, which last met in 1969 and was wound
>> up formally
>> when the JCO was established, should be reconstituted in order to
>> advise on
>> future research policy.
>>
>> The USDA concern is based on observations that the chronic progressive
>> degeneration of the central nervous system characteristic of scrapie
>> has points
>> of similarity with certain neurological diseases of man. Although
>> there is no
>> evidence that sheep meat causes these disorders in man, the fear of
>> such a possibility could have serious consequences for the sheep
>> industry.
>>
>> This development adds emphasis to a topic which already has a high
>> priority in
>> scrapie research, viz,, the development of a test for the early
>> diagnosis of
>> scrapie in the clinically healthy animal. It is at present
>> impossible to
>> identify animals infected with scrapie which are in a pre-clinical
>> state. A
>> number of promising approaches have been pursued, but so far without
>> success.
>>
>> Another important topic is the assessment of the hazard to man of the
>> scrapie
>> agent. This depends to a large extent on gaining knowledge of the
>> nature of the
>> agent, a problem which still awaits clarification in spite of a very
>> substantial
>> amount of research. Although the agent is known to be transmissible,
>> filterable,
>> and self-replicating, it has characteristics which are not typical of
>> conventional
>> viruses. It is very resistant to heat and chemical disinfectants.
>> Its replication
>> in cell culture is unusual. It provokes no immune response in the
>> usual way,
>> although there are indications that new techniques are detecting a
>> type of response.
>> Its nucleic acid statue is not typical of viruses and this is an
>> aspect which has
>> been attracting considerable biochemical effort with the objective of
>> isolating
>> scrapie—specific nucleic acid molecules.
>>
>> The feasibility of breeding sheep resistant to scrapie is being
>> investigated.
>> There are a number of different strains of agent, however, and there
>> is the
>> problem that increased resistance to one strain might be accompanied
>> by increased
>> susceptibility to another.
>>
>> Another approach to control of the disease is the investigating of
>> "blocking
>> agents" which might successfully compete with the acrapie agent for
>> replication
>> sites.
>>
>> The type of advice which should be given on control measures is being
>> discussed
>> by the Ministry of Agriculture, Fisheries and Food's Scrapie Working
>> Group on
>> which there are two ARS scrapie research workers.
>>
>> There are a number of technical problems which although not unique to
>> scrapie,
>> combine to make difficulties and increase expense. Examples are the
>> need to
>> maintain experimental animals during the long incubation period in
>> accommodation
>> sufficiently secure to prevent cross—infection, to take precautions
>> in the
>> microbiological laboratories to prevent cross-contamination, and to
>> provide
>>
>> 76/10.12/2.1
>>
>> elaborate controls for the biochemical investigations.
>>
>> Another aspect is that scrapie ie a disease which is not only of
>> agricultural
>> importance but is also of medical and biological significence. It is
>> the most
>> convenient model for this type of infection by virtue of the
>> susceptibility
>> of small laboratory animals, and certain cell lines. This raises the
>> question
>> of whether scrapie research should be funded by more than one body,
>> viz MRC
>> as well as ARC.
>>
>> Council may feel that, in view of the complex and specialised nature
>> of the
>> subject and the probability of requests for substantial financial
>> support, it
>> would be advantageous to have an expert group to assess current and
>> proposed
>> research and to make recommendations.
>>
>> http://www.bseinquiry.gov.uk/files/yb/1976/10/12002001.pdf
>>
>> TSS
>>
>> ######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html
>> ##########
>>
>>
>

######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########






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