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From: TSS ()
Subject: ENDOSCOPY EQUIPMENT (Terminal ileal biopsies should not be used) and CJD (ALL PHENOTYPES)
Date: March 8, 2005 at 1:09 pm PST

-------- Original Message --------
Subject: Terminal ileal biopsies should not be used to document extent of colonoscopic examination
Date: Tue, 8 Mar 2005 09:17:50 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy

##################### Bovine Spongiform Encephalopathy #####################

Greetings again,

seems Bramble et al have failed to take heed to the latest data on
atypical TSEs. UNTIL the BSE/nvCJD 'ONLY THEORY' is put to rest
once and for all, this agent will continue to spread. with the findings
of the testing with CDI from Prusiner et al and Aguzzi continued
warnings of muscle tissue and Collinge warnings about sporadic CJD,
to continue with this BSE/nvCJD 'ONLY THEORY' should be regarded
with great suspicion. WITH many atypical TSEs showing up in cattle,
sheep and goats in many different parts of the Globe, with the findings
of BASE in cattle in Italy of Identification of a second bovine
amyloidotic spongiform encephalopathy: Molecular similarities
with sporadic Creutzfeldt-Jakob disease

Adaptation of the bovine spongiform encephalopathy agent to primates and
comparison with Creutzfeldt- Jakob disease: Implications for human
health THE findings from Corinne Ida Lasmézas*, [dagger] , Jean-Guy
Fournier*, Virginie Nouvel*, Hermann Boe*, Domíníque Marcé*, François
Lamoury*, Nicolas Kopp [Dagger ] , Jean-Jacques Hauw§, James Ironside¶,
Moira Bruce [||] , Dominique Dormont*, and Jean-Philippe Deslys* et al,
that The agent responsible for French iatrogenic growth hormone-linked
CJD taken as a control is very different from vCJD but is similar to
that found in one case of sporadic CJD and one sheep scrapie isolate;

Characterization of two distinct prion strains derived from bovine
spongiform encephalopathy transmissions to inbred mice

threat will only allow this agent to continue to spread...TSS

Gut 2005;54:566
© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology


Terminal ileal biopsies should not be used to document extent of
colonoscopic examination

M D Rutter1 and M G Bramble2

1 University Hospital of North Tees, Stockton-on-Tees, Cleveland, UK
2 James Cook University Hospital, Middlesbrough, Cleveland, UK

Correspondence to:
Dr M D Rutter
University Hospital of North Tees, Stockton-on-Tees, Cleveland, TS19
8PE, UK;

Keywords: ileal biopsies; colonoscopy; guidelines

The first 150 words of the full text
of this article
appear below.

We commend the British Society of Gastroenterology and the authors for
the excellent publication of guidelines for the management of
inflammatory bowel disease in adults (Gut 2004;53(suppl V):v1v16).
However, we feel that their recommendation for routine terminal ileal
biopsying is inappropriate. Although it is important to biopsy the
terminal ileum if there is macroscopic evidence of an abnormality, their
statement that "a terminal ileal biopsy performed at colonoscopy
documents the extent of examination" is not recommended practice, due to
the potential risk of variant Creutzfeld-Jacob disease transmission from
prion proteins which are prevalent in the lymphoid tissue of Peyers
patches in the ileum. Although the use of disposable forceps may reduce
the risk of transmission, there could still be contamination of the
intubation channel of the colonoscope and prion protein is resistant to
the standard endoscopic cleaning process.1 If the extent of examination
needs to . . . [Full text of this article

-------- Original Message --------
Subject: Re: gutjnl_el;110 Terry S. Singeltary Sr. (22 Aug 2003) ""CJDs
(all human TSEs) and Endoscopy Equipment
Date: Tue, 26 Aug 2003 15:10:51 -0500
From: "Terry S. Singeltary Sr."

hello Professor Spiller and GUT, this has become a real challenge trying
to raise my concerns to GUT about sporadic CJD. but i will not give up.
you only have to see it once. i hope you take the time to read over all
data below...thank you > unsubstantiated opinion and emotion these are
not my unsubstantiated opinions, they are backed up by science
(transmission studies and or lack of transmissions studies), and i will
try and leave my emotions out. > I feel that we need a proper evidence
based approach to this. > There is too much unsubstantiated opinion i
agree... to categorically state that nv/v CJD is the only risk to
endoscopy equipment, while ignoring all other TSEs, is very
unsubstantiated. i will try and give more evidence for my concerns
below. 1st, there has never been to date any _documented_ transmission
of nv/v CJD via the medical surgical arena. this has only been
hypothesized... 2nd, However, there has been _documented_ evidence of
transmission of sporadic CJD via the medical and surgical arena. TO
continue to hide behind the nv/v CJD only theory, when there are over 20
strains of scrapie, most of which transmits to all mammalian species
that has been tried upon, CWD which no one knows if or if not it can
transmit to humans (to date no transmission studies of any TSEs done on
man), but studies have shown transmission to humans as easy as BSE, and
does transmit to primate. there are now 6 _documented_ phenotypes of
sporadic CJD. with CWD and Scrapie running rampant in the USA, no real
active surveillance in cattle for TSEs and no rapid testing done to find
BSE agent (48,000+ BSE/TSE test in 14 years TOTAL USA), who knows how
these strains of CJD will act and how they will transmit. also, in vitro
experiments have demonstrated that scrapie/cwd prions are as efficient
as BSE prions in transforming normal human prion protein to PrPSc. this
data strongly supports that scrapie/cwd is as infectious as BSE. IN
fact, scrapie seems to be more infectious than BSE due to higher
concentration of TSE infectious agents in ovine muscle meat and other
parts of the sheep, when compared to cattle, and CWD could even be more
infectious than all of them, if you consider how it has rapidly spread
across the USA. but to categorically state that only nv/v CJD to be of
risk to endoscopy equipment when no such documented transmission has
ever been documented, while ignoring such similar medical _documented_
transmissions in sporadic CJD, this is very disturbing and most
unsubstantiated, and potentially risking TSE exposure to millions and
millions due to nothing more than denial and wishful thinking. if i
could deny this and wish it away, i would have done this six years ago.
but we cant, all we can do is warn the public and the medical community
of what we know to date. i am surprised GUT has chosen not to do this,
and only to go with the BSE/nv/v/CJD only theory. 85%+ of all CJDs don't
just happen without route and source. my fear is a great deal are being
mis-diagnosed and un-reported, but being acquired via the medical
surgical arena. but one will never know without making all human TSEs
reportable in every State, and issuing a CJD Questionnaire to all
families of victims of CJD/TSE and asking the _real_ questions that
pertain to route and source of agent...TSS REFERENCES




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