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From: TSS ()
Subject: Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge
Date: February 10, 2005 at 1:12 pm PST

-------- Original Message --------
Subject: Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge
Date: Thu, 10 Feb 2005 14:38:05 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Tissue distribution of bovine spongiform encephalopathy infectivity in
Romney sheep up to the onset of clinical disease after oral challenge

Sixty Romney sheep of three prion protein genotypes were dosed orally at
six months of age with an inoculum prepared from the brains of cattle
clinically affected with BSE, and 15 sheep were left undosed as
controls. They were randomly assigned within genotype to groups and were
sequentially euthanased and examined postmortem at intervals of six or
12 months, depending on their predicted susceptibility. Tissue pools
prepared from the three, four or five dosed animals in each group were
inoculated into groups of 20 RIII mice as a bioassay for infectivity.
Separate inocula were prepared from the matched control sheep killed at
each time. In the ARQ/ARQ sheep killed four months after inoculation,
infectivity was detected in the Peyer's patch tissue pool, and at 10
months it was detected in the spleen pool; from 16 months, infectivity
was detected in a range of nervous and lymphoreticular tissues,
including the spinal cord pool, distal ileum excluding Peyer's patches,
liver, Peyer's patches, mesenteric and prescapular lymph nodes, spleen,
tonsil and cervical thymus. No infectivity was detected in the tissue
pools from the ARQ/ARR and ARR/ARR sheep killed 10 months or 22 months
after infection.

http://www.vetrecord.co.uk/abs1033.htm

TSS

######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########






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