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From: TSS (pool144-69.dial-u1.hou.wt.net)
Subject: Health Alert on Certain Sheep Milk Cheese 2000 TSS SUBMISSION VERMONT HEALTH DEPARTMENT 2005
Date: February 7, 2005 at 7:21 pm PST

-------- Original Message --------
Subject: Health Alert on Certain Sheep Milk Cheese 2000 TSS SUBMISSION VERMONT HEALTH DEPARTMENT 2005
Date: Sun, 6 Feb 2005 12:26:20 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Don't eat sheep cheese, public told

July 19, 2000

By JOHN DILLON and STEFAN HARD

Staff Writers

WARREN - State health officials are warning the public not to eat cheese
made from the milk of sheep the federal government claims are infected
with a form of mad cow disease.

Health Commissioner Dr. Jan Carney issued the warning Tuesday after
consulting with the federal Centers for Disease Control in Atlanta about
the safety of milk from the infected animals.

The Health Department warning is the latest move in an ongoing battle
over the fate of 376 sheep on two Vermont farms. The U.S. Department of
Agriculture last week announced it would seize and destroy the animals
because a test had shown four were infected with a form of transmissible
spongiform encephalopathy, or TSE.

TSE is a class of degenerative, always fatal, brain diseases that
includes mad cow disease, a mysterious ailment that ravaged the British
beef industry and led to 53 deaths in the United Kingdom. The USDA is
concerned that the Vermont sheep or their forebears were exposed to the
disease before they were imported from Europe in the mid-1990s.

Federal officials had maintained until Monday that the cheese made from
the Vermont sheep's milk was safe to consume. However, the CDC has now
told Carney there is a risk that humans could contract the disease from
eating the cheese, she said.

Carney noted, however, that the risk is very slight because studies have
not shown that people got the illness through eating dairy products
during an outbreak of mad cow disease in the United Kingdom.

"The emphasis is on the word precaution," Carney said. The CDC
"characterized the risk (of eating the cheese) as theoretical, meaning
to date no one has ever become ill from eating milk or milk products
from cows exposed" to the disease.

The Health Department warning applies to cheese sold under the name
Three Shepherds of the Mad River Valley and Northeast Kingdom Sheep Milk
Cheese.

Carney said officials - despite Tuesday's warning - are not ordering the
cheese be taken off store shelves.

"As of today, there is no recall," she said. "This is intended as a
recommendation for the public."

At the Warren farm where the Three Shepherds cheese is made, owners
Larry and Linda Faillace handed out cheese to friends and neighbors
Tuesday. The Faillaces maintain the cheese is safe to eat and are
considering going to court to block the federal seizure of their flock.

"This (Health Department warning) is just another example of
pseudo-science. It's another example of them trying to put us out of
business," Linda Faillace said.

The Faillaces have set up a phone tree that would summon supporters to
their Warren farm within 15 minutes should federal officials arrive to
seize the animals.

A U.S. Department of Agriculture official, accompanied by two U.S.
Marshals, served the Faillaces with a seizure order Monday afternoon and
locked up 18 wheels of cheese produced from the sheep's milk.

The Warren couple was cheered Monday night by about 60 people who filled
the upstairs of the Old Schoolhouse in Warren for a rally. A large "Save
Our Sheep" banner stretched across the front of the Old Schoolhouse,
where Roger Hussey moderated an emotional meeting that lasted nearly two
hours.

Linda Faillace told the crowd that "Big Brother" USDA was using "bad
science" to indict their herd of sheep for political reasons, partly to
protect the U.S. beef industry from suspicion that it may be
contaminated with mad cow disease.

Belgian sheep farmer Freddy Michiels supported the Faillaces' theory. He
said the USDA seemed to be acting irrationally and precipitously in the
Faillace case, based on his experience in Belgium where his East
Friesian sheep have been tested repeatedly for forms of mad cow disease.

Michiels is staying with the Faillaces this week to teach cheesemaking
classes, and knows the history of the Faillaces' herd. He said the
animals pose no danger to the public.

However, Dr. Linda Detwiler, a USDA veterinarian dealing with the
Faillace case, said two lab tests have shown the Vermont flock has TSE.
She said the tests are scientifically valid and must be taken seriously.

Detwiler said Tuesday the tests found an abnormal protein used as a
marker that indicates a form of TSE. "This is what prompted this
action," she said. "We actually had a confirmatory test in these animals."

She said the tests cannot differentiate whether the sheep have a form of
scrapie - a fairly common TSE sheep disease - or a version of mad cow
disease. "We can say now there is infection (in the animals)," she said.
"This marker would indicate an infectious agent in sheep."

But Thomas Pringle, an Oregon molecular biologist and TSE expert, said
the USDA should have done a double-blind study - one in which the
samples were not identified - before condemning the sheep. He said
instead the samples were labeled as coming from the controversial
Vermont herd, which could have prejudiced the results.

"This is basic high-school science fair stuff," he said.

Pringle said there would be no harm to the public or to the American
livestock industry if the government waited while the tests on the
Vermont sheep were compared to tissue slides of TSE in British sheep.
But the USDA is rushing, he said, because it wants to impress the
European Union - which has banned imports of U.S. beef - that it is
doing everything possible to curb the spread of mad cow disease.

"From the point of view of the U.S. beef industry, these Vermont sheep
farms had to go. They were pawns in a larger game," he said. "This is
high profile image-buffing to demonstrate our resolve to deal with any
whiff of BSE (bovine spongiform encephalopathy) in American livestock.
The intended target is not the American consumer. The intended target is
European authorities" who control U.S. beef imports.

In addition to the Warren flock, about 200 sheep owned by Stowe
philanthropist Houghton Freeman is also subject to the seizure order.

Freeman's attorney, Thomas Amidon of Stowe, said he will likely use a
two-fold argument against the seizure. "We will discuss whether the USDA
followed its own rules and regulations, and whether this extraordinary
measure is justified given that it is based on results from one test,"
he said.

© 1999 Rutland Herald

http://www.rutlandherald.com/sheep/leahyjeffords.html


July 19, 2000

Health Alert on Certain Sheep Milk Cheese

Based on advice from the Centers for Disease Control & Prevention, the
Vermont Health Department recommends that people not eat two brands of
Vermont sheep milk cheese.

(November 9, 2001: This Health Alert has been lifted.)


http://www.healthyvermonters.info/news.shtml


-------- Original Message --------

Subject: CJD HUMAN/ANIMAL TSEs VERMONT i.e. ATYPICAL VERMONT SHEEP FROM
BELGIUM AND THAT CHEESE/MILK
Date: Sun, 06 Feb 2005 10:01:37 -0600
From: "Terry S. Singeltary Sr."
To: "Terry S. Singeltary Sr."
CC: pressrelease@rutlandherald.com, letters@rutlandherald.com,
john.mitchell@rutlandherald.com

A kind Greetings to all. FYI, i think some of you should
look into this again...............TSS

> Don't eat sheep cheese, public told
>
> July 19, 2000
>
> By JOHN DILLON and STEFAN HARD
>
> Staff Writers
>


-------- Original Message --------
Subject: CJD HUMAN/ANIMAL TSEs VERMONT i.e. ATYPICAL VERMONT SHEEP FROM
BELGIUM AND THAT CHEESE/MILK
Date: Sat, 05 Feb 2005 21:22:59 -0600
From: "Terry S. Singeltary Sr.
To: bapao@vdh.state.vt.us
CC: lcrist@vdh.state.vt.us, smoffat@vdh.state.vt.us

Greetings to

Vermont Department of Health

Division of Health Surveillance P.O. Box 70 Burlington, VT 05402-0070

Agency of Human Services

Jan K. Carney, MD, MPH

Commissioner

Ann R. Fingar, MD, MPH

State Epidemiologist Managing Editor

Apao,William K

Moffatt, Sharon G

I would like to write to you about my concerns of the most
recent findings of BSE to the GOAT under natural field
conditions and the recent findings of the Atypical Case of Bovine
Spongiform Encephalopathy in an East-Flemish Cow in Belgium,
in relations to the ATYPICAL VERMONT SHEEP and the
cheese and milk that was distributed to the public. THIS should
highten the concern of that situation, that was in all essence,
given the ALL CLEAR. I would also like to know why the
USDA put off those mouse bio assays of those sheep in
Vermont for 2 years, when we were told they had started?

July 19, 2000

Health Alert on Certain Sheep Milk Cheese

Based on advice from the Centers for Disease Control & Prevention, the
Vermont Health Department recommends that people not eat two brands of
Vermont sheep milk cheese.

(November 9, 2001: This Health Alert has been lifted.)

Retrieved on 2/5/05, NO link to original warning...TSS

http://www.healthyvermonters.info/news.shtml

Vermont Department of Health
Health Surveillance Division Reportable Diseases Updated 03/15/2004

Creutzfeldt-Jakob disease/transmissible
spongiform encephalopathies

snip...

Reporting of Diseases
The law requires that health care providers report diseases of public
health importance. Persons who are required to report: health care
facilities,
health care providers, health maintenance organizations, hospital
administrators, laboratory directors, managed care organizations, nurse
practitioners, nurses, physician assistants, physicians, school health
officials, town health officers. Cases of reportable diseases should be
reported to the Division within 24 hours.
24 Hour Telephone Reporting Line (802)951-4080 or 1-888-588-7781
Consultation and Inquiries 802-863-7240 (7:45AM  4:30PM M-F) or
1-800-640-4374 (VT only)
Emergency Consultation after normal business hours also available at
numbers above

http://www.healthyvermonters.info/hs/epi/idepi/reportable/reportablephysician2004.pdf

http://www.healthyvermonters.info/hs/epi/idepi/reportable/Reportablelaboratory2004.pdf

1. Reportable Diseases and Syndromes (to include any rare infectious
disease or one dangerous to public health)
Any unexpected pattern of cases, suspected cases, deaths or increased
incidence of any other illness of major
public health concern, because of the severity of illness or potential
for epidemic spread, which may indicate a newly
recognized infectious agent, an outbreak, epidemic, related public
health hazard or act of bioterrorism.

snip...

Creutzfeldt-Jakob disease/transmissible
spongiform encephalopathies

snip...

http://www.healthyvermonters.info/hs/epi/idepi/reportable/CommunicableDiseaseRegs2004.pdf

Quality Improvement

Death certificates report both the Cause of Death and the Manner of
Death. As part of new death surveillance practices and to improve death
reporting, the Office of the Chief Medical Examiner now reviews the
cause and manner of death statements on all certificates. Death
certificates can only be amended after discussion and agreement between
the chief medical examiner and the certifying physician.

In November 2001, the cause of death was amended on approximately 7
percent of all death certificates. Recently the rate of amendment has
dropped to about 5 percent, indicating improved reporting. In addition,
the Manner of Death has been changed on 2 percent of certificates. In
most cases, discussions about amendments take only a few minutes and can
be done at the physicians convenience.

Common Errors in Cause of Death

By far, the most common error in Cause of Death statements has been lack
of etiologic specificity. The Cause of Death section should explain
completely why someone died by listing the Underlying Cause and its
sequelae that led to the Immediate Cause of Death. Physicians sometimes
enter only the Mechanism of Death but not the underlying cause.

Definitions

The Mechanism, Mode or Immediate Cause of Death is the altered
physiology or biochemistry by which the cause exerts its lethal effect.
Mechanisms lack etiologic specificity and cannot stand alone on the
death certificate. Examples of mechanisms of death include
bronchopneumonia, liver failure, and pulmonary embolism. Immediate
causes of death are sequelae of the underlying cause of death.

The Underlying Cause of Death is the original cause, which in a natural
and continuous sequence, unbroken by any efficient intervening cause,
produces the fatality and without which the end result would not have
occurred.

Cause of Death Examples:
Incorrect: Sudden cardiac death
Correct: Sudden cardiac death
Due to hypertensive and atherosclerotic cardiovascular disease
Incorrect: Aspiration pneumonia
Correct: Aspiration pneumonia
Due to dysphagia
Due to cerebral infarct
Due to atherosclerotic cardiovascular disease
Incorrect: Renal failure
Correct: Renal failure
Due to acute/chronic pyelonephritis
Due to indwelling catheter
Due to dementia

The Manner of Death describes how the cause arose or the circumstances
surrounding the death. The Death Certificate allows only four possible
manners of death: Natural, Accident, Suicide, or Homicide. By law a
physician who is not a medical examiner can only certify natural deaths.
Natural deaths are by definition deaths caused solely by natural
disease. Anything else that contributes (such as trauma) makes the death
not natural and must be certified by a medical examiner. The timeframe
does not matter. For example: a person with dementia who sustains a
femoral fracture from a fall, has it repaired surgically, and then
develops pneumonia several weeks later as a result of being bedridden
since the fall. This is an accidental death, not a natural death. It
should be classified as follows:
Part 1. Immediate Cause: Bronchopneumonia
Due to Immobility
Due to Femoral fracture
Due to Blunt Impact (fell from standing height)
Part 2. Other significant conditions contributing to death but not
resulting in the underlying cause listed in Part 1: Dementia;
Atherosclerosis;
Osteoporosis 27a. Manner of Death: Accident

To discuss the wording in difficult cases or for more information, call
the Office of the Chief Medical Examiner at (802) 863-7320.


snip...

http://www.healthyvermonters.info/dcb/092002.shtml


NOW FOR THE DISTURBING FACTOR OF CJD SURVEILLANCE IN VERMONT,
they only seem to be concerned with humans under the age of 55.
THIS IS NOT ACCEPTABLE! WE have new strains
of TSE (BASE) in cattle that are not similar to nvCJD but
very similar to that of sporadic CJD. WE also have sporadic
CJD very similar to a French Scrapie strain in sheep.


Creutzfeldt-Jakob Disease Surveillance

Effective August 2001, Creutzfeldt-Jakob disease (CJD) became reportable
under Vermonts Communicable Disease Regulations. Health care providers
are required to report suspect and confirmed cases of CJD to the Vermont
Department of Health.

The Health Department is participating in CDCs Creutzfeldt-Jakob
disease mortality surveillance system. This system was initiated in
1996, after the announcement in the United Kingdom of the emergence of a
new variant form of CJD (vCJD) in humans due to infection by the agent
of bovine spongiform encephalopathy (mad cow disease). As part of this
surveillance system, CDC reviews routinely collected multiple
cause-of-death data submitted to the National Center for Health
Statistics (NCHS). Because of the over 12-month delay in the
availability of NCHS mortality data, CDC has asked state health
departments to conduct quarterly reviews of vital statistics data to
identify CJD deaths among individuals younger than age 55. For any such
deaths, clinical records are reviewed to consider the diagnosis of CJD
vs. vCJD.

CJD deaths among individuals younger than age 55 occur at the rate of
approximately one case per ten million United States population per
year. We expect an average of fewer than one CJD death per year among
Vermonters younger than age 55. Since over 99 percent of vCJD cases to
date have occurred among people under the age of 55, detailed review of
young CJD cases is a sensitive way to assess the presence or absence of
vCJD in the United States. There have been four deaths from CJD in
Vermont in individuals younger than 55 years of age between 1968 and 2001.

Prompt reporting of suspect and confirmed cases of CJD is an important
part of this surveillance effort. To report a case, call the Health
Department at 802-863-7240 or 1-800-640-4374 (in VT) or call the 24-hour
confidential reporting line at 802-951-4080 or 1-888-588-7781 (in VT).

------------------------------------------------------------------------

http://www.healthyvermonters.info/dcb/092002.shtml

TO DATE, the oldest documented case of nvCJD is 74
years old and the sporadic CJD cases are being documented
in people as young as 16 years old in the USA. TO continue
this nvCJD/BSE one species risk to humans ONLY theory is
no longer logical or scientific.

HOWEVER, even more disturbing is the fact of all the atypical
TSEs in all species, including the East-Flemish Cow in Belgium,
which makes those VERMONT SHEEP AT MAD RIVER
VALLEY even more interesting. THEY most likely would have consumed the
same type tainted BSE feed as this cow ;

Atypical Case of Bovine Spongiform Encephalopathy in an East-Flemish
Cow in Belgium

H. De Bosschere, DVM, PhD

S. Roels, DVM, PhD

E. Vanopdenbosch, DVM, Lic

Veterinary and Agrochemical Research Centre (CODA/CERVA)

National Reference Laboratorium for Veterinary TSEs

Groeselenberg 99, B-1180

Ukkel (Brussels), Belgium

KEY WORDS: Bovine spongiform encephalopathy, BSE, Western blot, atypical
BSE.

ABSTRACT

For many years, researchers believed that only one bovine spongiform
encephalopathy (BSE) strain existed, in contrast to the many different
scrapie strains found. However, only very recently reports emerged about
unconventional BSE strains seen in Italy, France, and Japan. The present
case describes an atypical strain of BSE in Belgium in a 64-month-old
East-Flemish cow with an electrophoretic profile and other features
similar to those described in Japan.

INTRODUCTION

snip...

DISCUSSION

For many years, researchers assumed that only one BSE strain
existed.710 Only in the past months, reports of atypical BSE cases
were announced.1113 The Japanese case11 describes a very young bull (23
months) characterized by the absence of spongiform changes and PrPsc
deposits immunohistochemically. The WB analysis revealed an
electrophoretic profile different from that of typical BSE,
characterized by low content of the di-glycosylated molecular form of
PrPsc and a faster migration of the nonglycosylated form of PrPsc. In
Italy,12 two BSE affected cattle with a previously unrecognized
neuropathologic profile and PrPsc type were seen. These cases were
determined using a different staining pattern on immunohistochemistry, a
difference in size and glycoform ratio of PrPsc on immunoblot and a
difference in regional distribution of lesions. The two cases in
France13 showed variant molecular features with a different PrPsc
electrophoretic profile from other BSE cases, mainly characterized by a
higher molecular mass of the nonglycosylated PrPsc. The present case
shows the most similarities (ie, identical electrophoretic profile, only
ELISA and WB positive and histopathology and immunohistochemistry
negative) with the Japanese case,11 although the cow in the Japanese
case was only 23 months old, and the cow in this case was 64 months old.

The fact that these strains were detected worldwide and in several
breeds suggest that there is no local or breed-dependent feature
involved. It could be that the WB techniques have become more specific
within the past year in the detection of minor differences in di-,
mono-, and nonglycosylated molecular forms of PrPsc. Infection of cattle
by scrapie could also be considered since scrapie can be transmitted by
direct contact between animals or through environmental contamination.13

In conclusion, this Belgian case should be added to the list of atypical
BSE strains only very recently detected worldwide and may contribute to
further research studies about epidemiologic significance. Current
continued research on BSE would appear to reveal different BSE strains
in analogy with the different scrapie strains.

ACKNOWLEDGMENTS

snip...


http://www.jarvm.com/articles/Vol2Iss1/DEBOSSCHERE.htm


DETECTION OF THE BOVINE SPONGIFORM ENCEPHALOPATHY AGENT IN THE CAPRINE
SPECIES IN FRANCE
Confirmation (final report)

See also: 19 November 2004


See Disease Information, 17 (47), 343, dated 19 November 2004

Translation of information received on 4 February 2005 from Dr Isabelle
Chmitelin, Delegate of France to the OIE:

Report date: 1 February 2005.

Reason for immediate notification: evidence of a change in the
epidemiology of a listed disease.

Precise identification of agent: pathological prion protein responsible
for bovine spongiform encephalopathy (BSE).

Date of confirmation of the event: 28 January 2005.

Date of start of the event: 19 November 2002.

Clinical disease: no.

Nature of diagnosis: laboratory.

Details of outbreak:

First administrative division Lower administrative division Type of
epide-miolo-gical unit Name of the location Date of start of the
outbreak Spe-cies Number of animals in the outbreak
susceptible cases deaths destroyed slaugh-tered
Rhône-Alpes region Ardèche department farm Plats 19 Nov. 2002 cap 580 1
0 580 0

Description of affected population: one caprine BSE case was detected in
a dairy goat herd with approximately 300 adult animals.

Diagnosis:

Laboratories where diagnosis was made Species examined Diagnostic tests
used Date Results
AFSSA(1), Lyon cap

- western blot,

- bioassay,

11 Jan. 2005 positive
CEA(2), Saclay and Fontenay-aux-Roses cap

- western blot,

- western blot, - ELISA(4).

11 Jan. 2005 positive
INRA(3), Tours and Jouy-en-Josas cap

- western blot,

- bioassay,

11 Jan. 2005 positive
Veterinary Schools, Toulouse and Paris cap

- western blot,

- bioassay,

11 Jan. 2005 positive

The case was confirmed on 28 January 2005 by VLA Weybridge(5), European
Union Reference Laboratory for Transmissible Spongiform Encephalopathies
and OIE Reference Laboratory for BSE.

Origin of infection: unknown or inconclusive.

Control measure applied: stamping out.

(1) AFSSA: Agence française de sécurité sanitaire des aliments (French
Agency for Food Safety)

(2) CEA: Commissariat à l'énergie atomique (French Atomic Energy Agency)

(3) INRA: Institut national de la recherche agronomique (French National
Institute for Agricultural Research)

(4) ELISA: enzyme-linked immunosorbent assay

(5) Veterinary Laboratories Agency, Weybridge, New Haw, United Kingdom

Note by the OIE Animal Health Information Department: the report from
the Reference Laboratory is available on the internet, at the following
address:
http://europa.eu.int/comm/food/food/biosafety/bse/crl_statement_tse_goats_28-01-05_en.pdf

*
* *

http://www.oie.int/eng/info/hebdo/a_current.htm#Sec3


Brussels, 26 November 2004
Statement
of the EFSA Scientific Expert Working Group on BSE/TSE
of the Scientific Panel on Biological Hazards
on the health risks of the consumption
of milk and milk derived products from goats
The former Scientific Steering Committee of the European Commission and
recently the European Food Safety Authority (in its opinion related to TSE
surveillance and product safety in small ruminants) have recommended that
research should intensify on the safety of milk of small ruminants with
regard
to TSE risks. Despite these repeated recommendations there is very limited
published research data on TSE in goats and infectivity of goat products.
Although limited new data are expected to be published in the near future,
there is still little research initiated in this area.
Some research data support the finding that milk, colostrum and tissues
of the
mammary gland from bovines can be classified in the category of no
detectable infectivity. However, based on a number of observations from
research data, mainly research concerning sheep, there are indications that
infectivity in the milk from small ruminants cannot be totally excluded.
In case
of mastitis, one could expect an infiltration of potentially infected
blood into the
milk as the blood-milk barrier may not or only partly exist. But even in
the case
of absence of mastitis the barrier may not be 100% effective.
>From the limited data available today it is concluded that in the
light of current
scientific knowledge and irrespective of their geographical origin, milk
and milk
derivatives (e.g. lactoferrin, lactose) from small ruminants are unlikely to
present any risk of TSE contamination provided that milk is sourced from
clinically healthy animals. Exclusion of animals with mastitis is
considered to
reduce the potential risk. Further assurance of healthy milk could
include milk
tests for total somatic cell counts indicative of inflammation.

http://www.efsa.eu.int/science/biohaz/biohaz_documents/709/bdoc_statement_goatsmilk_en1.pdf


THE new findings of BASE in cattle in Italy of Identification of a
second bovine amyloidotic spongiform encephalopathy: Molecular
similarities with sporadic Creutzfeldt-Jakob disease

http://www.pnas.org/cgi/content/abstract/0305777101v1


Adaptation of the bovine spongiform encephalopathy agent to primates and
comparison with Creutzfeldt- Jakob disease: Implications for human
health THE findings from Corinne Ida Lasmézas*, [dagger] , Jean-Guy
Fournier*, Virginie Nouvel*, Hermann Boe*, Domíníque Marcé*, François
Lamoury*, Nicolas Kopp [Dagger ] , Jean-Jacques Hauw§, James Ironside¶,
Moira Bruce [||] , Dominique Dormont*, and Jean-Philippe Deslys* et al,
that The agent responsible for French iatrogenic growth hormone-linked
CJD taken as a control is very different from vCJD but is similar to
that found in one case of sporadic CJD and one sheep scrapie isolate;
http://www.pnas.org/cgi/content/full/041490898v1

Characterization of two distinct prion strains derived from bovine
spongiform encephalopathy transmissions to inbred mice
http://vir.sgmjournals.org/cgi/content/abstract/85/8/2471

BSE prions propagate as either variant CJD-like or sporadic CJD-like
prion strains in transgenic mice expressing human prion protein

Emmanuel A. Asante, Jacqueline M. Linehan, Melanie Desbruslais, Susan
Joiner, Ian Gowland, Andrew L. Wood, Julie Welch, Andrew F. Hill, Sarah
E. Lloyd, Jonathan D.F. Wadsworth and John Collinge1

MRC Prion Unit and Department of Neurodegenerative Disease, Institute of
Neurology, University College, Queen Square, London WC1N 3BG, UK 1
Corresponding author e-mail: j.collinge@prion.ucl.ac.uk


Received August 1, 2002; revised September 24, 2002; accepted October
17, 2002

Abstract


Variant CreutzfeldtJakob disease (vCJD) has been recognized to date
only in individuals homozygous for methionine at PRNP codon 129. Here we
show that transgenic mice expressing human PrP methionine 129,
inoculated with either bovine spongiform encephalopathy (BSE) or variant
CJD prions, may develop the neuropathological and molecular phenotype of
vCJD, consistent with these diseases being caused by the same prion
strain. Surprisingly, however, BSE transmission to these transgenic
mice, in addition to producing a vCJD-like phenotype, can also result in
a distinct molecular phenotype that is indistinguishable from that of
sporadic CJD with PrPSc type 2. These data suggest that more than one
BSE-derived prion strain might infect humans; it is therefore possible
that some patients with a phenotype consistent with sporadic CJD may
have a disease arising from BSE exposure...

http://embojournal.npgjournals.com/cgi/content/full/21/23/6358

J Infect Dis 1980 Aug;142(2):205-8


Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of
sheep and goats were transmitted to squirrel monkeys (Saimiri
sciureus) that were exposed to the infectious agents only by their
nonforced consumption of known infectious tissues. The asymptomatic
incubation period in the one monkey exposed to the virus of kuru was
36 months; that in the two monkeys exposed to the virus of
Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and
that in the two monkeys exposed to the virus of scrapie was 25 and
32 months, respectively. Careful physical examination of the buccal
cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has
remained asymptomatic during the 39 months that it has been under
observation.

PMID: 6997404

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6997404&dopt=Abstract


12/10/76
AGRICULTURAL RESEARCH COUNCIL
REPORT OF THE ADVISORY COMMITTE ON SCRAPIE
Office Note
CHAIRMAN: PROFESSOR PETER WILDY

snip...

A The Present Position with respect to Scrapie
A] The Problem

Scrapie is a natural disease of sheep and goats. It is a slow
and inexorably progressive degenerative disorder of the nervous system
and it ia fatal. It is enzootic in the United Kingdom but not in all
countries.

The field problem has been reviewed by a MAFF working group
(ARC 35/77). It is difficult to assess the incidence in Britain for
a variety of reasons but the disease causes serious financial loss;
it is estimated that it cost Swaledale breeders alone $l.7 M during
the five years 1971-1975. A further inestimable loss arises from the
closure of certain export markets, in particular those of the United
States, to British sheep.

It is clear that scrapie in sheep is important commercially and
for that reason alone effective measures to control it should be
devised as quickly as possible.

Recently the question has again been brought up as to whether
scrapie is transmissible to man. This has followed reports that the
disease has been transmitted to primates. One particularly lurid
speculation (Gajdusek 1977) conjectures that the agents of scrapie,
kuru, Creutzfeldt-Jakob disease and transmissible encephalopathy of
mink are varieties of a single "virus". The U.S. Department of
Agriculture concluded that it could "no longer justify or permit
scrapie-blood line and scrapie-exposed sheep and goats to be processed
for human or animal food at slaughter or rendering plants" (ARC 84/77)"
The problem is emphasised by the finding that some strains of scrapie
produce lesions identical to the once which characterise the human
dementias"

Whether true or not. the hypothesis that these agents might be
transmissible to man raises two considerations. First, the safety
of laboratory personnel requires prompt attention. Second, action
such as the "scorched meat" policy of USDA makes the solution of the
acrapie problem urgent if the sheep industry is not to suffer
grievously.

snip...

76/10.12/4.6

http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf

http://www.bseinquiry.gov.uk/files/yb/1976/10/12002001.pdf

SO, back to those VERMONT SHEEP imported from BELGIUM.
WHY were the mouse bio assays put off for 2 years after we
were told they would be started due the very important aspect
of the situation (human health) ?

Greetings list members,

It seems my efforts to find the truth behind the lies the USDA keep
telling us about the animal TSEs in the USA just keep getting deeper
and deeper. IT's like a revolving door of lies and deceit about
mad cow disease and other TSEs in animals in the USA. I would say
watching this administration crumble before our eyes after the
re-election, i would say these people deserve every bit that they get,
they voted for this chronic liar, put him back in office for us all to
endure another 4 years of the same old BSeee. HOWEVER, after
great consideration and thought i am deeply saddened at all this.
WHERE does it all end? HOW far is this administration willing
to go? IT's really become very very frightening. I feel like we are
not living in a Democracy anymore, but under a Dictatorship.
Everyone is entitled to an opinion, and that is mine.

WITH that said, I got a reply finally from SEAC about the infamous
VERMONT sheep from Belgium with the atypical TSE.

IF you remember correctly, Dr. Detwiler kindly replied to me about
this ;

> 6/12/04
>
> Mr. Singeltary.

> I hope this finds you well. As you are aware I left the USDA last
> year. I can only update you on the sheep before that time. Contact was
> established with the UK on doing the bioassay studies. They agreed.
> However, we were prioritized after their own needs, hence the delay. I
> am aware that there are now additional labs in Europe running the
> mouse bioassay strain typing. You will have to contact USDA for
> further word.
>
>>
>>
>> Linda Detwiler
>
>
>

TODAY, i finally recieve this from SEAC about these so called
mouse bioassays that never took place on the Vermont sheep,
and it still looks like the ball was dropped by the USDA to me.
I guess like everything else they do, we will never know the truth...


-------- Original Message --------
Subject: re-85th Meeting of SEAC - 30.11.04
Date: Tue, 21 Dec 2004 16:56:55 -0000
From: "Barlow, Tom (SEAC)"
To: "'flounder@wt.net'"

Dear Mr Singeltary

Thank you for you enquiry to the SEAC secretariat about mouse bioassays
commissioned by the USDA to investigate TSE cases in imported sheep.
After making a number of enquiries, it appears that Defra were not involved
with this work. However, it is possible that a UK research laboratory was
contacted by the USDA about such tests but I have been unable to find out
any further information. You may wish to make further enquiries with the
USDA.

Yours sincerely

Tom Barlow

Dr Tom Barlow
Spongiform Encephalopathy Advisory Committee (SEAC) Secretariat
Area 108, 1A Page Street, London SW1P 4PQ

Tel: 0207 904 6267
-----Original Message-----
From: Terry S. Singeltary Sr. [mailto:flounder@wt.net]
Sent: 02 December 2004 20:19
To: Dale, Tabitha J (SEAC)
Subject: re-85th Meeting of SEAC - 30.11.04


***GREETINGS AGAIN VERMONT***


THE AGE BRACKET FOR CJD stipulation concerns me;

> CDC has asked state health departments to conduct quarterly reviews of
> vital statistics data to identify CJD deaths among individuals younger
> than age 55. For any such deaths, clinical records are reviewed to
> consider the diagnosis of CJD vs. vCJD.
>

AGAIN, this makes no sense, this age brack will not stop the spread of
this agent via surgical instruments, implants and or blood, even with
sporadic
CJD, especially considering the different atypical phenotypes in other
species.
THE age bracket should be omitted and all human TSEs should be reported
quarterly.


DO you intend on making some sort of statement about this
to all the consumers of the cheese and milk from those
VERMONT SHEEP from MAD RIVER VALLEY that
had the ATYPICAL TSE and the new data that has come
out?


Thank you,

Kindest Regards,

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
CJD WATCH

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