SEARCH VEGSOURCE:

 

 

Follow Ups | Post Followup | Back to Discussion Board | VegSource
See spam or
inappropriate posts?
Please let us know.
  




From: TSS (pool144-69.dial-u1.hou.wt.net)
Subject: MONTHLY CREUTZFELDT JAKOB DISEASE STATISTICS February 07, 2005
Date: February 7, 2005 at 7:17 pm PST

-------- Original Message --------
Subject: MONTHLY CREUTZFELDT JAKOB DISEASE STATISTICS February 07, 2005
Date: Mon, 7 Feb 2005 08:53:09 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Date: February 07, 2005 Time: 09:45

MONTHLY CREUTZFELDT JAKOB DISEASE STATISTICS

The Department of Health is today issuing the latest information about
the numbers of known cases of Creutzfeldt Jakob disease. This includes
cases of variant Creutzfeldt Jakob disease (vCJD) - the form of the
disease thought to be linked to BSE. The position is as follows:

CREUTZFELDT-JAKOB DISEASE IN THE UK
By Calendar Year
REFERRALS OF SUSPECT CJD
DEATHS OF DEFINITE AND PROBABLE CJD

Year Ref's Year Sporadic Iatrogenic Familial GSS vCJD Total Deaths

1990 [53] 1990 28 5 0 0 - 33

1991 75 1991 32 1 3 0 - 36

1992 96 1992 45 2 5 1 - 53

1993 78 1993 37 4 3 2 - 46

1994 118 1994 53 1 4 3 - 61

1995 87 1995 35 4 2 3 3 47

1996 134 1996 40 4 2 4 10 60

1997 161 1997 60 6 4 1 10 81

1998 154 1998 63 3 3 2 18 89

1999 170 1999 62 6 2 0 15 85

2000 178 2000 50 1 2 1 28 82

2001 179 2001 58 4 3 2 20 87

2002 163 2002 72 0 4 1 17 94

2003 162 2003 77 5 4 2 18 106

2004 112 2004 47 1 2 1 9 60

2005* 8 2005 4 0 0 1 0 5

Total 1928 Total 763 47 43 24 148 1025 Ref's Deaths

Ref's = Referrals
* As at 4 February 2005

Summary of vCJD cases

Deaths
Deaths from definite vCJD (confirmed): 106
Deaths from probable vCJD (without neuropathological confirmation): 41
Deaths from probable vCJD (neuropathological confirmation pending): 1
Number of deaths from definite or probable vCJD (as above): 148

Alive
Number of definite/probable vCJD cases still alive: 6

Total number of definite or probable vCJD (dead and alive): 154

Definite and probable CJD cases in the UK are provided in the PDF attatched.

The next table will be published on Monday 7th of March.

Referrals: a simple count of all the cases which have been referred to
the National CJD Surveillance Unit for further investigation in the year
in question. CJD may be no more than suspected; about half the cases
referred in the past have turned out not to be CJD. Cases are notified
to the Unit from a variety of sources including neurologists,
neuropathologists, neurophysiologists, general physicians,
psychiatrists, electroencephalogram (EEG) departments etc. As a safety
net, death certificates coded under the specific rubrics 046.1 and 331.9
in the 9th ICD Revisions are obtained from the Office for National
Statistics in England and Wales, the General Register Office for
Scotland and the General Register Office for Northern Ireland.

Deaths: All columns show the number of deaths that have occurred in
definite and probable cases of all types of CJD and GSS in the year
shown. The figures include both cases referred to the Unit for
investigation while the patient was still alive and those where CJD was
only discovered post mortem (including a few cases picked up by the Unit
from death certificates). There is therefore no read across from these
columns to the referrals column. The figures will be subject to
retrospective adjustment as diagnoses are confirmed.

Definite cases: this refers to the diagnostic status of cases. In
definite cases the diagnosis will have been pathologically confirmed, in
most cases by post mortem examination of brain tissue (rarely it may be
possible to establish a definite diagnosis by brain biopsy while the
patient is still alive).

Probable vCJD cases: are those who fulfil the 'probable' criteria set
out in the Annex and are either still alive, or have died and await post
mortem pathological confirmation. Those still alive will always be shown
within the current year's figures.

Sporadic: Classic CJD cases with typical EEG and brain pathology.
Sporadic cases appear to occur spontaneously with no identifiable cause
and account for 85% of all cases.

Probable sporadic: Cases with a history of rapidly progressive dementia,
typical EEG and at least two of the following clinical features;
myoclonus, visual or cerebellar signs,
pyramidal/extrapyramidalsigns or akinetic mutism.

Iatrogenic: where infection with classic CJD has occurred accidentally
as the result of a medical procedure. All UK cases have resulted from
treatment with human derived pituitary growth hormones or from grafts
using dura mater (a membrane lining the skull).

Familial: cases occurring in families associated with mutations in the
PrP gene (10 - 15% of cases).

GSS: Gerstmann-Straussler-Scheinker syndrome - an exceedingly rare
inherited autosomal dominant disease, typified by chronic progressive
ataxia and terminal dementia. The clinical duration is from 2 to 10
years, much longer than for CJD.

vCJD: Variant CJD, the hitherto unrecognised variant of CJD discovered
by the National CJD Surveillance Unit and reported in The Lancet on 6
April 1996. This is characterised clinically by a progressive
neuropsychiatric disorder leading to ataxia, dementia and myoclonus (or
chorea) without the typical EEG appearance of CJD. Neuropathology shows
marked spongiform change and extensive florid plaques throughout the brain.

Definite vCJD cases still alive: These will be cases where the diagnosis
has been pathologically confirmed (by brain biopsy).

ANNEX
DIAGNOSTIC CRITERIA FOR VARIANT CJD

I A) PROGRESSIVE NEUROPSYCHIATRIC DISORDER
B) DURATION OF ILLNESS > 6 MONTHS
C) ROUTINE INVESTIGATIONS DO NOT SUGGEST AN ALTERNATIVE DIAGNOSIS D) NO
HISTORY OF POTENTIAL IATROGENIC EXPOSURE

II A) EARLY PSYCHIATRIC SYMPTOMS *
B) PERSISTENT PAINFUL SENSORY SYMPTOMS **
C) ATAXIA
D) MYOCLONUS OR CHOREA OR DYSTONIA
E) DEMENTIA

III A) EEG DOES NOT SHOW THE TYPICAL APPEARANCE OF SPORADIC CJD *** (OR
NO EEG PERFORMED)
B) BILATERAL PULVINAR HIGH SIGNAL ON MRI SCAN

IV A) POSITIVE TONSIL BIOPSY

DEFINITE: IA (PROGRESSIVE NEUROPSYCHIATRIC DISORDER) and
NEUROPATHOLOGICAL CONFIRMATION OF vCJD ****

PROBABLE: I and 4/5 OF II and III A and III B

or I and IV A

* depression, anxiety, apathy, withdrawal, delusions.

** this includes both frank pain and/or unpleasant dysaesthesia

*** generalised triphasic periodic complexes at approximately one per second

****spongiform change and extensive PrP deposition with florid plaques,
throughout the cerebrum and cerebellum.

http://www.wired-gov.net/WGLaunch.aspx?ARTCL=29668

TSS

######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########






Follow Ups:



Post a Followup

Name:
E-mail: (optional)
Subject:

Comments:

Optional Link URL:
Link Title:
Optional Image URL: