SEARCH VEGSOURCE:

 

 

Follow Ups | Post Followup | Back to Discussion Board | VegSource
See spam or
inappropriate posts?
Please let us know.
  




From: TSS (216-119-156-61.ipset36.wt.net)
Subject: Creutzfeldt-Jakob disease and inclusion body myositis: Abundant disease-associated prion protein in MUSCLE
Date: January 29, 2005 at 7:14 pm PST

-------- Original Message --------
Subject: Creutzfeldt-Jakob disease and inclusion body myositis: Abundant disease-associated prion protein in muscle
Date: Sat, 29 Jan 2005 17:03:25 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Creutzfeldt-Jakob disease and inclusion body myositis: Abundant
disease-associated prion protein in muscle
Gabor G. Kovacs, MD PhD 1 2, Elisabeth Lindeck-Pozza, MD 1, Leila
Chimelli, MD, PhD 3, Abelardo Q. C. Araújo, MD, PhD 4, Alberto A.
Gabbai, MD, PhD 5, Thomas Ströbel, PhD 1, Markus Glatzel, MD 6, Adriano
Aguzzi, MD, PhD 6, Herbert Budka, MD 1 *
1Institute of Neurology, University of Vienna, and Austrian Reference
Centre for Human Prion Diseases, Vienna, Austria
2National Institute of Psychiatry and Neurology, Budapest, Hungary
3Department of Pathology, School of Medicine, Federal University of Rio
de Janeiro
4Department of Neurology, School of Medicine, Federal University of Rio
de Janeiro
5Department of Neurology, School of Medicine, Federal University of Sao
Paulo, Brazil
6Institute of Neuropathology, University Hospital of Zürich, Zürich,
Switzerland
email: Herbert Budka (h.budka@akh-wien.ac.at
)

*Correspondence to Herbert Budka, Institute of Neurology, AKH 4J,
Wühringer Gürtel 18-20, POB 48, A-1097 Vienna, Austria

Funded by:
European Union (EU) Project; Grant Number: TSELAB QLK2-CT-2002-81523
EU Concerted Action PRIONET; Grant Number: QLK2-2000-CT-00837

Abstract

Pathologicalprion protein (PrPSc) is the hallmark of prion diseases
affecting primarily the central nervous system. Using
immunohistochemistry, paraffin-embedded tissue blot, and Western blot,
we demonstrated abundant PrPSc in the muscle of a patient with sporadic
Creutzfeldt-Jakob disease and inclusion body myositis. Extraneural
PrPC-PrPSc conversion in Creutzfeldt-Jakob disease appears to become
prominent when PrPC is abundantly available as substrate, as in
inclusion body myositis muscle.

------------------------------------------------------------------------
Received: 16 June 2003; Revised: 11 September 2003; Accepted: 11
September 2003
Digital Object Identifier (DOI)


10.1002/ana.10813 About DOI

http://www3.interscience.wiley.com/cgi-bin/abstract/106598055/ABSTRACT

NINDS Inclusion Body Myositis Information Page

http://www.ninds.nih.gov/disorders/inclusion_body_myositis/inclusion_body_myositis.htm

TSS


######### https://listserv.kaliv.uni-karlsruhe.de/warc/bse-l.html ##########





Follow Ups:



Post a Followup

Name:
E-mail: (optional)
Subject:

Comments:

Optional Link URL:
Link Title:
Optional Image URL: