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From: Terry S. Singeltary Sr. (216-119-143-74.ipset23.wt.net)
Subject: Re: Research Project: Study of Atypical Bse Project Number: 3625-32000-073-07
Date: January 3, 2005 at 9:39 am PST

In Reply to: Research Project: Study of Atypical Bse Project Number: 3625-32000-073-07 posted by Terry S. Singeltary Sr. on January 1, 2005 at 2:41 pm:

-------- Original Message --------
Subject: Re: Research Project: Study of Atypical Bse Project Number: 3625-32000-073-07
Date: Sun, 2 Jan 2005 11:21:30 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE
References: <41D723D7.60809@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

Greetings list members,

I was going over the data from the 1st documented BSE/TSE cow
in the USA and find it disturbing they thought it important enough
to use WB to verify there immunohistochemistry test then. HOWEVER,
on the 3, 4, and 5 mad cow in the USA, they refused to use WB
to confirm this. I guess it worked so well the first time they could not
afford to use it again. (please note the 2nd USA mad cow was the
one in TEXAS they cover-up after witnessing the stumbling and staggering
cow and then refusing to BSE/TSE test it, just decided to send to
the render to get rid of all evidence. SO, if you count that Texas cow,
there would have most likely have been 5 confirmed cases of BSE/TSE in
the USA, if they would have used the WB like they did on the first cow)...


TSEs Touch Off
ARS Research


A year ago this month, a group of ARS
scientists and technicians gave up their Christmas time off and even
delayed family vacations to provide characterization of the first case
of bovine spongiform encephalopathy (BSE)—commonly called mad cow
disease—to be found in the United States.

On December 23, 2003, a Canadian cow shipped to slaughter from a farm in
Mabton, Washington, had come up presumptively positive for BSE in
testing by USDA's Animal and Plant Health Inspection Service (APHIS),
which has diagnostic responsibility and regulatory oversight for BSE
issues. APHIS had already used the "gold standard" diagnostic
immunohistochemistry test, which was originally developed by ARS. But
for the first U.S. case of BSE, APHIS wanted additional scientific
information that could be provided by the Western blot test.

So APHIS put in a high-priority call to veterinary medical officer
Juergen Richt and his colleagues at the Virus and Prion Diseases of
Livestock Laboratory, which is part of ARS's National Animal Disease
Center (NADC) in Ames, Iowa.

"We had experience with the Western blot test and we had all the
reagents on hand," explains Richt. "So we put our holiday plans on hold
and got everything ready so that APHIS would have verification of the
results from the immunohistochemistry test." ........... snip

full text;

http://www.ars.usda.gov/is/AR/archive/dec04/tse1204.htm
http://www.ars.usda.gov/is/AR/archive/dec04/

TSS

Terry S. Singeltary Sr. wrote:

> ##################### Bovine Spongiform Encephalopathy
> #####################
>
> Research Project: Study of Atypical Bse
>
> Location:
>
>
>
> Virus and Prion Diseases of Livestock
>
>
> Project Number: 3625-32000-073-07
> Project Type: Specific C/A
>
> Start Date: Sep 15, 2004
> End Date: Sep 14, 2007
>
> Objective:
> The objective of this cooperative research project with Dr. Maria
> Caramelli from the Italian BSE Reference Laboratory in Turin, Italy,
> is to conduct comparative studies with the U.S. bovine spongiform
> encephalopathy (BSE) isolate and the atypical BSE isolates identified
> in Italy. The studies will cover the following areas: 1. Evaluation of
> present diagnostics tools used in the U.S. for the detection of
> atypical BSE cases. 2. Molecular comparison of the U.S. BSE isolate
> and other typical BSE isolates with atypical BSE cases. 3. Studies on
> transmissibility and tissue distribution of atypical BSE isolates in
> cattle and other species.
>
> Approach:
> This project will be done as a Specific Cooperative Agreement with the
> Italian BSE Reference Laboratory, Istituto Zooprofilattico
> Sperimentale del Piemonte, in Turin, Italy. It is essential for the
> U.S. BSE surveillance program to analyze the effectiveness of the U.S
> diagnostic tools for detection of atypical cases of BSE. Molecular
> comparisons of the U.S. BSE isolate with atypical BSE isolates will
> provide further characterization of the U.S. BSE isolate. Transmission
> studies are already underway using brain homogenates from atypical BSE
> cases into mice, cattle and sheep. It will be critical to see whether
> the atypical BSE isolates behave similarly to typical BSE isolates in
> terms of transmissibility and disease pathogenesis. If transmission
> occurs, tissue distribution comparisons will be made between cattle
> infected with the atypical BSE isolate and the U.S. BSE isolate.
> Differences in tissue distribution could require new regulations
> regarding specific risk material (SRM) removal.
>
> http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490
>
>> Differences in tissue distribution could require new regulations
>> regarding specific risk material (SRM) removal.
>
>
>
>




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