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From: TSS (216-119-143-141.ipset23.wt.net)
Subject: Re: Creutzfeldt-Jakob disease: Possible medical risk factors (October 1985)
Date: December 27, 2004 at 3:09 pm PST

In Reply to: Creutzfeldt-Jakob disease: Possible medical risk factors (October 1985) posted by Terry S. Singeltary Sr. on December 27, 2004 at 2:57 pm:

10 January 1990 COMMERCIAL IN CONFIDENCE

NOT FOR PUBLICATION

COMMITTEE ON SAFETY OF MEDICINES
WORKING PARTY ON BOVINE SPONGIFORM ENCEPHALOPATHY

SURGICAL CATGUT SUTURES
2.1 At the first meeting of the Working Party on Bovine
Spongiform Encephalopathy on 6 September 1989, detailed
consideration was given to XXXXX Surgical Catgut. This
arose from the Company's response to the Letter to Licence
Holders, indicating that the bovine small intestine source
material was derived from UK cattle, unlike 8 other
licenced catgut sutures. In contrast XXXXX Surgical
Catgut was stated to hold over 90% share of the market for
catgut sutures, and to constitute approximately 83% of all
sutures used in U.K.
IMPORTS OF SUTURES FROM THE KNOWN BSE COUNTRY;


3006.10.0000: STERILE SURGICAL CATGUT, SIMILAR STERILE SUTURE MATERIALS AND STERILETISSUE ADHESIVES FOR SURGICAL WOUND CLOSURE; AND SIMILAR STERILE MATERIAL U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 ---> <--- 1998 YTD --->
Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 10,801 3,116 143,058 40,068

Belgium . . . . . . . . . --- --- 107 14
France . . . . . . . . . 81 49 2,727 1,132
Switzerland . . . . . . . --- --- 1,357 1,693
United Kingdom . . . . . 1,188 242 35,001 5,564

U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
Subheading 300210: ANTISERA AND OTHER BLOOD FRACTIONS, AND MODIFIED
IMMUNOLOGICAL PRODUCTS

3002.10.0010: HUMAN BLOOD PLASMA
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 25,740 1,827 270,357 20,476
Belgium . . . . . . . . . 14 8 145 60
France . . . . . . . . . --- --- 134 60
Netherlands . . . . . . . --- --- 11 5
Switzerland . . . . . . . 10,462 597 86,101 5,894
United Kingdom . . . . . --- --- 335 62
3002.10.0020: NORMAL HUMAN BLOOD SERA, WHETHER OR NOT FREEZE-DRIED
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 1,039 817 19,056 22,678
Austria . . . . . . . . . --- --- 9,194 18,707
Belgium . . . . . . . . . --- --- 22 15
Netherlands . . . . . . . 353 2 6,733 41
Switzerland . . . . . . . 374 218 1,084 440
United Kingdom . . . . . --- --- 1 4
3002.10.0030: HUMAN IMMUNE BLOOD SERA
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 1,926 461 14,484 3,563
...
United Kingdom . . . . . 2 8 464 192

3002.10.0040: FETAL BOVINE SERUM (FBS)
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 2,727 233 131,486 8,502
...
Belgium . . . . . . . . . --- --- 17 32
United Kingdom . . . . . 329 82 743 756
3002.10.0090: OTHER BLOOD FRACTIONS NOT ELSEWHERE SPECIFIED OR INCLUDED
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 88,467 27,343 944,412 309,947
...
United Kingdom . . . . . 1,887 2,300 26,823 23,585
===================================================================
http://www.ita.doc.gov/industry/otea/Trade-Detail/Latest-December/
Imports/30/300290.html
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
Subheading 300290: HUMAN BLOOD; ANIMAL BLOOD PREPARED FOR THERAPEUTIC,
ETC. USES; TOXINS, CULTURES OF MICRO-ORGANISMS (EXCLUDING YEASTS) AND
SIMILAR PRODUCTS NESOI
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 36,178 643 250,982 11,604
...
United Kingdom . . . . . 584 39 11,292 588
http://www.ita.doc.gov/industry/otea/Trade-Detail/Latest-Month/Imports/
05/051199.html
U.S. Imports for Consumption: March 1999 and 1999 Year-to-Date
Subheading 051199: ANIMAL PRODUCTS, NESOI; DEAD HORSES AND OTHER EQUINE
ANIMALS, BOVINE ANIMALS, SHEEP, GOATS AND POULTRY, UNFIT FOR HUMAN
CONSUMPTION, NESOI
0511.99.2000: PARINGS AND SIMILAR WASTE OF RAW HIDES OR SKINS; GLUE
STOCK, NOT ELSEWHERE SPECIFIED OR INCLUDED
U.S. Imports for Consumption: March 1999 and 1999 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)

0511.99.4024: DAIRY CATTLE EMBRYOS
U.S. Imports for Consumption: March 1999 and 1999 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Number)
<--- Mar 1999 --- <--- 1999 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . --- --- 53 16
Canada . . . . . . . . . --- --- 9 3
France . . . . . . . . . --- --- 44 13
0511.99.4050: ANIMAL PRODUCTS NOT ELSEWHERE SPECIFIED OR INCLUDED;
DEAD ANIMALS OF CHAPTER 1, UNFIT FOR HUMAN CONSUMPTION
U.S. Imports for Consumption: March 1999 and 1999 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)
<--- Mar 1999 --- <--- 1999 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 718,476 2,313 2,206,867 4,739
Belgium . . . . . . . . . --- --- 13 18
France . . . . . . . . . 1,088 14 1,489 20
United Kingdom . . . . . 11 3 38 9

http://www.ita.doc.gov/industry/otea/Trade-Detail/Latest-December/
Imports/30/300220.html
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
Subheading 300220: VACCINES FOR HUMAN MEDICINE

3002.20.0000: VACCINES FOR HUMAN MEDICINE
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 25,702 26,150 550,258 378,735
Belgium . . . . . . . . . 14,311 12,029 248,041 199,036
France . . . . . . . . . 3,902 4,859 87,879 92,845
Switzerland . . . . . . . 716 353 9,303 4,271
United Kingdom . . . . . 4,075 1,172 162,960 47,148
==================================================================
http://www.ita.doc.gov/industry/otea/Trade-Detail/Latest-December/
Imports/30/300230.html
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
Subheading 300230: VACCINES FOR VETRINARY MEDICINE
List of (6-digit) Subheadings in this (2-digit) Chapter
Next (6-Digit) Subheading ... Descending ... Ascending
Latest Monthly Data
Switch from U.S. Imports to U.S. Exports
About These Trade Data Tables
3002.30.0000: VACCINES FOR VETRINARY MEDICINE
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars)
(Units of Quantity: Kilograms)
<--- Dec 1998 --- <--- 1998 YTD --- Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 6,528 237 87,149 2,715
Canada . . . . . . . . . --- --- 2,637 305
Federal Rep. of Germany --- --- 104 5
Netherlands . . . . . . . 138 64 472 192
New Zealand . . . . . . . 6,390 173 83,882 1,895
United Kingdom . . . . . --- --- 54 318
=================================================================

http://www.ita.doc.gov/industry/otea/Trade-Detail/Latest-December/
Imports/30/300610.html
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
Subheading 300610: STERILE SURGICAL CATGUT, SIMILAR STERILE SUTURE
MATERIALS AND STERILE TISSUE ADHESIVES FOR SURGICAL WOUND CLOSURE;
STERILE HAEMOSTATICS, ETC.

3006.10.0000: STERILE SURGICAL CATGUT, SIMILAR STERILE SUTURE MATERIALS
AND STERILETISSUE ADHESIVES FOR SURGICAL WOUND CLOSURE; AND SIMILAR
STERILE MATERIAL
U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
Belgium . . . . . . . . . --- --- 107 14
Federal Rep. of Germany 1,795 356 16,878 3,741
France . . . . . . . . . 81 49 2,727 1,132

Subject: Re: exports from the U.K. of it's MBM to U.S.???
Date: Tue, 8 Feb 2000 14:03:16 +0000
From: S.J.Pearsall@esg.maff.gsi.gov.uk
To: flounder@wt.net (Receipt Notification Requested) (Non Receipt
Notification Requested)

Terry meat and bonemeal is not specifically classified for overseas trade
purposes. The nearest equivalent is listed as "flours and meals of meat
or offals (including tankage), unfit for human consumption; greaves". UK
exports of this to the US are listed below:

Country Tonnes
1980
1981 12
1982
1983
1984 10
1985 2
1986
1987
1988
1989 20
1990

Subject: Re: Imports of MBM or Ruminants to the U.S. from foreign Countries with the potential risk of BSE...
Date: Tue, 28 Dec 1999 17:19:15 -0500
From: Linda Detwiler To: flounder@wt.net (Receipt Notification Requested)
I have attached the file ibov96.txt containing all of the bovine imports for 1996.
Subject: [Fwd: IMPORTED UK AND NETHERLANDS BEEF?] -Reply
Date: Thu, 3 Sep 1998 6:54:00 -0400
From: Linda Detwiler To: flounder@wt.net (Receipt Notification Requested)

I will check on this as I had not heard about the UK. The Netherlands
would not have suprised me as they did not have a case until March
1997. ...
now my question would be, how many of these animals that fed on MBM's
from these countries, were imported to the United States,
via 3rd country routes??? i will give you that answer below...TSS
Marva Thompson
Foreign Trade Reference Room
202/482-2185

"The U.S. is apparently still importing beef, pork, sheep, and lamb from countries in which BSE is found [this is probably
completely legal under regulations applicable at time of import-- webmaster]:
Bovine anmls bnlss ex prcssd frozen/U.S. Imports for Consumption 1997 year to date (custom value, in thousands of dollars) (units of quantity: kilograms) United Kingdom 37,122 kilograms, 43 thousand dollars Netherlands 56,260 kilograms, 413 thousand dollars Canada 18,141,481 kilograms, 23,914 million dollars Livers of bovine animals, edible, frozen. U.S. Imports for consumption

Netherlands 19,230 kilograms, 25 thousand dollars Canada 160,632 kilograms, 147 thousand dollars
Tongues of bovine animals, edible, frozen U.S. Imports for consumption

Netherlands 1,047 kilograms, 4 thousand dollars Canada 767,859 kilograms, 2,028 million Hi-qulty beef cuts w/bone in prcssd f/c u.S. Imports for consumption
Canada 25,332 kilograms, 37 thousand dollars Beef cuts w/bone in excpt prcdssd fr/ch u.S. Imports for consumption
Netherlands 5,276 kilograms, 30 thousand dollars Canada 117,142 kilograms, 353 thousand dollars

Meat bovine anmls cuts w/bone ex prrocssd fr us imports for consumption

Netherlands 51,836 kilograms, 444 thousand dollars Canada 120,955,010 kilograms, 253,199 million
Cattle hides, whole, fresh or wet-salt u.S. Imports for consumption
Belgium 1,270 pieces, 112 thousand dollars United kingdom 36 pieces, 3 thousand dollars Ireland 12,797 pieces, 839 thousand dollars Italy 50 pieces, 10 thousand dollars Fr germany 2,500 pieces, 36 thousand dollars Canada 1,405,430 pieces, 67,320 million dollars Hides/skins bovine anmls nesoi whole frh/wet-saltd u.S. Imports for consumption United kingdom 13 pieces, 1 thousand dollars Italy 4 pieces, 4 thousand dollars Germany 9,455 pieces, 139 thousand dollars Canada 567,816 pieces, 17,196 million dollars
Cattle hides, whole, fresh or wet-salted u.S. Imports for consumption
1998 year to date Italy 7 pieces, 2 thousand dollars Ireland 1,408 pieces, 85 thousand dollars France 25 pieces 2 thousand dollars Canada 965,355 pieces, 37,244 million dollars Hides and skins of bovine animals, whole, nesoi, fresh or wet-salted
U.S. Imports for consumption United kingdom 18 pieces, 3 thousand dollars Sweden 1 pieces, 1 thousand dollars Italy 2 pieces, 2 thousand dollars Germany 5,565 pieces, 72 thousand dollars Canada 84,327 pieces, 2,257 million dollars
Sheep, lamb skins, no wool, nesoi, pickled not split, u.S. Imports for Consumption United kingdom 9,504 pieces, 88 thousand dollars Sheep, lamb skins, no wool, nesoi, pickled, split u.S. Imports for Consumption
United Kingdom 149,580 pieces, 1,212 million dollars Netherlands 50,400 pieces, 267 thousand dollars Italy 4,175 pieces, 64 thousand dollars France 13,644 pieces, 57 thousand dollars Canada 131,642 pieces, 241 thousand dollars
http://www.mad-cow.org/00/jul00_dont_eat_sheep.html#hhh

The documents below were provided by Terry S. Singeltary Sr on 8 May 2000. They are optically character read (scanned into computer) and so may contain typos and unreadable parts.

TIP740203/l 0424 CONFIDENTIAL

Mr Cunningham CMP3 From: D O Hagger MBI
Dr Salisbury MED/IMCD3
Mr Burton PD/STB/PG1B B/17/2 Date: 15.02.1989
Mr Dudley PD/AD4

BOVINE SPONGIFORM ENCEPHALOPATHY

1. The purpose of this minute is to alert you to recent developments on
BSE as they affect medicines and to invite representatives to a meeting
in Market Towers on 22 February 1989.

2. The report of the Working Party on Bovine Spongiform
Encephalopathy (BSE) was submitted by the CMO to the Secretary of State
for Health and Minister for Agriculturer on 9 February.

3. The summary at the end of the report records, inter alia: 'we have
drawn the attention of the Licensing Authority to the potential of
transfer of BSE agent in human and veterinary medicinal products. In
paragraph 7 of his submission (Annex A), the CMO notes:

"I am also putting work urgently in hand to satisfy myself that
everything possible has been done to ensure .... that transfer of the
BBE agent in human and veterinary medicinal products does not occur."

4. The Veterinary products Committee meets on 16 February and The
committee on Safety of Medicines on 23 February when each will be
considering a draft of some joint guidelines for manufacturers of
medicinal products which use bovine material as an ingredient or an
intermediate in the manufacturing process (Annex B).....

6. Although a wide range of medicines may be implicated - and the
present proposal is to write to companies for more information - an
"instant" telephone survey of manufacturer of vaccines used for children
has already been undertaken in response to a request from Dr Harris. The
results are in Dr Adams' minute of 14 February (Annex C) - the proviso
in his second paragraph, last sentence should be noted. 89/02.15/11.1

89/02.15/11.2 MF580439/1 0584
SOUTHWOOD REPORT: BSE AND MEDICINAL PRODUCTS

1. I attach a list of questions on BSE and medicines compiled with the
aim of providing question and answer briefing to DH and MAFF Ministers
upon publication of the Southwood Report. I have suggested names of
those who may be able to provide answers.
All recipients are invited to consider which if any important areas have
been missed. Also attached is copy QA briefing being proposed by MAFF. I
understand MAFF have produced General QA briefing on the reports as a
whole.
..

MF580439/1 0585 Question

1. Which medicines are affected? (person to provide reply) Dr. Jefferys

2. Are the risks greater with some medicines than others? Dr. Jefferys

3. Why are medicines affected? Dr. Jefferys

4. Are some affected products available over the counter from pharmacies or shops? Dr. Purves

5. Are only UK products at risk? Dr. Jefferys

6. Are existing stocks safe? Dr. Jefferys

7. Are pre 1980 stocks available? Mr. Burton

8. Are these alternatives to the use of bovine material? Dr. Purves

9. Why can't we throw away suspect stock and import or manufacture safe medicines? Dr. Jefferys

10. Which patients are at risk? Dr. Jefferys

11. Are some patients particularly vulnerable? Dr Jefferys

12. What risks exist to those who have already used these medicines? Dr. Jefferys

13. HOW might patients be affected? Dr. Jefferys

14. Can BSE be transmitted to patients by medicines? Dr. Jefferys

15. How long will it be before risks are quantified? Dr. Jefferys

100 89/02.17/10.2 MF580439/1 0586

16. What research is going on to find out if medicines can transmit this disease and if any patients have been affected? Dr Jefferys

17. Could recent cases of Creuuzfeld Jacob Disease have been caused by transmission of BSE through medicines? Dr. Jefferys

18. What action is the Licensing Authority taking to ensure proper scrutinising of source materials and manufacturing processes? Dr. Jefferys/Dr. Purves

19. Are the guidelines practical? Dr. Jefferys/Dr. Purves

20. Will the guidelines remove the risk? Dr. Jefferys

21. How will the guidelines be enforced? Dr. Jefferys/Dr. Purves

22. How soon will they come into force? Dr. Jefferys

23. Will the guidelines be published? Mr. Hagger

24. What is being done to reassure patients, parents etc? Mr. Hagger/Dr. Salisbury

25. What advice is being given to doctors, pharmacists etc? Mr. Hagger

26. What advice is the Government giving about its vaccination programme? Dr. Salisbury

27. Is the vaccination programme put at risk because of BSE? Dr. Salisbury

89/02.17/10.3

Q. Will government act on this?

A. Yes - thymus is not used in preparation of baby foods but it is
contacting all manufacturers to seek their urgent views on use of
kidneys and liver from ruminants. Will consider any necessary measures
in the light of their response.

VETERINARY MEDICINES

Q. Can medicines spread BSE to other cattle/animals?

A. The report describes any risks as remote.

Q. How can risks be avoided?

A. In liaison with the DOH the Veterinary Products Committee is
examining guidelines for the veterinary pharmaceutical industry
which will be issued shortly.

Q. What will Guidelines say?

A. In essence they call for non-bovine sources to be used if possible,
including synthetic material of biotechnological origin. Where this is
not possible the industry should look for sources which are free of BSE
and which are collected in a manner which avoids risk of contamination
by the BSE agent.


89/02.17/10.4 MF580439/1 0588

A. Bovine source material is used in [garbled, cannot read...TSS] and some other medicines.

Q. How many medicines are involved?

A. Computer records show that about 300 of the 3,050 veterinary
medicines licensed in the U.K. are manufactured directly from bovine
source material. However, other medicines may be produced from
bovine sources and a letter is going to all license holders so that a
comprehensive list can be drawn up.

89/06.19/8.1 BSE3/1 0191 Hr J Maslin (MAFF) Ref: Maslin3g

From: Dr H Pickles Med SEB/B Date: 3 July 1989

CATTLE BY-PRODUCTS AND BSE

I was interested to see the list of by-products sent to the HSE. Those
of particular concern included:

* small intestines: sutures (I thought the source was ovine but you are
checking this)

* spinal cord: pharmaceuticals

* thymus: pharmaceuticals

Are you able to give me more information on which UK manufacturers use
these materials? Our proposed ban on bovine offal for human consumption
would not affect these uses, I assume.


Id No. 1934/RD/1 89/08.10/6.1 117A

BOVINE SPONGIFORM ENCEPHALAPATHY MEETING
HELD ON 21 AUGUST 1989 AT 2;15 IN ROOM 720
Miss M Duncan (Chairman)
Mr W Burton
Dr E Hoxey
Mrs J Dhell
Ms K Turner
Dr S Whittle
Mr N Weatherhead
...
5. The MCA had sent 2700 questionnaires out, 1,124 had made valid
returns; of these 122 use animal material of some kind and there are 582
products involved.
...
6. The MCA/BSE working group will meet on 6th September. Their
aim is to review responses from professional officers in MCA who have
suggested seven categories of importance (with 1 being the most
important} for medical products:

ID 2267/NRE/1 89/08.21/10.1
1. Products with Bovine brain/lymph tissue administered by injection.

2. Products with bovine tissue other than brain/lymph administered by
inection.

3. Tissue implants/open wound dressing/surgical materials/dental and
ophthlamic products with bovine ingredients.

4. Products with bovine ingredients administered topically.

5. Products with bovine ingredients administered orally.

6. Products with other animal/fish/insect/bird ingredients administered
by injection/topically/oral routes.

7. Products with ingredients derived from animal material by chemical
processing (eg stearic acid, gelatine, lanolin ext.

The BSE working group will decide which of these are important, and
should be examined more closely, and which categories can be eliminated.

The responses by the companies were presented by Ms Turner and were
categorised by MCA standards, the products that were discussed were all
low volume usage products eg sutures, heart valves.

8. As the responses included some materials of human origin it
was decided that more information should be sought about CJD. There had
been 2 recent deaths reported associated with human growth hormone.
These were being investigated.

9. Re-editing of the Paper on "Incubation of Scrapie-like Agents"

It was suggested that the document could be sent out to companies with
the non-standard sterilization Document. The document could have severe
implications on the companies whose products have a high risk factor as
decided by the MCA working group....

11. The Need for a list of High Priority Implantables The commitee decided that no list is necessary as all implantables, including ones from a human source are of high priority. Concern was
shown over Killingbeck who use human material but had not yet responded.
The company will be chased for a response. Concern was shown over the fact that there may be other scrapie-like
organisms in other animals and further enquiries should be made.

2334q/RD/4 89/08.21/10.7


BOVINE MATERIAL USED IN THE MANUFACTURE OF SURGICAL IMPLANTS AND
BLOOD CONTACT MEDICAL DEVICES

Glutaraldehyde, formaldehyde, and ethylene oxide are used in the
sterilization of these devices.

However, glutaraldehyde 4,10,12,19 formaldehyde 5,10,11,13,19 and
ethylene oxide 19,23 are all reported to be ineffective methods for
sterilization of material infected with the agents of CJD or scrapie.

Previous advice and research using the agents of CJD and scrapie, has
concentrated on the decontamination of equipment; protection of health
care workers from contaminated human material; human growth hormone; and
dura mater. The methods developed may not be directly applicable or
transferable to material of bovine origin for use in human implantation.


2334q/RD/7 89/08.21/10.10 BSE11/2 020 SC1337

DEPARTMENT OF HEALTH AND SOCIAL SECURITY
Richmood House 79 Whitehall, London SW1A 2NS
Telephone 01-210-3000
From the Chief Medical Officer
Sir Donald Acheson KBE DM DSc FRCP FFCM FFOM

Mr K C Meldrum
Chief Veterinary Officer
Ministry of Agriculture, Fisheries and Food
Government Buildings
Hook Rise South
Tolworth
Surbiton
Surrey
KT6 7NG

3 January 1990

Dear Mr. Meldrum,

BOVINE SPONGIFORM ENCEPHALOPATHY

You will recall that we have previously discussed the potential risks of
BSE occurring in other Countries as a result of the continuing export
from the UK of meat and bone that may be contaminated by scrapie or
possibly BSE.

I remain concerned that we are not being consistent in our attempts to
contain the risks of BSE. Having banned the feeding of meat and bone
meal to ruminants in 1988, we should take steps to prevent these UK
products being fed to ruminants in other countries. This could be
achieved either through a ban on the export of meat and bone meal, or at
least by the proper labelling of these products to make it absolutely
clear they should not be fed to ruminants. Unless some such action is
taken the difficult problems we have faced with BSE may well occur in
other countries who import UK meat and bone meal. Surely it is short
sighted for us to risk being seen in future as having been responsible
for the introduction of BSE to the food chain in other countries.

I would be very interested to hear how you feel this gap in the present
prcautionary measures to eliminate BSE should be closed. We should be
aiming at the global elimination of this new bovine disease. The export
of our meat and bone meal is a continuing risk to other countries.

Signed
Sincerely Donald Acheson

Did the US import fetal calf serum and vaccines from BSE-affected countries?

3002.10.0040: FETAL BOVINE SERUM (FBS) U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 ---> <--- 1998 YTD --->
Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 2,727 233 131,486 8,502
Australia . . . . . . . . --- --- 19,637 2,623
Austria . . . . . . . . . --- --- 2,400 191
Belgium . . . . . . . . . --- --- 17 32
Canada . . . . . . . . . 900 110 30,983 3,220
Costa Rica . . . . . . . 500 20 4,677 169
Federal Rep. of Germany --- --- 105 21
Finland . . . . . . . . . 1 8 9 83
France . . . . . . . . . --- --- 73 7
Guatemala . . . . . . . . --- --- 719 42
Honduras . . . . . . . . --- --- 1,108 88
Israel . . . . . . . . . --- --- 24 165
Netherlands . . . . . . . --- --- 1 5
New Zealand . . . . . . . 26 5 65,953 913
Panama . . . . . . . . . --- --- 1,195 64
Switzerland . . . . . . . 971 8 1,078 23
United Kingdom . . . . . 329 82 743 756
Uruguay . . . . . . . . . --- --- 2,764 98
------------------------------------------------------------------
3002.20.0000: VACCINES FOR HUMAN MEDICINE U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 ---> <--- 1998 YTD --->
Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 25,702 26,150 550,258 378,735
Austria . . . . . . . . . --- --- 45 225
Belgium . . . . . . . . . 14,311 12,029 248,041 199,036
Canada . . . . . . . . . 1,109 1,527 15,798 16,305
Denmark . . . . . . . . . 80 234 246 682
Federal Rep. of Germany 1,064 4,073 12,001 6,329
France . . . . . . . . . 3,902 4,859 87,879 92,845
Ireland . . . . . . . . . --- --- 120 478
Italy . . . . . . . . . . --- --- 2,359 81
Japan . . . . . . . . . . 445 1,903 11,350 11,298
Netherlands . . . . . . . --- --- 94 6
Republic Of South Africa --- --- 2 1
Spain . . . . . . . . . . --- --- 60 30
Switzerland . . . . . . . 716 353 9,303 4,271
United Kingdom . . . . . 4,075 1,172 162,960 47,148
------------------------------------------------------------------
3002.30.0000: VACCINES FOR VETRINARY MEDICINE U.S. Imports for Consumption: December 1998 and 1998 Year-to-Date
(Customs Value, in Thousands of Dollars) (Units of Quantity: Kilograms)
<--- Dec 1998 ---> <--- 1998 YTD --->
Country Quantity Value Quantity Value
=================================================================
WORLD TOTAL . . . . . . . 6,528 237 87,149 2,715
Canada . . . . . . . . . --- --- 2,637 305
Federal Rep. of Germany --- --- 104 5
Netherlands . . . . . . . 138 64 472 192
New Zealand . . . . . . . 6,390 173 83,882 1,895
United Kingdom . . . . . --- --- 54 318

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