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From: TSS (216-119-138-193.ipset18.wt.net)
Subject: Recognition of the Nor98 variant of scrapie in the Swedish sheep population
Date: December 17, 2004 at 2:30 pm PST

-------- Original Message --------
Subject: Recognition of the Nor98 variant of scrapie in the Swedish sheep population
Date: Fri, 17 Dec 2004 16:26:34 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

1: J Vet Diagn Invest. 2004 Nov;16(6):562-7.


Recognition of the Nor98 variant of scrapie in the Swedish sheep
population.

Gavier-Widen D, Noremark M, Benestad S, Simmons M, Renstrom L,
Bratberg B, Elvander M, af Segerstad CH.

National Veterinary Institute (SVA), Uppsala, Sweden.

Within the framework of the active surveillance for transmissible
spongiform encephalopathies in sheep in Sweden, 4 cases of the
atypical form of scrapie, Nor98, were identified during 2003. Nor98
is a recently recognized and poorly understood variant of scrapie,
first described in Norway. The cases were positive by the rapid test
(enzyme-linked immunosorbent assay). Immunohistochemical staining
showed diffuse thin-granular staining of the cerebellar cortex.
Western immunoblotting analysis of specimens of brain stem and
cerebellum showed a light band of approximately 12 kDa. Typical
scrapie was ruled out based on the confirmatory testing. The
affected ewes were from 4 different flocks. They were between 7 and
9 years old. Two were of the ARQ/ARQ genotype, 1 ARR/ARQ, and 1
ARR/AHQ. Two ewes had shown ataxia, and the other 2 had no clinical
signs. Whole-flock slaughter was applied, and testing of the flock
mates did not reveal additional cases. Nor98 differs from typical
scrapie in its epidemiology, frequency of genotypes of sheep
affected, clinical signs, microscopic lesions, distribution of
scrapie prion protein in the brain, and characteristics of the
immunostaining and immunoblotting profiles.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15586572

TSS

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