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From: TSS (216-119-144-42.ipset24.wt.net)
Subject: Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases
Date: December 16, 2004 at 1:51 pm PST

Short Communication


Polymorphisms at codons 141 and 154 in the ovine prion protein gene
are associated with scrapie Nor98 cases

Truls Moum1, Ingrid Olsaker2, Petter Hopp3, Torfinn Moldal3, Mette Valheim3, Torbjørn Moum4 and Sylvie L. Benestad3

1 Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Kyrkjevegen 332-334, N-4325 Sandnes, Norway
2 Norwegian School of Veterinary Science, Department of Basic Sciences and Aquatic Medicine, PO Box 8146 Dep., N-0033 Oslo, Norway
3 National Veterinary Institute, PO Box 8156 Dep., N-0033 Oslo, Norway
4 University of Oslo, Department of Behavioural Sciences in Medicine, PO Box 1111, N-0317 Oslo, Norway

Correspondence
Truls Moum
Truls.Moum@veths.no

Until June 2004, thirty-eight scrapie cases with unusual features, designated Nor98, have been diagnosed in Norway. This study investigated the distribution of PrP genotypes among Nor98 cases, their flock-mates and a random sample of Norwegian slaughtered sheep. The PrP genotype distribution of Nor98 cases differed markedly from that of previous cases of classical scrapie. A leucine/phenylalanine polymorphism at codon 141 with hitherto unknown significance to scrapie was strongly associated with Nor98 cases. Twenty of 38 (52·6 %) cases were either homozygous or heterozygous for phenylalanine at codon 141. In contrast, this allele was present in only 10·5 % of the flock-mates and 4·5 % of the random sample of slaughtered sheep. Moreover, the H154 allele was represented in 24 of 38 (63·2 %) of Nor98 cases, as opposed to 27·0 % of Nor98 flock-mates and 17·0 % of the slaughtered sheep.

Published online ahead of print on 2 November as DOI 10.1099/vir.0.80437-0.

http://vir.sgmjournals.org/cgi/content/abstract/86/1/231?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=prion&searchid=1103233248550_1294&stored_search=&FIRSTINDEX=0&volume=86&issue=1&search_url=http%3A%2F%2Fvir.sgmjournals.org%2Fcgi%2Fsearch

TSS





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