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##################### Bovine Spongiform Encephalopathy #####################
1: Environ Sci Technol. 2004 Nov 15;38(22):6155-60.
Infectivity studies of both ash and air emissions from simulated
incineration of scrapie-contaminated tissues.
Brown P, Rau EH, Lemieux P, Johnson BK, Bacote AE, Gajdusek DC.
Laboratory of CNS Studies, National Institute of Neurological Disorders
and Stroke, and Div. of Environmental Protection, Office of Research
Facilities Development and Operations, NIH, US Dept. of HHS, Bethesda,
MD 20892, USA. paulwbrown@comcast.net
We investigated the effectiveness of 15 min exposures to 600 and 1000
degrees C in continuous flow normal and starved-air incineration-like
conditions to inactivate samples of pooled brain macerates from hamsters
infected with the 263K strain of hamster-adapted scrapie with an
infectivity titer in excess of 10(9) mean lethal doses (LD50) per g.
Bioassays of the ash, outflow tubing residues, and vented emissions from
heating 1 g of tissue samples yielded a total of two transmissions among
21 inoculated animals from the ash of a single specimen burned in normal
air at 600 degrees C. No other ash, residue, or emission from samples
heated at either 600 or 1000 degrees C, under either normal or
starved-air conditions, transmitted disease. We conclude that at
temperatures approaching 1000 degrees C under the air conditions and
combustion times used in these experiments, contaminated tissues can be
completely inactivated, with no release of infectivity into the
environment from emissions. The extent to which this result can be
realized in actual incinerators and other combustion devices will depend
on equipment design and operating conditions during the heating process.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15575075
Infectivity Studies of Both Ash and Air Emissions from Simulated
Incineration of Scrapie- Contaminated Tissues
Brown, P.; Rau, E. H.; Lemieux, P.; Johnson, B. K.; Bacote, A. E.;
Gajdusek, D. C.;
Environ. Sci. Technol.; (Article); 2004; 38(22); 6155-6160. DOI:
10.1021/es040301z
http://pubs.acs.org/cgi-bin/sample.cgi/esthag/2004/38/i22/abs/es040301z.html
TSS
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