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From: TSS (216-119-143-160.ipset23.wt.net)
Subject: Proposed changes would ban BSE-related material from pet food, fertilizer CANADA
Date: December 10, 2004 at 2:24 pm PST

-------- Original Message --------
Subject: Proposed changes would ban BSE-related material from pet food, fertilizer CANADA
Date: Fri, 10 Dec 2004 16:32:19 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@LISTSERV.KALIV.UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Proposed changes would ban BSE-related material from pet food, fertilizer


Canadian Press


Friday, December 10, 2004


OTTAWA (CP) - Federal regulators have proposed banning high risk
material from animal feed, pet food and fertilizers, in an effort to
prevent mad cow disease.

The Canadian Food Inspection Agency said Friday the amendments are
intended to further protect Canadian cattle from bovine spongiform
encephalopathy (BSE).

The proposed amendments would prohibit the use of specified risk
material, or SRMs, in animal feeds.

Such materials are cattle tissues that may contain the agent that causes
BSE.

The amendments also prohibit the use of SRMs in fertilizers.

"This provision is intended to prevent the potential accidental or
intentional misuse of fertilizers as feed," the agency said in a release.

It would also remove the possible danger of contaminating grazing pastures.

The federal government already requires the removal of SRMs from the
human food supply.

As a precaution, the government banned the feeding of most mammal
proteins to ruminant animals in 1997.

But authorities believe taking S-R-M's out of the feed production chain
will eliminate potential cross-contamination of animal feeds. The
public, industries and anyone else with an interest will have until Feb.
24 to comment on the proposed regulations.

http://www.canada.com/health/story.html?id=8d81194e-dac0-4563-b5ce-5aeb7ad289c3

no comment......TSS

############## BSE-L-subscribe-request@kaliv.uni-karlsruhe.de ##############

-------- Original Message --------
Subject: PETFOODS, DOGS, CATS AND TSEs aka mad cow disease
Date: Fri, 10 Dec 2004 16:34:46 -0600
From: "Terry S. Singeltary Sr."
To: dgoldstein1@bloomberg.net
CC: sstroth@bloomberg.net

-------- Original Message --------
Subject: PETFOODS, DOGS, CATS AND TSEs
Date: Fri, 12 Sep 2003 21:06:35 -0500
From: "Terry S. Singeltary Sr."

X-Virus-Scanner: Found to be clean
Message-ID: <>
Date: Tue, 27 May 2003 08:07:58 -0500
Reply-To: Bovine Spongiform Encephalopathy
Sender: Bovine Spongiform Encephalopathy
From: "Terry S. Singeltary Sr."
Subject: FDA BSE Update - Pet Food from Canadian Manufacturer & MAD DOG
DATA

######## Bovine Spongiform Encephalopathy
#########

Statement

FOR IMMEDIATE RELEASE Statement May 26, 2003

Media Inquiries: 301-827-6242 Consumer Inquiries: 888-INFO-FDA

FDA BSE Update - Pet Food from Canadian Manufacturer

The Food and Drug Administration (FDA) has learned from the government
of Canada that rendered material from a Canadian cow that last week
tested positive for bovine spongiform encephalopathy (BSE, also known
as mad cow disease) may have been used to manufacture pet food,
specifically dry dog food, some of which was reported to have been
shipped to the United States. The Canadian government prevented the BSE
positive cow from being processed for human food. Therefore, consumers
can be assured that their food does not contain any remnants of the BSE
positive cow.

It is also important to stress that there is no scientific evidence to
date that dogs can contract BSE or any similar disease. In addition
there is no evidence that dogs can transmit the disease to humans.

FDA notified the U.S. pet food firm, The Pet Pantry International, of
Carson City, Nevada, when FDA learned that the pet food that the firm
received may have included rendered material from the BSE positive cow.
The manufacturer of the pet food is Champion Pet Food, Morinville,
Alberta. Even though there is no known risk to dogs from eating this dog
food, as a prudent measure to help assure that the U.S. stays BSE free
The Pet Pantry International is asking its customers who may have
purchased the suspect product to hold it for pickup by the distributor
so that the dog food will not mistakenly be mixed into cattle or other
feeds if any of the dog food is discarded or otherwise not used to feed
dogs. The suspect dog food was produced by Champion Pet Food between
February 4, 2003, and March 12, 2003.

The Pet Pantry products were packaged in 50 lb bags, distributed to
franchises around the country, and sold by home delivery only. There was
no retail distribution of the product. Consumers purchase Pet Pantry
products by phone or email orders. The product is then delivered by the
nearest franchisee directly to the consumers home.

The product subject to this notification includes Maintenance Diet
labeled with a use by date of 17FEB04 and Beef with Barley with a
use by date of 05MAR04. Consumers who have purchased dog food from The
Pet Pantry since February of this year are asked to check their present
supplies and see if any match the description of the product being
removed. If so, consumers are asked to contact The Pet Pantry at
1-800-381-7387 for further information on how to return the product to
The Pet Pantry for proper disposal. Consumers are asked not to destroy
or discard the product themselves. The Pet Pantry will also use its
sales records to contact consumers who purchased the affected product.

FDA is working closely with the Pet Pantry International to assure for
proper disposal of the recovered product.

FDA will continue to provide updates on this case of BSE in Canada as
additional information becomes available.

http://www.fda.gov/bbs/topics/NEWS/2003/NEW0910.html

It was thought likely that at least some, and probably all, of the cases
in zoo animals were caused by the BSE agent. Strong support for this
hypothesis came from the findings of Bruce and others (1994) ( Bruce,
M.E., Chree, A., McConnell, I., Foster, J., Pearson, G. & Fraser, H.
(1994) Transmission of bovine spongiform encephalopathy and scrapie to
mice: strain variation and species barrier. Philosophical Transactions
of the Royal Society B 343, 405-411: J/PTRSL/343/405 ), who demonstrated
that the pattern of variation in incubation period and lesion profile in
six strains of mice inoculated with brain homogenates from an affected
kudu and the nyala, was similar to that seen when this panel of mouse
strains was inoculated with brain from cattle with BSE. The affected zoo
bovids were all from herds that were exposed to feeds that were likely
to have contained contaminated ruminant-derived protein and the zoo
felids had been exposed, if only occasionally in some cases, to tissues
from cattle unfit for human consumption.

snip...

http://www.bseinquiry.gov.uk/files/ws/s324.pdf

cases have been reported in domestic cats), are characterised by long
asymptomatic incubation periods followed by progressive symptoms and
signs of degeneration of the brain, leading eventually to death.

http://www.bsereview.org.uk/download/draft_2.pdf

PET FOODS MAD CATS AND MAD DOGS BSE/TSEs

worse still, there is serious risk the media could get to hear of such a
meeting...

snip...

Crushed heads (which inevitably involve brain and spinal cord material)
are used to a limited extent but will also form one of the constituent
raw materials of meat and bone meal, which is used extensively in pet
food manufacturer...

http://www.bseinquiry.gov.uk/files/yb/1989/03/17004001.pdf

2. The Parliamentary Secretary said that he was concerned about the
possibility that countries in which BSE had not yet been detected could
be exporting raw meat materials (in particular crushed heads)
contaminated with the disease to the UK for use in petfood manufacture...

snip...

YOU explained that imported crushed heads were extensively used in the
petfood industry...

http://www.bseinquiry.gov.uk/files/yb/1989/04/14001001.pdf

In particular I do not believe one can say that the levels of the
scrapie agent in pet food are so low that domestic animals are not
exposed...

http://www.bseinquiry.gov.uk/files/yb/1989/04/24003001.pdf

http://www.bseinquiry.gov.uk/files/yb/1989/04/25001001.pdf

some 100+ _documented_ TSE cats of all types later...tss

on occassions, materials obtained from slaughterhouses will be derived
from sheep affected with scrapie or cattle that may be incubating BSE
for use in petfood manufacture...

http://www.bseinquiry.gov.uk/files/yb/1989/05/03007001.pdf

Meldrum's notes on pet foods and materials used

http://www.bseinquiry.gov.uk/files/yb/1989/05/16001001.pdf

http://www.bseinquiry.gov.uk/files/yb/1989/05/16002001.pdf

IN CONFIDENCE CJD TO CATS...

http://www.bseinquiry.gov.uk/files/yb/1989/05/18002001.pdf

Confidential BSE and __________________

http://www.bseinquiry.gov.uk/files/yb/1989/05/22012001.pdf

1st case natural FSE

http://www.bseinquiry.gov.uk/files/yb/1990/05/09002001.pdf

FSE and pharmaceuticals

http://www.bseinquiry.gov.uk/files/yb/1990/05/10005001.pdf

confidential cats/dogs and unsatisfactory posture MAFFs failure to
assure key research

http://www.bseinquiry.gov.uk/files/yb/1990/06/14006001.pdf

can't forget about the mad man and his mad cat;

Deaths of CJD man and cat linked

http://news.bbc.co.uk/1/hi/health/184558.stm

In October 1998 the simultaneous occurrence of spongiform encephalopathy
in a man and his pet cat was reported. The report from Italy noted that
the cat did not display the same clinical features as FSE cases
previously seen. Indeed, the presence of a new type of FSE was
suggested. The man was diagnosed as having sporadic CJD, and neither
case (man nor cat) appeared to be affected by a BSE-related condition.

http://www.defra.gov.uk/animalh/bse/bse-science/level-4-othertses.html

indeed there have been 4 documented cases of TSE in Lions to date.

Lion 32 December 98 Born November 86

Lion 33 May 1999 (euthanased) Born November 81.

Lion 36 Euthanased August 2000 Born July 87. Deteriorating hind limb
ataxia.

Lion 37 Euthanased November 2001 Male, 14 years. Deteriorating hind limb
ataxia since September 2001. (Litter mate to Ref. 36.)

http://www.defra.gov.uk/animalh/bse/index.html

go to the url above, on the bar at the top, click on _statistics_, then
in middle of next page, click on _other TSEs_.

or go here;

http://www.defra.gov.uk/animalh/bse/bse-statistics/level-3-tsestat.html

and

http://www.defra.gov.uk/animalh/bse/bse-science/level-4-othertses.html

http://www.bseinquiry.gov.uk/files/yb/1992/11/13001001.pdf

also;

Reports on the clinical symptoms presented by these cats give a
relatively homogeneous picture: Affected cats show a lack of
coordination with an ataxia mainly of the hind limbs, they often fall
and miss their target when jumping. Fear and increased aggressiveness
against the owner and also other animals is often seen. They do not
longer tolerate to be touched (stroked) and start hiding. These
behavioural chances might be the result of a hypersensibility to touch
and noise, but also to increased fear. Excessive salivation is another
more frequently seen symptom. Cats with FSE in general show severe
behavioural disturbances, restlessness and depression, and a lack of
coat cleaning. Symptoms in large cats in general are comparable to those
in domestic cats. A report on FSE (in german) has been presented in 2001
in the Swiss FVO Magazin. A paper on the first FSE case in a domestic
cat in Switzerland is currently in press in the Journal Schweizer Archiv
für Tierheilkunde (SAT).

http://www.neurocenter-bern.ch/tse_e.shtml

Subject: DEER SPONGIFORM ENCEPHALOPATHY SURVEY & HOUND STUDY Date: Thu,
17 Oct 2002 17:04:51 -0700 From: "Terry S. Singeltary Sr." Reply-To:
Bovine Spongiform Encephalopathy To: BSE-L

Greetings BSE-L,

is there any other CWD surveys/testing in the UK on their deer? what
sort of testing has been done to date on UK/EU deer? any input would be
helpful... thank you

DEER SPONGIFORM ENCEPHALOPATHY SURVEY

http://www.bseinquiry.gov.uk/files/yb/1991/11/20004001.pdf

http://www.bseinquiry.gov.uk/files/yb/1992/11/04002001.pdf

hope they did not go by the wayside as the hound study;

http://www.bseinquiry.gov.uk/files/yb/1991/10/18001001.pdf

http://www.bseinquiry.gov.uk/files/yb/1993/12/06001001.pdf

37.Putative TSE in hounds - work started 1990 -(see para 41)

Robert Higgins, a Veterinary Investigation Officer at Thirsk, had been
working on a hound survey in 1990. Gerald Wells and I myself received
histological sections from this survey along with the accompanying
letter (YB90/11.28/1.1) dated November 1990. This letter details
spongiform changes found in brains from hunt hounds failing to keep up
with the rest of the pack, along with the results of SAF extractions
from fresh brain material from these same animals. SAFs were not found
in brains unless spongiform changes were also present. The spongiform
changes were not pathognomonic (ie. conclusive proof) for prion disease,
as they were atypical, being largely present in white matter rather than
grey matter in the brain and spinal cord. However, Tony Scott, then head
of electron microscopy work on TSEs, had no doubt that these SAFs were
genuine and that these hounds therefore must have had a scrapie-like
disease. I reviewed all the sections myself (original notes appended)
and although the pathology was not typical, I could not exclude the
possibility that this was a scrapie-like disorder, as white matter
vacuolation is seen in TSEs and Wallerian degeneration was also present
in the white matter of the hounds, another feature of scrapie.

38.I reviewed the literature on hound neuropathology, and discovered
that micrographs and descriptive neuropathology from papers on 'hound
ataxia' mirrored those in material from Robert Higgins' hound survey. Dr
Tony Palmer (Cambridge) had done much of this work, and I obtained
original sections from hound ataxia cases from him. This enabled me
provisionally to conclude that Robert Higgins had in all probability
detected hound ataxia, but also that hound ataxia itself was possibly a
TSE. Gerald Wells confirmed in 'blind' examination of single restricted
microscopic fields that there was no distinction between the white
matter vacuolation present in BSE and scrapie cases, and that occurring
in hound ataxia and the hound survey cases.

39.Hound ataxia had reportedly been occurring since the 1930's, and a
known risk factor for its development was the feeding to hounds of
downer cows, and particularly bovine offal. Circumstantial evidence
suggests that bovine offal may also be causal in FSE, and TME in mink.
Despite the inconclusive nature of the neuropathology, it was clearly
evident that this putative canine spongiform encephalopathy merited
further investigation.

40.The inconclusive results in hounds were never confirmed, nor was the
link with hound ataxia pursued. I telephoned Robert Higgins six years
after he first sent the slides to CVL. I was informed that despite his
submitting a yearly report to the CVO including the suggestion that the
hound work be continued, no further work had been done since 1991. This
was surprising, to say the very least.

41.The hound work could have provided valuable evidence that a
scrapie-like agent may have been present in cattle offal long before the
BSE epidemic was recognised. The MAFF hound survey remains unpublished.

Histopathological support to various other published MAFF experiments

42.These included neuropathological examination of material from
experiments studying the attempted transmission of BSE to chickens and
pigs (CVL 1991) and to mice (RVC 1994).

http://www.bseinquiry.gov.uk/witness/htm/stat067.htm

nothing to offer scientifically;

http://www.bseinquiry.gov.uk/files/yb/1991/10/17001001.pdf

maddogs and Englishman

http://www.bseinquiry.gov.uk/files/yb/1990/11/28001001.pdf

kind regards, terry

###########bse-l ############

Subject: Re: DEER SPONGIFORM ENCEPHALOPATHY SURVEY & HOUND STUDY Date:
Fri, 18 Oct 2002 23:12:22 +0100 From: Steve Dealler Reply-To: Bovine
Spongiform Encephalopathy Organization: Netscape Online member To:
BSE-L@ References: <3DAF5023.4080804@wt.net>

Dear Terry, An excellent piece of review as this literature is
desparately difficult to get back from Government sites.

What happened with the deer was that an association between deer meat
eating and sporadic CJD was found in about 1993. The evidence was not
great but did not disappear after several years of asking CJD cases what
they had eaten. I think that the work into deer disease largely stopped
because it was not helpful to the UK industry...and no specific cases
were reported. Well, if you dont look adequately like they are in USA
currenly then you wont find any!

Steve Dealler ===============

Incubation periods for BSE are proportional to the life expectancy of
the animal affected. The disease's incubation period is 18% of a cow's
life expectancy and would be expected to about double when crossing to
another species [---] that is, to 36% of 70 years in humans.

Steve Dealler, consultant in medical microbiology. Burnley General
Hospital, Burnley BB10 2PQ deal@airtime.co.uk

TSS

########### http://mailhost.rz.uni-karlsruhe.de/warc/bse-l.html
############


Docket Management Docket: 02N-0273 - Substances Prohibited From Use in
Animal Food or Feed; Animal Proteins Prohibited in Ruminant Feed Comment
Number: EC -10 Accepted - Volume 2 [PART 1]

http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be07.html

Docket Management Docket: 02N-0273 - Substances Prohibited From Use in
Animal Food or Feed; Animal Proteins Prohibited in Ruminant Feed Comment
Number: EC -11 Accepted - Volume 2 [PART 2]

http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be09.html

FDA BSE Update - Pet Food from Canadian Manufacturer & MAD DOG DATA

snip...

PET FOODS MAD CATS AND MAD DOGS BSE/TSEs

http://www.vegsource.com/talk/madcow/messages/483.html

August 22, 2003 5:11 PM

Mad cat disease

A second case of feline spongiform encephalopathy (FSE), a disease
affecting the brain tissue of cats, has been recorded in Switzerland.
The veterinary authorities said the likely cause of the infection, which
is similar to mad cow disease, was contaminated pet food. A first case
of FSE was reported two years ago. Experts say the disease poses no
health risk for people.

swissinfo

http://www.swissinfo.org/sen/Swissinfo.html?siteSect=113&sid=4155897

============================

Docket No. 03-080-1 -- USDA ISSUES PROPOSED RULE TO ALLOW LIVE ANIMAL
IMPORTS FROM CANADA [takes a few minutes to load]


https://web01.aphis.usda.gov/BSEcom.nsf/BSEFrameset?OpenFrameSet&Frame=BottomFrame&Src=_25t156hb3dtmisrjjconjcc9n6ph6ccr66oqjgdpo74qm6e1l68qjcp9hc4o30dhgckq34phfc8rjgoj16orjep9ic8o66c9i64s3achl6pi68cpg60r38eb675i3ujrgcln48rr3elmmarjk4p0nat3f8pp62rb5cg0_


Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION]

http://www.fda.gov/ohrms/dockets/dockets/03n0312/03N-0312_emc-000001.txt

Docket Management Docket: 02N-0273 - Substances Prohibited From Use in

Animal Food or Feed; Animal Proteins Prohibited in Ruminant Feed

Comment Number: EC -10

Accepted - Volume 2


http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be07.html

PART 2


http://www.fda.gov/ohrms/dockets/dailys/03/Jan03/012403/8004be09.html

PDF]Freas, William TSS SUBMISSION

File Format: PDF/Adobe Acrobat -

Page 1. J Freas, William From: Sent: To: Subject: Terry S. Singeltary

Sr. [flounder@wt.net] Monday, January 08,200l 3:03 PM freas ...

http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf

Asante/Collinge et al, that BSE transmission to the 129-methionine

genotype can lead to an alternate phenotype that is indistinguishable

from type 2 PrPSc, the commonest _sporadic_ CJD;

http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm

snip........TSS





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