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From: TSS (216-119-129-30.ipset9.wt.net)
Subject: DETECTION IN A GOAT, OF AN INFECTIVE AGENT MOLECULARLY AND BIOLOGICALLY COMPATIBLE WITH THE BSE AGENT, IN FRANCE OIE REPORT
Date: November 19, 2004 at 10:51 am PST

-------- Original Message --------
Subject: DETECTION IN A GOAT, OF AN INFECTIVE AGENT MOLECULARLY AND BIOLOGICALLY COMPATIBLE WITH THE BOVINE SPONGIFORM ENCEPHALOPATHY AGENT, IN FRANCE
Date: Fri, 19 Nov 2004 12:50:23 -0600
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

DETECTION IN A GOAT, OF AN INFECTIVE AGENT MOLECULARLY AND BIOLOGICALLY
COMPATIBLE WITH THE BOVINE SPONGIFORM ENCEPHALOPATHY AGENT, IN FRANCE

Translation of information received on 12 November 2004 from Dr Isabelle
Chmitelin, Deputy Director General, General Directorate for Food (DGAL),
Ministry of Agriculture, Food, Fisheries and Rural Affairs, Paris:

Date of the report: 2 November 2004.

The French network for typing strains in cases of scrapie detected
within the framework of the European Union surveillance programme(1),
has reported the presence of an infective agent molecularly and
biologically compatible with the bovine spongiform encephalopathy (BSE)
agent, in a goat slaughtered in 2002.

This network of seven public sector research laboratories in France(2)
was set up in 2002. Its aim is to conduct research into the development
of analytical methods capable of distinguishing between the BSE strain
and the natural scrapie strain in small ruminants.

Virtually all the positive isolates obtained from small ruminants with
scrapie detected through the various surveillance programmes established
in France since 1996 have undergone diagnostic testing. This consists of
first-line molecular tests supplemented, for samples considered to be
Ďatypicalí, by inoculation into transgenic mice, which is the reference
test to distinguish BSE from scrapie.

Scrapie cannot be confirmed until the end of the incubation period in
mice - a minimum of six months for the strains of mice with the shortest
incubation period. Among the atypical samples inoculated into mice, one
sample presented suspicious characteristics when the mice had reached
the end of the incubation period. The sample came from a goat aged two
and a half years when it was slaughtered in 2002. This goat was the only
animal affected in its herd of origin, which totalled 600 animals (300
adult goats in production and 300 young goats). The whole herd was
culled and all the adult goats were tested at that time, with negative
results. All the carcasses, including that of the affected goat, were
destroyed.

Experimental studies still need to be carried out to determine the exact
nature of the pathogen. The data have also been forwarded to the
Weybridge laboratory in the United Kingdom.

Scrapie surveillance programmes in small ruminants in France


http://www.oie.int/eng/maps/041119FRA.pdf

(1) See also:
http://europa.eu.int/rapid/pressReleasesAction.do?reference=IP/04/1324&format=HTML&aged=0&language=EN&guiLanguage=en


(2) AFSSA Lyon, CEA Saclay, CEA Fontenay-aux-Roses, INRA Jouy-en-Josas,
INRA Tours, Maisons-Alfort National Veterinary School and Toulouse
National Veterinary School

*
* *

http://www.oie.int/eng/info/hebdo/AIS_18.HTM#Sec0

TSS

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