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From: TSS (216-119-144-88.ipset24.wt.net)
Subject: RE-Researchers Identify Brain Protein That Halts Progression Of Alzheimer's (WHAT ABOUT sCJD? 'good idea')
Date: November 11, 2004 at 9:47 am PST

-------- Original Message --------
Subject: Fwd: Re: Fwd: FW: RE-Researchers Identify Brain Protein That Halts Progression Of Alzheimer's
Date: Tue, 9 Nov 2004 14:27:52 -0600
From: "Jeffrey A. Johnson"
To: flounder@wt.net


Dear Mr. Singeltary,

Please see Thor's comments below and thank you for you interest in
our research.

>Date: Mon, 08 Nov 2004 23:28:25 -0600
>From: THOR DANIEL STEIN
>Subject: Re: Fwd: FW: RE-Researchers Identify Brain Protein That Halts
> Progression Of Alzheimer's
>To: "Jeffrey A. Johnson"
>X-Accept-Language: en
>Priority: normal
>X-Spam-Report: TrustedSender=yes, SenderIP=144.92.197.153
>X-Spam-PmxInfo: Server=avs-1, Version=4.7.0.111621, Antispam-Engine: 2.0.2.0,
> Antispam-Data: 2004.11.8.5, SenderIP=144.92.197.153
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>Status: U
>
>Jeff, My thoughts on our pathway with prion disease are as follows,
>
>For years people have been comparing the amyloidopathies with the
>prion diseases by suggesting that in both cases it is the abnormal
>aggregation of protein that causes disease. There is no direct
>evidence to suggest that transthyretin or other proteins in this
>pathway would protect against TSEs, but it's never been tested.
>Frankly, it's a very good idea and there is some limited evidence to
>suggest that it might work. However, this is an active
>area of interest of ours and worthy of further study.
>
>Talk to you soon,
>Thor
>
>
>----- Original Message -----
>From: "Jeffrey A. Johnson"
>Date: Monday, November 8, 2004 11:56 am
>Subject: Fwd: FW: RE-Researchers Identify Brain Protein That Halts
>Progression Of Alzheimer's
>
>> Thor,
>>
>> What do you think?
>>
>> Jeff
>>
>> >From: "Peterson, John (NIH/NIEHS)"
>> >To: "'jajohnson@pharmacy.wisc.edu'"
>> >Subject: FW: RE-Researchers Identify Brain Protein That Halts
>> Progression> Of Alzheimer's
>> >Date: Mon, 8 Nov 2004 11:10:56 -0500
>> >X-RCPT-TO:
>> >Status: U
>> >
>> >Jeff,
>> >
>> > Could you please answer this question from Terry Singeltary?
>> Hope you are
>> >doing well ...
>> >
>> >
>> >
>> >John Peterson
>> >
>> >Office of Communications
>> >
>> >-----Original Message-----
> > >From: Terry S. Singeltary Sr. [mailto:flounder@wt.net]
>> >Sent: Friday, November 05, 2004 2:05 PM
>> >To: Peterson, John (NIH/NIEHS)
>> >Subject: RE-Researchers Identify Brain Protein That Halts
>> Progression Of
>> >Alzheimer's
>> >
>> >
>> >Greetings NIH et al,
>> >
>> >I kindly wish to ask a question please;
>> >
>> >Researchers Identify Brain Protein That Halts Progression Of
>> Alzheimer's>
>> >http://www.nih.gov/news/pr/oct2004/niehs-26.htm
>> >
>> >> Dr. Thor Stein, a researcher in Johnsons laboratory and first
>> author>> of the study, then analyzed the brains of mice and
>> noticed that the
>> >> levels of transthyretin had increased dramatically. When Stein
>> treated>> the mouse brain with an antibody that prevented
>> transthyretin from
>> >> reacting with the beta-amyloid protein, the mice showed brain
>cell
>> >> death. We concluded that the transthyretin must have
>> protected the
>> >> brain cells from the toxic effects of the beta-amyloid, says
>> Johnson.>>
>> >
>> >IS it possible this will work on human TSEs such as sporadic CJD ?
>> >
>> >thank you,
>> >kindest regards,
>> >
>> >Terry S. Singeltary Sr.
>> >P.O. Box 42
>> >Bacliff, TEXAS USA 77518
>>
>>
>> --
>> Jeffrey A. Johnson, Ph.D.
>> Director, Pharmacology and Toxicology B.S. Program
>> Associate Director, Molecular and Environmental Toxicology Ph.D.
>> ProgramUniversity of Wisconsin-Madison
>> School of Pharmacy
>> 6125 Rennebohm Hall
>> 777 Highland Avenue
>> Madison, WI 53705-2222
>> Telephone: (608) 262-2893
>> Fax: (608) 262-5345
>> e-mail: jajohnson@pharmacy.wisc.edu
>> http://www.pharmacy.wisc.edu/SOPDir/PersonDetails.cfm?Type=F&ID=38
>>


--
Jeffrey A. Johnson, Ph.D.
Director, Pharmacology and Toxicology B.S. Program
Associate Director, Molecular and Environmental Toxicology Ph.D. Program
University of Wisconsin-Madison
School of Pharmacy
6125 Rennebohm Hall
777 Highland Avenue
Madison, WI 53705-2222
Telephone: (608) 262-2893
Fax: (608) 262-5345
e-mail: jajohnson@pharmacy.wisc.edu
http://www.pharmacy.wisc.edu/SOPDir/PersonDetails.cfm?Type=F&ID=38

TSS



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