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From: TSS (216-119-132-57.ipset12.wt.net)
Subject: Experimental Cross-Species Transmission of Chronic Wasting Disease (Cwd) at the National Animal Disease Center (Nadc), Ames, Iowa: An Update
Date: November 7, 2004 at 6:47 pm PST

-------- Original Message --------
Subject: Experimental Cross-Species Transmission of Chronic Wasting Disease (Cwd) at the National Animal Disease Center (Nadc), Ames, Iowa: An Update
Date: Sun, 07 Nov 2004 20:46:13 -0600
From: "Terry S. Singeltary Sr."
To: BSE-L , CJDVOICE@YAHOOGROUPS.COM


Research
Research >

Title: Experimental Cross-Species Transmission of Chronic Wasting
Disease (Cwd) at the National Animal Disease Center (Nadc), Ames, Iowa:
An Update Author
item Hamir, Amirali


http://www.ars.usda.gov/research/publications/publications.htm?seq_no_115=167763tss
Submitted to: Meeting Abstract
Publication Acceptance Date: September 29, 2004
Publication Date: N/A
Technical Abstract: Experimental cross-species transmission of
transmissible spongiform encephalopathies (TSEs) provides valuable
information for identification of potential host ranges, and generates
much needed prion-infected tissues for research. At NADC, studies
utilizing CWD agent(s) were initiated in 1997. However, since these
studies involve long incubation periods under BL-2 conditions, to date
only one study has been completed. Initially our studies were restricted
to farm livestock (cattle and sheep). However, as a result of increased
demand from our stakeholders, we now also conduct research on wildlife
(herbivores and carnivores). Following are some of the significant
findings of past and on-going experiments at NADC: Completed study:
CATTLE: Intracerebral inoculation of CWD-mule-deer resulted in
amplification of PrPres in a small number of inoculated cattle (5 of 13;
38%). However, none of the animals with PrPres had classic
histopathologic lesions of spongiform encephalopathy. Studies utilizing
CWD-elk and CWD-white-tailed-deer in cattle are in progress. Preliminary
findings of ongoing CWD experiments in other species indicate that: 1.
SHEEP: CWD-mule-deer can be transmitted intracerebrally to sheep (1 of
8; 5 yrs PI). 2. WHITE-TAILED DEER: CWD-elk, CWD-white-tailed-deer, and
CWD-mule-deer are pathogenic for white-tailed deer (60%; 2 yrs PI). 3.
FALLOW DEER: Compared with other cervids studies, appear to be resistant
to intracerebral inoculation of CWD-elk and CWD-white-tailed-deer (0%; 2
yrs PI). White-tailed deer with CWD-mule-deer are pending. 4. RACCOONS:
TME and scrapie can be transmitted within 6 months and 2 years,
respectively, whereas CWD cannot. (Therefore, may be possible to
differentiate these 3 TSE agents in raccoons). Study utilizing BSE in
raccoons is pending.





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