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From: TSS (216-119-129-14.ipset9.wt.net)
Subject: Re: IFST updated Information Statement on BSE and Variant Creutzfeldt-Jakob Disease (vCJD)
Date: October 28, 2004 at 2:14 pm PST

In Reply to: IFST updated Information Statement on BSE and Variant Creutzfeldt-Jakob Disease (vCJD) posted by TSS on October 28, 2004 at 8:27 am:

Greetings,

> BASE: Atypical cases of BSE in individual cattle have been found in
> Japan, France, Italy, the Netherlands, Belgium, Denmark and Poland.
> This appears to be a second cattle TSE which has been named bovine
> amyloidotic spongiform encephalopathy (BASE).


funny how this report fails to mention the most important aspect of this
study;

MOLECULAR SIMILARITIES WITH SPORADIC CJD !

nope, they cannot even bring themselves to say it $

THE new findings of BASE in cattle in Italy of Identification of a
second bovine amyloidotic spongiform encephalopathy: Molecular
similarities with sporadic Creutzfeldt-Jakob disease


http://www.pnas.org/cgi/content/abstract/0305777101v1

PLEASE ALLOW ME to correct the statement above with the following;

-------- Original Message --------
Subject: Re: IFST updated Information Statement on BSE and Variant Creutzfeldt-Jakob Disease (vCJD)
Date: Thu, 28 Oct 2004 17:54:30 +0100
From: "J Ralph Blanchfield, MBE"
Reply-To: Bovine Spongiform Encephalopathy
Organization: Consultant
To: BSE-L@UNI-KARLSRUHE.DE
References: <4181113D.50407@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

Dear Terry,

You are evidently so anxious to take the opportunity to expound your conspiracy
theories that you rushed into print before bothering to go beyond the seven page
Summary to the 68 page full text. If you had bothered to go to the full text to
which you and others were directed, you would have found

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
BASE: atypical TSE in cattle

Casalone et al (2004) have provided evidence of a second cattle TSE. The
disorder, in a cow in Italy, was pathologically characterized by the presence of
PrP-immunopositive amyloid plaques, as opposed to the lack of amyloid deposition
in typical BSE cases, and by a different pattern of regional distribution and
topology of brain PrPSc accumulation. In addition, Western blot analysis showed
a PrPSc type with predominance of the low molecular mass glycoform and a
protease-resistant fragment of lower molecular mass than BSE-PrPSc. Strikingly,
the molecular signature of this previously undescribed bovine PrPSc was similar
to that encountered in a distinct subtype of sporadic CJD. This new form with
amyloid plaques has been named bovine amyloidotic spongiform encephalopathy
(BASE). Similar cases have been described in France [Biacabe et al (2003)],
Belgium, Denmark, The Netherlands and Japan,

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

You added the $ insult when you know full well that IFST is not influenced by $$
or ££.

Don't you think an apology is due from you, and a promise of more care in the
future?

Best wishes
Ralph
******************************************************
Prof J Ralph Blanchfield, MBE
Food Science, Food Technology and Food Law Consultant
Chair, External Affairs, Institute of Food Science and Technology
Webmaster / Web Editor, Institute of Food Science and Technology
Vice President, European Food Law Association of the UK
Adjunct Professor, Michigan State University
IFST Web address
Personal Web address
***************************************************************

-------- Original Message --------
Subject: Re: IFST updated Information Statement on BSE and Variant
Date: Thu, 28 Oct 2004 12:33:52 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@UNI-KARLSRUHE.DE
References: <4181113D.50407@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

hello there Ralph,

many thanks for your kind reply ;-)

but why bury it in 68 pages when it should have been put in the short
summary most people would read?

>Don't you think an apology is due from you, and a promise of more care in the
>future?
>

nope.............

kind regards,
terry

-------- Original Message --------
Subject: Re: IFST updated Information Statement on BSE and Variant
Date: Thu, 28 Oct 2004 18:52:30 +0100
From: "J Ralph Blanchfield, MBE"
Reply-To: Bovine Spongiform Encephalopathy
Organization: Consultant
To: BSE-L@UNI-KARLSRUHE.DE
References: <4181113D.50407@wt.net> <41812D80.6050603@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

Hello Terry,

Anyone seriously interested in the subject (instead of merely wanting to grind
an axe) would read the full text. I am really surprised that you did not bother
to do so or, having seen the item in the Summary, did not even do a (Control+F)
search for "BASE" or "Castelone" in the full text. In these days of ability to
search electronic documents, nothing is "buried", as you well know.

For someone who provides a lot of valuable information on BSE-L as you do, it
is very sad that you also behave so boorishly. The hardest word to say is
"Sorry". Evidently it is beyond you. I really pity you.

Best wishes
Ralph
******************************************************
Prof J Ralph Blanchfield, MBE
Food Science, Food Technology and Food Law Consultant
Chair, External Affairs, Institute of Food Science and Technology
Webmaster / Web Editor, Institute of Food Science and Technology
IFST Web address
Personal Web address
***************************************************************
Note: All outgoing e-mails have been scanned for all
known viruses by the latest version of Norton Anti-virus.

-------- Original Message --------
Subject: Re: IFST updated Information Statement on BSE and Variant
Date: Thu, 28 Oct 2004 15:03:39 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@UNI-KARLSRUHE.DE
References: <4181113D.50407@wt.net> <41812D80.6050603@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

Hello again Ralph,

>For someone who provides a lot of valuable information on BSE-L as you do, it
>is very sad that you also behave so boorishly. The hardest word to say is
>"Sorry". Evidently it is beyond you. I really pity you.
>
>

oh Ralph, don't pity me, you should pity the fools that got us
in this mess, some that seem to want to make the same mistakes
over and over again.

also, your mind seems to slip you there friend,
i am the first to say i am sorry or admit things if i am
wrong, and have said it before to you ;

Date: Sat, 27 Nov 1999 12:03:22 +0000
Reply-To: BSE-L
Sender: BSE-L
From: J Ralph Blanchfield
Organization: Consultant
Subject: Re: Girl, 13, shows CJD symptoms. [re-baby food]
In-Reply-To:

BSE-L

Hello Terry and Everyone,

On Fri, 26 Nov 1999 10:36:34 -0600, Terry wrote:

>Hello Ralph and All, >I think you are correct Ralph, after reading
back over my comments, I was a bit >hasty, and in a friends eyes, may
have even seemed rude. >For that I would like to apologize to Heather
and You.

Thank you. I shall forward your post on to Heather, and invite her to
send me a response, which I shall forward to BSE-L.

>It still does not change my position on the matter. It would have been
better >directed, if I would have directed my haste, to the _whole_
industry involved, as >opposed to Heather and the Baby Food industry.
>For obvious reasons, if the DFA's are accurate, and the statements
within from the >Working Party and the Gov. and the statement from the
manufacturers of Baby Foods, >where they are stating in DFA 9; >"152.
There is no evidence of written assurances from the manufacturers
supplied >to either Maff or the Department of Health asserting that Baby
Food did not >contain bovine brain, spinal cord, spleen, intestines or
thymus".


snip...end

hello again Ralph,


>Anyone seriously interested in the subject (instead of merely wanting to grind
>an axe) would read the full text.
>

dont' worry there, i had intended on it, just have not had time yet,
i was more interested in the TSE infection in a goats brain which tests
cannot distinguish from BSE, this was big news to me and was still
reading that.

Ralph, it seems i have hit your sore spot again and did not intend to do
so. but i am very disturbed that every time a report comes out from
Gov. officials and or food safety experts, studies that support sporadic
CJD as not being so sporadic/spontaneous as some in the industry would
like, studies that show 'Molecular similarities with sporadic
Creutzfeldt-Jakob disease ', i mean, how much space would that have
taken up in the summary?

you have a second TSE in cattle, BUT THIS TIME it has molecular
similarities with sporadic CJD, and it is being documented in a growing
number of countries? why is not the media reading this and reporting it?
could it because it was not in the summary and they did not read the
full report?
i hope not...

something _this_ important should have read ;

''BASE: Atypical cases of BSE in individual cattle have been found in
Japan, France, Italy, the Netherlands, Belgium, Denmark and Poland. This
appears to be a second cattle TSE which has been named bovine
amyloidotic spongiform encephalopathy (BASE), with Molecular
similarities with sporadic Creutzfeldt-Jakob disease.''

i mean, this is how the title reads ;


Medical Sciences
Identification of a second bovine amyloidotic spongiform
encephalopathy: Molecular similarities with sporadic
Creutzfeldt-Jakob disease


NOW, that is how it should have read, unless the PUBLIC FEAR FACTOR
CONTROL switched was turned on again, to omit the most important aspect
of this research in the summary. just my opinion, and i hate to play the
race
card, but you called it, so YES, i have a grind to ax, hvCJD Mom dod
12/14/97.
BUT i grind my ax with facts, all of them.

MY point was not to turn on Ralphs mad button:-)

FACTS are facts and fact is, the 85%+ of all CJD 'sporadic' needs to be
at the forefront of this research, not on the back burners. call it a rant,
call it a grind to ax, call it whatever you want, but here are the
facts that are being ignored, and this was my point ;

IN light of Asante/Collinge et al findings that BSE transmission to the
129-methionine genotype can lead to an alternate phenotype that is
indistinguishable from type 2 PrPSc, the commonest _sporadic_ CJD;

-------- Original Message -------- Subject: re-BSE prions propagate as

either variant CJD-like or sporadic CJD Date: Thu, 28 Nov 2002 10:23:43

-0000 From: "Asante, Emmanuel A" To:
"'flounder@wt.net'"

Dear Terry,

I have been asked by Professor Collinge to respond to your request. I am

a Senior Scientist in the MRC Prion Unit and the lead author on the

paper. I have attached a pdf copy of the paper for your attention. Thank

you for your interest in the paper.

In respect of your first question, the simple answer is, yes. As you

will find in the paper, we have managed to associate the alternate

phenotype to type 2 PrPSc, the commonest sporadic CJD.

It is too early to be able to claim any further sub-classification in

respect of Heidenhain variant CJD or Vicky Rimmer's version. It will

take further studies, which are on-going, to establish if there are

sub-types to our initial finding which we are now reporting. The main

point of the paper is that, as well as leading to the expected new

variant CJD phenotype, BSE transmission to the 129-methionine genotype

can lead to an alternate phenotype which is indistinguishable from type

2 PrPSc.

I hope reading the paper will enlighten you more on the subject. If I

can be of any further assistance please to not hesitate to ask. Best
wishes.

Emmanuel Asante

<> ____________________________________

Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial

College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG

Tel: +44 (0)20 7594 3794 Fax: +44 (0)20 7706 3272 email:

e.asante@ic.ac.uk (until 9/12/02)

New e-mail: e.asante@prion.ucl.ac.uk (active from now)

____________________________________

snip...

full text ;

http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm

BSE prions propagate as either variant CJD-like or sporadic CJD-like
prion strains in transgenic mice expressing human prion protein

Emmanuel A. Asante, Jacqueline M. Linehan, Melanie Desbruslais, Susan
Joiner, Ian Gowland, Andrew L. Wood, Julie Welch, Andrew F. Hill, Sarah
E. Lloyd, Jonathan D.F. Wadsworth and John Collinge1

MRC Prion Unit and Department of Neurodegenerative Disease, Institute of
Neurology, University College, Queen Square, London WC1N 3BG, UK 1
Corresponding author e-mail: j.collinge@prion.ucl.ac.uk


Received August 1, 2002; revised September 24, 2002; accepted October
17, 2002

Abstract


Variant CreutzfeldtJakob disease (vCJD) has been recognized to date
only in individuals homozygous for methionine at PRNP codon 129. Here we
show that transgenic mice expressing human PrP methionine 129,
inoculated with either bovine spongiform encephalopathy (BSE) or variant
CJD prions, may develop the neuropathological and molecular phenotype of
vCJD, consistent with these diseases being caused by the same prion
strain. Surprisingly, however, BSE transmission to these transgenic
mice, in addition to producing a vCJD-like phenotype, can also result in
a distinct molecular phenotype that is indistinguishable from that of
sporadic CJD with PrPSc type 2. These data suggest that more than one
BSE-derived prion strain might infect humans; it is therefore possible
that some patients with a phenotype consistent with sporadic CJD may
have a disease arising from BSE exposure...

http://embojournal.npgjournals.com/cgi/content/full/21/23/6358

THE new findings of BASE in cattle in Italy of Identification of a
second bovine amyloidotic spongiform encephalopathy: Molecular
similarities with sporadic Creutzfeldt-Jakob disease


http://www.pnas.org/cgi/content/abstract/0305777101v1


Adaptation of the bovine spongiform encephalopathy agent to primates
and comparison with Creutzfeldt- Jakob disease: Implications for
human health

THE findings from Corinne Ida Lasmézas*, [dagger] , Jean-Guy Fournier*,
Virginie Nouvel*,

Hermann Boe*, Domíníque Marcé*, François Lamoury*, Nicolas Kopp [Dagger

] , Jean-Jacques Hauw§, James Ironside¶, Moira Bruce [||] , Dominique

Dormont*, and Jean-Philippe Deslys* et al, that The agent responsible
for French iatrogenic growth hormone-linked CJD taken as a control is
very different from vCJD but is similar to that found in one case of
sporadic CJD and one sheep scrapie isolate;

http://www.pnas.org/cgi/content/full/041490898v1

Characterization of two distinct prion strains
derived from bovine spongiform encephalopathy
transmissions to inbred mice

Sarah E. Lloyd, Jacqueline M. Linehan, Melanie Desbruslais,
Susan Joiner, Jennifer Buckell, Sebastian Brandner,
Jonathan D. F. Wadsworth and John Collinge

Correspondence
John Collinge
j.collinge@prion.ucl.ac.uk

MRC Prion Unit and Department of Neurodegenerative Disease, Institute of
Neurology,
University College, London WC1N 3BG, UK
Received 9 December 2003
Accepted 27 April 2004

Distinct prion strains can be distinguished by differences in incubation
period, neuropathology
and biochemical properties of disease-associated prion protein (PrPSc)
in inoculated mice.
Reliable comparisons of mouse prion strain properties can only be
achieved after passage in
genetically identical mice, as host prion protein sequence and genetic
background are known
to modulate prion disease phenotypes. While multiple prion strains have
been identified in
sheep scrapie and CreutzfeldtJakob disease, bovine spongiform
encephalopathy (BSE) is
thought to be caused by a single prion strain. Primary passage of BSE
prions to different lines
of inbred mice resulted in the propagation of two distinct PrPSc types,
suggesting that two
prion strains may have been isolated. To investigate this further, these
isolates were
subpassaged in a single line of inbred mice (SJL) and it was confirmed
that two distinct prion
strains had been identified. MRC1 was characterized by a short
incubation time (110±3 days),
a mono-glycosylated-dominant PrPSc type and a generalized diffuse
pattern of PrP-immunoreactive
deposits, while MRC2 displayed a much longer incubation time (155±1 days),
a di-glycosylated-dominant PrPSc type and a distinct pattern of
PrP-immunoreactive deposits
and neuronal loss. These data indicate a crucial involvement of the host
genome in modulating
prion strain selection and propagation in mice. It is possible that
multiple disease phenotypes
may also be possible in BSE prion infection in humans and other animals.

http://vir.sgmjournals.org/cgi/content/abstract/85/8/2471

1: J Infect Dis 1980 Aug;142(2):205-8


Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of
sheep and goats were transmitted to squirrel monkeys (Saimiri
sciureus) that were exposed to the infectious agents only by their
nonforced consumption of known infectious tissues. The asymptomatic
incubation period in the one monkey exposed to the virus of kuru was
36 months; that in the two monkeys exposed to the virus of
Creutzfeldt-Jakob disease was 23 and 27 months, respectively; and
that in the two monkeys exposed to the virus of scrapie was 25 and
32 months, respectively. Careful physical examination of the buccal
cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has
remained asymptomatic during the 39 months that it has been under
observation.

PMID: 6997404

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6997404&dopt=Abstract

ALL animals for human/animal consumption must be tested for TSE.

ALL human TSEs must be made reportable Nationally and Internationally...tss

P.S.

Ralph, sorry i hurt your feelings, but i am not sorry for trying to tell
the whole truth.

this i will continue to do.

have a nice day...

kind regards,
terry





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