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From: TSS (216-119-144-36.ipset24.wt.net)
Subject: Maternal transmission studies of BSE in sheep
Date: October 1, 2004 at 2:07 pm PST

-------- Original Message --------
Subject: Maternal transmission studies of BSE in sheep
Date: Fri, 1 Oct 2004 15:13:39 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@UNI-KARLSRUHE.DE


##################### Bovine Spongiform Encephalopathy #####################

Short Communication


Maternal transmission studies of BSE in sheep

J. D. Foster, W. Goldmann, C. McKenzie, A. Smith, D. W. Parnham and N.
Hunter

Institute for Animal Health, Neuropathogenesis Unit, West Mains Road,
Edinburgh EH9 3JF, UK

Correspondence
N. Hunter
nora.hunter@bbsrc.ac.uk

If BSE (bovine spongiform encephalopathy) infected the UK sheep
population concurrently with cattle, it would only now be maintained by
transmission between sheep by routes which could include from mother to
lamb either in utero or via perinatal close contact. In this study of
experimental BSE, Cheviot ewes challenged orally with BSE cattle brain
produced lambs of various PrP genotypes over the next 7 years. Of 72
surviving to >30 months of age, 29 are of the most susceptible PrP
genotype (AQ/AQ) and born to mothers that were challenged with BSE. None
of the progeny have shown any signs of disease. The results suggest that
in these sheep, BSE could only transmit by the maternal route at a
frequency of less than one in four (95 % confidence limit) from
clinically affected ewes, a rate which if replicated in other breeds may
not be sufficient to maintain BSE within the sheep population.

http://vir.sgmjournals.org/cgi/content/abstract/85/10/3159

TSS

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