SEARCH VEGSOURCE:

 

 

Follow Ups | Post Followup | Back to Discussion Board | VegSource
See spam or
inappropriate posts?
Please let us know.
  




From: Terry S. Singeltary Sr. (216-119-139-252.ipset19.wt.net)
Subject: Re: TSE REPORT USA September 14, 2004
Date: September 27, 2004 at 12:22 pm PST

-------- Original Message --------
Subject: Re: TSE REPORT USA September 14, 2004
Date: Mon, 27 Sep 2004 13:46:53 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@UNI-KARLSRUHE.DE
References: <41474C8C.30602@wt.net>


##################### Bovine Spongiform Encephalopathy #####################

Greetings,

> Agencies Postpone Issuing New Rules Until After Election
>
> By STEPHEN LABATON
> New York Times
>
> WASHINGTON, Sept. 26 - After a case of mad cow disease surfaced in
> Washington State late last year, federal regulators vowed to move
> swiftly to adopt rules to reduce the risks of further problems and
> restore confidence in the nation's meat industry.
>
> Some rules were adopted this year. But a few weeks ago, the Food and
> Drug Administration, after heavy lobbying from the beef and feed
> industries, took steps to delay - and to the concern of food safety
> groups, possibly kill - completion of the most controversial and perhaps
> most expensive proposal for cattle companies.
>
> That proposal would sharply restrict what could be included in animal
> feed. Shortly after the administration slowed its consideration of the
> rule, the National Cattlemen's Beef Association broke its nonpartisan
> tradition and endorsed President Bush for re-election.
>
> The F.D.A. decision was part of a broader pattern.
>
> In recent weeks, federal agencies across the vast Washington bureaucracy
> have delayed completion of a range of proposed regulations from food
> safety and the environment to corporate governance and
> telecommunications policy until after Election Day, when regulatory
> action may be more politically palatable. ...
>
> snip...
>
>
> http://www.nytimes.com/2004/09/27/business/27regs.html?hp


I heard through the USA MAD COW grapevine that there will
be NO POSITIVE results from any BSE/TSE positive cow
that would be found between now and election time, and that
it would be most unlikely for them to find one anyway. they seem
to be concealing all the most likely cases of BSE/TSE by simply
not testing them, as in the case with the TEXAS mad cow and
the other 500+ that UPI found...

TSS

Terry S. Singeltary Sr. wrote:

> Prepared by
> National Center for Animal Health Programs
> Eradication and Surveillance Team
> July 31, 2004
>
>
>
> SCRAPIE
>
> INFECTED AND SOURCE FLOCKS
>
> AS of July 31, 2004, there were 71 scrapie infected and source flocks
> (figure 3). There were 4 new infected and source flocks reported in July
> (figure 4) with a total of 90 flocks reported for FY 2004 (figure 5).
> The total infected and source flocks that have been released in FY 2004
> are 62 (figure 6), with 15 flocks released in July. The ratio of
> infected and source flocks released to newly infected and source flocks
> for FY 2004 = 0.69 : 1.
> IN ADDITION, AS OF JULY 31, 2004, 282 SCRAPIE CASES HAVE
> BEEN CONFIRMED and reported by the National Veterinary Services
> Laboratories (NVSL) in FY 2004, OF WHICH 42 WERE RSSS CASES (figure 7).
> This includes 60 NEWLY CONFIRMED CASES IN JULY 2004 (figure 8). THIRTEEN
> cases of scrapie in GOATS have been reported since 1990 (figure 9). ONE
> NEW GOAT CASE WAS REPORTED IN FY 2004. New infected flocks, source
> flocks, and flocks released or put on clean-up plans for FY 2004 are
> depicted in figure 10...
>
> snip...
>
> http://www.aphis.usda.gov/vs/nahps/scrapie/monthly_report/monthly-report.html
>
>
>
> Emergency Programs
>
> *
>
>
> Imported Belgium/Netherlands Sheep Test Results
>
>
>
> APRIL 2002
>
> snip...
>
> The Western-blot test however cannot differentiate
> between scrapie and BSE. The only known validated
> method to differentiate between these two diseases
> requires a series of mouse bioassay systems, which
> take at least 23 years for completion.
>
> snip...
>
> http://www.aphis.usda.gov/lpa/pubs/fsheet_faq_notice/fs_ahvtsheeptr.pdf
>
> -------- Original Message --------
> Subject: Re: AW: [BSE-L] USDA did not test possible mad cows - Dr.
> Detwiler, what about those sheep?
> Date: Sun, 13 Jun 2004 11:27:24 -0500
> From: "Terry S. Singeltary Sr."
> Reply-To: Bovine Spongiform Encephalopathy
>
>
>
> Greetings list members,
>
> Thought I should let the list know that Dr. Detwiler kindly replied to
> my question about the delayed 'atypical' TSE testing in the Vermont
> sheep and tried to explain what caused the delay. If I interpreted it
> correctly, seems it was the fault of the U.K. ;
>
> -------- Original Message --------
>
> Subject: Sheep Date: Sat, 12 Jun 2004 14:26:04 EDT
>
> From: LAVET22@aol.com
>
> To: flounder@wt.net
>
> Mr. Singeltary. I hope this finds you well. As you are aware I left the
> USDA last year. I can only update you on the sheep before that time.
> Contact was established with the UK on doing the bioassay studies. They
> agreed. However, we were prioritized after their own needs, hence the
> delay. I am aware that there are now additional labs in Europe running
> the mouse bioassay strain typing. You will have to contact USDA for
> further word.
>
> Linda Detwiler
> =========
> My reply to Dr. Detwiler;
>
> -------- Original Message --------
>
> Subject: Re: Sheep
> Date: Sat, 12 Jun 2004 13:53:57 -0500
> From: "Terry S. Singeltary Sr."
> To: LAVET22@aol.com
> References: <54.2bd2ac1e.2dfca4bc@aol.com>
>
> hello Dr. Detwiler, thanks for your kind reply.
>
> > However, we were prioritized after their own needs, hence the delay.
> not sure i understand that?
> > You will have to contact USDA for further word. already done that,
> and there answer was;
> >5/20/04
> > >Dear Mr. Singeltary,
> > >The Western blot tests on these animals were completed in April of
> this >year. That means that we can begin the mouse inoculations. To get
> the >results of the Western blot tests, you will need to submit a
> Freedom of >Information Act request through our FOIA office. The FAX
> number there is
> >301-734-5941.
> > >Have a nice day,
> > >Jim Rogers
> >APHIS LPA
> > and with my previous attempts for information via the FOIA through
> this administration (as you are probably very well aware of) they have
> all been ignored/refused. so any further attempts would be fruitless i
> am sure. thanks anyway... kindest regards, Terry LAVET22@aol.com wrote:
> > Mr. Singeltary. snip... TSS
> =============================================
>
> 12/10/76
>
> AGRICULTURAL RESEARCH COUNCIL
> REPORT OF THE ADVISORY COMMITTE ON SCRAPIE
>
> Office Note
> CHAIRMAN: PROFESSOR PETER WILDY
>
> snip...
>
> A The Present Position with respect to Scrapie
> A] The Problem
>
> Scrapie is a natural disease of sheep and goats. It is a slow
> and inexorably progressive degenerative disorder of the nervous system
> and it ia fatal. It is enzootic in the United Kingdom but not in all
> countries.
>
> The field problem has been reviewed by a MAFF working group
> (ARC 35/77). It is difficult to assess the incidence in Britain for
> a variety of reasons but the disease causes serious financial loss;
> it is estimated that it cost Swaledale breeders alone $l.7 M during
> the five years 1971-1975. A further inestimable loss arises from the
> closure of certain export markets, in particular those of the United
> States, to British sheep.
>
> It is clear that scrapie in sheep is important commercially and
> for that reason alone effective measures to control it should be
> devised as quickly as possible.
>
> Recently the question has again been brought up as to whether
> scrapie is transmissible to man. This has followed reports that the
> disease has been transmitted to primates. One particularly lurid
> speculation (Gajdusek 1977) conjectures that the agents of scrapie,
> kuru, Creutzfeldt-Jakob disease and transmissible encephalopathy of
> mink are varieties of a single "virus". The U.S. Department of
> Agriculture concluded that it could "no longer justify or permit
> scrapie-blood line and scrapie-exposed sheep and goats to be processed
> for human or animal food at slaughter or rendering plants" (ARC 84/77)"
> The problem is emphasised by the finding that some strains of scrapie
> produce lesions identical to the once which characterise the human
> dementias"
>
> Whether true or not. the hypothesis that these agents might be
> transmissible to man raises two considerations. First, the safety
> of laboratory personnel requires prompt attention. Second, action
> such as the "scorched meat" policy of USDA makes the solution of the
> acrapie problem urgent if the sheep industry is not to suffer
> grievously.
>
> snip...
>
> 76/10.12/4.6
>
> http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf
>
> http://www.bseinquiry.gov.uk/files/yb/1976/10/12002001.pdf
>
>
> CHRONIC WASTING DISEASE
>
> http://www.aphis.usda.gov/vs/nahps/cwd/cwd-distribution.html
>
> http://www.cwd-info.org/index.php/fuseaction/about.map
>
> MULTI-STATE GUIDLELINES
> FOR CHRONIC WASTING DISEASE MANAGEMENT
> IN FREE-RANGING WHITE-TAILED DEER, MULE DEER AND ELK
> April 2004
>
> http://www.cwd-info.org/pdf/Multi-state.pdf
>
> LANCET INFECTIOUS DISEASE JOURNAL
> Volume 3, Number 8 01 August 2003
> Newsdesk
> Tracking spongiform encephalopathies in North America
> Xavier Bosch
>
> snip...
>
> Norman Foster, director of the Cognitive Disorders Clinic at the
>
> University of Michigan (Ann Arbor, MI, USA), says that current
>
> surveillance of prion disease in people in the USA is inadequate to
>
> detect whether CWD is occurring in human beings; adding that, the
>
> cases that we know about are reassuring, because they do not suggest the
>
> appearance of a new variant of CJD in the USA or atypical features in
>
> patients that might be exposed to CWD. However, until we establish a
>
> system that identifies and analyses a high proportion of suspected prion
>
> disease cases we will not know for sure. The USA should develop a
>
> system modelled on that established in the UK, he points out.
>
>
>
> Ali Samii, a neurologist at Seattle VA Medical Center who recently
>
> reported the cases of three hunterstwo of whom were friendswho died
>
> from pathologically confirmed CJD, says that at present there are
>
> insufficient data to claim transmission of CWD into humans; adding that
>
> [only] by asking [the questions of venison consumption and deer/elk
>
> hunting] in every case can we collect suspect cases and look into the
>
> plausibility of transmission further. Samii argues that by making both
>
> doctors and hunters more aware of the possibility of prions spreading
>
> through eating venison, doctors treating hunters with dementia can
>
> consider a possible prion disease, and doctors treating CJD patients
>
> will know to ask whether they ate venison.
>
>
> CDC spokesman Ermias Belay says that the CDC will not be investigating
>
> the [Samii] cases because there is no evidence that the men ate
>
> CWD-infected meat. He notes that although the likelihood of CWD
>
> jumping the species barrier to infect humans cannot be ruled out 100%
>
> and that [we] cannot be 100% sure that CWD does not exist in humans&
>
> the data seeking evidence of CWD transmission to humans have been very
>
> limited.
>
> snip...
>
> http://infection.thelancet.com/journal/journal.isa
>
>
> From: "Belay, Ermias"
> To:
> Cc: "Race, Richard (NIH)" ; ; "Belay,
> Ermias"
> Sent: Monday, September 30, 2002 9:22 AM
> Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG
> HUNTERS
>
> Dear Sir/Madam,
> In the Archives of Neurology you quoted (the abstract of which was
> attached to your email), we did not say CWD in humans will present like
> variant CJD.
>
> That assumption would be wrong. I encourage you to read the whole
> article and call me if you have questions or need more clarification
> (phone: 404-639-3091). Also, we do not claim that "no-one has ever been
> infected with prion disease from eating venison." Our conclusion stating
> that we found no strong evidence of CWD transmission to humans in the
> article you quoted or in any other forum is limited to the patients we
> investigated.
>
> Ermias Belay, M.D.
> Centers for Disease Control and Prevention
>
> > > -----Original Message-----
> > > From:
> > > Sent: Sunday, September 29, 2002 10:15 AM
> > > To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV
> > > Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG
> > > HUNTERS
>
> continued...tss
>
> Chronic Wasting Disease and Potential Transmission to Humans
>
> Ermias D. Belay,*Comments
> Ryan A.
> Maddox,* Elizabeth S. Williams, Michael W. Miller,! Pierluigi Gambetti,§
> and Lawrence B. Schonberger*
> *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;
> University of Wyoming, Laramie, Wyoming, USA; !Colorado Division of
> Wildlife, Fort Collins, Colorado, USA; and §Case Western Reserve
> University, Cleveland, Ohio, USA
>
> http://www.cdc.gov/ncidod/EID/vol10no6/03-1082.htm
>
>
> Environmental Sources of Prion Transmission in Mule Deer
>
> Michael W. Miller,*Comments
> Elizabeth S.
> Williams, N. Thompson Hobbs,! and Lisa L. Wolfe*
> *Colorado Division of Wildlife, Fort Collins, Colorado, USA; University
> of Wyoming, Laramie, Wyoming, USA; and !Colorado State University, Fort
> Collins, Colorado, USA
>
> Suggested citation for this article: Miller MW, Williams ES, Hobbs
> NT, Wolfe LL. Environmental sources of prion transmission in mule
> deer. Emerg Infect Dis [serial on the Internet]. 2004 Jun [date
> cited]. Available from:
> http://www.cdc.gov/ncidod/EID/vol10no6/04-0010.htm
>
> http://www.cdc.gov/ncidod/EID/vol10no6/04-0010.htm
>
> PAGE 25
>
> Transmission Studies
>
> Mule deer transmissions of CWD were by intracerebral inoculation and
> compared with natural cases resulted in a more rapidly
> progressive clinical disease with repeated episodes of synocopy ending
> in coma. One control animal became affected, it is believed through
> contamination of inoculam (?saline). Further CWD transmissions were
> carried out by Dick Marsh into ferret, mink and squirrel monkey.
> Transmission occurred in all of these species with the shortest
> incubation period in the ferret.
>
> snip...
>
> The occurrence of CWD must be viewed against the context of the
> locations in which it occurred. It was an incidental and unwelcome
> complication of the respective wildlife research programmes. Despite its
> subsequent recognition as a new disease of cervids, therefore justifying
> direct investigation, no specific research funding was forthcoming.
> The USDA viewed it as a wildlife problem and consequently not their
> province!
>
> [figures...TSS]
>
> snip...
>
> VISIT TO USA - DR A E WRATHALL - INFO ON BSE AND SCRAPIE
>
> 1. Dr Clark lately of the Scrapie Research Unit, Mission Texas has
> successfully transmitted ovine and caprine scrapie to cattle. The
> experimental results have not been published but there are plans to do
> this. This work was initiated in 1978. A summary of it is:-
>
> snip...
>
> Gerald Wells: Report of the Visit to USA, April-May 1989
>
> http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
>
> Aguzzi warns of CWD danger
>
> The TSE family of diseases also includes chronic wasting disease (CWD)
> in deer, a condition that has spread in the US in recent years (Nature
> 416, 569; 2002). Speaking at the Days of Molecular Medicine conference
> in La Jolla in March, prion expert Adriano Aguzzi issued a strong
> warning against underestimating this form of TSE.
>
> "For more than a decade, the US has by-and-large considered mad cows
> to be an exquisitely European problem. The perceived need to protect
> US citizens from this alien threat has even prompted the deferral of
> blood donors from Europe," he said. "Yet the threat-from-within
> posed by CWD needs careful consideration, since the evidence that CWD
> is less dangerous to humans than BSE is less-than-complete. Aguzzi
> went on to point out that CWD is arguably the most mysterious of all
> prion diseases.
>
> "Its horizontal spread among the wild population is exceedingly
> efficient, and appears to have reached a prevalence unprecedented even
> by BSE in the UK at its peak. The pathogenesis of CWD, therefore,
> deserves a vigorous research effort. Europeans also need to think
> about this problem, and it would be timely and appropriate to increase
> CWD surveillance in Europe too." Aguzzi has secured funding from the
> National Institutes of Health to investigate CWD, and the effort will
> be lead by Christina Sigurdson in his department at the University of
> Zurich. KAREN BIRMINGHAM, LONDON
>
> This quote from Dr. Gambetti is especially significant since he is the
> rather cautious TSE researcher under contract with the Centers for
> Disease
> Control to examine the brains of individuals who have died of CJD.
> -----------------
>
> Pierluigi Gambetti, director of the National Prion Disease Pathology
> Surveillance Center at Case Western Reserve University in Cleveland,
> said all deer should be tested for chronic wasting disease before any
> processing is done.
>
> "There is no way around it," he said. "Nobody should touch that meat
> unless it has been tested."
> --------------------------------------
>
> http://www.ledger-enquirer.com/
>
>
> TRANSMISSIBLE MINK ENCEPHALOPATHY
>
> Transmissible Mink Encephalopathy
>
> Transmissible mink encephalopathy (TME) is a rare
> illness that affects the central nervous system of
> ranch-raised mink. It was first detected in the United
> States in 1947. Since then, TME outbreaks have
> been reported in numerous locations worldwide,
> including the United States, Canada, Finland,
> Germany, and the republics of the former Soviet
> Union.
>
> snip...
>
> The first documented TME outbreak in the United
> States occurred in 1947 on one ranch in Wisconsin
> and then on a ranch in Minnesota that had received
> mink from the Wisconsin ranch. In 1961, TME outbreaks
> occurred on five ranches in Wisconsin. In
> 1963, outbreaks occurred in Idaho, Minnesota, and
> Wisconsin. Epidemiologic data from the Minnesota
> and Wisconsin outbreaks trace the cases in those
> States to one common purchased food source.
> The 1985 Stetsonville Outbreak
> The most recent TME outbreak occurred on one
> mink ranch in Stetsonville, WI, in 1985. In the herd of
> 7,300 adult mink, 60 percent of the animals died.
> Clinical signs included tail arching, incoordination, and
> hyperexcitability. At the most advanced stages of the
> disease, the animals were in trancelike states and
> eventually died.
> The outbreak lasted 5 months. Microscopic
> examination of sections of the brain confirmed the
> spongelike changes characteristic of TME. Diagnostic
> tests identified the prion protein. The following year,
> mink born during the outbreak showed no signs of
> TME.
> The late Richard Marsh, a veterinary virologist at
> the University of Wisconsin who studied the transmission
> of TME and other TSEs, investigated this outbreak.
> Marsh learned that the mink were fed a diet
> composed of fresh meat products from downer cattle
> and commercial sources of fish, poultry, and cereal.
> Downer cattle are nonambulatory and cannot rise
> because they are affected with a condition such as a
> metabolic disease, broken limbs, or a central nervous
> system disorder. Marsh theorized that the meat from
> these downer cattle introduced a TSE agent to the
> mink in which TME resulted.
> Although Marshs hypothesis is based on speculation
> and anecdotal evidence, in 1993 APHIS adjusted
> its national BSE surveillance program to include testing
> downer cattle for evidence of a TSE. The brains of
> more than 20,141 cattle have been examined at
> APHIS National Veterinary Services Laboratories and
> other State diagnostic laboratories. Not a single tissue
> sample has revealed evidence of BSE or another
> TSE in cattle...
>
> snip...
>
> http://www.aphis.usda.gov/lpa/pubs/fsheet_faq_notice/fs_ahtme.pdf
>
> http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf
>
> BOVINE SPONGIFORM ENCEPHALOPATHY
>
> No mad cow results for nearly 500 cows
>
> By Steve Mitchell
> United Press International
> Published 8/11/2004 11:23 AM
>
>
> WASHINGTON, Aug. 11 (UPI) -- The U.S. Department of Agriculture failed
> to test for mad cow disease or collect the correct portion of the brain
> on nearly 500 suspect cows over the past two years -- including some in
> categories considered most likely to be infected -- according to agency
> records obtained by United Press International.
>
> The testing problems mean it may never be known with certainty whether
> these animals were infected with the deadly disease. Department
> officials said these animals were not included in the agency's final
> tally of mad cow tests, but the records, obtained by UPI under the
> Freedom of Information Act, indicate at least some of them were
> counted...
>
> snip...
>
> --
>
> Steve Mitchell is UPI's Medical Correspondent. E-mail sciencemail@upi.com
> Copyright © 2001-2004 United Press International
>
> http://www.upi.com/view.cfm?StoryID=20040810-042935-2066r
>
> July 13, 2004
>
> IG Audit Finds Multiple Flaws in Mad Cow Surveillance Plan
> Rep. Waxman raises questions about the effectiveness and credibility of
> USDA's response to mad cow disease, citing an audit by the USDA
> Inspector General that finds systemic deficiencies in the Department's
> surveillance plan and new evidence that USDA misled the public in the
> wake of the detection of an infected cow in Washington State.
>
> - Letter to USDA
>
> IG Draft Audit
>
> http://www.house.gov/reform/min/pdfs_108_2/pdfs_inves/pdf_food_usda_mad_cow_july_13_ig_rep.pdf
>
>
>
>
> May 13, 2004
>
> Failure To Test Staggering Cow May Reflect Wider Problems
> Rep. Waxman raises concerns that the recent failure of USDA to test an
> impaired cow for BSE may not be an isolated incident, citing the failure
> of USDA to monitor whether cows condemned for central nervous system
> symptoms are actually tested for mad cow disease.
>
> - Letter to USDA
>
> http://www.house.gov/reform/min/pdfs_108_2/pdfs_inves/pdf_food_usda_mad_cow_may_13_let.pdf
>
>
>
>
> EFSA Scientific Report on the Assessment of the Geographical BSE-Risk
> (GBR) of the United States of America (USA)
>
> Adopted July 2004 (Question N° EFSA-Q-2003-083)
>
> [20 August 2004]
>
> http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/573_en.html
>
>
>
> http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/catindex_en.html
>
>
>
>
> From: Terry S. Singeltary Sr. [flounder@wt.net]
> Sent: Tuesday, July 29, 2003 1:03 PM
> To: fdadockets@oc.fda.gov
> Cc: ggraber@cvm.fda.gov; Linda.Grassie@fda.gov; BSE-L
> Subject: Docket No. 2003N-0312 Animal Feed Safety System [TSS SUBMISSION
> TO DOCKET 2003N-0312]
>
> Greetings FDA,
>
> snip...
>
> PLUS, if the USA continues to flagrantly ignore the _documented_ science
> to date about the known TSEs in the USA (let alone the undocumented TSEs
> in cattle), it is my opinion, every other Country that is dealing with
> BSE/TSE should boycott the USA and demand that the SSC reclassify the
> USA BSE GBR II risk assessment to BSE/TSE GBR III 'IMMEDIATELY'. for the
> SSC to _flounder_ any longer on this issue, should also be regarded with
> great suspicion as well. NOT to leave out the OIE and it's terribly
> flawed system of disease surveillance. the OIE should make a move on CWD
> in the USA, and make a risk assessment on this as a threat to human
> health. the OIE should also change the mathematical formula for testing
> of disease. this (in my opinion and others) is terribly flawed as well.
> to think that a sample survey of 400 or so cattle in a population of 100
> million, to think this will find anything, especially after seeing how
> many TSE tests it took Italy and other Countries to find 1 case of BSE
> (1 million rapid TSE test in less than 2 years, to find 102 BSE cases),
> should be proof enough to make drastic changes of this system. the OIE
> criteria for BSE Country classification and it's interpretation is very
> problematic. a text that is suppose to give guidelines, but is not
> understandable, cannot be considered satisfactory. the OIE told me 2
> years ago that they were concerned with CWD, but said any changes might
> take years. well, two years have come and gone, and no change in
> relations with CWD as a human health risk. if we wait for politics and
> science to finally make this connection, we very well may die before any
> decisions or changes are made. this is not acceptable. we must take the
> politics
> and the industry out of any final decisions of the Scientific community.
> this has been the problem from day one with this environmental man made
> death sentence. some of you may think i am exaggerating, but you only
> have to see it once, you only have to watch a loved one die from this
> one time, and you will never forget, OR forgive...yes, i am still very
> angry... but the transmission studies DO NOT lie, only the politicians
> and the industry do... and they are still lying to this day...TSS
>
> http://www.fda.gov/ohrms/dockets/dockets/03n0312/03N-0312_emc-000001.txt
>
> EFSA Scientific Report on the Assessment of the Geographical BSE-Risk
> (GBR) III of the United States of America (USA)
>
> Adopted July 2004 (Question N° EFSA-Q-2003-083)
>
> [20 August 2004]
>
>
>
>
> http://www.efsa.eu.int/science/efsa_scientific_reports/gbr_assessments/catindex_en.html
>
>
>
>
> THE MAD COW DOWNER THAT WALKED
>
> Dave Louthan - Killed the Mad Cow
>
> http://maddeer.org/video/embedded/louthan.html
>
> Stanley Prusiner
>
> ''nobody has ever ask us to comment''
>
> ''they don't want us to comment''
>
> ''they never ask''
>
>
> i tried to see Venemon, after Candian cow was discovered with BSE.
> went to see lyle. after talking with him... absolute ignorance... then
> thought i should see Venemon... it was clear his entire policy was to
> get cattle boneless beef prods across the border... nothing else
> mattered... his aids confirmed this... 5 times i tried to see Venemon,
> never worked... eventually met with carl rove the political... he is the
> one that arranged meeting with Venemon... just trying to give you a sense
> of the distance... healh public safety... was never contacted... yes i
> believe that prions are bad to eat and you can die from them...END
>
>
> Dr. Stan bashing Ann Veneman - 3 minutes
>
>
> http://maddeer.org/video/embedded/08snip.ram
>
> On September 13, 2004, no positive or inconclusive test results were
> reported.
>
> Weekly Summary
>
> Cumulative Total from June 1, 2004: 57,064
>
> http://www.aphis.usda.gov/lpa/issues/bse_testing/test_results.html
>
> Research Project: Bovine Spongiform Encephalopathy and Other
> Transmissible Spongiform Encephalopathies
>
>
>
>
> Location:
>
>
>
> Virus and Prion Diseases of Livestock
>
>
>
> Title: Experimental Inoculation of Tme, Scrapie, and Cwd to Raccoons
> (Procyon Lotor) and the Utilization of Raccoons for Strain-Typing of
> Unknown Tses in the United States
>
> Authors
> item Hamir, Amirali
>
> item Miller, Janice
> item Cutlip, Randall
>
> item Stack, M - VSA, WEYBRIDGE, UK
> item Chaplin, M - VSA, WEYBRIDGE, UK
> item Bartz, J - CREIGHTON UNIVERSITY
> item Jenny, A - USDA, APHIS
> item Williams, E - UNIVERSITY OF
> WYOMINGhttp://iapreview.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=134670&pf=1
>
>
>
> Submitted to: American Association Of Veterinary Laboratory
> Diagnosticians
> Publication Acceptance Date: April 29, 2002
> Publication Date: October 17, 2002
> Abstract only
> Technical Abstract: Raccoons (Procyon lotor) are omnivorous and their
> diet may include carrion. It is, therefore, possible that in the wild
> they may get exposed to carcasses of animals with transmissible
> spongiform encephalopathies (TSEs). To determine the susceptibility of
> raccoons to transmissible mink encephalopathy (TME), scrapie, and
> chronic wasting disease (CWD), each of these agents was inoculated
> intracerebrally into a group of 4 kits. Three uninoculated kits served
> as controls. All raccoons in the TME-inoculated group developed
> neurologic signs and were euthanized within 6 months post inoculation
> (PI). In the scrapie-inoculated group, 3 animals became sick and were
> euthanized between 18 and 22 PI. Although the fourth raccoon in this
> group did not show any clinical signs, it was euthanized at 24 months
> PI. At present, 3 years PI, all CWD-infected raccoons are alive and
> apparently healthy. At necropsy all clinically affected raccoons had
> extensive microscopic lesions of spongiform encephalopathy and
> protease-resistant prion protein (PrPres) was detected in the CNS by
> immunohistochemistry and Western blot. These preliminary findings
> demonstrate that TME and scrapie can be transmitted to raccoons within 6
> months and 2 years, respectively, whereas CWD cannot. Based on these
> incubation periods, it may be possible to differentiate these 3 TSEs.
> Such a laboratory model would be relatively simple, fast and inexpensive
> for strain-typing of unknown TSEs in the United States.
>
>
>
>
>
> CJD/TSE SURVEILLANCE HUMANS USA
>
>
> THE PATHOLOGICAL PROTEIN
>
> CHAPTER 14 LAYING ODDS
>
> Answering critics like Terry Singeltary, who feels that the U.S. under-
> counts CJD, Schonberger conceded that the current surveillance system
> has errors but stated that most of the errors will be confined to the
> older
> population.
>
>
> http://www.thepathologicalprotein.com/
>
> INTRODUCTION
>
> http://www.thepathologicalprotein.com/_wsn/page3.html
>
> CJD screening may miss thousands of cases
>
> By Steve Mitchell
> UPI Medical Correspondent
> Published 7/21/2003 3:00 PM
> View printer-friendly version
>
>
> WASHINGTON, July 21 (UPI) -- The federal government's monitoring system
> for cases of Creutzfeldt-Jakob disease, a fatal human brain illness,
> could be missing tens of thousands of victims, scientists and consumer
> advocates have told United Press International.
>
> Creutzfeldt-Jakob disease or CJD can be caused by eating beef
> contaminated with mad cow disease, but the critics assert without a
> better tracking system it might be impossible to determine whether any
> CJD cases are due to mad cow or obtain an accurate picture of the
> prevalence of the disorder in the United States.
>
> Beginning in the late 1990s, more than 100 people contracted CJD in the
> United Kingdom and several European countries after eating beef infected
> with bovine spongiform encephalopathy -- the clinical name for mad cow
> disease.
>
> No case of mad cow has ever been detected in U.S. cattle and the Centers
> for Disease Control and Prevention's monitoring system has never
> detected a case of CJD due to eating contaminated American beef.
> Nevertheless, critics say, the CDC's system misses many cases of the
> disease, which currently is untreatable and is always fatal.
>
> The first symptoms of CJD typically include memory loss and difficulty
> keeping balance and walking. As the disease destroys the brain, patients
> rapidly progress in a matter of months to difficulty with movement, an
> inability to talk and swallow and, finally, death.
>
> Spontaneously-occurring or sporadic CJD is a rare disorder. Only about
> 300 cases appear nationwide each year, but several studies have
> suggested the disorder might be more common than thought and as many as
> tens of thousands of cases might be going unrecognized.
>
> Clusters of CJD have been reported in various areas of the United States
> -- Pennsylvania in 1993, Florida in 1994, Oregon in 1996, New York in
> 1999-2000 and Texas in 1996. In addition, several people in New Jersey
> developed CJD in recent years, including a 56 year old woman who died on
> May 31, 2003. Although in some instances, a mad cow link was suspected,
> all of the cases ultimately were classified as sporadic.
>
> People who develop CJD from eating mad-cow-contaminated beef have been
> thought to develop a specific form of the disorder called variant CJD.
> But new research, released last December, indicates the mad cow pathogen
> can cause both sporadic CJD and the variant form.
>
> "Now people are beginning to realize that because something looks like
> sporadic CJD they can't necessarily conclude that it's not linked to
> (mad cow disease)," said Laura Manuelidis, section chief of surgery in
> the neuropathology department at Yale University, who conducted a 1989
> study that found 13 percent of Alzheimer's patients actually had CJD.
>
> Several studies, including Manuelidis', have found that autopsies reveal
> 3 percent to 13 percent of patients diagnosed with Alzheimer's or
> dementia actually suffered from CJD. Those numbers might sound low, but
> there are 4 million Alzheimer's cases and hundreds of thousands of
> dementia cases in the United States. A small percentage of those cases
> could add up to 120,000 or more CJD victims going undetected and not
> included in official statistics.
>
> Experiences in England and Switzerland -- two countries that discovered
> mad cow disease in their cattle -- have heightened concerns about the
> possibility some cases of sporadic CJD are due to consuming
> mad-cow-tainted beef. Both countries have reported increases in sporadic
> CJD since mad cow was first detected in British herds in 1986.
>
> Switzerland discovered last year its CJD rate was twice that of any
> other country in the world. Switzerland had been seeing about eight to
> 11 cases per year from 1997 to 2000. Then the incidence more than
> doubled, to 19 cases in 2001 and 18 cases in 2002.
>
> The CDC says the annual rate of CJD in the United States is one case per
> million people, but the above studies suggest the true prevalence of CJD
> is not known, Manuelidis told UPI.
>
> Diagnosing CJD or Alzheimer's is difficult because no test exists that
> can identify either disease in a living patient with certainty. So
> physicians must rely on the patient's symptoms to determine which
> illness might be present. Sometimes, however, the symptoms of one
> disease can appear similar to the other disorder. The only way to
> determine the disease conclusively is to perform an autopsy on the brain
> after death.
>
> Unfortunately, although autopsies once were performed on approximately
> half of all corpses, the frequency has dropped to 15 percent or less in
> the United States. The National Center for Health Statistics -- a branch
> of the CDC -- stopped collecting autopsy data in 1995.
>
> "If we don't do autopsies and we don't look at people's brains ... we
> have no idea about what is the general prevalence of these kinds of
> infections and (whether) it is changing," Manuelidis said.
>
> At the same time autopsies have been declining, the number of deaths
> attributed to Alzheimer's has increased more than 50-fold since 1979,
> going from 857 deaths then to nearly 50,000 in 2000. Though it is
> unlikely the dramatic increase in Alzheimer's is due entirely to
> misdiagnosed CJD cases, it "could explain some of the increase we've
> seen," Manuelidis said.
>
> "Neurodegenerative disease and Alzheimer's disease have become a
> wastebasket" for mental illness in the elderly that is difficult to
> diagnose conclusively, she said. "In other words, what people call
> Alzheimer's now is more broad than what people used to call it, and that
> has the possibility of encompassing more diseases -- including CJD."
>
> The autopsy studies that found undiagnosed CJD cases raise the question
> of whether the United States "already has an undetected epidemic here,"
> Jeff Nelson, director of vegsource.com, a vegetarian advocacy Web site,
> told UPI.
>
> "What's the source of that?" Nelson asked. "Could it be the same source
> of encephalitis we saw in minks?"
>
> Nelson referred to an outbreak of a mad-cow-type disorder in minks in
> Wisconsin in the 1980s. The origin was traced back to the animals' diet,
> which included parts of so-called downer cattle -- sick cows that are
> unable to stand, which often indicates a neurological disease, including
> mad cow. The mink disease raised concerns about whether U.S. cattle were
> carrying a mad-cow-like pathogen even prior to the U.K. epidemic that
> began in 1986.
>
> Andrew Monjan, chief of the neuropsychology of aging program at the
> National Institute of Aging -- part of the National Institutes of Health
> in Bethesda, Md. -- acknowledged there has been an increase in U.S.
> Alzheimer's cases. However, he told UPI, this probably is due to the
> aging of the population -- as people grow older, they develop a higher
> risk of developing Alzheimer's.
>
> "There's been no change in the number of CJD cases in the country and
> there has been clearly a tracking of the unusual cases of CJD" that
> could be due to mad cow disease, Monjan said. However, Terry Singletary,
> coordinator of CJD Watch -- an organization founded to track CJD cases
> -- says efforts to track the disease have been close to nonexistent. For
> example, only 12 states require such reports. Therefore, many cases
> might be going undetected, unreported or misdiagnosed.
>
> If more states made CJD a reportable illness, there would be more
> clusters detected across the United States, said Singletary, who became
> involved with CJD advocacy after his mother died from a form of CJD
> known as Heidenhain variant. In the 18-year period between 1979 and
> 1996, he noted, the country saw a jump from one case of sporadic CJD in
> people under the age of 30 -- a warning sign for a link to mad cow
> because nearly all of the U.K. victims were 30 years of age or younger
> -- to five cases in five years between 1997 and 2001. "That represents a
> substantial blip," he told UPI.
>
> Singletary also said there have been increases in sporadic CJD in
> France, Germany and Italy, all of which have detected mad cow disease in
> their cattle.
>
> So far, the CDC has refused to impose a national requirement that
> physicians and hospitals report cases of the disease. The agency has not
> chosen to make CJD a reportable disease because "making it reportable is
> not necessarily directly helpful in surveillance because in some states
> where it's reportable you may not get the physician to report it," said
> Dr. Ermias Belay, CDC's medical epidemiologist working on CJD.
>
> Instead, the agency relies on other methods, including death
> certificates and urging physicians to send suspicious cases to the
> National Prion Disease Pathology Surveillance Center at Case Western
> Reserve University in Cleveland, which is funded by the CDC. However,
> because autopsies generally are not done, if a CJD case is misdiagnosed
> as Alzheimer's or dementia, a correct diagnosis might never be
> determined and therefore the cause of death listed on a death
> certificate might be inaccurate.
>
> Belay told UPI he discounted this possibility. It is unlikely to happen,
> he said, because it is easy to distinguish CJD from Alzheimer's -- the
> two conditions display different symptoms.
>
> Manuelidis disagreed. It can be quite difficult to determine accurately
> if a patient has CJD, as evidenced by her study, in which respected and
> competent neurologists and psychiatrists at Yale originally diagnosed
> patients with Alzheimer's, yet were wrong at least 13 percent of the
> time. Another study conducted at the University of Pennsylvania, which
> found 6 percent of dementia patients actually were suffering from CJD,
> supports the difficulty in distinguishing the illnesses correctly.
>
> The U. Penn. researchers concluded: "These results show that in patients
> with a clinical diagnosis of dementia, the etiology (cause) cannot be
> accurately predicted during life."
>
> In addition, the NPDPSC sees less than half of all the CJD cases each
> year, so the CDC's investigational system not only is missing many of
> the misdiagnosed CJD cases, it also is not conducting autopsies on most
> of the detected cases.
>
> Belay said the CDC follows up on all cases of CJD that occur in people
> under age 55, as these could be linked to variant -- mad-cow-related --
> CJD. But so far, all have turned out to be sporadic forms of the
> disease. About 30 cases of the disorder occur each year in the United
> States in this age group, while the remaining 270 or so are older.
>
> The case of Carrie Mahan -- a Philadelphia woman who developed a brain
> disorder that appeared to be CJD and died from it in 2000 at the age of
> 29 -- illustrates just how difficult it can be to diagnose the disease.
>
> Mahan's physician, Dr. Peter Crinos of the University of Pennsylvania
> Medical Center, ruled out other disorders and felt certain the young
> woman had died of CJD, a concern that raised the possibility of a link
> to mad cow disease because of her young age. When neuropathologist
> Nicholas Gonatas, who had seen CJD before, examined Mahan's brain after
> her death, he, likewise, was confident he detected the microscopic,
> sponge-like holes caused by the disease. But when he sent brain samples
> to the NPDPSC, the results came back negative. Gonatas, convinced the
> surveillance center's finding was erroneous, sent off two more samples,
> only to have them both come back negative.
>
> Subsequent research, however, has shown the test used by the
> surveillance center cannot rule out CJD, said Crinos, an assistant
> professor of neurology.
>
> "There's no question that Carrie had a spongiform encephalopathy,"
> Crinos said, but added although it appeared to be CJD, it is difficult
> if not impossible to say if it was due to mad cow disease.
>
> Crinos told UPI until the CDC implements a better tracking system, a lot
> of questions will remain about CJD and cases like Carrie Mahan's. One
> central question: Why are cases of what is presumed to be a rare disease
> popping up in clusters in certain areas of the country? Crinos said the
> clustering suggests an environmental or food-borne cause, but so far,
> "No one knows the answer to that."
>
> Copyright © 2001-2003 United Press International
>
> http://www.upi.com/view.cfm?StoryID=20030721-102924-4786r
>
>
> THE EPIDEMIOLOGY OF CJD RG WILL 1984 (182 PAGES)
>
> snip...
>
> One reason for this was the _inaccuracy_ in coding of cases correctly
> certified as CJD Coding is carried out by staff who are not medically
> qualified and it is not surprising that coding errors occur in the
> processing of large numbers of certificates. In 1982, 12,000
> certificates per week were processed at the office of population
> censuses and surveys bu 15 coders and 6 checkers (Alderson et al.,
> 1983). The occurrence of both inter- and intra-observer coding errors
> has been described (Curb et al., 1983) and the _inaccuracies_ of BOTH
> certification and coding discovered in this study _support_ the
> introduction of a more accurate system of death certificates and a more
> detailed and specific coding system...
>
> snip...
>
> http://www.bseinquiry.gov.uk/files/mb/m26/tab01.pdf
>
>
>
> RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob
> disease in the United States
>
>
> Email Terry S. Singeltary:
> flounder@wt.net
>
>
> I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to
>
> comment on the CDC's attempts to monitor the occurrence of emerging
>
> forms of CJD. Asante, Collinge et al [1] have reported that BSE
>
> transmission to the 129-methionine genotype can lead to an alternate
>
> phenotype that is indistinguishable from type 2 PrPSc, the commonest
>
> sporadic CJD. However, CJD and all human TSEs are not reportable
>
> nationally. CJD and all human TSEs must be made reportable in every
>
> state and internationally. I hope that the CDC does not continue to
>
> expect us to still believe that the 85%+ of all CJD cases which are
>
> sporadic are all spontaneous, without route/source. We have many TSEs in
>
> the USA in both animal and man. CWD in deer/elk is spreading rapidly and
>
> CWD does transmit to mink, ferret, cattle, and squirrel monkey by
>
> intracerebral inoculation. With the known incubation periods in other
>
> TSEs, oral transmission studies of CWD may take much longer. Every
>
> victim/family of CJD/TSEs should be asked about route and source of this
>
> agent. To prolong this will only spread the agent and needlessly expose
>
> others. In light of the findings of Asante and Collinge et al, there
>
> should be drastic measures to safeguard the medical and surgical arena
>
> from sporadic CJDs and all human TSEs. I only ponder how many sporadic
>
> CJDs in the USA are type 2 PrPSc?
>
>
> http://www.neurology.org/cgi/eletters/60/2/176#535
>
> TSS
>

################# BSE-L-subscribe-request@uni-karlsruhe.de #################





Follow Ups:



Post a Followup

Name:
E-mail: (optional)
Subject:

Comments:

Optional Link URL:
Link Title:
Optional Image URL: