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From: TSS (216-119-134-141.ipset14.wt.net)
Subject: Prion Diseases and the Spleen
Date: September 26, 2004 at 9:46 am PST

-------- Original Message --------
Subject: Prion Diseases and the Spleen
Date: Sun, 26 Sep 2004 11:50:29 -0500
From: "Terry S. Singeltary Sr."
To: Bovine Spongiform Encephalopathy

Title: Prion Diseases and the Spleen
Author(s): Nathalie Daude
Source: Viral Immunology

Volume: 17 Number: 3 Page: 334 -- 349
DOI: 10.1089/0882824041857139
Publisher: Mary Ann Liebert, Inc.
Abstract: Transmissible spongiform encephalopathies are fatal
neurodegenerative disorders that include Creutzfeldt-Jakob disease in
humans, bovine spongiform encephalopathy and scrapie in sheep and goats.
Transmissible spongiform encephalopathies are thought by some to result
from changes in the conformation of a membrane glycoprotein called PrPC
(prion protein) into a pathogenic form, PrPSc, which constitutes the
major component of an unprecedented type of infectious particle
supposedly devoid of nucleic acid. Although there is no primary
immunological response to the infectious agent, several lines of
evidence indicate an involvement of the lymphoreticular system in the
development of prion diseases. Studies in rodents have shown that after
peripheral infection, uptake of the scrapie agent is followed by an
initial phase of replication in the lymphoreticular system, particularly
the spleen and lymph nodes. Moreover, infectivity titers in
lymphoreticular organs reach a maximum relatively quickly, well before
those in the brain, and then maintain a plateau for the remainder of the
disease progression. The presence of PrPSc in peripheral lymphoid organs
of all cases of variant Creutzfeldt-Jakob disease strongly underscores
the importance of the lymphoreticular system. Thus, a better
understanding of the cells participating in PrPSc replication and
dissemination into the central nervous system is of particular interest.
This review will therefore discuss the present knowledge of the role of
the spleen in transmissible spongiform encephalopathies as well as the
participation of the different spleen cell types in the disease process.
Copyright © by Mary Ann Liebert, Inc. 2004
Reference Links: 159

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http://ariel.ingentaselect.com/

TSS





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