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From: TSS (216-119-143-149.ipset23.wt.net)
Subject: Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease
Date: August 5, 2004 at 7:16 pm PST

-------- Original Message --------
Subject: Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease
Date: Thu, 05 Aug 2004 21:17:08 -0500
From: "Terry S. Singeltary Sr."
To: Bovine Spongiform Encephalopathy


Acta Neuropathologica
Publisher: Springer-Verlag Heidelberg
ISSN: 0001-6322 (Paper) 1432-0533 (Online)
DOI: 10.1007/s00401-004-0879-2
Issue: Volume 108, Number 3
Date: September 2004
Pages: 194 - 200


Regular Paper

Extracellular protein deposition correlates with glial activation and
oxidative stress in Creutzfeldt-Jakob and Alzheimerrsquo s disease

Bart Van Everbroeck1 Contact Information
,
Itte Dobbeleir1, Michèle De Waele1, Evelyn De Leenheir2, Ursula Lübke2,
Jean-Jacques Martin2 and Patrick Cras1, 2

(1) Laboratory of Neurobiology, Born Bunge Foundation, University of
Antwerp, Universiteitsplein 1, Campus Drie Eiken, 2610 Antwerp, Belgium

(2) Laboratory of Neuropathology, Born Bunge Foundation, University of
Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium

Received: 10 November 2003 Revised: 5 April 2004 Accepted:
6 April 2004 Published online: 19 June 2004

Abstract The relation of protein deposition with glial cells and
oxidative stress was studied in Creutzfeldt-Jakob disease (CJD),
Alzheimerrsquo s disease (AD) and neurologically healthy control
patients. Three neocortical areas, the hippocampus, and the cerebellum
of 20 CJD, 10 AD and 10 control patients were immunohistochemically
examined for the presence of astroglia, microglia, and protein
depositions. To investigate the level of oxidative stress the percentage
of neurons with cytoplasmic hydroxylated DNA was determined. Astroglia,
microglia and oxidative stress were located around amyloid-beta
depositions and a clear quantitative relation was identified. These
markers were only increased in the hippocampus of AD compared to
controls. Quantitative analysis in these groups showed a correlation
between the oxidative stress level and the number of microglia in the
grey matter. All markers were increased in the grey matter and the
cerebellum of CJD when compared to AD and controls. The highest numbers
of lesions were observed in a CJD population with a rapid disease
progression. Quantitative analysis showed a correlation between the
oxidative stress level and all glial cells. Further analysis showed that
the number of microglia was related to the intensity of the prion
depositions. Glial cells in the brain are thought to be the main
producers of oxidative stress, resulting in neuronal death. Our results
confirm that this close relationship exists in both AD and CJD. We also
show that an increased number of glial cells and therefore possibly
oxidative stress is associated with the disease progression.

Keywords Extracellular protein deposition - Alzheimerrsquo s
disease - Creutzfeldt-Jakob disease - Oxidative stress - Glial cell
activation

------------------------------------------------------------------------

Contact Information Bart Van Everbroeck
Email: bart.vaneverbroeck@ua.ac.be
Phone: +32-3-8202650
Fax: +32-3-8202669

The references of this article are secured to subscribers.

http://springerlink.metapress.com/app/home/contribution.asp?wasp=g19tay35dg4vnkdf386q&referrer=parent&backto=issue,4,12;journal,2,129;linkingpublicationresults,1:100394,1

TSS





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