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From: TSS (216-119-139-168.ipset19.wt.net)
Subject: Re: RE-CJD, Alzheimer's, one-in-a-million and the USA CJD FOUNDATION CJD Questionnaire (if that is what you want to call it)
Date: April 11, 2004 at 6:53 am PST
In Reply to: Re: RE-CJD, Alzheimer's, one-in-a-million and the USA CJD FOUNDATION CJD Questionnaire (if that is what you want to call it) posted by KL Norton on March 13, 2004 at 8:29 am:
-------- Original Message --------
Subject: Coexistence of CJD and Alzheimer's disease: An autopsy case showing typical clinical features of CJD
Date: Sat, 10 Apr 2004 21:01:13 -0500
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@uni-karlsruhe.de
######## Bovine Spongiform Encephalopathy #########
Neuropathology
Volume 24 Issue 1 Page 46 - March 2004
doi:10.1111/j.1440-1789.2003.00513.x Coexistence of CJD and Alzheimer's disease: An autopsy case showing
typical clinical features of CJD
Kuniaki Tsuchiya1,2,3
,
Saburo Yagishita4
,
Kenji Ikeda2
,
Michio Sano5
,
Kazuhiro Taki6
,
Keisuke Hashimoto6
,
Sadakiyo Watabiki3 and Hidehiro Mizusawa7
The present report concerns an autopsy case of CJD showing typical
clinical features of CJD. The patient was a Japanese woman without
hereditary burden or dementing disorder anamnesis who was 70-years-old
at the time of death. She developed gait disturbance at age 68, followed
by memory impairment, visual disturbance, and myoclonus. A neurological
examination approximately 2 months after the disease onset revealed
akinetic mutism, in addition to periodic synchronous discharges on
electroencephalogram. Serial neuroradiological examinations disclosed
progressive atrophy of the brain. She died of bronchopneumonia 25 months
after the disease onset. The brain weighed 560 g (cerebrum 490 g,
brainstem with cerebellum 70 g). Macroscopically, neuropathological
examination showed prominent atrophy of the cerebrum, caudate nucleus,
and cerebellum, in addition to necrosis of the cerebral white matter,
compatible with panencephalopathic CJD. Histologically, there was
neuronal loss with or without spongiform change in the cerebral cortex,
parahippocampal gyrus, amygdala, striatum, pallidum, thalamus, pontine
nucleus, and cerebellar granule cells, in addition to diffuse
synaptic-type prion staining in the cerebrum and cerebellum.
Furthermore, senile plaques, compatible with definite Consortium to
establish a registry for Alzheimer's disease rank Alzheimer's disease,
and neurofibrillary changes of the limbic system, consistent with stage
IV of Braak's classification, were found. Based on these
clinicopathological findings and a review of the published literature,
it is concluded that there were two forms of coexistence of CJD and
Alzheimer's disease in the same patient.
Received 14 May 2003; revised and accepted 23 July 2003.
Affiliations
1Department of Laboratory Medicine and Pathology, Tokyo Metropolitan
Matsuzawa Hospital,
2Department of Neuropathology, Tokyo Institute of Psychiatry,
3Department of Neurology, Musashino Red Cross Hospital, Tokyo,
4Department of Pathology, Kanagawa Rehabilitation Center, Kanagawa,
5Department of Internal Medicine, Musashisakai Hospital,
6Department of Pathology, Musashino Red Cross Hospital and
7Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan
Correspondence
Kuniaki Tsuchiya, md, PhD, Department of Laboratory Medicine and
Pathology, Tokyo Metropolitan Matsuzawa Hospital, 2-1-1, Kamikitazawa,
Setagaya-ku, Tokyo, 156-0057, Japan. Email: ktsuchi@jcom.home.ne.jp To cite this article
Tsuchiya, Kuniaki, Yagishita, Saburo, Ikeda, Kenji, Sano, Michio, Taki,
Kazuhiro, Hashimoto, Keisuke, Watabiki, Sadakiyo & Mizusawa, Hidehiro (2004)
Coexistence of CJD and Alzheimer's disease: An autopsy case showing
typical clinical features of CJD.
Neuropathology 24 (1), 46-55.
doi: 10.1111/
j.1440-1789.2003.00513.x
http://www.blackwell-synergy.com/
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