To: BSE-L@uni-karlsruhe.deTSE Project Details
Project Ref M03024
Theme Risk assessment of SEs
Sub Theme An evaluation of SEs transmission modalities from cattle to
man and other food animals, environment vectors
MRC Priority
Title Susceptibility of red deer (Cervus elaphus elaphus) to BSE
Funder(s)
Principle Investigator Dr Hawkins PI Department Veterinary Laboratories
Agency
PI Location Weybridge PI Organisation Veterinary Laboratories Agency
Last Year Cost £ This Year Cost £
Start Date 01/04/2003 End Date 01/04/2010
Status Current Total Cost £ 1,485,458
Abstract The major cause of the spread of BSE was attributed to the
feeding of contaminated meat and bone meal (MBM) in the protein rations
fed to cattle. The use of MBM in animal feed was not restricted to
cattle rations and it is known that MBM was included in the concentrates
fed to farmed deer. BSE has been shown to be naturally or experimentally
transmissible to a wide range of different ungulate species and deer are
known to be susceptible to an endemic TSE (chronic wasting disease, CWD)
which is prevalent in North America. However, to date, no TSE infections
of UK deer have been reported. The initial objective of the study is to
determine whether orally infected UK red deer are susceptible to bovine
BSE agent. Groups of orally dosed deer will be sacrificed at 6, 12 and
60 months post inoculation and necropsies carried out. A range of tissue
samples will be retained for further analysis such as
immunohistochemistry. All animals will also be monitored clinically
throughout the experiment to define any clinical phenotype.
©2004 Medical Research Council
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