To: BSE-L@uni-karlsruhe.de
######## Bovine Spongiform Encephalopathy #########
Richard Kimberlin has obviously declined and suggested to OIE that
Ray Bradley
takes on the role of both author of the introductory chapter and
coordinator...
http://www.bseinquiry.gov.uk/files/yb/1991/03/04002001.pdf
OIE Scientifoc and Technical Review, Vol 11 (2) June 1992 Sub Acute
Spongiform Encephalopathies in Animals
91\02.20\1.1-1.2 20/02/91 Minute S C Hutchins I Crawford
snip...
a) I think it would be advisable to include scrapie, BSE and
transmissible mink encephalopathy (hence the proposed title)...
snip...
http://www.bseinquiry.gov.uk/files/yb/1991/02/19004001.pdf
and i proposed to OIE years ago to include CWD. but with
these new atypical case of TSE showing up in cattle and sheep, it will
be interesting to see how the OIE handles the USA demands on
weakening the BSE/TSE regs for exporting countries;
>Date: Fri, 12 Jul 2002 16:11:42 -0700
>Reply-To: B S E-l
>Sender: Bovine Spongiform Encephalopathy
>From: TSS
>Subject: CWD/USA -- CWD/OIE?
>
snip...
> Greetings List Members,
>
> speaking with someone at the OIE about my concerns with CWD and the
> non-testing for TSEs in USA cattle, i find it very sad that the OIE
> does not follow CWD related issues. BUT, they voice my same concerns
> and said changes are in the makings. sadly, the changes will take
> about 2 years?
>
> snip...
>
> ''I agree with you Dr Terry. The OIE, namely the International Animal
> Health Code Commission is working on making proposals to Member
> Countries to change the OIE lists so to avoid some the problems
> mentioned in you e-mail. This will take at least two years before
> adoption by the International Committee.''
>
> snip...
>
> two years is a very long time, on an issue of such importance to both
> humans and animals...
>
> kind regards, terry
>
snip...
PAGE 25 Transmission Studies Mule deer transmissions of CWD were by
intracerebral inoculation and compared with natural cases resulted in a
more rapidly progressive clinical disease with repeated episodes of
synocopy ending in coma. One control animal became affected, it is
believed through contamination of inoculam (?saline). Further CWD
transmissions were carried out by Dick Marsh into ferret, mink and
squirrel monkey. Transmission occurred in _all_ of these species with
the shortest incubation period in the ferret...
http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
Clearly, it is premature to draw firm conclusions about CWD
passing naturally into humans, cattle and sheep, but the present
results suggest that CWD transmissions to humans would be as
limited by PrP incompatibility as transmissions of BSE or sheep
scrapie to humans. Although there is no evidence that sheep
scrapie has affected humans, it is likely that BSE has caused variant
CJD in 74 people (definite and probable variant CJD cases to
date according to the UK CJD Surveillance Unit). Given the
presumably large number of people exposed to BSE infectivity,
the susceptibility of humans may still be very low compared with
cattle, which would be consistent with the relatively inefficient
conversion of human PrP-sen by PrPBSE. Nonetheless, since
humans have apparently been infected by BSE, it would seem prudent
to take reasonable measures to limit exposure of humans
(as well as sheep and cattle) to CWD infectivity as has been
recommended for other animal TSEs.
snip...
http://www.emboj.org/current.shtml
and why do we not want to do TSE transmission studies on chimpanzees $
snip...
5. A positive result from a chimpanzee challenged severly would likely
create alarm in some circles even if the result could not be interpreted
for
man. I have a view that all these agents could be transmitted provided a
large
enough dose by appropriate routes was given and the animals kept long
enough.
Until the mechanisms of the species barrier are more clearly understood
it might
be best to retain that hypothesis.
snip...
R. BRADLEY
http://www.bseinquiry.gov.uk/files/yb/1990/09/23001001.pdf
same reason CJD/TSE is not reportable Nationally in the USA.
same reason no CJD questionnaire exists in the USA that is issued to all
victims and
families of victims asking real questions pertaining to route and source
of agent.
no autopies for all demented of young AND OLD!
same reason the USA is steadfast refusing to this day to rapid TSE test all
cattle for human/animal consumption.
the USA simply does not want to know$
hell, we should just retain it all, and just play like it has not happened
for the next 40 years as well. hmm, something else to ponder ;
> 5. A positive result from a chimpanzee challenged severly would likely
> create alarm in some circles even if the result could not be
> interpreted for
> man
so, when/where is our first case transmission study of TSE on man going
to be?
i wish to witness this and have a few suggestions for our first human
guinea-pigs ;-)
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, TEXAS USA 77518
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