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From: TSS ()
Subject: Re: Two deaths in Castilla y León Spain confirmed to be from Mad Cow disease
Date: April 12, 2008 at 7:23 pm PST

In Reply to: Two deaths in Castilla y León Spain confirmed to be from Mad Cow disease posted by TSS on April 9, 2008 at 2:39 pm:

please note ;


> laboratory-confirmed vCJD cases were reported to the Spanish CJD state
registry


Euro Surveill 2008;13(15) Published online April 2008
Two cases of variant Creutzfeldt-Jakob disease reported in Spain in 2007 and
2008


J de Pedro Cuesta (jpedro@isciii.es), Instituto de Salud Carlos III,
Department of Applied Epidemiology, National Centre of Epidemiology, Madrid,
Spain

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In 2005, the first case of variant Creutzfeldt-Jakob disease (vCJD) was
reported in Spain, in a woman born in 1978 with clinical onset of symptoms
in 2004 [1]. She subsequently died in 2005.

Recently, two more laboratory-confirmed vCJD cases were reported to the
Spanish CJD state registry. In February 2006, a woman born in 1957 developed
progressive cognitive deterioration, and died in December 2007 with
suspected sporadic CJD (typical EEG in October 2007) MM at codon 129 and no
mutations in PRPN gene. A man born in 1967 had onset in May 2007 with
psychiatric symptoms, and after several months developed progressive
cognitive decline with dementia, typical MRI, MM at codon 129, no mutations
in PRPN gene. He died in February 2008. Post-mortem, neuropathology with
histochemistry confirmed vCJD in both cases. No clear specific dietary
habits, blood donations or reception were recorded. Neither case appears to
have visited the United Kingdom before 2004.

The latest two cases were resident in the same region of the country,
Castilla y Leon, but no link between them was established.


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References

Centro Nacional de Epidemiología, Instituto de Salud Carlos III. First case
of vCJD reported in Spain. Euro Surveill. 2005;10(8):E050804.1. Available
from: http://www.eurosurveillance.org/ew/2005/050804.asp#1


Citation style for this article: . Two cases of variant Creutzfeldt-Jakob
disease reported in Spain in 2007 and 2008. Euro Surveill 2008;13(15).
Available online:
http://www.eurosurveillance.org/edition/v13n15/080410_3.asp


http://www.eurosurveillance.org/edition/v13n15/080410_3.asp

TSS




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