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From: TSS ()
Subject: SCRAPIE DOCUMENTED IN CLINICAL SUSPECT GOAT, WITH TWO MORE DOCUMENTED IN SAME BIRTH HERD OF CLINICAL CASE
Date: March 4, 2008 at 1:31 pm PST

SCRAPIE USA UPDATE MONTHLY REPORT JANUARY 2008


prepared February 20, 2008

Infected and Source Flocks

There were 27 scrapie infected and source flocks with open statuses (Figure
3) as of January 31, 2008. Two new source flocks and one new infected flock
were reported in January (Figure 4) with a total of 22 reported for FY 2008
(Figure 5). ....


snip...


Positive Scrapie Cases

As of January 31, 2008, 58 new scrapie cases have been confirmed and
reported by the National Veterinary Services Laboratories (NVSL) in FY 2008
(Figure 7). Of these, 52 were field cases and 6* were Regulatory Scrapie
Slaughter Surveillance (RSSS) cases (collected in FY 2008 and reported by
February 20, 2008). There were 8 positive cases for January which are
depicted in Figure 8. Seventeen cases of scrapie in goats have been
confirmed by NVSL since implementation of the regulatory changes in FY 2002
(Figure 9). The most recent positive goat cases were from the SAME HERD and
WERE BOTH CONFIRMED IN JANAURY 2008.


snip...


Caprine Scrapie Prevalence Study (CSPS)

CSPS was initiated in May 2007 to estimate the national prevalance of
scrapie in adult goats at slaughter. If no scrapie is found we will be able
to conclude that the prevalence in goats is greater than zero and less than
0.1 percent. AS of January 31, 2008, 2,942 goats have been sampled for
scrapie testing (1,515 in FY 2007 and 1,427 in FY 2008). Collection numbers
by quarter in FY 2008 is shown in Chart 8. To date, no goats have tested
positive for scrapie as part of this surveillance program. HOWEVER, THREE
POSITIVE GOATS have been identified this fiscal year through field
investigations. One was a clinical suspect submitted for testing and THE
OTHER TWO WERE MEMBERS OF THE OF THE BIRTH HERD OF THE CLINICAL CASE.


snip...


please see full text ;


http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps


PLEASE NOTE OUT OF SIGHT, OUT OF MIND REPORT atypical Scrapie NOR-98 CASES
USA

IT seems that if they do not discuss, and or report on there scrapie page,
the 5 documented ATYPICAL NOR-98,
in 5 different states in 2007, it's seems they think that all will forget.
However, I am here to tell you this will not happen.
or the fact that the atypical scrapie NOR-98 is more virulent and resembles
that of the sporadic CJD in humans. nope,
we cannot forget this either. I have spoken with the USDA, APHIS, VS last
year about making a separate map in their
PPS presentation to show how many, and where these atypical scrapie NOR-98
cases are documented.

Their reply ;


TSS QUESTION - AND, if these are new cases, and i understand this correctly,
how do we know
what state they were reported in ?

USDA, APHIS, VS ANSWER - you can't from the report. The flocks of origin
were in WY, CO and CA

TSS SUGGESTION - maybe you might can add these atypical cases to the pps
presentation on the
monthly chart some how,.... just a suggestion ?

USDA, APHIS, VS ANSWER - We are considering it.


==================================


SINCE THEN, two more documented atypical scrapie NOR-98 cases have been
documented in two more states ;

ATYPICAL NOR-98 SCRAPIE LOCATION UPDATE ON 5 DOCUMENTED CASES THIS YEAR ;


The flocks of origin are WY, CO, CA, IN, and MN.


personal communication USDA et al. ...TSS

snip...

INFECTED AND SOURCE FLOCKS AS of August 31, 2007, there were 33 scrapie
infected and source flocks with open statuses (Figure 3). Five new source
flocks and one new infected flock were reported n August (Figure 4) with a
total of 64 reported for FY 2007(Figure 5).


snip...


IN FY 2007 TWO FIELD CASES, ONE VALIDATION CASE, AND TWO RSSS CASES WERE
CONSISTENT WITH NOR-98 SCRAPIE. ...


(BRINGS A TOTAL OF 5 NOR-98 CASES DOCUMENTED IN 2007 IN USA. ...TSS)


http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps


TAFS

INTERNATIONAL FORUM FOR TRANSMISSIBLE ANIMAL DISEASES AND FOOD SAFETY

a non-profit Swiss Foundation

(May 16, 2007)

TAFS1 Position Paper on Atypical scrapie and Atypical BSE


Although most atypical cases occur singly in flocks, there are some
instances where
two affected sheep have been identified in flocks. This may indicate that
natural
transmission may occur, or that the sheep were infected from a common
alternative
source(22, 29). Possible indications of an association with the feeding of
vitamins and
mineral feed supplements were detected in Norway, but remain to be
proven(22).


snip...


Atypical BSE may arise spontaneously in a small proportion of cattle. The
existence
of sporadic CJD in humans has led to postulation that disease could arise
spontaneously
in any animal, but this is still not proven to happen. Despite the small
numbers of atypical
BSE detected so far, in some countries the numbers are too great to suggest
that they all
arise spontaneously, if it were assumed that such a phenomenon occurred at
the same
frequency as sporadic CJD in humans.

http://www.tseandfoodsafety.org/position_papers/TAFS_POSITION_PAPER_ON_ATYPICAL_SCRAPIE_AND_%20ATYPICAL_BSE_070516.pdf


Tissue distribution. For atypical scrapie, what is PrPres and
infectivity distribution within sheep of different genotypes,
particularly with respect to SRM removal? For classical
scrapie and experimental BSE in sheep, tissue distribution of
infectivity is widespread. Thus, even with SRM controls in
place, an infected sheep poses around 1000 times the risk to
human health than does an infected cow22. Does the
distribution depend on whether infection is by the oral or


21 Gubbins S. Prevalence of BSE in sheep: interpreting the results of
retrospective and
prospective testing of sheep TSE cases. SEAC 84 open meeting
22 paper presented to Food Standards Agency board on 9 December 2004.
http://www.foodstandards.gov.uk/multimedia/pdfs/fsa041204.pdf
Also see paper SEAC/84/2 Annex 2: McLean, A.
Page 13
© SEAC 27 February 2006


intracerebral route? Are some VRQ sheep carriers with no
neurological symptoms?

SEAC SHEEP SUBGROUP
POSITION STATEMENT


http://www.seac.gov.uk/pdf/positionstatement-sheep-subgroup.pdf

P03.141


Aspects of the Cerebellar Neuropathology in Nor98


Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1
1National Veterinary Insitute, Sweden; 2National Veterinary Institute,
Norway


Nor98 is a prion disease of old sheep and goats. This atypical form of
scrapie was first
described in Norway in 1998. Several features of Nor98 were shown to be
different
from classical scrapie including the distribution of disease associated
prion protein
(PrPd) accumulation in the brain. The cerebellum is generally the most
affected brain
area in Nor98. The study here presented aimed at adding information on the
neuropathology in the cerebellum of Nor98 naturally affected sheep of
various
genotypes in Sweden and Norway. A panel of histochemical and
immunohistochemical
(IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic
protein,
amyloid, and cell markers for phagocytic cells were conducted. The type of
histological
lesions and tissue reactions were evaluated. The types of PrPd deposition
were
characterized. The cerebellar cortex was regularly affected, even though
there was a
variation in the severity of the lesions from case to case. Neuropil
vacuolation was
more marked in the molecular layer, but affected also the granular cell
layer. There was
a loss of granule cells. Punctate deposition of PrPd was characteristic. It
was
morphologically and in distribution identical with that of synaptophysin,
suggesting
that PrPd accumulates in the synaptic structures. PrPd was also observed in
the
granule cell layer and in the white matter. ***The pathology features of
Nor98 in the
cerebellum of the affected sheep showed similarities with those of sporadic
Creutzfeldt-Jakob disease in humans.


http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf

NOR-98 ATYPICAL SCRAPIE USA UPDATE AS AT OCT 2007


typical scrapie transmits to primates by there NON-FORCED ORAL CONSUMPTION ;


76/10.12/4.6


http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf


http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=6997404&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus

full text ;


http://nor-98.blogspot.com/


http://scrapie-usa.blogspot.com/


TSS




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