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From: TSS ()
Subject: CWD spreading to new hunt areas in Wyoming
Date: November 13, 2007 at 7:27 am PST



LARAMIE – A cow elk near Encampment and two mule deer near Kaycee have tested positive for chronic wasting disease (CWD) marking the first time either area has had positive tests for elk or deer in those hunt areas. CWD is a brain disease known to affect some moose, deer and elk.

“Although CWD has been found in southeastern Wyoming for a number of years, this is the first time we have found CWD in elk in hunt area 110,” says Bob Lanka, Wyoming Game and Fish regional information specialist in Laramie. Likewise, the positive tests for deer in hunt area 163 southwest of Kaycee is the first time deer have tested positive from that hunt unit. According to the Game and Fish, finding CWD in both locations is not that surprising since the disease has been documented in animals in neighboring hunt areas. CWD was found in deer in the same hunt area near Encampment in 2002 and in elk in areas located east and west of unit 110. It has also been found south of the state line in Colorado for a number of years. While deer area 163 has never had a positive test, in 2004 the Game and Fish found two deer that tested positive in nearby hunt areas 30 and 31. Since that time hundreds of deer have been tested near Kaycee with no positive tests until this year.

Department personnel collected the lymph nodes from the hunter harvested deer and elk in October. Personnel in the Wyoming Game and Fish Department laboratory analyzed the samples and discovered the positive results. Both hunt areas will be added to the Department’s list of areas known to have CWD. The Game and Fish recommends that hunters in those areas transport only cut and wrapped meat, boned meat, animal quarters or other pieces with no portion of the spinal column or head attached, hides without the head, cleaned skull plates, and antlers with no meat or other tissue attached. The head, spine and other nervous tissue, areas where the abnormal protein or prion causing the disease is found in affected animals, should be left at the site of the kill or disposed of in an approved landfill.

There is no evidence that CWD is a human health risk. After a review of scientific data, the World Health Organization in December 1999 stated, “There is currently no evidence that CWD in cervidae (deer and elk) is transmitted to humans.” In 2004, Dr. Ermias Belay of the Center for Disease Control said, “The lack of evidence of a link between CWD transmission and unusual cases of CJD (Cruetzfeldt-Jacob disease, a human prion disease) despite several epidemiological investigations, suggest the risk, if any, of transmission of CWD to humans is low.” Nonetheless to avoid risk, both organizations say parts or products from any animal that looks sick or tests positive for CWD or other TSEs should not be eaten.

Contact: Bob Lanka, (307) 745-5180 ex. 229


Chronic wasting turns up in Lovell-area deer
By The Associated Press

LOVELL - A white-tailed deer killed by a hunter west of Lovell has tested positive for chronic wasting disease.

The Wyoming Game and Fish Department says it's the first occurrence of chronic wasting disease in that area.

Chronic wasting disease is a deadly neurological disease that occurs in elk and deer. The disease has been spreading eastward and westward since it first appeared in southern Wyoming and in Colorado a few decades ago.

There are no known cases of chronic wasting disease being spread to humans. But the Game and Fish Department wants to know where the disease occurs and asks hunters to voluntarily bring their game in for testing.

Species barriers for chronic wasting disease by in vitro conversion of prion

Li Li a, Michael B. Coulthart b, Aru Balachandran c, Avi Chakrabartty d,
Neil R. Cashman a,*
a Brain Research Centre, Division of Neurology, Department of Medicine,
University of British Columbia and Vancouver Coastal Health,
UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
b Prion Diseases Program, National Microbiology Laboratory, Public Health
Agency of Canada, Winnipeg, Man., Canada R3E 3R2 Q1
c National Reference Laboratory for Scrapie and CWD, Animal Diseases
Research Institute, Canadian Food Inspection Agency,
3851 Fallowfield Road, Nepean, Ont., Canada K2H 8P9
d University Health Network, Department of Medical Biophysics, University of
Toronto, Toronto, Ont., Canada M5G 1L7
Received 6 October 2007


Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy
that can affect North American cervids (deer, elk, and
moose). Using a novel in vitro conversion system based on incubation of
prions with normal brain homogenates, we now report that
PrPCWD of elk can readily induce the conversion of normal cervid PrP (PrPC)
molecules to a protease-resistant form, but is less efficient
in converting the PrPC of other species, such as human, bovine, hamster, and
mouse. However, when substrate brain homogenates are
partially denatured by acidic conditions (pH 3.5), PrPCWD-induced conversion
can be greatly enhanced in all species. Our results dem-
onstrate that PrPC from cervids (including moose) can be efficiently
converted to a protease-resistant form by incubation with elk CWD
prions, presumably due to sequence and structural similarities between these
species. Moreover, partial denaturation of substrate PrPC
can apparently overcome the structural barriers between more distant


Although Syrian hamsters were initially deemed resistant to CWD [19], a
recent publication demonstrates that CWD can be transmitted
and adapted to hamster [20].


Substrate denaturation and human health

We confirm with multiple species that acid/GdnHCl-
treated brain PrPC is a superior substrate for in vitro con-
version than untreated PrPC, possibly by overcoming con-
formational barriers in partial denaturation of substrate
PrPC. PrP conversion in scrapie-infected neuroblastoma
cells is believed to occur in endosomes, a low-pH and
reducing environment [26]. The non-ruminant stomach
possesses a low pH lumen, and PrPC is expressed in this
organ [27]. Such acidic (denaturing) organ or cellular
organellar environments might also promote CWD trans-
mission to non-cervid species, including humans.


This work was supported by the Canadian Institutes of
Health Research (Institute of Infection and Immunity, Safe
Food and Water program) and PrioNet Canada.

[20] G.J. Raymond, L.D. Raymond, K.D. Meade-White, A.G. Hughson,
C. Favara, D. Gardner, E.S. Williams, M.W. Miller, R.E. Race, B.
Caughey, Transmission and adaptation of chronic wasting disease to
hamsters and transgenic mice: evidence for strains, J. Virol. 81 (2007)

2007 Elsevier Inc. All rights reserved.

Please cite this article in press as: L. Li et al., Species barriers for
chronic wasting disease by in vitro...,
Biochem. Biophys. Res. Commun. (2007), doi:10.1016/j.bbrc.2007.10.087

From: "Terry S. Singeltary Sr."
Subject: CWD UPDATE 88 AUGUST 31, 2007

Date: Wed, 29 Aug 2007 21:13:08 -0500
From: "Terry S. Singeltary Sr."
Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)

Subject: Monitoring the Potential Transmission of Chronic Wasting Disease to
Humans Using a Hunter Registry Database in Wyoming
Date: August 30, 2007 at 6:46 pm PST

Re: Colorado Surveillance Program for Chronic Wasting Disease
Transmission to Humans (TWO SUSPECT CASES)


From: TSS (
Date: September 30, 2002 at 7:06 am PST

From: "Belay, Ermias"
Cc: "Race, Richard (NIH)" ; ; "Belay,
Sent: Monday, September 30, 2002 9:22 AM

Dear Sir/Madam,

In the Archives of Neurology you quoted (the abstract of which was
attached to your email), we did not say CWD in humans will present like
variant CJD.

That assumption would be wrong. I encourage you to read the whole
article and call me if you have questions or need more clarification
(phone: 404-639-3091). Also, we do not claim that "no-one has ever been
infected with prion disease from eating venison." Our conclusion stating
that we found no strong evidence of CWD transmission to humans in the
article you quoted or in any other forum is limited to the patients we

Ermias Belay, M.D.
Centers for Disease Control and Prevention

> > -----Original Message-----
> > From:
> > Sent: Sunday, September 29, 2002 10:15 AM
> > To:;; ebb8@CDC.GOV

Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS


PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increase

1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17
inconclusive and 9 pending (1 from 2006, 8
from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1
from 2001, 1 from 2003, 4 from 2004, 3
from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,

*** 26 from 2007)


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