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From: TSS ()
Subject: SOUTH DAKOTA Seven deer, four elk found to have CWD
Date: October 10, 2007 at 7:33 am PST

Chronic wasting persists in Hills
Seven deer, four elk found to have chronic wasting disease.
By The Associated Press

PIERRE -- Seven deer and four elk were found to have chronic wasting disease
from 2,539 samples in the most recent testing done for the state Department
of Game, Fish & Parks.

All of the infected animals were from Custer, Fall River and Pennington
counties in southwest South Dakota -- the location of all previous CWD cases
in the wild.

Chronic wasting disease attacks the brain in deer and elk and is always
fatal. It's been found in the wild in more than a half-dozen states.

Researchers test for the disease from samples submitted by hunters and from
sick animals observed in the wild.

The positive cases in the July 1, 2006 to June 30, 2007 period included two
elk from Custer State Park and an elk from Wind Cave National Park.

Samples also were taken in the past year from deer killed by hunters in
Grant and Deuel counties in eastern South Dakota. Those counties were added
to the surveillance plan because a CWD-infected deer was discovered at a
farm in Minnesota.

The GF&P said testing will again be done on elk and deer taken by hunters
this fall in the Black Hills and Fall River, Custer, Pennington, Deuel and
Grant counties.

Thirty-nine cases of CWD have been found in deer and 19 in elk from the
18,846 samples tested in South Dakota since 1997, the GF&P said. Seventeen
of the infected animals came from Wind Cave National Park.

Maps Showing Locations of Positive CWD Tests
Map of CWD Positives in S.D. 2006 - June 2007
Statewide View of Positive CWD Cases 2001 - June 2007
Map of CWD Positives in Black Hills 2006 to June 2007
Black Hills View of Positive CWD Cases 2001 - June 2007

From: "Terry S. Singeltary Sr."
Subject: CWD UPDATE 88 AUGUST 31, 2007

Date: Wed, 29 Aug 2007 21:13:08 -0500
From: "Terry S. Singeltary Sr."
Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)

Monitoring the Potential Transmission of Chronic Wasting Disease to Humans
Using a Hunter Registry Database in Wyoming (405 lines)
From: Terry S. Singeltary Sr. <[log in to unmask]>
Date: Thu, 30 Aug 2007 21:23:42 -0500

Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain

Date: August 25, 2007 at 12:42 pm PST

Subject: Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease
creates a new prion strain
Date: August 25, 2007 at 12:42 pm PST

J Biol Chem. 2007 Aug 20; : 17709374

Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a
new prion strain.

[My paper] Atsushi Kobayashi , Masahiro Asano , Shirou Mohri , Tetsuyuki

The genotype (methionine or valine) at polymorphic codon 129 of the human
prion protein (PrP) gene and the type (type 1 or type 2) of abnormal isoform
of PrP (PrP(Sc)) are major determinants of the clinicopathological
phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD). Here we found that
transmission of sCJD prions from a patient with valine homozygosity (129V/V)
and type 2 PrP(Sc) (sCJD-VV2 prions) to mice expressing human PrP with
methionine homozygosity (129M/M) generated unusual PrP(Sc) intermediate in
size between type 1 and type 2. The intermediate type PrP(Sc) was seen in
all examined dura mater graft-associated CJD cases with 129M/M and
plaque-type PrP deposits (p-dCJD). p-dCJD prions and sCJD-VV2 prions
exhibited similar transmissibility and neuropathology, and the identical
type of PrP(Sc) when inoculated into PrP-humanized mice with 129M/M or
129V/V. These findings suggest that p-dCJD could be caused by cross-sequence
transmission of sCJD-VV2 prions.


In this study, the strain-dependent traits of sCJDMM1
prions were inherited through cross-sequence
transmission without any modification. The
humanized mice with 129V/V produced type 1 PrPres
after inoculation with sCJD-MM1 prions. Because
sCJD-VV1 cases are extremely rare (at most 1-2%
of the total number of sCJD cases) and characterized
by early onset (mean age at onset: 39.3 years) (5),


our results raise the possibility that CJD cases
classified as VV1 may include cases caused by
iatrogenic transmission of sCJD-MM1 prions or
food-borne infection by type 1 prions from animals,
e.g., chronic wasting disease prions in cervid. In fact,
two CJD-VV1 patients who hunted deer or
consumed venison have been reported (40, 41). The
results of the present study emphasize the need for
traceback studies and careful re-examination of the
biochemical properties of sCJD-VV1 prions.


In conclusion, cross-sequence transmission of
sCJD-VV2 prions generates a new prion strain with
altered conformational properties and disease
phenotypes as p-dCJD prions. Furthermore, the
newly generated prions have unique transmissibility
including the traceback phenomenon. In the future, if
atypical prion strains emerge through cross-sequence
transmission, especially from animals, traceback
studies will enable us to identify the origin of the



Re: Colorado Surveillance Program for Chronic Wasting Disease
Transmission to Humans (TWO SUSPECT CASES)


Date: August 23, 2007 at 11:30 am PST


Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

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