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From: TSS ()
Subject: Transmissible Spongiform Encephalopathies 26-27 June 2007
Date: July 26, 2007 at 7:02 am PST

Transmissible Spongiform Encephalopathies 26-27 June 2007, Kempinski Bristol
Hotel, Berlin, Germany

Our international speaker line-up includes:
• Dr Sol Ruiz, Division of Biologicals and Biotechnology, Spanish Medicines
Agency, Spain
• Dr Robert Rohwer, Director of Molecular Neurovirology Unit, University of
Maryland, Baltimore, USA
• Professor Charles Weissmann, Department of Infectology, Scripps Florida,
• Dr Michael Beekes, Team Leader, Robert Koch Institute, Germany
• Dr Robert A. Somerville, Neuropathogenesis Unit, Institute for Animal
Health, UK
• Professor James W Ironside, National CJD Surveillance Unit, University of
Edinburgh, UK
• Dr Albecht Gröner, Head of Virology, ZLB Behring AG, Germany
• Dr Anne Buschmann, Veterinary Microbiologist, Friedrich-Loeffler Insitute,

16.00 Detection of prions in body fluids and tissues
We will present actual data about the evaluation of our
BSE test for live cattle, alicon PrioMax® Blood Cattle, as
well as on a recently developed, highly sensitive BSE
post mortem test, alicon PrioMax® Brain. The new post
mortem test detects proteinase K-resistant PrPSc within a
more than 100.000-fold diluted sample of brain
homogenate from scrapie-infected sheep. Moreover, we
will show recent data confirming the presence of prion
protein in milk from humans, cows, sheep and goats.
Dr Ralph Zahn, CEO, Alicon AG, Switzerland

16.35 Progress with TSE blood tests
We are developing a blood test for TSEs using the prion
specific antibody 15B3 for the detection of disease
associated prion proteins in plasma and serum.
Analytical sensitivity studies using vCJD and scrapie
brain homogenates suggest that the limit of detection is
in the range of 10 – 100 infectious units per millilitre. We
have analysed blood samples collected at defined
intervals during preclinical and clinical scrapie and
results on the levels and kinetics of abnormal PrP during
disease incubation time will be presented.
Dr Alex J. Raeber, Director of Research, Prionics AG,
17.05 End of TSE conference

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