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From: TSS ()
Subject: A Bovine Prion Acquires an Epidemic Bovine Spongiform Encephalopathy Strain-Like Phenotype on Interspecies Transmission
Date: June 27, 2007 at 11:10 am PST


Neurobiology of Disease
A Bovine Prion Acquires an Epidemic Bovine Spongiform Encephalopathy Strain-Like Phenotype on Interspecies Transmission

Vincent Béringue,1 Olivier Andréoletti,2 * Annick Le Dur,1 * Rachid Essalmani,3 Jean-Luc Vilotte,3 Caroline Lacroux,2 Fabienne Reine,1 Laëtitia Herzog,1 Anne-Gaëlle Biacabé,4 Thierry Baron,4 Maria Caramelli,5 Cristina Casalone,5 and Hubert Laude1

1Institut National de la Recherche Agronomique (INRA), Unité de Recherche 892, Virologie Immunologie Moléculaires, F-78350 Jouy-en-Josas, France, 2INRA, Unité Mixte de Recherche 1225, Interactions Hôtes-Agents Pathogènes, Ecole Nationale Vétérinaire, F-31000 Toulouse, France, 3INRA, Unité de Recherche 339, Génétique Biochimique et Cytogénétique, F-78350 Jouy-en-Josas, France, 4Agence Française de Sécurité Sanitaire des Aliments, Unité Agents Transmissibles Non Conventionnels, F-69000 Lyon, France, and 5Instituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle, d'Aosta, Torino, Italy

Correspondence should be addressed to either Hubert Laude or Vincent Béringue, Institut National de la Recherche Agronomique, Unité de Recherche 892, Virologie Immunologie Moléculaires, F-78350 Jouy-en-Josas, France. Email: hubert.laude@jouy.inra.fr or Email: vincent.beringue@jouy.inra.fr


Implementation in Europe of large-scale testing to detect bovine spongiform encephalopathy (BSE)-infected cattle and prevent the transmission of this prion disease to humans has recently led to the discovery of novel types of bovine prions. We characterized atypical isolates called BSE L-type by analyzing their molecular and neuropathological properties during transmission to several mouse lines transgenic for the prion protein (PrP). Unexpectedly, such isolates acquired strain features closely similar to those of BSE-type agents when propagated in mice expressing ovine PrP, although they retained phenotypic traits distinct from BSE in other lines, including bovine PrP mice. These findings further underline the relationship between the crossing of species barrier and prion strain diversification, and, although the origin of the epidemic BSE agent has only been speculative until now, they provide new insight into the nature of the events that could have led to the appearance of this agent.


Key words: bovine prion; BSE; atypical BSE; strain evolution; degeneration; transgenic

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Received Feb. 15, 2007; revised April 25, 2007; accepted April 28, 2007.

Correspondence should be addressed to either Hubert Laude or Vincent Béringue, Institut National de la Recherche Agronomique, Unité de Recherche 892, Virologie Immunologie Moléculaires, F-78350 Jouy-en-Josas, France. Email: hubert.laude@jouy.inra.fr or Email: vincent.beringue@jouy.inra.fr

http://www.jneurosci.org/cgi/content/abstract/27/26/6965?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=prion&searchid=1&FIRSTINDEX=0&volume=27&issue=26&resourcetype=HWCIT

TSS




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