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From: TSS ()
Subject: CFIA LAUNCHES MASSIVE BSE MAD COW MBM FEED INVESTIGATION OF 100 FARMS
Date: November 21, 2006 at 2:06 pm PST


CFIA LAUNCHES FEED INVESTIGATION
OTTAWA, November 18, 2006 - The Canadian Food Inspection Agency (CFIA) has launched an investigation and is monitoring livestock movement related to non-compliant feed shipments to cattle farms in Quebec and Ontario during the past two to three weeks. The safety of the Canadian food supply is not affected.

Information provided by the supplier, Agribrands Canada Inc., indicates that a very small amount of meat and bone meal came into contact with ingredients used in the production of ruminant feed. The supplier is moving quickly to remove any feed that made its way to the farm level.

Teams of CFIA inspectors are visiting approximately 100 farms in Ontario and Quebec. As a precaution, the CFIA is identifying implicated animals and monitoring movement of all cattle and other ruminant animals exposed to the feed, pending the completion of an investigation and science-based assessment to determine the potential risk to animal health. Investigators are confirming the amount of feed that each farm received and to which animals it was fed, to indicate potential levels of exposure. This will allow for effective identification and movement control. Previous movement of animals will be verified through farmers' records.

The CFIA is verifying that suppliers to Agribrands Canada Inc. have revised their processes and procedures as required to prevent similar situations in the future. The Agency will also be inspecting all feed mills, farms and transport vehicles that handled the contaminated material to ensure that equipment has been properly cleaned.

Specified risk materials (SRM) are removed from every animal slaughtered in Canada for human consumption. This measure is internationally recognized as the most effective means to protect the safety of the food supply system from bovine spongiform encephalopathy (BSE). Furthermore, given the long incubation period of BSE and the brief period since the potential exposure, there is no food safety concern associated with animals that may have consumed the feed.

The CFIA has a program in place to ensure that the current feed ban remains effectively enforced and to protect the health of the national cattle herd from BSE. To date, industry has demonstrated a high level of compliance with Canada's feed ban. Enhancements to the feed ban, which come into effect next July, address the remaining risks posed by contamination through the removal of more than 99% of potential BSE infectivity from the animal feed system. SRM-tissues where BSE concentrates in infected cattle-are being banned from all livestock feeds, pet foods and fertilizers.

As the investigation proceeds, updates will be provided on the CFIA's web site.

-30-

For information:
Canadian Food Inspection Agency
Media Relations: (613) 228-6682

http://www.inspection.gc.ca/english/corpaffr/newcom/2006/20061118e.shtml


look at the table and you'll see that as little as 1 mg (or 0.001 gm) caused
7% (1 of 14) of the cows to come down with BSE;


Risk of oral infection with bovine spongiform encephalopathy agent in
primates

Corinne Ida Lasmézas, Emmanuel Comoy, Stephen Hawkins, Christian Herzog,
Franck Mouthon, Timm Konold, Frédéric Auvré, Evelyne Correia, Nathalie
Lescoutra-Etchegaray, Nicole Salès, Gerald Wells, Paul Brown, Jean-Philippe
Deslys
Summary The uncertain extent of human exposure to bovine spongiform
encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease
(vCJD)--is compounded by incomplete knowledge about the efficiency of oral
infection and the magnitude of any bovine-to-human biological barrier to
transmission. We therefore investigated oral transmission of BSE to
non-human primates. We gave two macaques a 5 g oral dose of brain homogenate
from a BSE-infected cow. One macaque developed vCJD-like neurological
disease 60 months after exposure, whereas the other remained free of disease
at 76 months. On the basis of these findings and data from other studies, we
made a preliminary estimate of the food exposure risk for man, which
provides additional assurance that existing public health measures can
prevent transmission of BSE to man.


snip...


BSE bovine brain inoculum

100 g 10 g 5 g 1 g 100 mg 10 mg 1 mg 0·1 mg 0·01 mg

Primate (oral route)* 1/2 (50%)

Cattle (oral route)* 10/10 (100%) 7/9 (78%) 7/10 (70%) 3/15 (20%) 1/15 (7%)
1/15 (7%)

RIII mice (ic ip route)* 17/18 (94%) 15/17 (88%) 1/14 (7%)

PrPres biochemical detection

The comparison is made on the basis of calibration of the bovine inoculum
used in our study with primates against a bovine brain inoculum with a
similar PrPres concentration that was

inoculated into mice and cattle.8 *Data are number of animals
positive/number of animals surviving at the time of clinical onset of
disease in the first positive animal (%). The accuracy of

bioassays is generally judged to be about plus or minus 1 log. ic
ip=intracerebral and intraperitoneal.

Table 1: Comparison of transmission rates in primates and cattle infected
orally with similar BSE brain inocula


Published online January 27, 2005

http://www.thelancet.com/journal/journal.isa


It is clear that the designing scientists must

also have shared Mr Bradley's surprise at the results because all the dose

levels right down to 1 gram triggered infection.


http://www.bseinquiry.gov.uk/files/ws/s145d.pdf

2

6. It also appears to me that Mr Bradley's answer (that it would take less
than say 100

grams) was probably given with the benefit of hindsight; particularly if one

considers that later in the same answer Mr Bradley expresses his surprise
that it

could take as little of 1 gram of brain to cause BSE by the oral route
within the

same species. This information did not become available until the "attack
rate"

experiment had been completed in 1995/96. This was a titration experiment

designed to ascertain the infective dose. A range of dosages was used to
ensure

that the actual result was within both a lower and an upper limit within the
study

and the designing scientists would not have expected all the dose levels to
trigger

infection. The dose ranges chosen by the most informed scientists at that
time

ranged from 1 gram to three times one hundred grams. It is clear that the
designing

scientists must have also shared Mr Bradley's surprise at the results
because all the

dose levels right down to 1 gram triggered infection.


http://www.bseinquiry.gov.uk/files/ws/s147f.pdf

Re: BSE .1 GRAM LETHAL NEW STUDY SAYS via W.H.O. Dr Maura Ricketts

[BBC radio 4 FARM news]


http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram

http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm

2) Infectious dose:

To cattle: 1 gram of infected brain material (by oral ingestion)


http://www.inspection.gc.ca/english/sci/bio/bseesbe.shtml

TSS




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