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From: TSS ()
Subject: Re: Geographical BSE Risk: EFSA consults on revision of assessment methodology
Date: November 21, 2006 at 10:15 am PST

In Reply to: Re: Geographical BSE Risk: EFSA consults on revision of assessment methodology posted by TSS on November 21, 2006 at 8:23 am:

----- Original Message -----
From: "Terry S. Singeltary Sr."
To: "EFSA Press"
Sent: Tuesday, November 21, 2006 12:21 PM
Subject: Re: re-Geographical BSE Risk: EFSA consults on revision of assessment methodology


Greetings Daniel,

i tried to submit a shorter version to the comment section.
i don't think it would take it??? this is what i posted (see
below), could you please check and make sure it was recieved,
and if not, could you please submit for me.....thank you, terry

Greetings EFSA,

a sad day. i think any weakening of the BSE GBR risk assessments, especially
for USA, is a huge mistake. i think the BSE GBR should be revised to include
all TSE i.e. TSE GBR. The USA has the most documented TSE in all the world,
BSE/BASE?/Scrapie/CWD/TME, all of which has been rendered and fed back to
animals for human and animal consumption for decades, and still are. The USA
is still feeding cows to cows as lates as Oct. 2006;

http://www.fda.gov/foi/warning_letters/g6104d.pdf

besides the other tons and tons of recall of potential BSE/BASE/TSE feed in
the USA in 2006;

http://www.fda.gov/bbs/topics/enforce/2006/ENF00968.html

http://www.fda.gov/bbs/topics/ENFORCE/2006/ENF00964.html

http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html

http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html

http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html

http://www.fda.gov/bbs/topics/enforce/2006/ENF00960.html

http://www.fda.gov/foi/warning_letters/g5883d.htm


> the need not to overstate risk in countries with a low BSE prevalence but
large cattle

> populations;


what about understating the risk???

PERSPECTIVE

On the Question of Sporadic

or Atypical Bovine SpongiformEncephalopathy and

Creutzfeldt-Jakob Disease

Paul Brown,* Lisa M. McShane,† Gianluigi Zanusso,‡ and Linda Detwiler§

Strategies to investigate the possible existence of sporadic

bovine spongiform encephalopathy (BSE) require

systematic testing programs to identify cases in countries

considered to have little or no risk for orally acquired disease,

or to detect a stable occurrence of atypical cases in

countries in which orally acquired disease is disappearing.

To achieve 95% statistical confidence that the prevalence

of sporadic BSE is no greater than 1 per million (i.e., the

annual incidence of sporadic Creutzfeldt-Jakob disease

[CJD] in humans) would require negative tests in 3 million

randomly selected older cattle. A link between BSE and

sporadic CJD has been suggested on the basis of laboratory

studies but is unsupported by epidemiologic observation.

Such a link might yet be established by the discovery

of a specific molecular marker or of particular combinations

of trends over time of typical and atypical BSE and various

subtypes of sporadic CJD, as their numbers are influenced

by a continuation of current public health measures that

exclude high-risk bovine tissues from the animal and

human food chains. ......


PLEASE READ FULL TEXT ;


http://www.cdc.gov/ncidod/EID/vol12no12/06-0965.htm?s_cid=eid06_0965_e


3:00 Afternoon Refreshment Break, Poster and Exhibit Viewing in the Exhibit
Hall


3:30 Transmission of the Italian Atypical BSE (BASE) in Humanized Mouse
Models
Qingzhong Kong, Ph.D., Assistant Professor, Pathology, Case Western Reserve
University
Bovine Amyloid Spongiform Encephalopathy (BASE) is an atypical BSE strain
discovered recently in Italy, and similar or different atypical BSE cases
were also reported in other countries. The infectivity and phenotypes of
these atypical BSE strains in humans are unknown. In collaboration with
Pierluigi Gambetti, as well as Maria Caramelli and her co-workers, we have
inoculated transgenic mice expressing human prion protein with brain
homogenates from BASE or BSE infected cattle. Our data shows that about half
of the BASE-inoculated mice became infected with an average incubation time
of about 19 months; in contrast, none of the BSE-inoculated mice appear to
be infected after more than 2 years. These results indicate that BASE is
transmissible to humans and suggest that BASE is more virulent than
classical BSE in humans.

6:30 Close of Day One


http://www.healthtech.com/2007/tse/day1.asp

SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM
1997 TO 2006. SPORADIC CJD CASES TRIPLED, with phenotype
of 'UNKNOWN' strain growing. ...


http://www.cjdsurveillance.com/resources-casereport.html


There is a growing number of human CJD cases, and they were presented last
week in San Francisco by Luigi Gambatti(?) from his CJD surveillance
collection.

He estimates that it may be up to 14 or 15 persons which display selectively
SPRPSC and practically no detected RPRPSC proteins.


http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm


http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf


[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk
Materials for Human Food and Requirement for the Disposition of
Non-Ambulatory Disabled Cattle

http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf


[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE)


http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf

THE SEVEN SCIENTIST REPORT ***


http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-EC244-Attach-1.pdf


PAUL BROWN M.D.

http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-c000490-vol40.pdf


9 December 2005
Division of Dockets Management (RFA-305)

SEROLOGICALS CORPORATION
James J. Kramer, Ph.D.
Vice President, Corporate Operations

http://www.fda.gov/ohrms/dockets/dockets/02n0273/02n-0273-c000383-01-vol35.pdf

Embassy of Japan
http://www.fda.gov/ohrms/dockets/dockets/02n0273/02N-0273-EC240.htm

Dockets Entered on December 22, 2005
2005D-0330, Guidance for Industry and FDA Review Staff on Collection of
Platelets
by Automated ... EC 203, McDonald's Restaurants Corporation, Vol #:, 34 ...
http://www.fda.gov/ohrms/dockets/dailys/05/Dec05/122205/122205.htm


03-025IF 03-025IF-631 Linda A. Detwiler [PDF]
Page 1. 03-025IF 03-025IF-631 Linda A. Detwiler Page 2. Page 3. Page 4.
Page 5. Page 6. Page 7. Page 8. Page 9. Page 10. Page 11. Page 12.
http://www.fsis.usda.gov/OPPDE/Comments/03-025IF/03-025IF-631.pdf


03-025IF 03-025IF-634 Linda A. Detwiler [PDF]
Page 1. 03-025IF 03-025IF-634 Linda A. Detwiler Page 2.
Page 3. Page 4. Page 5. Page 6. Page 7. Page 8.
http://www.fsis.usda.gov/OPPDE/Comments/03-025IF/03-025IF-634.pdf


Page 1 of 17 9/13/2005 [PDF]
... 2005 6:17 PM To: fsis.regulationscomments@fsis.usda.gov Subject: [Docket
No. 03-025IFA]
FSIS Prohibition of the Use of Specified Risk Materials for Human Food ...
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf

03-025IFA 03-025IFA-6 Jason Frost [PDF]
... Zealand Embassy COMMENTS ON FEDERAL REGISTER 9 CFR Parts 309 et al
[Docket No. 03-
025IF] Prohibition of the Use of Specified Risk Materials for Human Food and
...
http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-6.pdf


In its opinion of 7-8 December 2000 (EC 2000), the SSC ... [PDF]
Page 1. Linda A. Detwiler, DVM 225 Hwy 35 Red Bank, New Jersey 07701 Phone:
732-741-2290
Cell: 732-580-9391 Fax: 732-741-7751 June 22, 2005 FSIS Docket Clerk US ...

http://www.fsis.usda.gov/OPPDE/Comments/03-025IF/03-025IF-589.pdf


Full Text

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285: 733-734.

http://jama.ama-assn.org/cgi/content/full/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=dignosing+and+reporting+creutzfeldt+jakob+disease&searchid=1048865596978_1528&stored_search=&FIRSTINDEX=0&journalcode=jama

http://www.neurology.org/cgi/eletters/60/2/176#535


BRITISH MEDICAL JOURNAL


BMJ


http://www.bmj.com/cgi/eletters/319/7220/1312/b#EL2


BMJ


http://www.bmj.com/cgi/eletters/320/7226/8/b#EL1

your only fooling yourselves with this stupid ukbsenvcjd only theory, and
the

BSE methology of the OIE. most any coutnry that went by those same OIE

BSE guidelines all went down with BSE.


THE OIE has now shown they are nothing more than a National Trading
Brokerage for all strains of animal TSE.
AS i said before, OIE should hang up there jock strap now, since it appears
they will buckle every time a country

makes some political hay about trade protocol, commodities and futures. IF
they are not going to be science based, they

should do everyone a favor and dissolve there organization. ...

http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf

Terry S. Singeltary SR.
P.O. Box 42
Bacliff, Texas USA 77518

----- Original Message -----
From: "EFSA Press"
To: "Terry S. Singeltary Sr."
Sent: Tuesday, November 21, 2006 10:29 AM
Subject: RE: re-Geographical BSE Risk: EFSA consults on revision of
assessment methodology

Dear Sir,

Thank you for your message. If you would like to contribute to the public
consultation, please note that you can give your comments by filling in the
form on the EFSA website at:
http://www.efsa.europa.eu/en/science/biohaz/biohaz_consultations/gbr_methodology.html.

Regards,

Daniel Glanville
EFSA Press Office

-----Original Message-----
From: Terry S. Singeltary Sr. [mailto:flounder9@verizon.net]
Sent: 21 November 2006 17:17
To: EFSA Press
Subject: re-Geographical BSE Risk: EFSA consults on revision of assessment
methodology

a sad day. i think any weakening of the BSE GBR risk assessments, especially
for USA, is a huge mistake. i think the BSE GBR should be revised to include
all TSE i.e. TSE GBR.


snip...end....TSS




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