From: TSS ()
Subject: Re: CJD (NEW VAR.) UPDATE 2006 (10) A ProMED-mail post
Date: October 4, 2006 at 9:07 am PST
In Reply to: CJD (NEW VAR.) UPDATE 2006 (10) A ProMED-mail post posted by TSS on October 2, 2006 at 5:57 pm:
4 October 2006 - The final minutes (154 KB) of the 93rd SEAC meeting held
on 6 July 2006 have been published.
will hold a reserved business session in the afternoon to allow
discussion of unpublished studies on BSE in cattle. This is in
accordance with the SEAC Code of Practice. Short summaries of
the open and reserved business discussions will be posted on the
SEAC website next week.
. The Chair noted that recent reports described two cases of
BSE in cattle in the United States of America (USA) as being
similar to atypical cases of BSE found in a number of
European countries. The Chair suggested that the term
"atypical BSE", used in the USA report, is potentially
confusing and that this would be discussed under any other
business. Dr Danny Matthews (Veterinary Laboratories
Agency [VLA]) explained that data from western blots of the
USA cases resembled that of a small number of atypical
cases of BSE in France. A study of the French cases had
shown the condition to be transmissible to mice by
intracerebral (ic) inoculation with the neuropathological
phenotype maintained on transmission3. Claims have been
made about the existence of atypical cases of BSE in other
countries but these have yet to be confirmed. No study has
yet examined the tissue distribution of abnormal prion protein
(PrPSc) or infectivity in such atypical cases of BSE. ...
[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine
Spongiform Encephalopathy (BSE)
3. WHY still now only partial ruminant feed ban, with the fact that now we
seem to have 3 cases of nvCJD to humans
i.e. humanbovineTSE that were responsible from blood, and the fact the last
2 mad cows documented in the USA were
that of an Atypical strain, would it not seem prudent to remove blood as
well from ruminant feed ?
Page 4 of 98
WOULD it not seem prudent to improve and expand the SRM list now? as per
your own thinking ;
> If transmission occurs, tissue distribution comparisons will be made
> infected with the atypical BSE isolate and the U.S. BSE isolate.
> tissue distribution could require new regulations regarding specific risk
> (SRM) removal.
FULL text ;
Research Project: Study of Atypical Bse
Location: Virus and Prion Diseases of Livestock
Project Number: 3625-32000-073-07
Project Type: Specific C/A
Start Date: Sep 15, 2004
End Date: Sep 14, 2007
The objective of this cooperative research project with Dr. Maria Caramelli
from the Italian BSE Reference Laboratory in Turin, Italy, is to
conduct comparative studies with the U.S. bovine spongiform encephalopathy
(BSE) isolate and the atypical BSE isolates identified in Italy.
The studies will cover the following areas: 1. Evaluation of present
diagnostics tools used in the U.S. for the detection of atypical BSE cases.
Molecular comparison of the U.S. BSE isolate and other typical BSE isolates
with atypical BSE cases. 3. Studies on transmissibility and tissue
distribution of atypical BSE isolates in cattle and other species.
This project will be done as a Specific Cooperative Agreement with the
Italian BSE Reference Laboratory, Istituto
Zooprofilattico Sperimentale del Piemonte, in Turin, Italy. It is essential
for the U.S. BSE surveillance program to
analyze the effectiveness of the U.S diagnostic tools for detection of
atypical cases of BSE. Molecular comparisons of
the U.S. BSE isolate with atypical BSE isolates will provide further
characterization of the U.S. BSE isolate.
Transmission studies are already underway using brain homogenates from
atypical BSE cases into mice, cattle and
sheep. It will be critical to see whether the atypical BSE isolates behave
similarly to typical BSE isolates in terms of
transmissibility and disease pathogenesis. If transmission occurs, tissue
distribution comparisons will be made between
cattle infected with the atypical BSE isolate and the U.S. BSE isolate.
Differences in tissue distribution could require
new regulations regarding specific risk material (SRM) removal.
Page 5 of 98
HOWEVER, JAPAN has already shown infectivity in tissues other than CNS in
there atypical TSE in cattle, so why should we wait,
and expose many to this agent needlessly, since the last two mad cows in the
USA were also atypical TSE ?
PrPSc distribution of a natural case of bovine spongiform encephalopathy
Yoshifumi Iwamaru, Yuka Okubo, Tamako Ikeda, Hiroko Hayashi, Mori- kazu
Imamura, Takashi Yokoyama and Morikazu Shinagawa
Priori Disease Research Center, National Institute of Animal Health, 3-1-5
Kannondai, Tsukuba 305-0856 Japan email@example.com
Abstract ... snip...full text 98 pages ;
Published online before print February 17, 2004, 10.1073/pnas.0305777101
Identification of a second bovine amyloidotic spongiform encephalopathy:
Molecular similarities with sporadic Creutzfeldt-Jakob disease
J Gen Virol 85 (2004), 2471-2478; DOI 10.1099/vir.0.79889-0
Characterization of two distinct prion strains derived from bovine
spongiform encephalopathy transmissions to inbred mice
[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk
Materials for Human Food and Requirement for the Disposition of
Non-Ambulatory Disabled Cattle
SEE STEADY INCREASE IN SPORADIC CJD IN THE USA FROM
1997 TO 2004. SPORADIC CJD CASES TRIPLED;
please note 'TYPE UNKNOWN' ???
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518