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From: TSS ()
Subject: A Novel Copper-Hydrogen Peroxide Formulation for Prion Decontamination
Date: September 19, 2006 at 12:40 pm PST

A Novel Copper-Hydrogen Peroxide Formulation for Prion Decontamination

Jérôme Solassol,1,2 Manuela Pastore,1 Carole Crozet,1 Véronique Perrier,4 and Sylvain Lehmann1,3

1Institut de Génétique Humaine du Centre National de la Recherche Scientifique, UPR1142, 2Laboratoire de Biologie Cellulaire, Hôpital A. de Villeneuve, 3Laboratoire de Biochimie, Hôpital St. Eloi, and 4Vieillissement Cérébral et Pathogenèse des Maladies Neurodégénératives, U710 INSERM, Montpellier, France

With the appearance of variant Creutzfeldt-Jakob disease (CJD) and the detection of infectious prions in the peripheral organs of persons with sporadic CJD, the development of decontamination methods that are compatible with medical equipment has become a major issue. Here, we show that a formulation of copper metal ions in combination with hydrogen peroxide dramatically reduces the level of prion protein (PrP)Sc (the scrapie isoform of PrP) present in homogenates of samples from prion-infected brains, including brain samples from humans with CJD. An animal bioassay confirmed the reduction in prion infectivity, indicating that this novel Cu2+-H2O2 formulation has great potential for prion decontamination.

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Received 3 January 2006; accepted 8 May 2006; electronically published 10 August 2006.
Potential conflicts of interest: none reported.
Financial support: Centre National de la Recherche Scientifique; GIS Prion.
The results of the present study formed the basis of an international patent (no. 2870458; published 25 November 2005).


http://www.journals.uchicago.edu/JID/journal/issues/v194n6/36170/brief/36170.abstract.html

TSS



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