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From: TSS ()
Subject: TSE surveillance in small ruminants and pigs: a pilot study
Date: August 9, 2006 at 1:56 pm PST

1: Schweiz Arch Tierheilkd. 2006 Jul;148(7):341-2, 344-8.

[TSE surveillance in small ruminants and pigs: a pilot study]
[Article in German]

Kofler M,

Seuberlich T,
Maurer E,
Heim D,
Doherr M,
Zurbriggen A,
Botteron C.

NeuroCenter, Departement fur klinische Veterinarmedizin der Universitat Bern.

Switzerland is controlling Transmissible Spongiform Encephalopathies (TSE) in cattle (BSE) and small ruminants (scrapie). Since BSE is potentially transmissible to sheep, goats or pigs through feeding of contaminated meat and bone meal, implementation of an active surveillance programme for TSE in these species is discussed. The aim of this pilot study was to obtain preliminary data on the prevalence ofTSE and other neurological disorders in these populations. For that purpose, a total of 398 perished and 825 slaughtered adult small ruminants and pigs was examined for the presence of neuropathological changes. None of these animals revealed positive for TSE. However, the investigations demonstrated that perished sheep and goats exhibited a higher prevalence of relevant neuropathological changes when compared with slaughtered animals. From these results, it is concluded that perished small ruminants are probably a risk population for TSE and should be considered as target populations for an active surveillance programme.

PMID: 16888920 [PubMed - in process]

Journal of Veterinary Medicine Series B
Volume 52 Page 55 - March 2005
Volume 52 Issue 2

Strain Typing of German Transmissible Spongiform Encephalopathies Field Cases in Small Ruminants by Biochemical Methods
A. Gretzschel1, A. Buschmann1, M. Eiden1, U. Ziegler1, G. Lühken2, G. Erhardt2 and M. H. Groschup1,3

Following the implementation of a large scale transmissible spongiform encephalopathies (TSE) surveillance programme of small ruminants, evidence for a natural transmission of bovine spongiform encephalopathy (BSE) to a French goat has been found. During the years 2002–2004, a massive TSE rapid testing programme on >250 000 small ruminants was carried out in Germany. In this national survey, 186 scrapie-affected sheep were found which originated from 78 flocks. The majority of these cases were of the classical TSE type (115 sheep belonging to 14 outbreaks). However, 71 cases coming from 64 flocks were of the novel atypical scrapie type. According to the regulation EU 999/2001, all TSE cases in small ruminants have to be examined by strain typing methods to explore any possibility of the existence of BSE cases in the field sheep population. Here we report on a biochemical typing strategy (termed FLI-test), which includes the determination of molecular masses, antibody binding affinities and glycosylation pattern of the TSE induced abnormal prion protein. Based on this typing approach none of the analysed German classical TSE outbreaks (total number of analysed sheep: 36) displayed biochemical features indicative for a BSE infection. However, in two cases distinct but BSE-unrelated PrPSc types were found, which alludes to the existence of different scrapie strains in the German sheep population.


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