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From: TSS ()
Subject: UPTAKE PrPSc via Peyer's Patches in Hamsters after Oral Exposure to Scrapie
Date: April 25, 2006 at 7:58 am PST

Short-term Study of the Uptake of PrPSc by the Peyer's Patches in Hamsters after Oral Exposure to Scrapie

A.-L. Bergströma, T.K. Jensena, P.M.H. Heegaarda, H. Cordesa, V.B. Hansena, H. Laursenb and P. Linda

aDepartment of Veterinary Diagnostics, The Danish Institute for Food and Veterinary Research, Bülowsvej 27, 1790 Copenhagen V, Denmark
bNeuropathology Laboratory, Rigshospitalet, 2100 Copenhagen Ø, Denmark

Received 18 March 2005; accepted 11 August 2005. Available online 10 February 2006.

The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.

Keywords: hamster; Peyer's patches; prion disease; scrapie; sheep!&_cdi=6861&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=90cd7410493d9654ce2cd9091f52cb51


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