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From: TSS ()
Subject: Re: Predicting susceptibility and incubation time of human-to-human transmission of vCJD
Date: March 27, 2006 at 9:06 am PST

In Reply to: Predicting susceptibility and incubation time of human-to-human transmission of vCJD posted by TSS on March 27, 2006 at 6:24 am:

RECALLS AND FIELD CORRECTIONS: BIOLOGICS -- CLASS I

_______________________________
PRODUCT
Human Tissue for Transplantation, Recall # B-0432-6:
a) Tricortical Wedge (R) 1.5 x 2.5 cm,
Freeze Dried Irradiated;
b) Tricortical Wedge ( L ) 1.7 x 3.0 cm,
Fresh Frozen Irradiated;
c) Cancellous Crushed 60.0 cc, Freeze Dried,
Irradiated;
d) Cancellous Crushed 30.0 cc Freeze Dried,
Irradiated;
e) Achilles Tendon OA ( R ) Fresh Frozen
Irradiated;
f) Achilles Tendon OA ( L ) Fresh Frozen
Irradiated;
g) Lumbar;
h) Cancellous Crushed 30.0 cc Fresh Frozen,
Irradiated
CODE
a) Tissue 04091-002;
b) Tissue 04113-003;
c) Tissues 04091-008, 04101-008, 04103-002,
04103-003, 04105-003;
d) Tissues 04091-005, 04091-006, 04091-007,
04101-006, 04101-007, 04102-004, 04102-005,
04104-003, 04104-004, 04104-005, 04105-002,
04109-003, 04109-004, 04120-004, 04124-003,
04124-004, 04138-002, 04138-003, 04140-002,
04143-002, 04143-003, 04146-001, 04152-001;
e) Tissues 04101-003, 04123-004;
f) Tissues 04101-004, 04123-003;
g) Tissues 03049-001, 03051-001, 04091-001,
04102-001, 04103-001, 04104-001, 04105-001,
04106-001, 04107-001, 04108-001, 04109-001,
04113-001, 04120-001, 04122-001, 04123-001,
04124-001;
h) Tissue 04108-002
RECALLING FIRM/MANUFACTURER
Recalling Firm: Central Texas Regional Blood & Tissue Center, Austin, TX, by telephone on October 4, 2005, and by letter dated October 11, 2005.
Manufacturer: Biomedical Tissue Services, Fort Lee, NJ, firm initiated recall is ongoing.
REASON
Human tissues, procured from donors without adequate donor eligibility determinations, were distributed.
VOLUME OF PRODUCT IN COMMERCE
51 allografts
DISTRIBUTION
TX and CO

PRODUCT
Human Corneal Tissues for Transplantation, Recall # B-0380-6
CODE
Tissues: CI044108 OD and CI044108 OS
RECALLING FIRM/MANUFACTURER
Michigan Eye Bank, Ann Arbor, MI, by letter dated November 22, 2005, and by facsimile dated November 28, 2005. Firm initiated recall is complete.
REASON
Human Corneas, collected from an ineligible donor, were distributed.
VOLUME OF PRODUCT IN COMMERCE
2 tissues
DISTRIBUTION
MI, CA and Germany

_______________________________

PRODUCT
a) Red Blood Cells Leukocytes Reduced,
Recall # B-0617-6;
b) Red Blood Cells (Apheresis) Leukocytes Reduced
(distributed as split product), Recall # B-0618-6;
c) Platelets Leukocytes Reduced, Recall # B-0619-6;
d) Fresh Frozen Plasma, Recall # B-0620-6;
e) Cryoprecipitated AHF, Recall # B-0621-6;
f) Plasma Cryoprecipitate Reduced, Recall # B-0622-6;
g) Recovered Plasma, Recall # B-0623-6
CODE
a) Unit numbers: 1136792, 1040212, 1011245;
b) Unit numbers: 1048247-1, 1048247-2;
c) Unit numbers: 1040212, 1011245;
d) Unit number: 1136792;
e) Unit numbers: 1040212, 1011245;
f) Unit number: 1040212;
g) Unit number: 1011245
RECALLING FIRM/MANUFACTURER
Hoxworth Blood Center, Cincinnati, OH, by letter dated September 6, 2005. Firm initiated recall is complete.
REASON
Blood products, collected from a donor considered to be at increased risk for variant Creutzfeldt-Jakob Disease (vCJD), were distributed.
VOLUME OF PRODUCT IN COMMERCE
12 units
DISTRIBUTION
OH and FL

_______________________________

END OF ENFORCEMENT REPORT FOR MARCH 1, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00941.html

PRODUCT
Recovered Plasma, Recall # B-0643-6
CODE
Unit numbers: R170537, R165863, and R158308
RECALLING FIRM/MANUFACTURER
Puget Sound Blood Center, Seattle, WA, by facsimile on October 7, 2003. Firm initiated recall is complete.
REASON
Blood products, which were collected from an unsuitable donor based on risk factors for variant Creutzfeldt-Jakob Disease (vCJD), were distributed.
VOLUME OF PRODUCT IN COMMERCE
3 units
DISTRIBUTION
Austria


END OF ENFORCEMENT REPORT FOR FEBRUARY 22, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00940.html


PRODUCT
a) Product is 1.0 cc Regenaform® RT. SINGLE PATIENT
USE ONLY. Recall # Z-0481-06;
b) OPTEFORM Allografts of varying sizes. SINGLE PATIENT
USE ONLY. Recall # Z-0482-06;
c) Product is OPTEFORM Allograft Paste of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0483-06;
d) OPTEFORM® RT Moldable Allograft of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0484-06;
e) Osteofil + RT Allograft Paste in varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0485-06;
f) Osteofil Allograft Paste (Bio) of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0486-06;
g) Osteofil IC Syringeable of varying sizes. SINGLE
PATIENT USE ONLY. Recall # 0487-06;
h) Osteofil ICM Moldable Strip of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0488-06;
i) Osteofil RT, ICM Allograft Paste of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0489-06;
j) OSTEOFIL® DBM Paste of varying sizes. SINGLE
PATIENT USE ONLY. Recall # Z-0490-06;
k) OsteoPack 3 FZ 22cc. SINGLE PATIENT USE ONLY.
Recall # Z-0491-06;
l) Regenafil IC. SINGLE PATIENT USE ONLY.
Recall # Z-0492-06;
m) REGENAFORM RT Allograft Paste, 1cc. SINGLE
PATIENT USE ONLY. Recall # Z-0493-06;
n) Product is REGENAFORM® Allograft Moldable Blocks,
of varying sizes. SINGLE PATIENT USE ONLY.
Recall # Z-0494-06;
o) Product is RTI Allograft Paste of varying sizes.
SINGLE PATIENT USE ONLY. Recall # Z-0495-06;
p) Product is REGENAFIL® Allograft Paste, Syringe,
0.5cc. SINGLE PATIENT USE ONLY. Recall # 0496-06;
q) Product is 1.0cc flowable paste from donor
approved for distribution in Italy. SINGLE
PATIENT USE ONLY. Recall # Z-0497-06;
r) Product is OPTEFIL Allograft Paste of varying
sizes. SINGLE PATIENT USE ONLY. Recall
# Z-0498-06;
s) Product is OPTEFIL Allograft Paste, Syringe
of varying sizes. SINGLE PATIENT USE ONLY.
Recall # Z-0499-06;
t) Product is OPTEFORM® Allograft Full Disc,
5 x 90mm, 32cc, Frozen. SINGLE PATIENT USE
ONLY, Recall # Z-0500-06;
u) Product is 2.0 cc Opteform® RT. SINGLE
PATIENT USE ONLY. Recall # Z-0501-06
CODE
2879130 2879131 2879132 2879133 2879134 2879135 2879136 2879137 2879138 2879139 2879350 2879351 2879352 2879353 2879354 2879355 2879440 2879441 2879442 2879443 2879444 2879445 2879446 2879447 2879448 2879449 2879450 2879451 2879452 2879453 2879454 2879455 2879456 2879457 2879458 2879459 2886780 2886781 2886782 2886783 2886784 2886785 2886786 2886787 2886788 2886789 2886950 2886951 2886952 2886953 2886954 2886955 2886956 2886957 2886958 2886959 2962280 2962281 2962282 2962283 2962284 2962285 2962286 2962287 2962288 2962289 2963820 2963821 2963822 2963823 2963824 2963825 2963826 2963827 2963828 2963829 2963910 2963911 2963912 2963913 2963914 2963915 2963916 2963917 2963918 2963919 2963990 2963991 2963992 2963993 2963994 2963995 2963996 2963997 2963998 2963999 2965900 2965901 2965902 2965903 2965904 2965905 2965906 2965907 2965908 2965909 2965910 2965911 2965912 2965913 2965914 2965915 2965916 2965917 2965918 2974861 2974862 2974863 2974864 2974865 2974866 2974867 2974868 2974869 2974870 3021827 3021829 3021830 3021831 3021832 3021833 3021834 3021836 3021877 3021878 3021882 3021883 3021885 3023281 3023282 3023283 3023284 3023285 3023286 3023287 3023288 3023289 3030571 3030572 3030573 3030574 3031471 3031473 3031474 3031475 3031476 3031477 3031478 3031479 3031480;
0756898 0756899 0774572 0829702 0829703 0829704 0829705 0829706 0829757 0829758 0829759 0829760 0829761 0849054 0849055 0849056 0849057 0849058 0849144 0849145 0849146 0849147 0849148 0849159 0849160 0849161 0849162 0849163 0849230 0849231 0849232 0849233 0849234 0850462 0850463 0850469 0850470 0850471 0852636 0852637 0852638 0852639 0852640 1483739 1483740 1483741 1483742 1494117 1494118 1494119 1494122 1494240 2121702 2121703 2121704 2121705 2121706 2121907 2121908 2121909 2121910 2121911 2121922 2121923 2121924 2121925 2121926 2125258 2125339 2125340 2125341 2125342 2125343 2147725 2147727 2147825 2147827 2147829 2147905 2147906 2147907 2147908 2147909 2147930 2147931 2147932 2147933 2147980 2147981 2147982 2147983 2147984 2147995 2147996 2147997 2147998 2147999 2151766 2151767 2151768 2151769 2151770 2151781 2151782 2151783 2151784 2151785 2151827 2151828 2151829 2151830 2151966 2151967 2151968 2151969 2151970 2153117 2153118 2153119 2153120 2153346 2153347 2153348 2153349 2153350 2153359 2153360 0843158 0843159 0843160 0843161 0843162 2124913 2124914 2124968 2124969 2124971 2124972 2135208 2135209 2135210 2135211 2135212 2135273 2135274 2135275 2135276 2135277 2135284 2135285 2135286 2135287 2135308 2135309 2135310 2135311 2135312 2135318 2135319 2135320 2135478 2142436 2142437 2142438 2142439 2145001 2145002 2145003 2145004 2145005 2145131 2145132 2145133 2145134 2145135 2161531 2161532 2161533 2161534 2161686 2161687 2161688 2161689 2161690 2166675 2166676 2188866 2188969 2188970 2188971 0837098 0837099 0837100 0837101 0837102 0837477 0837478 0837479 0837480 2040067 2040068 2040069 2174843 2174844 2174845 2174846 2174847 2995331 2995332 2995333 2995334 2997901 2997902 2997903 2997904 2997905 2997906 2997907 2997908 2997909 2997910;
3043561 3043562 3043563 3043564 3043565 3043566 3043567 3043568 3043569 3043570 3047041 3047042 3047043 3051158 3051159 3051160 3051193 3051194 3051195 3051196 3051197 3051198 3051199 3051491 3051493 3051495 3051497 3050703 3050705 3050706 3050710 3056760 3060591 3027677 3027678 3027679 3044581 3044582 3044583 3044584 3044585 3044586 3044587 3044588 3044589 3044590 3044931 3044932 3044933 3044934 3044935 3044936 3044937 3044938 3044939 3044940 3044941 3044942 3044943 3044944 3044945 3044946 3044947 3044948 3044949 3044950 3045571 3045572 3045573 3045574 3045575 3045576 3045941 3045942 3045943 3045944 3045946 3045947 3045948 3045949 3046341 3046342 3046343 3046344 3046345 3046346 3046347 3046348 3046349 3046350 3046531 3046532 3046533 3046534 3046535 3046536 3046537 3046538 3046539 3046540 3046621 3046622 3046623 3046624 3046625 3046626 3046627 3046628 3046629 3046630 3046661 3046662 3046663 3046664 3046665 3046666 3046667 3046668 3046669 3046670 3046671 3046672 3046673 3046674 3046675 3046676 3046677 3046678 3046679 3046680 3046731 3046732 3046733 3046734 3046735 3046736 3046737 3046738 3046739 3046740 3046831 3046832 3046833 3046834 3046835 3046836 3046837 3046838 3046839 3046840 3046971 3046972 3046973 3046974 3046975 3046976 3046977 3046978 3046979 3046980 3046981 3046982 3046983 3046984 3046985 3046986 3046987 3046988 3046989 3046990 3047401 3047402 3047403 3047404 3047405 3047406 3047407 3047408 3047409 3047410 3051101 3051102 3051103 3051104 3051105 3051161 3051162 3051163 3051164 3051165 3051166 3051167 3051168 3051169 3051170 3051221 3051222 3051223 3051224 3051226 3051227 3051228 3051229 3051230 3051231 3051232 3051233 3051234 3051235 3051236 3051237 3051238 3051239 3051240 3051241 3051242 3051243 3051244 3051245 3051246 3051247 3051248 3051249 3051250 3051271 3051272 3051273 3051274 3051275 3051276 3051277 3051278 3051279 3051280 3051381 3051382 3051383 3051384 3051385 3051386 3051387 3051388 3051389 3051390 3051422 3051423 3051424 3051425 3051426 3051427 3060550 3060551 3060552;
2613431 2613432 2613433 2613434 2613435 2613436 2613437 2613438 2613439 2613440 2613901 2613902 2613903 2613904 2613905 2613906 2613907 2614881 2614882 2614883 2614884 2614885 2614886 2614887 2614888 2614889 2614890 2653106 2653107 2653108 2654250 2654251 2654252 2654253 2654254 2654255 2654256 2654257 2654258 2654259 2699840 2699841 2699842 2699843 2485231 2485232 2485233 2485234 2485235 2485236 2485237 2485238 2485239 2485240 2595521 2595522 2595921 2595922 2595923 2595924 2595925 2595926 2595927 2595928 2595929 2595930 2978531 2978532 2978533 2978534 2978535 2978536 2978537 2978538 2978539 2978540 2983613 2983614 2983615 2983616 2983831 2983832 2983842 2983843 2983844 2984801 2984802 2984803 2984804 2984805 2984806 2984807 2984808 2984809 2984810 2985721 2985722 2985723 2985724 2985725 2985726 2985727 2985728 2985729 2985730 2985791 2985792 2985793 2985794 2985795 2985796 2985797 2985798 2985799 2985800 2985911 2985912 2985913 2985914 2985915 2985916 2985917 2985918 2985919 2985920 2985991 2985992 2985993 2985994 2985995 2985996 2985997 2985998 2985999 2986000 2986841 2986842 2986843 2986844 2986845 2986846 2986847 2986848 2986849 2986850 2986861 2986862 2986863 2986864 2986865 2986866 2986867 2986868 2986869 2986870 2987907 2987908 2999921 2999922 2999923;
2488121 2488122 2488123 2488124 2488125 2488126 2488127 2488128 2488130 2497251 2497252 2497253 2497253 2497254 2497255 2497256 2497257 2497258 2497259 2497260 2497361 2497362 2497363 2497364 2497365 2497366 2497367 2497368 2497369 2497370 2501782 2501783 2501784 2501785 2501786 2501787 2501788 2501789 2501790 2501791 2501791 2501832 2501833 2501834 2501835 2501836 2501837 2501838 2501839 2501840 2501841 2501872 2501873 2501874 2501875 2501876 2501877 2501878 2501879 2501880 2501881 2502191 2502192 2502193 2502194 2502195 2502196 2502197 2502198 2502199 2502200 2559851 2559852 2559853 2559854 2559855 2559856 2559857 2559858 2559859 2559951 2559952 2559953 2559954 2559955 2559956 2559957 2559958 2559959 2559960 2559991 2559992 2559993 2559994 2559995 2559996 2559997 2559998 2559999 2560000 2560071 2560072 2560073 2560074 2560075 2560076 2560077 2560078 2560079 2560080 2560221 2560222 2560223 2560224 2560225 2560226 2560227 2560228 2560229 2560230 2560273 2560274 2560275 2560276 2560277 2560278 2560279 2560280 2560471 2560472 2560473 2560474 2560475 2560476 2560477 2560478 2560479 2560480 2561641 2561642 2561643 2561645 2561646 2561647 2561648 2561649 2561650 2561841 2561842 2561843 2564571 2564572 2564573 2564574 2564575 2564576 2564577 2564578 2564579 2564580 2564591 2564592 2564593 2564594 2564595 2564596 2564598 2564599 2564600 2565581 2565582 2565583 2565584 2565585 2565586 2565587 2565588 2565589 2565971 2565972 2565973 2565974 2565975 2565976 2565977 2565978 2565979 2565980 2613351 2613352 2613353 2613354 2613355 2613356 2613358 2613359 2613461 2613462 2613463 2613465 2613466 2613467 2613468 2613469 2613470 2613524 2613525 2613526 2613527 2613528 2613529 2613908 2613909 2613910 2613931 2613932 2613933 2613934 2613935 2613936 2613937 2613938 2613939 2613940 2613971 2613972 2613974 2613975 2613976 2613977 2613978 2613979 2613980 2614371 2614372 2614373 2614374 2614375 2614376 2614377 2614551 2614552 2614553 2614554 2614555 2614556 2614558 2614591 2614592 2614593 2614594 2614595 2614596 2614597 2614599 2614891 2614892 2614893 2614894 2614895 2614896 2614899 2614900 2614982 2614984 2614989 2614990 2616221 2616222 2616223 2616224 2616227 2616228 2616229 2616230 2616491 2616492 2616493 2616494 2616495 2616496 2616497 2616500 2620221 2620223 2620225 2620227 2620229 2620271 2620272 2620276 2620277 2620278 2620279 2620280 2689161 2689163 2689165 2689166 2689168 2689169 2689371 2689372 2689373 2689374 2689375 2689376 2689378 2690294 2690295 2690297 2690299 2690300 2690301 2690303 2692921 2692922 2692923 2692926 2692927 2692928 2692929 2692939 2713197 2713198 2713199 2713200 2713202 2713203 2713228 2713230 2713231 2713232 2713234 2713235 2713236 2713388 2713389 2713390 2713391 2713392 2713393 2713394 2713395 2713396 2713427 2713428 2713429 2713430 2713431 2713433 2713434 2713435 2713436 2718753 2718754 2718755 2718756 2718758 2718760 2718791 2718793 2718794 2718795 2718796 2718798 2718800 2718931 2718932 2718934 2718935 2718936 2718937 2718940 2718961 2718962 2718965 2718969 2718970 1901774 1901775 1901776 1901777 1901778 1901779 1901780 1901781 1901782 1901783 1901804 1901805 1901806 1901807 1901808 1901809 1901810 1901811 1901812 1901813 1909226 1909227 1909228 2679851 2679852 2689260 2689261 2689262 2689263 2689264 2689265 2689266 2689267 2689268 2689269 2692940 2692941 2692942 2692943 2692944 2692945 2692946 2692947 2692948 2692949;
1700271 1700272 1700273 1700274 1700275 1700276 1700277 1700278 1700279 1700280 1879091 1879092 1879093 1879094 1879095 1879096 1879097 1879098 1879099 1879100 1907051 1907052 1907053 1907054 1907055 1907056 1907057 1907058 1907059 1907060 1907141 1907142 1907143 1907144 1907145 1907146 1907147 1907148 1907149 1907150 1951240 1951241 1951242 1951243 1951244 1951245 2436853 2436854 2436855 2436856 2436857 2436858 2436859 2436860 2436861 2436862 2442511 2442512 2442513 2442514 2442515 2442516 2442517 2442518 2442519 2442520 2442581 2442582 2442583 2442584 2442585 2442586 2442587 2442588 2442589 2442590 2443901 2443902 2443903 2443904 2443905 2443906 2443907 2443908 2443909 2443910 2444551 2444552 2444553 2444554 2444555 2444557 2444558 2444559 2444560 2446181 2446182 2446183 2446184 2446185 2446186 2446187 2446188 2446190 2446491 2446492 2446493 2446494 2446495 2446496 2446497 2446498 2446499 2446500 2446851 2446852 2446853 2446854 2446855 2446856 2446857 2446858 2446859 2446860 2446911 2446912 2446913 2446914 2446915 2446916 2446917 2446918 2446919 2446920 2446951 2446952 2446953 2446954 2446955 2446956 2446957 2446958 2446959 2446960 2446971 2446972 2446973 2446974 2446975 2446976 2446977 2446978 2446979 2446980 2446981 2446982 2446983 2446984 2446985 2446986 2446987 2446988 2446989 2446990 2456961 2456962 2456963 2456964 2456965 2456966 2456967 2456968 2456969 2456970 2822090 2822091 2822092 2822093 2822094 2822095 2822096 2822097 2822098 2822099 2822460 2822461 2822462 2822463 2822464 2822465 2822466 2822467 2822468 2822469 2823610 2823611 2823612 2823613 2823614 2823615 2823616 2823617 2823618 2823619 2823850 2823851 2823852 2823853 2823854 2823855 2823856 2823857 2823858 2823859 2824090 2824091 2824092 2824093 2824094 2824095 2824096 2824097 2824098 2824099 2824320 2824321 2824322 2824323 2824324 2824325 2824326 2824327 2824328 2824329 2158083 2184601 2184602 2184603 2184604 2184605 2184606 2184607 2184608 2184609 2184610 2190451 2190452 2190453 2190454 2190455 2190471 2190472 2190473 2190474 2190475 2190476 2190477 2190478 2190479 2190480 2835023 2835029 2839737 2158050 2158051 2158052 2158053 2158054 2158055 2158056 2158057 2158058 2158059 2158060 2158061 2158062 2158063 2158064 2158065 2158066 2158067 2158068 2158069 2158070 2158071 2158072 2158073 2158074 2158075 2158076 2158077 2158078 2158079 2158080 2158081 2158082 2614476 2614477 2614478 2614479 2614729 2614730 2616471 2616472 2616473 2616474 2616475 2616476 2616477 2616478 2616479 2616480 2622781 2622783 2622784 2622785 2622786 2622787 2622788 2622789 2622790 2700000 2700001 2700002 2700003 2700004 2700005 2700006 2700007 2700008 2700009 2713098 2713099 2713100 2713101 2713102 2713103 2713104 2713105 2713106 2713307 2713308 2713309 2713310 2713311 2713312 2713313 2713314 2713315 2713316 2720173 2720174 2720175 2720176 2720177 2720178 2720179 2720180 2720181 2720182 2732530 2732531 2732532 2732533 2732534 2732535 2732536 2732537 2732538 2732539 2732690 2732691 2732692 2732693 2732694 2732695 2732696 2732697 2842690 2842691 2842692 2842693 2842694 2842695 2842696 2842697 2842698 2842699 2844190 2844191 2844193 2847760 2847763 2847766 2847767 2848514 2848515;
2250274 2250275 2250276 2443591 2443592 2443593 2443594 2443595 2444941 2444942 2444943 2444944 2444945 2444946 2444947 2444948 2444949 2444950 2446231 2446232 2446233 2446234 2446235 2446236 2446237 2446238 2446239 2446240 2000898 2000899 2000900 2000901 2000902 2000903 2000952 2000953 2000954 2000955 2000956 2000957 2000958 2000959 2000960 2000961 2000962 2000963 2000964 2000965 2000966 2000967 2000968 2000969 2250269 2250270;
2511671 2511672 2511673 2511674 2511675 2511676 2511677 2511678 2614471 2614472 2614473 2614474 2614475 2614721 2614722 2614723 2614724 2614725 2614726 2614727 2614728 2730530 2730531 2730532 2730533 2730534 2730535 2730536 2730537 2742463 2742464 2742465 2742466 2746363 2746364 2746365 2746366 2746367 2746368 2746369 2747870 2764991 2764992 2764993 2764994 2764995 2764996 2764997 2764998 2764999 2766699 2766700 2766701 2766702 2766703 2766704 2924612 2924613 2924730 2924731 2924732 2924733 2924734 2924735 2924736 2924737 2924738 2924739 2184631 2184633 2184634 2184635 2184636 2184637 2184638 2184639 2184640 2185751 2185752 2185753 2185754 2185755 2185756 2185757 2185758 2185759 2185760 2275371 2275372 2275373 2275374 2275375 2275376 2275377 2275378 2275379 2275380 2277521 2277522 2277523 2277524 2277525 2277526 2277527 2277528 2697923 2697924 2697925 2697926 2697927 2697928 2697929 2699572 2699573 2699574 2699575 2699576 2699577 2699732 2699733 2699734 2699735 2699736 2699737 2699738 2701392 2701393 2703640 2703961 2703962 2703963 2703964 2703965 2703966 2703967 2730383 2730384 2730385 2730386 2730387 2730388 2749681 2749682 2749683 2749684 2749685 2749686 2749687 2749688 2754459 2754460 2754461 2754462 2754463 2788895 2788896 2788897 2894236 2924780 2924781 2924782 2924783 2924784 2924785 2924786 2924787 2924788 2924933 2926150 2926151 2926152 2926153 2926154 2926155 2926156 2926157 2926158 2926159 2945532 2945533 2945534 2945535 2945536 2945537 2945538 2946230 2946231 2946232 2946233 2946234 2946235 2946236 2946237 2946238 2946239 2946350 2946351 2946352 2946353 2946354 2946355 2946356 2946357 2946358 2946359 2955822 2955823 2955824 2955825 2955826 2955827 2955828 2955829 2959010 2959011 2959012 2959013 2959014 2959015 2959016 2959017 2959018 2959019 2964612 2964613 2964614 2985046 2985048 2985049 2985112 2985113 2985114 2985115 2985116 2985117 2985118 2985119 2985120 2985393 3003673 3003674 3003675 3003676 3003677 3003678;
1942724 1942725 1942726 1942727 1942728 1942729 1942730 1942731 1942732 1942733 2348778 2348779 2348780 2348782 2348783 2348786 2348787 2353581 2353582 2353583 2353584 2353585 2353586 2353587 2353588 2353589 2355891 2355892 2357191 2357192 2357194 2357195 2357197 2357199 2357200 2357352 2357353 2357354 2357355 2357356 2357357 2357358 2357359 2555281 2555282 2555283 2555284 2555285 2555286 2702230 2702231 2702232 2707030 2707031 2707032 2707033 2707034 2707035 2707036 2707037 2707038 2707039 2707080 2707081 2707082 2707083 2707084 2707085 2707086 2707087 2707088 2707089 2736580 2736582 2736583 2736584 2745510 2745511 2745512 2745513 2745514 2745515 2745516 2745517 2745518 2745519 2745810 2745811 2745812 2745813 2745815 2745816 2745817 2790531 2792751 2792752 2792753 2792754 2792755 2792756 2801580 2801581 2819213 2819214 2819215 2819216 2819217 2819218 2819219 2822200 2822201 2822202 2822203 2822204 2822205 2822206 2822207 2822208 2822209 2822690 2822691 2822692 2822693 2822694 2822695 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2924976 2924977 2924978 2927580 2927581 2927582 2927583 2927584 2927585 2927586 2927587 2927588 2927589 2927990 2927991 2927992 2927993 2927994 2928200 2928201 2928202 2928203 2928204 2928205 2928206 2928207 2928208 2928209 2928450 2928451 2928452 2928453 2928454 2928455 2928456 2928457 2928458 2928459 2946140 2946141 2946142 2946143 2946144 2946145 2946146 2946147 2946148 2946180 2946181 2946182 2946183 2946184 2946185 2946186 2946187 2946188 2946189 2949810 2949811 2950032 2950033 2950034 2950035 2950036 2950037 2950290 2950292 2950293 2950294 2950295 2950296 2950297 2950298 2950299 2954658 2954659 2954660 2954661 2954662 2954663 2954664 2954665 2954666 2954667 2954908 2954909 2954910 2954911 2954912 2954913 2954914 2954915 2954916 2954917 2955246 2955248 2955249 2955250 2955251 2955252 2955253 2960350 2960351 2960352 2960353 2960354 2960355 2960356 2960357 2960358 2960359 2962920 2962921 2962922 2962923 2962924 2962925 2962926 2962927 2962928 2962929 2964790 2964791 2964792 2964793 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3005597 3005598 3005599 3005600 3007581 3007582 3007583 3007584 3007585 3007586 3007587 3007588 3007589 3007590 3007621 3007622 3007624 3007625 3007626 3007627 3007628 3007629 3007630 3013741 3013742 3013743 3013744 3013746 3013747 3013748 3013749 3013750 3013781 3013782 3013784 3013785 3013786 3013787 3013788 3013790 3013961 3013962 3013963 3013964 3013965 3013966 3013967 3013968 3013969 3013970 2880362 2880363 2880364 2880365 2880366 2880367 2880368 2908994 2910330 2910331 2910332 2910333 2910334 2910335 2910336 2910337 2910338 2910339 2927630 2927631 2927633 2927634 2927635 2927636 2927637 2927638 2927639 2927910 2927911 2927912 2927914 2927915 2927916 2962764 2962766 2649790 2649791 2649792 2649793 2649794 2649795 2649796 2649797 2649798 2649799 2654240 2654241 2654242 2654243 2654244 2654245 2654246 2654247 2654248 2654249 2663020 2663021 2663022 2663023 2663024 2663025 2663026 2663027 2663028 2663029 2663141 2663142 2663143 2663144 2663170 2663171 2663172 2663173 2663174 2663175 2663176 2663177 2663178 2663179 2679590 2679592 2679593 2679594 2679595 2679596 2679597 2679598 2679599 2689190 2689191 2689192 2689193 2689194 2689195 2689196 2689197 2689198 2689199 2690374 2690375 2691490 2691491 2725370 2725371 2725372 2725373 2725375 2725376 2725377 2725378 2725379 2726260 2726261 2726264 2726265 2726266 2729450 2729451 2729452 2729453 2729454 2729455 2729456 2729457 2730720 2730721 2730722 2730725 2730727 2730729 2730760 2730761 2730762 2730764 2730765 2730766 2730767 2730768 2732600 2732601 2732603 2732604 2732605 2732607 2732608 2732609 2732870 2732871 2732874 2732876 2732878 2732900 2732901 2732902 2732903 2732905 2732906 2732907 2732908 2732909 2739050 2739051 2739052 2739053 2739054 2739055 2739056 2739057 2739058 2739059 2745750 2745751 2745752 2745753 2745754 2745755 2745756 2745757 2745758 2745759 2745980 2745981 2745982 2745983 2745984 2745985 2745986 2748180 2748181 2748182 2748183 2748184 2748185 2748187 2748188 2748189 2748200 2748201 2748202 2748203 2748204 2748205 2748206 2748207 2748208 2748209;
2819000 2819001 2819002 2819003 2819004 2819005 2819006 2819007 2819008 2819009 2819080 2819081 2819082 2819083 2819084 2819085 2819086 2819087 2819088 2819089 2819470 2819471 2819472 2819473 2819474 2819475 2819476 2819477 2819478 2819479 2820000 2820001 2820002 2820003 2820004 2820005 2820110 2820111 2820112 2820113 2820114 2820115 2820116 2820117 2820118 2820119 2820210 2820211 2820212 2820213 2820214 2820215 2820216 2820217 2820218 2820219 2820430 2820431 2820432 2820433 2820434 2820435 2820436 2820437 2820438 2820439 2820440 2820441 2820442 2820443 2820444 2820445 2820446 2820447 2820448 2820449 2820480 2820481 2820482 2820483 2820484 2820485 2820486 2820487 2820488 2820489 2821340 2821341 2821342 2821343 2821344 2821345 2821346 2821347 2821348 2821349 2821350 2821351 2821352 2821353 2821354 2821355 2821356 2821357 2821358 2821359 2821480 2821481 2821482 2821483 2821484 2821485 2821486 2821487 2821488 2821489 2821500 2821501 2821502 2821503 2821504 2821505 2821506 2821507 2821508 2821509 2821936 2821937 2821938 2821939 2824520 2824521 2824522 2824523 2824524 2824525 2824526 2824527 2824528 2824529 2824802 2824803 2824804 2824805 2824806 2824807 2824808 2824809 2824810 2824811 2824812 2824813 2824814 2824815 2824816 2824817 2824818 2824819 2824820 2824821 2824822 2824823 2824824 2824825 2824826 2824827 2824828 2824829 2824830 2824831 2824882 2824883 2824884 2824885 2824886 2824887 2824888 2824889 2824890 2824891 2824982 2824983 2824984 2824985 2824986 2824987 2824988 2824989 2824990 2824991 2825360 2825361 2825362 2825363 2825364 2825365 2825366 2825367 2825368 2825369 2728210 2728211 2728212 2728213 2728214 2728215 2728216 2728217 2728218 2728219 2729190 2729191 2729192 2729194 2729195 2735390 2735391 2735392 2735393 2735394 2735395 2764520 2764521 2764522 2764523 2764524 2764525 2764526 2764527 2764528 2764529 2766656 2766657 2766659 2766660 2769420 2769421 2769422 2769423 2769424 2769425 2769426 2769427 2769428 2769429 2826080 2826082 2826083 2826084 2826087 2826088 2826089 2826190 2826191 2826192 2826194 2826196 2826198 2826199 2826220 2826221 2826222 2826223 2826224 2826225 2826226 2826227 2826228 2826320 2826321 2826322 2826324 2826326 2826327 2826329 2826400 2826401 2826402 2826403 2826404 2826406 2826408 2826409 2831060 2831061 2831063 2831065 2831067 2831340 2831342 2831344 2831345 2831346 2831348 2831350 2831353 2831354 2831355 2831357 2831358 2831359 2831420 2831421 2831422 2831423 2831424 2831425 2831426 2831427 2831429 2833250 2833253 2833254 2833323 2833324 2833325 2833328 2833329 2833380 2833381 2833382 2833383 2833384 2833386 2833388 2833389 2835290 2835291 2835293 2835296 2835297 2835298 2835300 2835302 2835303 2835304 2835305 2835306 2835307 2835308 2835691 2835692 2835695 2835696 2835698 2835699 2729620 2729621 2729622 2729623 2729624 2729625 2729626 2729627 2729628 2729629 2770951 2770952 2770953 2770954 2770955 2774620 2774621 2774622 2774623 2774624 2774625 2774626 2774627 2774628 2774629 2774881 2774882 2774883 2774884 2774885 2774889 2777760 2777761 2777762 2777763 2777764 2777765 2777766 2777767 2777768 2777769 2777790 2777791 2777792 2777793 2777794 2777795 2777796 2777797 2777798 2777799 2779040 2779041 2779042 2779043 2779044 2779045 2779046 2779047 2779048 2779049 2779490 2779491 2779492 2779493 2779494 2779495 2779496 2779497 2779498 2779499 2796951 2796952 2796953 2796954 2796955 2796956 2796957 2796958 2796959 2796960;
2726001 2726002 2726003 2730281 2730282 2730283;
2396521 2396522 2396523 2396524 2396525 2396526 2396527 2396528 2396529 2397301 2397302 2397303 2397304 2397305 2397306 2397307 2397308 2397309 2397310 2000878 2000879 2000880 2000881 2000882 2000883 2000884 2000885 2000886 2000887 2000888 2000889 2000890 2000891 2000892 2000893 2000894 2000895 2000896 2000897 2158322 2158324 2158325 2158326 2158327 2158329;
3047051 3047052 3047053 3047054 3047055 3047056 3047057 3047058 3047059 3047060 3049351 3049352 3049353 3049354 3049355 3049356 3049357 3049358 3049359 3049360 3049421 3049422 3049423 3049424 3049425 3049426 3049427 3049428 3049429 3049430 3049471 3049472 3049473 3049474 3049475 3049476 3049477 3049478 3049479 3049480 3056740 3056817 3056818 3056819 3056820 3056981 3056982 3056983 3056984 3056985 3056986 3056987 3056988 3056989 3056990 3057141 3057142 3057143 3057144 3057145 3057146 3057147 3057148 3057149 3057150 3057161 3057162 3057163 3057165 3057166 3057167 3057168 3057169 3057170 3057241 3057242 3057243 3057244 3057245 3057246 3057248 3057249 3057250 3057251 3057252 3057253 3057254 3057255 3057256 3057257 3057258 3057259 3057260 3057281 3057282 3057283 3057284 3057285 3057286 3057287 3057288 3057289 3057290 3057915 3057917 3057918 3057919 3057920 3057921 3057922 3057923 3057924 3057985 3057986 3057987 3057988 3057989 3057990 3057991 3057992 3057993 3057994 3059151 3059152 3059153 3059154 3059155 3059156 3059157 3059158 3059159 3059160 3059521 3059522 3059523 3059524 3059525 3059526 3059527 3059528 3059529 3059530 3059621 3059622 3059623 3059624 3059625 3059626 3059627 3059628 3059629 3059630 3060574 3060575 3060576 3064501 3064502 3064503 3064504 3064505 3064506 3064507 3064508 3064509 3064510 3064561 3064562 3064563 3064564 3064565 3064566 3064567 3064568 3064569 3064570 3064761 3064762 3064763 3064764 3064765 3064766 3064767 3064768 3064769 3064770 3064781 3064782 3064783 3064785 3064786 3064787 3064788 3064789 3064790 3064821 3064822 3064823 3064824 3064826 3064827 3064828 3064829 3064830 3064881 3064882 3064884 3064885 3064886 3064887 3064888 3064889;
2825210 2825211 2825212 2825213 2825214 2825215 2825216 2825217 2825218 2825219 2828500 2828501 2828502 2828590 2828591 2828592 2828593 2828594 2828595 2828596 2828597 2828598 2828599 2828600 2828601 2828602 2828603 2828604 2828605 2828606 2828607 2828608 2828609 2828640 2828641 2828642 2828643 2828644 2828645 2828646 2828648 2828649 2828820 2828821 2828822 2828823 2828824 2828825 2828826 2828827 2828828 2828829 2831070 2831071 2831072 2831073 2831074 2831075 2831076 2831077 2831078 2831079 2831090 2831091 2831092 2831093 2831094 2831096 2831097 2831098 2831099 2831150 2831151 2831152 2831153 2831154 2831155 2831156 2831157 2831158 2831159 2834480 2834481 2834482 2834483 2834484 2834485 2834486 2834487 2834488 2834489 2835022 2835110 2835111 2835112 2835113 2835114 2835115 2835116 2835117 2835118 2835119 2835320 2835321 2835322 2835323 2835324 2835325 2835326 2835327 2835328 2835329 2835720 2835721 2835722 2835723 2835724 2835725 2835726 2835727 2835728 2835729 2835730 2835731 2835732 2835733 2835734 2835735 2835736 2835737 2835738 2835739 2836030 2836031 2836032 2836033 2836034 2836035 2836036 2836037 2836038 2836039 2836130 2836131 2836132 2836133 2836134 2836135 2836136 2836137 2836138 2836139 2836150 2836151 2836152 2836153 2836154 2836155 2836156 2836157 2836158 2836159 2836490 2836491 2836492 2836493 2836494 2836495 2836496 2836498 2836499 2837000 2837001 2837002 2837003 2837004 2837005 2837006 2837007 2837008 2837009 2837050 2837051 2837052 2837053 2837054 2837055 2837056 2837057 2837058 2837059 2837060 2837061 2837062 2837063 2837064 2837065 2837066 2837067 2837068 2837069 2837090 2837091 2837092 2837093 2837094 2837095 2837096 2837097 2837098 2837099 2837170 2837171 2837172 2837173 2837174 2837175 2837176 2837177 2837178 2837179 2839620 2839621 2839622 2839623 2839624 2839625 2839626 2839627 2839628 2839629 2841890 2841891 2841892 2841893 2841894 2841895 2841896 2841897 2841898 2841899 2842080 2842081 2842082 2842083 2842084 2842085 2842086 2842087 2842088 2842089 2842170 2842171 2842172 2842173 2842174 2842175 2842176 2842177 2842178 2842179 2844150 2844151 2844152 2844153 2844154 2844155 2844156 2844157 2844158 2844159 2844160 2844161 2844162 2844163 2844164 2844165 2844166 2844167 2844168 2844169 2844240 2844241 2844242 2844243 2844244 2844245 2844246 2844247 2844248 2844249 2846312 2846313 2846314 2846315 2846316 2846317 2846318 2846319 2846320 2846321 2846432 2846433 2846434 2846435 2846436 2846437 2846438 2846439 2846440 2846441 2846452 2846453 2846454 2846455 2846456 2846457 2846458 2846459 2846460 2846461 2858100 2858101 2858102 2858103 2858104 2858105 2858106 2858107 2858108 2858109 2858230 2858231 2858232 2858233 2858234 2858235 2858236 2858237 2858238 2858239 2858310 2858311 2858312 2858313 2858314 2858315 2858316 2858317 2858318 2858319 2858978 2858979 2858980 2858981 2858982 2858983 2858984 2858985 2858986 2858987 2880020 2880021 2880022 2880023 2880024 2880025 2880026 2880027 2880028 2880029 2880090 2880091 2880092 2880093 2880094 2880095 2880096 2880097 2880098 2880099 2880400 2880401 2880402 2880403 2880404 2880405 2880406 2880407 2880408 2880409 2881910 2881911 2881912 2881913 2881914 2881915 2881916 2881917 2881918 2881919 2886799 2902808 2902809 2902810 2902811 2902812 2902928 2902929 2902930 2902931 2902932 2902933 2902934 2902935 2902936 2902937 2903090 2903091 2903092 2903093 2903094 2903095 2903096 2903097 2903098 2903099 2903190 2903191 2903192 2903193 2903194 2903195 2903196 2903197 2903198 2903199 2903340 2903341 2903342 2903343 2903344 2903345 2903346 2903347 2903348 2903349 2903360 2903361 2903362 2903363 2903364 2903365 2903366 2903367 2903368 2903369 2904130 2904131 2904132 2904133 2904134 2904135 2904136 2904137 2904138 2904139 2904350 2904351 2904352 2904353 2904354 2904355 2904356 2904357 2904358 2904359 2904440 2904441 2904442 2904443 2904444 2904445 2904446 2904447 2904448 2904449 2826060 2826061 2826062 2826063 2826064 2826065 2826066 2826067 2826068 2826069 2831010 2831011 2831012 2831013 2831014 2831015 2831016 2831017 2831018 2831019 2835650 2835651 2835652 2835653 2835654 2835655 2835656 2835657 2835658 2835659 2835810 2835811 2835812 2835813 2835814 2835815 2835816 2835817 2835818 2835819 2842840 2842841 2842842 2842843 2842844 2842845 2842846 2842847 2842848 2842849 2844080 2844081 2844082 2844083 2844084 2844085 2844086 2844087 2844088 2844089 2844480 2844481 2844482 2844483 2844484 2844485 2844486 2844487 2844488 2844489 2822374 2822375 2822376;
2819380 2819382 2819383 2819384 2819386 2819387 2819388 2820151 2820153 2820154 2820156 2820157 2820158 2820159 2820281 2820282 2820283 2820284 2820285 2820286 2820287 2820288 2820289 2820341 2820343 2820520 2820521 2820523 2820525 2820526 2820527 2820528 2820529 2822391 2822392 2822393 2822394 2822395 2822396 2822397 2822398 2822840 2822841 2822844 2822845 2822846 2822847 2822849 2822860 2822861 2822862 2822863 2822864 2822865 2822867 2822868 2822869 2822990 2822991 2822992 2822995 2822997 2822998 2822999 2824351 2824356 2824358 2824359 2824972 2824974 2824976 2824977 2824980 2824981 2825230 2825231 2825233 2825234 2825235 2825236 2825238 2825239 2825310 2825312 2825313 2825314 2825315 2825317 2825318 2827841 2827842 2827843 2827844 2827846 2827847 2827848 2827849 2828930 2828931 2828932 2828934 2828935 2828936 2828937 2828938 2828939 2831133 2831135 2831136 2831139 2835180 2835182 2835183 2835184 2835185 2835186 2835188 2835189 2835471 2835479 2836210 2836211 2836212 2836214 2836215 2836216 2836218 2837142 2837143 2837144 2837145 2837147 2837148 2837149 2841740 2841741 2841742 2841743 2841744 2841746 2841747 2841748 2841811 2841812 2841813 2841816 2841819 2841822 2841824 2841825 2841829 2841860 2841863 2841864 2841865 2841869 2841980 2841981 2841984 2841988 2842860 2842861 2842863 2842864 2842865 2842866 2842867 2842868 2842869 2842880 2842881 2842883 2842884 2842885 2842889 2842901 2842903 2842905 2842909 1942715 1942716 1942717 1942719 1942720 1942721 1942722 2878543 2878544 2878545 2878546 2878548 2878549 1942714 2764410 2764411 2764412 2764413 2764414 2821780 2821781 2821782 2821783 2821784 2821785 2821786 2821787 2821788 2823650 2823651 2823652 2823653 2823654 2823655 2823656 2823657 2823658 2823659 2825130 2825131 2825132 2825133 2825134 2825135 2825136 2825137 2825138 2825139 2847641 2847643 2847649 2870100 2870101 2870102 2870103 2870104 2870105 2870106 2870107 2870108 2870109 2870454 2870455 2443516 2443520 2443741 2443745 2726490 2726491 2726492 2726493 2666749 2672330 2672332 2672390 2672391 2672393 2672394 2672395 2672396 2672397 2672398 2672399 2672400 2672401 2672402 2672403 2672404 2672405 2672406 2672407 2672409 2673830 2673831 2673832 2673833 2673834 2673835 2673836 2673839 2674111 2674112 2674113 2674114 2674116 2674117 2674118 2674119 2713227 2718751 2718752 2718757 2718759 2718792 2718933 2718938 2718963 2718967 2718968;
2389280 2389281 2389282 2389283 2389284 2389285 2389286 2389287 2389288 2389289 2395001 2395002 2395003 2395004 2395005 2395006 2395007 2395008 2395009 2395010 2395021 2395022 2395023 2395024 2395025 2395026 2395027 2395028 2395029 2395030 2395141 2395142 2395143 2395144 2395145 2395146 2395147 2395148 2395149 2395150 2395301 2395302 2395303 2395304 2395305 2395306 2395307 2395308 2395309 2395310 2396221 2396222 2396223 2396224 2396225 2396226 2396227 2396228 2396229 2396230 2396321 2396322 2396323 2396324 2396325 2396326 2396327 2396328 2396329 2396330 2396371 2396372 2396373 2396374 2396375 2396376 2396377 2396378 2396379 2396380 2396401 2396402 2396403 2396404 2396405 2396406 2396407 2396408 2396409 2396410 2396421 2396422 2396423 2396424 2396425 2396426 2396427 2396428 2396429 2396430 2396531 2396532 2396533 2396534 2396535 2396536 2396537 2396538 2396539 2396540 2397051 2397052 2397053 2397054 2397055 2397056 2397057 2397058 2397059 2397060 2397071 2397072 2397073 2397074 2397075 2397076 2397077 2397078 2397079 2397080 2397321 2397322 2397323 2397324 2397325 2397326 2397327 2397328 2397329 2397330 2764320 2764321 2764322 2764323 2764324 2764325 2764326 2764327 2764328 2764329 2764370 2764371 2764372 2764373 2764374 2764375 2764376 2764377 2764378 2764379 2764460 2764461 2764462 2764463 2764464 2764465 2764466 2764467 2764468 2764469 2801600 2801601 2801602 2801603 2801604 2801605 2801606 2801607 2801608 2801609 2820250 2820251 2820252 2820253 2820254 2820255 2820256 2820257 2820258 2820259 2821120 2821121 2821122 2821123 2821124 2821125 2821126 2821127 2821128 2821129 2821210 2821211 2821212 2821213 2821214 2821215 2821216 2821217 2821218 2821219 2821230 2821231 2821232 2821233 2821234 2821235 2821236 2821237 2821238 2821239 2821470 2821471 2821472 2821473 2821474 2821475 2821476 2821477 2821478 2821479 2824610 2824611 2824612 2824613 2824614 2824615 2824616 2824617 2824618 2824619 2824772 2824773 2824774 2824775 2824776 2824777 2824778 2824779 2824780 2825290 2825291 2825292 2825293 2825294 2825295 2825296 2825297 2825298 2825299 2846352 2846353 2846354 2846355 2846356 2846357 2846358 2846359 2846360 2846361 2846382 2846383 2846384 2846385 2846386 2846387 2846388 2846389 2846390 2846391 2858000 2858001 2858002 2858003 2858004 2858005 2858006 2858007 2858008 2858009 2858040 2858041 2858042 2858043 2858044 2858045 2858046 2858047 2858048 2858049 2858080 2858081 2858082 2858083 2858084 2858085 2858086 2858087 2858090 2858091 2858092 2858093 2858094 2858095 2858096 2858097 2858098 2858099 2858350 2858351 2858352 2858353 2858354 2858355 2858356 2858357 2858358 2858359 2858440 2858441 2858442 2858443 2858444 2858445 2858446 2858447 2858448 2858449 2864468 2864469 2864470 2864471 2864472 2864473 2864474 2864475 2864476 2864477 2865860 2865861 2865862 2865863 2865864 2865865 2865866 2865867 2865868 2865869 2865883 2865884 2865885 2865886 2865887 2865888 2865889 2865950 2865951 2865952 2865953 2865954 2865955 2865956 2865957 2865958 2865959 2879030 2879031 2879032 2879033 2879034 2879035 2879036 2879037 2879038 2879039 2879040 2879041 2879042 2879043 2879044 2879045 2879046 2879047 2879048 2879049 2879060 2879061 2879062 2879063 2879064 2879065 2879066 2879068 2879069 2879080 2879081 2879082 2879083 2879084 2879086 2879087 2879088 2879140 2879141 2879142 2879143 2879144 2879145 2879146 2879147 2879148 2879149 2879240 2879241 2879242 2879243 2879244 2879245 2879246 2879247 2879248 2879249 2879370 2879371 2879372 2879373 2879375 2879376 2879377 2879378 2879379 2879430 2879431 2879432 2879433 2879434 2879435 2879436 2879437 2879438 2879439 2886750 2886751 2886752 2886753 2886754 2886755 2886756 2886757 2886758 2886759 2900930 2900931 2900932 2900933 2900934 2900935 2900936 2900937 2900938 2900939 2902040 2902041 2902042 2902043 2902044 2902045 2902046 2902047 2902048 2902049 3021777 3021778 3021779 3021780 3021781 3021782 3021783 3021784 3021785 3021786 3021917 3021918 3021919 3021920 3021921 3021922 3021923 3021924 3021925 3021926 3021947 3021948 3021949 3021950 3021951 3021952 3021953 3021954 3021955 3021956 3022871 3022872 3022873 3022874 3022875 3022876 3022877 3022878 3022879 3022880 3024038 3024039 3024040 3024041 3024042 3024043 3024044 3024045 3024046 3024047 3024178 3024179 3024180 3024181 3024182 3024183 3024184 3024185 3024186 3024187 3024188 3024189 3024190 3024191 3024192 3024193 3024194 3024195 3024196 3024197 3024731 3024732 3024733 3024734 3024735 3024736 3024737 3024738 3024739 3024740 3024741 3024742 3024743 3024744 3024745 3024746 3024747 3024748 3024749 3024750 3024921 3024922 3024923 3024924 3024925 3024926 3024927 3024928 3024929 3024930 3030584 3030585 3030586 3030587 3031421 3031422 3031423 3031424 3031425 3031426 3031427 3031428 3031429 3031430 3031441 3031442 3031443 3031444 3031445 3031446 3031447 3031448 3031449 3031450 2764189 2764250 2764251 2764252 2764253 2764254 2764255 2764256 2764257 2764258 2764259 2829290 2829291 2829292 2829293 2829294 2829295 2829296 2829297 2829298 2829299 2829360 2829361 2829362 2829363 2829364 2829365 2829366 2829367 2829368 2829369 2833436 2833437 2833438 2833439 2858220 2858221 2858222 2858223 2858224 2858225 2858226 2858227 2858228 2858229 2858299 2389490 2389491 2389492 2389493 2389494 2389495 2389496 2389497 2389498 2389499 2389500 2395281 2395282 2395283 2395284 2395285 2395286 2395287 2395288 2395289 2395290 2395291 2395292 2395293 2395294 2395295 2395296 2395297 2395298 2395299 2395300 2396021 2396022 2396023 2396024 2396025 2396026 2396027 2396028 2396029 2396030 2396481 2396482 2396483 2396484 2396485 2396486 2396487 2396488 2396489 2396490 2396611 2396612 2396613 2396614 2396615 2396616 2396617 2396618 2396619 2396620 2396811 2396812 2396813 2396814 2396815 2396816 2396817 2396818 2396819 2396820 2396831 2396832 2396833 2396834 2396835 2396836 2396837 2396838 2396839 2396840 2396981 2396982 2396983 2396984 2396985 2396987 2396988 2396989 2396990 2397021 2397022 2397023 2397024 2397025 2397026 2397027 2397028 2397029 2397030 2397031 2397032 2397033 2397034 2397035 2397036 2397037 2397038 2397039 2397040 2397041 2397042 2397043 2397044 2397045 2397046 2397047 2397048 2397049 2397050 2397081 2397082 2397083 2397084 2397085 2397086 2397087 2397088 2397089 2397090 2397121 2397122 2397123 2397124 2397125 2397126 2397127 2397128 2397129 2397130 2397271 2397272 2397273 2397274 2397275 2397276 2397277 2397278 2397279 2397280 2397311 2397312 2397313 2397314 2397315 2397316 2397317 2397318 2397319 2397320 2879410 2879411 2879412 2879413 2879414 2879415 2879416 2879417 2879418 2879419 2879420 2879421 2879422 2879423 2879424 2879425 2879426 2879427 2879428 2879429 2886920 2886921 2886922 2886923 2886924 2886925 2886926 2886927 2886928 2886929 2886940 2886941 2886942 2886943 2886944 2886945 2886946 2886947 2886948 2886949 2886970 2886971 2886972 2886973 2886974 2886975 2886976 2886977 2886978 2886979 3021736 3021776 3021837 3024152 3024154 3030705 3031791 3031793;
2679850 2689160 2689162 2689164 2689167 2689370 2689377 2690296 2690298 2690302 2692920 2692925 2692931 2692932 2692933 2692934 2692935 2692936 2692937;
3043361 3043362 3043364 3043365 3043366 3043367 3043368 3043369 3043370 3043441 3043443 3043445 3043446 3043471 3043472 3043473 3043475 3043476 3043477 3043479 3026931 3026932 3026934 3026935 3026937 3026939 3027181 3027185 3027187 3027189 3027462 3027463 3032194 3032196 3032200 3034771 3034776 3034777 3034779 3034780 3034851 3034852 3034853 3034854 3034855 3034857 3034858 3034859 3034860 3035411 3035412 3035414 3035415 3035416 3035417 3035418 3035420 3035951 3035952 3035953 3035954 3035959;
2984056 2984062 2984064 2984065 2984067 2986825 2986827 2986829 2995321 2995322 2995323 2995324 2995325 2995326 2995327 2995328 2995329 2995330 2999692 2999693 2999694 2999695 2999696 2999697 2999698 2999699 2999700 2999924 2999925 2999926 2999927 2999928 2999929 2713387 2718732 2718736 2718737 2718738 2559751 2559752 2559753 2559754 2559755 2559756 2559757 2559758 2559759 2559760 2560031 2560032 2560033 2560034 2560035 2560036 2560037 2560038 2560039 2560040 2560271 2560272 2610521 2610522 2610523 2610524 2610525 2610526 2610527 2610528 2610529 2610530 2610541 2610542 2610543 2610544 2610545 2610546 2610547 2610548 2610549 2610550 2610581 2610582 2610583 2610584 2610585 2610586 2610601 2610602 2610603 2610604 2610605 2610606 2610607 2610608 2610609 2610610 2610611 2610612 2610613 2610614 2610615 2610616 2610617 2610618 2610619 2610620 2610761 2610762 2610763 2610764 2610765 2610766 2610767 2610768 2610769 2610770 2666740 2666741 2666742 2666743 2666744 2666745 2666746 2666747 2666748;
2956993 2956994;
2667541 2667542 2667543 2667548 2667981 2667983 2667984 2667985 2667987 2667988 2667989 2669552 2669553 2669554 2669556 2669559 2669633 2669636 2669639 2669640 2669965 2669967 2669968 2669969 2669981 2669983 2669985
RECALLING FIRM/MANUFACTURER
Regeneration Technologies, Inc., Alachua, FL, by letter on October 14, 2005. Firm initiated recall is ongoing.
REASON
The tissue was collected from donors for whom there is no verifiable identity or consent. The medical records and social histories of the donors cannot be ascertained. The devices which incorporate these donor bone tissues undergo processing, including sterilization, which has been validated to inactivate and/or remove all viral diseases for which human tissue donors are tested.
VOLUME OF PRODUCT IN COMMERCE
5,320
DISTRIBUTION
Nationwide and Internationally

END OF ENFORCEMENT REPORT FOR FEBRUARY 15, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00939.html


_______________________________
PRODUCT
Source Plasma, Recall # B-0584-6
CODE
Units VL53767, ZZ031076, ZZ030881, ZZ03046, VL151413, VL151144, VL50837
RECALLING FIRM/MANUFACTURER
BioLife Plasma Services LP, Shreveport, LA, by facsimile dated October 6, 2003. Firm initiated recall is complete.
REASON
Source Plasma, collected from a donor who was at increased risk for variant Creutzfeldt-Jakob Disease (vCJD), was distributed.
VOLUME OF PRODUCT IN COMMERCE
7 units
DISTRIBUTION
NC

END OF ENFORCEMENT REPORT FOR FEBRUARY 1, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00937.html


_______________________________
PRODUCT
Red Blood Cells, Recall # B-0552-6
CODE
Unit number: 4426304
RECALLING FIRM/MANUFACTURER
Florida's Blood Center, Inc., St. Petersburg, FL, by facsimile on July 8, 2005. Firm initiated recall is complete.
REASON
Blood product, collected from a donor who may have been at increased risk for new variant Creutzfeldt-Jakob Disease (nvCJD), was distributed.
VOLUME OF PRODUCT IN COMMERCE
1 unit
DISTRIBUTION
FL

END OF ENFORCEMENT REPORT FOR JANUARY 25, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00936.html


RECALLS AND FIELD CORRECTIONS: BIOLOGICS -- CLASS I

_______________________________
PRODUCT
Human Tissue for Transplantation, Recall # B-0322-6
a) Alloquent CC Allograft (8, 9 & 10 mm);
b) Achilles Tendon;
c) Cancellous Bone 4-10 mm (15 & 30 cc);
d) Patella Tendon-Hemi;
e) Iliac Crest Wedge (14-17mm, 11-13mm,
<10mm, and 18+mm);
f) Tibialis Tendon
CODE
a) Code: BS30-4008, BS30-4009, BS30-4010;
b) Code: LATM;
c) Code: LCISM & LCIPM;
d) Code: LTTM;
e) Code: LIWXLM, LIWLM, LIWMM, LIWSM;
f) Code: LTTM
RECALLING FIRM/MANUFACTURER
Recalling Firm: Lost Mountain Tissue Bank, Kennesaw, GA, by letters dated October 12, and October 21, 2005.
Manufacturer: Biomedical Tissue Services, Ltd., Fort Lee, NJ. Firm initiated recall is ongoing.
REASON
Human tissues, procured from donors without adequate donor eligibility determinations, were distributed.
VOLUME OF PRODUCT IN COMMERCE
283 tissues
DISTRIBUTION
Nationwide and Turkey

_______________________________
PRODUCT
PUROS Allograft Bone;
Suspend Tutoplast Processed Fascia Lata,
Recall # B-0375-6
CODE
a) U00000000045293 U00000000045294 U00000000045295 U00000000045296 U00000000045297 U00000000045298 U00000000045299 U00000000045300 U00000000045301 U00000000045302 U00000000045303 U00000000045368 U00000000045369 U00000000045370 U00000000045371 U00000000045372 U00000000045373 U00000000045374 U00000000045375 U00000000045425 U00000000045426 U00000000045427 U00000000045428 U00000000045429 U00000000045430 U00000000045532 U00000000045533 U00000000045534 U00000000045535 U00000000045536 U00000000045537 U00000000045618 U00000000045619 U00000000045620 U00000000045621 U00000000045622 U00000000045623 U00000000045624 U00000000045625 U00000000045626 U00000000045627 U00000000045628 U00000000045629 U00000000045630 U00000000045680 U00000000045681 U00000000045682 U00000000045683 U00000000045684 U00000000045685 U00000000045686 U00000000045821 U00000000045822 U00000000045823 U00000000045846 U00000000045847 U00000000045848 U00000000045849 U00000000045850 U00000000045851 U00000000045852 U00000000045853 U00000000045854 U00000000045855 U00000000045895 U00000000045896 U00000000045897 U00000000045898 U00000000045899 U00000000045900 U00000000045901 U00000000045902 U00000000045903 U00000000045904 U00000000045905 U00000000045931 U00000000045932 U00000000045933 U00000000045934 U00000000045935 U00000000045936 U00000000045937 U00000000045938 U00000000045939 U00000000045945 U00000000045946 U00000000045947 U00000000045948 U00000000045949 U00000000045950 U00000000045951 U00000000045952 U00000000045962 U00000000045963 U00000000045964 U00000000045965 U00000000045966 U00000000045967 U00000000045968 U00000000014542 U00000000014210 U00000000014211 U00000000014212 U00000000014213 U00000000014214 U00000000014215 U00000000014216 U00000000014217 U00000000014218 U00000000014219 U00000000014220 U00000000014221 U00000000014222 U00000000014223 U00000000014224 U00000000014225 U00000000014226 U00000000014227 U00000000014228 U00000000014229 U00000000014230 U00000000014231 U00000000014232 U00000000014233 U00000000014234 U00000000014235 U00000000014236 U00000000014237 U00000000014238 U00000000014239 U00000000014240 U00000000014241 U00000000014242 U00000000014243 U00000000014294 U00000000014295 U00000000014296 U00000000014297 U00000000014298 U00000000014299 U00000000014300 U00000000014301 U00000000014302 U00000000014303 U00000000014304 U00000000014305 U00000000014306 U00000000014307 U00000000014308 U00000000014309 U00000000014310 U00000000014311 U00000000014312 U00000000014313 U00000000014314 U00000000014315 U00000000014316 U00000000014317 U00000000014318 U00000000014319 U00000000014320 U00000000014321 U00000000014322 U00000000014323 U00000000014324 U00000000014325 U00000000014326 U00000000014327 U00000000014328 U00000000014329 U00000000014330 U00000000014331 U00000000014332 U00000000014333 U00000000014334 U00000000014335 U00000000014336 U00000000014337 U00000000014338 U00000000014339 U00000000014340 U00000000014341 U00000000014342 U00000000014343 U00000000014344 U00000000014345 U00000000014346 U00000000014347 U00000000014348 U00000000014349 U00000000014350 U00000000014351 U00000000014352 U00000000014354 U00000000014355 U00000000014356 U00000000014357 U00000000014358 U00000000014359 U00000000014360 U00000000014361 U00000000014362 U00000000014363 U00000000014364 U00000000014365 U00000000014366 U00000000014367 U00000000014368 U00000000014369 U00000000014370 U00000000014371 U00000000014372 U00000000014373 U00000000014374 U00000000014375 U00000000014376 U00000000014377 U00000000014378 U00000000014379 U00000000014380 U00000000014381 U00000000014382 U00000000014383 U00000000014384 U00000000014385 U00000000014386 U00000000014387 U00000000014388 U00000000014389 U00000000014390 U00000000014391 U00000000014392 U00000000014393 U00000000014394 U00000000014395 U00000000014396 U00000000014397 U00000000014398 U00000000014399 U00000000014400 U00000000014401 U00000000014402 U00000000014403 U00000000014404 U00000000014405 U00000000014406 U00000000014407 U00000000014408 U00000000014409 U00000000014410 U00000000014411 U00000000014412 U00000000014413 U00000000014414 U00000000014415 U00000000014416 U00000000014417 U00000000014418 U00000000014419 U00000000014420 U00000000014421 U00000000014422 U00000000014423 U00000000014424 U00000000014425 U00000000014426 U00000000014427 U00000000014428 U00000000014429 U00000000014430 U00000000014431 U00000000014432 U00000000014433 U00000000014434 U00000000014435 U00000000014436 U00000000014437 U00000000014438 U00000000014439 U00000000014440 U00000000014441 U00000000014442 U00000000014443 U00000000014444 U00000000014445 U00000000014446 U00000000014447 U00000000014448 U00000000014449 U00000000014450 U00000000014451 U00000000014452 U00000000014453 U00000000014454 U00000000014460 U00000000014461 U00000000014462 U00000000014463 U00000000014464 U00000000014465 U00000000014466 U00000000014467 U00000000014468 U00000000014469 U00000000014470 U00000000014471 U00000000014472 U00000000014473 U00000000014474 U00000000014475 U00000000014477 U00000000014478 U00000000014479 U00000000014480 U00000000014481 U00000000014482 U00000000014483 U00000000014484 U00000000014485 U00000000014486 U00000000014487 U00000000014488 U00000000014489 U00000000014490 U00000000014491 U00000000014492 U00000000014493 U00000000014494 U00000000014495 U00000000014496 U00000000014497 U00000000014498 U00000000014499 U00000000014500 U00000000014501 U00000000014502 U00000000014503 U00000000014504 U00000000014505 U00000000014506 U00000000014507 U00000000014508 U00000000014509 U00000000014510 U00000000014511 U00000000014512 U00000000014513 U00000000014514 U00000000014515 U00000000014516 U00000000014517 U00000000014518 U00000000014519 U00000000014520 U00000000014521 U00000000014522 U00000000014523 U00000000014524 U00000000014525 U00000000014526 U00000000014527 U00000000014528 U00000000014529 U00000000014530 U00000000014531 U00000000014532 U00000000014533 U00000000014534 U00000000014535 U00000000014536 U00000000014537 U00000000014538 U00000000014539 U00000000014540 U00000000014541 U00000000014543 U00000000014544 U00000000014545 U00000000014546 U00000000014547 U00000000018019 U00000000042694 U00000000042695 U00000000042696 U00000000042697 U00000000042698 U00000000042699 U00000000042700 U00000000042701 U00000000042703 U00000000042704 U00000000042705 U00000000042706 U00000000042707 U00000000042708 U00000000042709 U00000000042710 U00000000042711 U00000000042712 U00000000042713 U00000000042714 U00000000042715 U00000000042716 U00000000042717 U00000000042718 U00000000042719 U00000000042720 U00000000042721 U00000000042722 U00000000042723 U00000000042724 U00000000042725 U00000000042726 U00000000042834 U00000000042835 U00000000042836 U00000000042838 U00000000042839 U00000000042840 U00000000042841 U00000000042842 U00000000042843 U00000000042844 U00000000042845 U00000000042893 U00000000042894 U00000000042895 U00000000042896 U00000000042897 U00000000042898 U00000000042899 U00000000042900 U00000000042901 U00000000042902 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b) BM03L11421A012031504 BM03L11821A012031504 BM04A11421A012041204 BM03K10421A017031504 BM03K10421B017031504 BM03K10421C017031504 BM03L11221A017020904 BM03L11421A017031504 BM03L11421B017031504 BM03L12121A017031504 BM03L12221A017031504 BM04B10421A017051704 BM03K10421A018031504 BM03K10421B018031504 BM03K11021A018031504 BM03K11021B018031504 BM03K11021C018031504 BM03K11021D018031504 BM03L10421A018020904 BM03L10421B018020904 BM03L11621A018031504 BM03L11621B018031504 BM03L12121A018031504 BM03L12221A018031504 BM04A11221A018041204 BM04A11321A018041204 BM04B10421A018051704 BM03L11521A023020904 BM03L11521B023020904 BM03L11521D023020904 BM03L11821A024031504 BM03L12321A024031504 BM04A11221A024041204 BM03K10421A045031504 BM03K12121A045020904 BM03L10421A045020904 BM03L10621A045020904 BM03L11621A045031504 BM03L11621B045031504 BM03L12121A045031504 BM03J11421A048011904 BM03J11421B048011904 BM03K12121A048020904 BM03L10621A048020904 BM03L10621B048020904 BM03L11221A048020904 BM03L11521A048020904 BM03L11521B048020904
RECALLING FIRM/MANUFACTURER
Recalling Firm: Tutogen Medical, Inc., Alachua, FL, by telephone, facsimile and letter on October 14, 2005 and by letter dated October 24, 2005.
Responsible Firm: Biomedical Tissue Services, Ltd., Fort Lee, NJ. Firm initiated recall is ongoing.
REASON
Human Tissues, procured from donors without adequate donor eligibility determinations, were distributed.
VOLUME OF PRODUCT IN COMMERCE
a) 5,676 allografts;
b) 48 allografts
DISTRIBUTION
Nationwide, and Canada


_______________________________
PRODUCT
a) Red Blood Cells, Leukocytes
Reduced, Recall # B-0492-6;
b) Recovered Plasma, Recall # B-0497-6
CODE
a) and b) Unit number: 4101212
RECALLING FIRM/MANUFACTURER
Northwest Florida Blood Center, Inc., Pensacola, FL, by telephone and facsimile on March 7, 2003. Firm initiated recall is complete.
REASON
Blood products, collected from an unsuitable donor due to a history of travel to an area considered at increased risk of exposure to variant Creutzfeldt-Jakob Disease (nvCJD), were distributed.
VOLUME OF PRODUCT IN COMMERCE
2 units
DISTRIBUTION
FL

_______________________________

END OF ENFORCEMENT REPORT FOR JANUARY 18, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00935.html


PRODUCT
Source Plasma, Recall # B-0391-6
CODE
Unit number: 7030260750
RECALLING FIRM/MANUFACTURER
ZLB Bioplasma, Inc., San Antonio, TX, by facsimile and telephone on September 29, 2003. Firm initiated recall is complete.
REASON
Blood product, which was collected from a donor who was deferred due to risk factors associated with variant Creutzfeldt-Jakob disease (vCJD) travel, was distributed.
VOLUME OF PRODUCT IN COMMERCE
1 unit
DISTRIBUTION
FL

_______________________________

______________________________
PRODUCT
a) Red Blood Cells, Leukocytes Reduced
Recall # B-0456-6;
b) Recovered Plasma, Recall # B-0457-6
CODE
a) Unit number: 06FR39967;
b) Unit numbers: 06FR37676, 06FR39967
RECALLING FIRM/MANUFACTURER
American National Red Cross, Southern California Region, Pomona, California, by telephone on June 2, 2002, and by letter dated, June 20, 2002, and by facsimile transmission dated June 19, 2002. Firm initiated recall is complete.
REASON
Blood products, collected from a donor who was at increased risk of variant Creutzfeldt-Jakob Disease (vCJD), were distributed.
VOLUME OF PRODUCT IN COMMERCE
3 units
DISTRIBUTION
CA and Switzerland

_______________________________

END OF ENFORCEMENT REPORT FOR JANUARY 4, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00933.html


TSS
----- Original Message -----
From: "Terry S. Singeltary Sr."
To:
Sent: Monday, March 27, 2006 8:51 AM
Subject: Predicting susceptibility and incubation time of human-to-human transmission of vCJD


##################### Bovine Spongiform Encephalopathy #####################

Subject: Predicting susceptibility and incubation time of human-to-human transmission of vCJD
Date: March 27, 2006 at 6:24 am PST
Lancet Neurology DOI:10.1016/S1474-4422(06)70413-6

Predicting susceptibility and incubation time of human-to-human transmission of vCJD
MT Bishop a, P Hart b, L Aitchison b, HN Baybutt b, C Plinston b, V Thomson b, NL Tuzi b, MW Head a, JW Ironside a, RG Will a and JC Manson b

Summary
Background
Identification of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion has caused concern over spread of the disease within the human population. We aimed to model iatrogenic spread to enable a comparison of transmission efficiencies of vCJD and bovine spongiform encephalopathy (BSE) and an assessment of the effect of the codon-129 polymorphism on human susceptibility.

Methods
Mice were produced to express human or bovine prion protein (PrP) by direct replacement of the mouse PrP gene. Since the human PrP gene has variation at codon 129, with MM, VV, and MV genotypes, three inbred lines with an identical genetic background were produced to express human PrP with the codon-129 MM, MV, and VV genotypes. Mice were inoculated with BSE or vCJD and assessed for clinical and pathological signs of disease.

Findings
BSE was transmitted to the bovine line but did not transmit to the human lines. By contrast, vCJD was transmitted to all three human lines with different pathological characteristics for each genotype and a gradation of transmission efficiency from MM to MV to VV.

Interpretation
Transmission of BSE to human beings is probably restricted by the presence of a significant species barrier. However, there seems to be a substantially reduced barrier for human-to-human transmission of vCJD. Moreover, all individuals, irrespective of codon-129 genotype, could be susceptible to secondary transmission of vCJD through routes such as blood transfusion. A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public-health issue.

Affiliations

a. National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
b. Institute for Animal Health, Neuropathogenesis Unit, King's Buildings, Edinburgh, UK

Correspondence to: Prof J C Manson, Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, King's Buildings, West Mains Road, Edinburgh EH9 3JF, UK


http://www.thelancet.com/journals/laneur/article/PIIS1474442206704136/abstract?isEOP=true


27 March 2006
Of mice and men... and vCJD
Destination Journal: The Lancet Neurology

Variant Creutzfeldt-Jakob Disease (vCJD) has become a serious public-health concern in Europe, especially in the UK, since it was first described in 1996. This new prion disease in human beings, acquired by ingestion of food contaminated by the bovine spongiform encephalopathy (BSE) agent, has raised new questions not only about food safety, but also about the possibility that human prion diseases could be transmitted from human to human. .....

http://www.thelancet.com/journals/laneur/article/PIIS1474442206704148/fulltext?isEOP=true

Scientists warn of high rate of vCJD infection

Polly Curtis, health correspondent
Monday March 27, 2006
The Guardian


A "significant level" of the population could be unknowingly infected with variant CJD, according to scientists whose study reveals the disease to be more easily transmitted than previously thought.
The debate about the number of people infected by vCJD - the human form of BSE - has ranged from estimates of a few hundred to hundreds of thousands.

Some people are understood to be more genetically susceptible to the disease but the study published today by Lancet Neurology shows that mice with all variations of the gene involved were susceptible to different degrees to vCJD passed on through infected blood transfusions.


The paper concludes: "All individuals ... could be susceptible to secondary transmission of vCJD through routes such as blood transfusion. A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public health issue."
The study confirms that the likelihood of transmission from animal to human via infected meat is low, but suggests human to human transmission through infected blood products and surgical equipment is more likely than previously thought.

The National CJD Surveillance Unit and the Institute for Animal Health in Edinburgh said there had been 161 reported cases of vCJD in the UK.

The degenerative brain disease causes progressive dementia, and is in most cases fatal. The incubation period is believed to be up to 15 years.

It is believed that the number of infections through infected meat has been reduced dramatically since safety measures were introduced in the 1990s.

But scientists fear a second wave of cases could be on the way, from people accidentally infected through contaminated surgical instruments or blood transfusion.

The government is considering ways of screening people during postmortems to see whether they are carriers in an effort to see how much hidden vCJD there is.


http://www.guardian.co.uk/bse/article/0,,1740397,00.html

Scots team finds dormant CJD could emerge to claim many more lives
LOUISE GRAY
New study claims vCJD may lie dormant without symptoms
Disease may also be contracted by blood transfusion
Fears that underlying vCJD may lead to second wave of deaths
Key quote
"You cannot rule out the possibility there may be some effect of BSE on people who have so far shown no effect" - PROF HUGH PENNINGTON

Story in full FAR more people could be at risk of contracting the human form of mad cow disease than previously thought after new evidence emerged that the condition could lie dormant for years before developing.

A long incubation period for the disease, together with an ability to pass it on through blood transfusions and surgical instruments, has the potential to create a "significant public health issue", scientists from Edinburgh said.

Through studies on mice, they concluded that variant Creutzfeldt Jakob Disease (vCJD) could lie in the body for many years without showing any symptoms.

Due to long incubation times for the disease, a "significant level" of underlying vCJD may already be present in the population, they said.

The number of deaths from vCJD rose steadily from 1995 to a peak of 28 in 2000, since when fatalities have fallen, leading many to conclude the worst had passed.

But the latest research suggests a second peak is still to come and the disease could claim many more lives.

The disease, believed to be passed from cattle to humans through eating meat infected with BSE during the 1980s and 90s, has killed 154 people in Britain to date, according to the vCJD Surveillance Unit at the Western General Hospital. Six people are still fighting the disease.

Until now, those who have died from the disease have been of a particular gene type - the MM genotype.

However, through studies on mice, scientists at the Institute for Animal Health in Edinburgh concluded that variant vCJD could also be found in other genotypes but lie in the body for many years without showing any symptoms.

This means a "significant level" of underlying vCJD may already be present in the population without knowledge.

The experts also found that vCJD could be passed from human to human through secondary transmission - such as blood transfusions and contaminated surgical equipment - in all genotypes.

The study, published on-line today by The Lancet Neurology, said the fact people may not know they are carrying the disease in its dormant form means it could be spread through blood transfusion to which all genotypes are susceptible.

"All individuals... could be susceptible to secondary transmission of vCJD through routes such as blood transfusion," the scientists warn in the study. A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public health issue."

Last November, about 50 people who received blood transfusions were warned they may have been exposed to vCJD.

In July, a similar warning was issued to about 100 blood donors whose blood was given to three people who later developed the disease.

Professor Hugh Pennington, the president of the Society of General Microbiology, said there could be a second wave of fatalities if more genotypes are affected but not yet coming down with symptoms. "You cannot rule out the possibility there may be some effect of BSE on people who have so far shown no effect," he said.

But, people with longer incubation periods are likely to be less susceptible to the disease and Prof Pennington thought a second wave would have begun to show.

More likely is the risk of unknowingly transmitting the infection. This would increase the risk to the population as a whole, but it is impossible to say how many people would die as a result.

"I do not think anybody could put a figure on it," said Prof Pennington.

Graham Steel, co-founder of the vCJD Alliance, whose brother died of the disease, said it was "not welcome news".

"This [is] certainly a 'warning sign' that should be taken with utmost seriousness," he said.

Marc Leighton Turner, a clinical director for the Scottish National Blood Transfusion Service, said the findings were of concern. "It may well be that people of all types of gene type have been infected but it is predominantly the MM gene type who have died of the disease, which suggests there may be a significant number of people in the general population who have been infected but who do not have the disease and indeed may never have the disease. This is a concern for us in the blood transfusion service and surgeons as they may be a source of secondary transmission."

Delusions, loss of mobility, and a young life cut short by this terrible illness
DONNA McIntyre was a successful young woman when signs of the human form of mad cow disease began to emerge.

Two months before her 21st birthday, the receptionist disappeared from her flat in Aberdeen. When she resurfaced, she was clearly ill. She had been living on the streets and had become delusional.

Donna was a meat-eater and liked her burgers and pies but her family never expected this to cause such a terrible illness. Over the next few months Donna lost her speech and mobility.

She died of vCJD aged 22, 12 months after she was diagnosed with the illness, in August 2001.

Malcolm Savidge, the former Labour MP for Aberdeen North who supported Donna's family through that difficult time, said it was always unclear whether it would be "hundreds or hundreds of thousands" affected by BSE-infected meat.

After the recent fall in deaths he was hopeful it would remain low, but the new research has led to fresh uncertainty.

"We have to be aware of the possibility that there may be still be a further terrible toll taken. But we must hope that is not going to be the case," he said.


http://news.scotsman.com/index.cfm?id=470922006


TSS

#################### https://lists.aegee.org/bse-l.html ####################




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