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From: TSS ()
Subject: SCRAPIE STRAINS IN GOATS LAST 3 YEARS UK
Date: March 22, 2006 at 6:36 am PST


Scrapie
The Countess of Mar asked Her Majesty's Government:

Which strains of scrapie were found in goats in the United Kingdom in the past three years. [HL4604]

The Parliamentary Under-Secretary of State, Department for Environment, Food and Rural Affairs (Lord Bach): In the past three years, six cases of classical scrapie have been detected in goats in the UK.

Strain typing of transmissible spongiform encephalopathies (TSEs) involves mouse bioassay, a costly process which can take up to four years and is therefore not routinely applied to all samples.

However, all sheep and goat TSE positive cases are tested by molecular methods that are capable of differentiating between classical scrapie, atypical scrapie and experimental BSE. Cases where the presence of BSE is ruled out and which are confirmed as classical or atypical scrapie are not routinely subjected to mouse bioassay. If the presence of BSE cannot be excluded, the sample is subjected to mouse bioassay.

In each of the six cases of TSE detected in goats in the past three years, both BSE and atypical scrapie have been ruled out; they have all been confirmed as classical scrapie.

http://www.publications.parliament.uk/pa/ld199697/ldhansrd/pdvn/lds06/text/60321w07.htm#60321w07_sbhd4

12/10/76
AGRICULTURAL RESEARCH COUNCIL
REPORT OF THE ADVISORY COMMITTE ON SCRAPIE
Office Note
CHAIRMAN: PROFESSOR PETER WILDY

snip...

A The Present Position with respect to Scrapie
A] The Problem

Scrapie is a natural disease of sheep and goats. It is a slow
and inexorably progressive degenerative disorder of the nervous system
and it ia fatal. It is enzootic in the United Kingdom but not in all
countries.

The field problem has been reviewed by a MAFF working group
(ARC 35/77). It is difficult to assess the incidence in Britain for
a variety of reasons but the disease causes serious financial loss;
it is estimated that it cost Swaledale breeders alone $l.7 M during
the five years 1971-1975. A further inestimable loss arises from the
closure of certain export markets, in particular those of the United
States, to British sheep.

It is clear that scrapie in sheep is important commercially and
for that reason alone effective measures to control it should be
devised as quickly as possible.

Recently the question has again been brought up as to whether
scrapie is transmissible to man. This has followed reports that the
disease has been transmitted to primates. One particularly lurid
speculation (Gajdusek 1977) conjectures that the agents of scrapie,
kuru, Creutzfeldt-Jakob disease and transmissible encephalopathy of
mink are varieties of a single "virus". The U.S. Department of
Agriculture concluded that it could "no longer justify or permit
scrapie-blood line and scrapie-exposed sheep and goats to be processed
for human or animal food at slaughter or rendering plants" (ARC 84/77)"
The problem is emphasised by the finding that some strains of scrapie
produce lesions identical to the once which characterise the human
dementias"

Whether true or not. the hypothesis that these agents might be
transmissible to man raises two considerations. First, the safety
of laboratory personnel requires prompt attention. Second, action
such as the "scorched meat" policy of USDA makes the solution of the
acrapie problem urgent if the sheep industry is not to suffer
grievously.

snip...

76/10.12/4.6


http://www.bseinquiry.gov.uk/files/yb/1976/10/12004001.pdf

Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to
nonhuman primates.

Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC.

Kuru and Creutzfeldt-Jakob disease of humans and scrapie disease of
sheep and goats were transmitted to squirrel monkeys (Saimiri sciureus) that
were exposed to the infectious agents only by their nonforced consumption of
known infectious tissues. The asymptomatic incubation period in the one
monkey exposed to the virus of kuru was 36 months; that in the two monkeys
exposed to the virus of Creutzfeldt-Jakob disease was 23 and 27 months,
respectively; and that in the two monkeys exposed to the virus of scrapie
was 25 and 32 months, respectively. Careful physical examination of the
buccal cavities of all of the monkeys failed to reveal signs or oral
lesions. One additional monkey similarly exposed to kuru has remained
asymptomatic during the 39 months that it has been under observation.


PMID: 6997404

http://www.ncbi.nlm.nih.gov/entrez/query.fcgicmd=Retrieve&db=PubMed&list_uids=6997404&dopt=Abstract


TSS






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