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From: TSS ()
Subject: BSE agent in spleen from an ARR/ARR orally exposed sheep
Date: March 12, 2006 at 6:30 am PST

Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep
Olivier Andréoletti1, Nathalie Morel2, Caroline Lacroux1, Virginie Rouillon1, Céline Barc3, Guillaume Tabouret1, Pierre Sarradin3, Patricia Berthon3, Philippe Bernardet3, Jacinthe Mathey1, Séverine Lugan1, Pierrette Costes1, Fabien Corbière1, Juan-Carlos Espinosa4, Juan Maria Torres4, Jacques Grassi2, François Schelcher1 and Frédéric Lantier3

1 UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France
2 CEA, Service de Pharmacologie et d'Immunologie, CEA/Saclay, 91191 Gif sur Yvette cedex, France
3 INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France
4 CISA, Instituto National de Investigacion y Tecnologia Agraria y Alimentaria, 28130 Valdeolmos, Spain

Olivier Andréoletti

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen.


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