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From: TSS ()
Subject: Re: CJD/GSS/BSE/CWD/SCRAPIE aka MAD COW DISEASE and Alzheimer's, another cover-up ???
Date: February 15, 2006 at 5:28 pm PST

In Reply to: Re: CJD/GSS/BSE/CWD/SCRAPIE aka MAD COW DISEASE and Alzheimer's, another cover-up ??? posted by TSS on February 15, 2006 at 8:02 am:

Wed Feb 15, 2006 19:46
70.110.87.43


doi:10.1016/j.tibs.2006.01.002
Copyright © 2006 Elsevier Ltd All rights reserved.
Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

Claudio Sotoa, b, , Lisbell Estradaa and Joaquín Castillaa

aGeorge and Cynthia Mitchell Center for Alzheimer's disease and related Neurodegenerative Disorders, Departments of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
bNeuroscience and Cell Biology and Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA

Available online 13 February 2006.


Misfolded aggregates present in amyloid fibrils are associated with various diseases known as ‘protein misfolding’ disorders. Among them, prion diseases are unique in that the pathology can be transmitted by an infectious process involving an unprecedented agent known as a ‘prion’. Prions are infectious proteins that can transmit biological information by propagating protein misfolding and aggregation. The molecular mechanism of prion conversion has a striking resemblance to the process of amyloid formation, suggesting that misfolded aggregates have an inherent ability to be transmissible. Intriguing recent data suggest that other protein misfolding disorders might also be transmitted by a prion-like infectious process.

http://www.sciencedirect.com/

TSS



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